Varman T Samuel

Varman T Samuel

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Varman T Samuel

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Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-Hydroxysteroid dehydrogenase type 1 transgenic mice.

Metabolism 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00260495183025
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http://dx.doi.org/10.1016/j.metabol.2018.12.003DOI Listing
December 2018

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases.

Cell Metab 2018 Jan 31;27(1):22-41. Epub 2017 Aug 31.

Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762395PMC
January 2018

The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis.

Trends Endocrinol Metab 2016 10 4;27(10):719-730. Epub 2016 Jul 4.

Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA; Veterans Affairs Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA. Electronic address:

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http://www.cell.com/trends/endocrinology-metabolism/pdf/S104
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http://dx.doi.org/10.1016/j.tem.2016.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035631PMC
October 2016

3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats.

PLoS One 2015 20;10(10):e0140837. Epub 2015 Oct 20.

Department of Internal Medicine,Yale University School of Medicine, New Haven, CT, United States of America; West Haven VAMC, West Haven, CT, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140837PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618341PMC
June 2016

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.

Proc Natl Acad Sci U S A 2016 06 31;113(24):E3423-30. Epub 2016 May 31.

Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510;

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http://dx.doi.org/10.1073/pnas.1606022113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914193PMC
June 2016

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.

FASEB J 2016 Mar 7;30(3):1207-17. Epub 2015 Dec 7.

*Department of Internal Medicine, Department of Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA; West Haven Veterans Affairs Medical Center, West Haven, Connecticut, USA; and ISIS Pharmaceuticals, Carlsbad, California, USA

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http://dx.doi.org/10.1096/fj.15-271999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750414PMC
March 2016

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21.

J Endocrinol 2015 Sep 22;226(3):207-17. Epub 2015 Jul 22.

Department of Internal MedicineHoward Hughes Medical InstituteYale University School of Medicine, New Haven, Connecticut 06536, USAService of EndocrinologyDiabetes and Metabolism, Lausanne University Hospital, Rue du Bugnon 46, 1011 Lausanne CHUV, Switzerland Department of Internal MedicineHoward Hughes Medical InstituteYale University School of Medicine, New Haven, Connecticut 06536, USAService of EndocrinologyDiabetes and Metabolism, Lausanne University Hospital, Rue du Bugnon 46, 1011 Lausanne CHUV, Switzerland

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http://dx.doi.org/10.1530/JOE-15-0136DOI Listing
September 2015

Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice.

J Nutr Biochem 2015 Jul 13;26(7):721-8. Epub 2015 Mar 13.

Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2015.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461460PMC
July 2015

Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle.

J Biol Chem 2015 Jun 5;290(23):14454-61. Epub 2015 May 5.

From the Section of Endocrinology and Metabolism, Department of Internal Medicine, and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8020,

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http://dx.doi.org/10.1074/jbc.C115.639203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505512PMC
June 2015

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.

J Lipid Res 2015 Mar 29;56(3):526-36. Epub 2014 Dec 29.

Departments of Internal Medicine Yale University School of Medicine, New Haven, CT Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT.

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http://www.jlr.org/content/56/3/526.full.pdf
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http://www.jlr.org/lookup/doi/10.1194/jlr.M054080
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http://dx.doi.org/10.1194/jlr.M054080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340301PMC
March 2015

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

Proc Natl Acad Sci U S A 2015 Jan 6;112(4):1143-8. Epub 2015 Jan 6.

Departments of Internal Medicine and Cellular and Molecular Physiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536; and

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http://dx.doi.org/10.1073/pnas.1423952112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313795PMC
January 2015

The emerging role of oestrogen-related receptor γ as a regulator of energy metabolism.

Authors:
Varman T Samuel

Diabetologia 2014 Dec 26;57(12):2440-3. Epub 2014 Sep 26.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA,

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http://link.springer.com/10.1007/s00125-014-3377-7
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http://dx.doi.org/10.1007/s00125-014-3377-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488899PMC
December 2014

A high-protein diet for reducing body fat: mechanisms and possible caveats.

Nutr Metab (Lond) 2014 19;11(1):53. Epub 2014 Nov 19.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut USA ; Departments of Veterans Affairs Medical Center, West Haven, Connecticut USA.

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http://dx.doi.org/10.1186/1743-7075-11-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258944PMC
December 2014

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.

Nature 2014 Jun 21;510(7506):542-6. Epub 2014 May 21.

1] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA [2] Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA [3] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA [4] Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark, DK-2200.

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http://dx.doi.org/10.1038/nature13270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074244PMC
June 2014

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes.

Nature 2014 Jun;510(7503):84-91

1] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [2] Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmark. [3] Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. [4] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06535-8012, USA.

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http://dx.doi.org/10.1038/nature13478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489847PMC
June 2014

Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.

Endocrinology 2014 Apr 23;155(4):1373-85. Epub 2014 Jan 23.

Sections of Digestive Diseases (A.K.G., Y.I., P.P., C.C.); Endocrinology, Department of Medicine (A.L.B., V.T.S.), Yale University School of Medicine, New Haven, Connecticut 06520; Veterans Affairs Connecticut Healthcare System (P.P., V.T.S., C.C.), West Haven, Connecticut 06516; Department of Biomedical Engineering (S.J., M.S.), Yale University, New Haven, Connecticut 06511; Department of Pathology (S.E.C.), St Louis University School of Medicine, St Louis, Missouri 63104; and Department of Biomedical Sciences (J.D.), University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201.

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http://dx.doi.org/10.1210/en.2013-1785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393334PMC
April 2014

Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association.

J Clin Lipidol 2013 Jul-Aug;7(4):304-83. Epub 2013 May 31.

Louisville Metabolic and Atherosclerosis Research Center, 3288 Illinois Avenue, Louisville, KY 40213, USA.

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http://dx.doi.org/10.1016/j.jacl.2013.04.001DOI Listing
October 2013

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation.

Aging (Albany NY) 2013 Oct;5(10):770-81

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838779PMC
http://dx.doi.org/10.18632/aging.100611DOI Listing
October 2013

Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice.

Endocrinology 2013 Sep 13;154(9):3099-109. Epub 2013 Jun 13.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536-9812, USA.

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http://dx.doi.org/10.1210/en.2013-1191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749479PMC
September 2013

Hepatic glucose production pathways after three days of a high-fat diet.

Metabolism 2013 Jan 12;62(1):152-62. Epub 2012 Sep 12.

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.metabol.2012.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518721PMC
January 2013

Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes.

Dis Model Mech 2012 Sep 3;5(5):681-5. Epub 2012 Aug 3.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1242/dmm.009035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424465PMC
September 2012

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability.

Cell Metab 2012 Aug;16(2):226-37

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480732PMC
August 2012

Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.

Proc Natl Acad Sci U S A 2012 Jul 25;109(28):11402-7. Epub 2012 Jun 25.

Department of Pharmacology and Vascular Biology and Therapeutic Program, Yale School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1073/pnas.1205015109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396493PMC
July 2012

Mechanisms for insulin resistance: common threads and missing links.

Cell 2012 Mar;148(5):852-71

Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286741200217
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http://dx.doi.org/10.1016/j.cell.2012.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294420PMC
March 2012

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16381-5. Epub 2011 Sep 19.

Howard Hughes Medical Institute and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1073/pnas.1113359108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182681PMC
September 2011

Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.

Diabetes 2011 Apr 23;60(4):1168-76. Epub 2011 Feb 23.

Obesity and Metabolism Laboratory, JM-USDA Human Nutrition esearch Center on Aging, Tufts University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/db10-0715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064090PMC
April 2011

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2.

Proc Natl Acad Sci U S A 2011 Apr 21;108(14):5748-52. Epub 2011 Mar 21.

Departments of Internal Medicine and Cellular and Molecular Physiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA.

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http://dx.doi.org/10.1073/pnas.1103451108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078388PMC
April 2011

Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.

Diabetes 2011 Mar 24;60(3):700-9. Epub 2011 Jan 24.

Department of Medicine, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.2337/db10-1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046830PMC
March 2011

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.

Science 2011 Mar;331(6024):1621-4

Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/science.1198363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076083PMC
March 2011

Fructose induced lipogenesis: from sugar to fat to insulin resistance.

Authors:
Varman T Samuel

Trends Endocrinol Metab 2011 Feb 9;22(2):60-5. Epub 2010 Nov 9.

Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536-8012, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10432760100017
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http://dx.doi.org/10.1016/j.tem.2010.10.003DOI Listing
February 2011

Lipid-induced insulin resistance: unravelling the mechanism.

Lancet 2010 Jun;375(9733):2267-77

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536-8012, USA.

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http://dx.doi.org/10.1016/S0140-6736(10)60408-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995547PMC
June 2010

MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice.

J Clin Invest 2009 Dec 16;119(12):3817-29. Epub 2009 Nov 16.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1172/JCI39054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786792PMC
December 2009

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Proc Natl Acad Sci U S A 2008 Dec 9;105(50):19926-31. Epub 2008 Dec 9.

Departments of Internal Medicine and Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1073/pnas.0810339105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2598730PMC
December 2008

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.

J Clin Invest 2007 Mar 22;117(3):739-45. Epub 2007 Feb 22.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.

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http://dx.doi.org/10.1172/JCI30400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797607PMC
March 2007

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

J Biol Chem 2004 Jul 27;279(31):32345-53. Epub 2004 May 27.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1074/jbc.M313478200DOI Listing
July 2004