Vasilena Gocheva

Vasilena Gocheva

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Vasilena Gocheva

Vasilena Gocheva

Publications by authors named "Vasilena Gocheva"

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20Publications

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Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.

Cancer Metab 2018 31;6. Epub 2018 May 31.

1David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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https://cancerandmetabolism.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40170-018-0179-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977456PMC
May 2018

Legumain is activated in macrophages during pancreatitis.

Am J Physiol Gastrointest Liver Physiol 2016 09 11;311(3):G548-60. Epub 2016 Aug 11.

Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia; and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia.

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http://www.physiology.org/doi/10.1152/ajpgi.00047.2016
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http://dx.doi.org/10.1152/ajpgi.00047.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075999PMC
September 2016

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers.

Nat Commun 2016 09 2;7:12685. Epub 2016 Sep 2.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue 75-453, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/ncomms12685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025814PMC
September 2016

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.

Cell Rep 2016 08 28;16(6):1762-1773. Epub 2016 Jul 28.

Centre for Blood Research, Life Sciences Institute and Faculty of Dentistry, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.086DOI Listing
August 2016

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Genes Dev 2016 05 28;30(9):1020-33. Epub 2016 Apr 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.278549.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863734PMC
May 2016

Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development.

Cancer Discov 2016 Feb 19;6(2):188-201. Epub 2015 Nov 19.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/content/early/2016/0
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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-15-0854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744583PMC
February 2016

Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.

Genes Dev 2016 Jan;30(2):220-32

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA; Department of Oncology, University of Lausanne, CH-1066, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, CH-1066, Lausanne, Switzerland.

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http://dx.doi.org/10.1101/gad.270439.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719311PMC
January 2016

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.

Genes Dev 2015 Sep;29(17):1850-62

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.267393.115
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http://dx.doi.org/10.1101/gad.267393.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573857PMC
September 2015

Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells.

Mol Cell Proteomics 2015 Aug 16;14(8):2213-28. Epub 2015 Jun 16.

From the ‡Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia; ‡‡Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins, Jamova cesta 39, SI-1000 Ljubljana, Slovenia;

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http://dx.doi.org/10.1074/mcp.M114.044628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528248PMC
August 2015

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion.

Genes Dev 2010 Feb 15;24(3):241-55. Epub 2010 Jan 15.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1874010
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http://dx.doi.org/10.1101/gad.1874010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811826PMC
February 2010

Distinct subcellular distribution of cyclin dependent kinase 6.

Cell Cycle 2009 Sep 14;8(17):2837-43. Epub 2009 Sep 14.

Department of Biology, Connecticut College, New London, CT 06371, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774137PMC
http://dx.doi.org/10.4161/cc.8.17.9521DOI Listing
September 2009

Cysteine cathepsins and the cutting edge of cancer invasion.

Cell Cycle 2007 Jan 6;6(1):60-4. Epub 2007 Jan 6.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.4161/cc.6.1.3669DOI Listing
January 2007

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.

Genes Dev 2006 Mar 15;20(5):543-56. Epub 2006 Feb 15.

Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1101/gad.1407406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410800PMC
March 2006