Publications Authored by Vania Broccoli

Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging.

Authors:

Anna Cozzi Daniel I Orellana Paolo Santambrogio Alicia Rubio Cinzia Cancellieri Serena Giannelli Maddalena Ripamonti Stefano Taverna Giulia Di Lullo Ermanna Rovida Maurizio Ferrari Gian Luca Forni Chiara Fiorillo Vania Broccoli Sonia Levi

Stem Cell Reports 2019 Nov 3;13(5):832-846. Epub 2019 Oct 3.

Proteomic of Iron Metabolism Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.09.002	DOI Listing

November 2019

SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.

Authors:

Alessandro Sessa Luca Fagnocchi Giuseppina Mastrototaro Luca Massimino Mattia Zaghi Marzia Indrigo Stefano Cattaneo Davide Martini Chiara Gabellini Cecilia Pucci Alessandra Fasciani Romina Belli Stefano Taverna Massimiliano Andreazzoli Alessio Zippo Vania Broccoli

Neuron 2019 Oct 9;104(2):271-289.e13. Epub 2019 Sep 9.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; CNR Institute of Neuroscience, 20129 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.07.013	DOI Listing

October 2019

TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.

Authors:

Edoardo Moretto Anna Longatti Luca Murru Ingrid Chamma Alessandro Sessa Jonathan Zapata Eric Hosy Matthieu Sainlos Julien Saint-Pol Eric Rubinstein Daniel Choquet Vania Broccoli Giampietro Schiavo Olivier Thoumine Maria Passafaro

Cell Rep 2019 Oct;29(5):1130-1146.e8

CNR, Institute of Neuroscience, Milan 20129, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.051	DOI Listing

October 2019

dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice.

Authors:

Gaia Colasante Gabriele Lignani Simone Brusco Claudia Di Berardino Jenna Carpenter Serena Giannelli Nicholas Valassina Simone Bido Raffaele Ricci Valerio Castoldi Silvia Marenna Timothy Church Luca Massimino Giuseppe Morabito Fabio Benfenati Stephanie Schorge Letizia Leocani Dimitri M Kullmann Vania Broccoli

Mol Ther 2019 Sep 3. Epub 2019 Sep 3.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; CNR Institute of Neuroscience, 20129 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.08.018	DOI Listing

September 2019

Correction: Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis.

Authors:

Marco Cassano Stefano Biressi Amanda Finan Laura Benedetti Claudia Omes Renata Boratto Frank Martin Marcello Allegretti Vania Broccoli Gabriella Cusella De Angelis Paolo M Comoglio Cristina Basilico Yvan Torrente Paolo Michieli Giulio Cossu Maurilio Sampaolesi

PLoS One 2019;14(7):e0220357. Epub 2019 Jul 24.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220357	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6655771	PMC

July 2019

Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors.

Authors:

Gaia Colasante Alicia Rubio Luca Massimino Vania Broccoli

Front Neurosci 2019 26;13:283. Epub 2019 Mar 26.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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https://www.frontiersin.org/article/10.3389/fnins.2019.00283	Publisher Site
http://dx.doi.org/10.3389/fnins.2019.00283	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445133	PMC

March 2019

KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes.

Authors:

Giulia Barbagiovanni Pierre-Luc Germain Michael Zech Sina Atashpaz Pietro Lo Riso Agnieszka D'Antonio-Chronowska Erika Tenderini Massimiliano Caiazzo Sylvia Boesch Robert Jech Bernhard Haslinger Vania Broccoli Adrian Francis Stewart Juliane Winkelmann Giuseppe Testa

Cell Rep 2018 10;25(4):988-1001

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20139 Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183152	Publisher Site
http://dx.doi.org/10.1016/j.celrep.2018.09.067	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218204	PMC

October 2018

Recipes for Making Neurons using Combinatorial Forward Genetics.

Authors:

Vania Broccoli Mirko Luoni

Cell Stem Cell 2018 07;23(1):13-14

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183029	Publisher Site
http://dx.doi.org/10.1016/j.stem.2018.06.012	DOI Listing

July 2018

SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.

Nat Commun 2018 06 6;9(1):2192. Epub 2018 Jun 6.

Department of Medicine and Surgery, University of Milano-Bicocca and San Gerardo hospital, 20900, Monza, Italy.

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http://dx.doi.org/10.1038/s41467-018-04462-8	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989213	PMC

June 2018

Reprogramming of somatic cells: iPS and iN cells.

Authors:

Vania Broccoli

Prog Brain Res 2017 6;230:53-68. Epub 2017 Feb 6.

San Raffaele Scientific Institute, Milan, Italy; CNR-Institute of Neuroscience, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/bs.pbr.2016.12.009	DOI Listing

May 2018

mSEL-1L deficiency affects vasculogenesis and neural stem cell lineage commitment.

Authors:

Marina Cardano Giuseppe R Diaferia Luciano Conti Simona Baronchelli Alessandro Sessa Vania Broccoli Andrea Barbieri Pasquale De Blasio Ida Biunno

J Cell Physiol 2018 04 12;233(4):3152-3163. Epub 2017 Sep 12.

Institute of Genetic and Biomedical Research (IRGB) of the National Research Council, Milano, Italy.

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http://dx.doi.org/10.1002/jcp.26153	DOI Listing

April 2018

PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity.

Authors:

Floriana Fruscione Pierluigi Valente Bruno Sterlini Alessandra Romei Simona Baldassari Manuela Fadda Cosimo Prestigio Giorgia Giansante Jacopo Sartorelli Pia Rossi Alicia Rubio Antonio Gambardella Thierry Nieus Vania Broccoli Anna Fassio Pietro Baldelli Anna Corradi Federico Zara Fabio Benfenati

Brain 2018 04;141(4):1000-1016

Department of Experimental Medicine, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.

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http://dx.doi.org/10.1093/brain/awy051	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888929	PMC

April 2018

Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery.

Authors:

Serena G Giannelli Mirko Luoni Valerio Castoldi Luca Massimino Tommaso Cabassi Debora Angeloni Gian Carlo Demontis Letizia Leocani Massimiliano Andreazzoli Vania Broccoli

Hum Mol Genet 2018 03;27(5):761-779

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1093/hmg/ddx438	DOI Listing

March 2018

Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.

Authors:

Vardine Sahakyan Robin Duelen Wai Long Tam Scott J Roberts Hanne Grosemans Pieter Berckmans Gabriele Ceccarelli Gloria Pelizzo Vania Broccoli Jan Deprest Frank P Luyten Catherine M Verfaillie Maurilio Sampaolesi

Sci Rep 2018 02 13;8(1):2942. Epub 2018 Feb 13.

Translational Cardiomyology Laboratory, Stem Cell Biology and Embryology Unit, Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41598-018-21103-8	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811493	PMC

February 2018

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson's Disease Models.

Authors:

Angelo Iannielli Simone Bido Lucrezia Folladori Alice Segnali Cinzia Cancellieri Alessandra Maresca Luca Massimino Alicia Rubio Giuseppe Morabito Leonardo Caporali Francesca Tagliavini Olimpia Musumeci Giuliana Gregato Erwan Bezard Valerio Carelli Valeria Tiranti Vania Broccoli

Cell Rep 2018 02;22(8):2066-2079

Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; National Research Council (CNR), Institute of Neuroscience, 20129 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.089	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842028	PMC

February 2018

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy.

Authors:

Giuseppe Morabito Serena G Giannelli Gabriele Ordazzo Simone Bido Valerio Castoldi Marzia Indrigo Tommaso Cabassi Stefano Cattaneo Mirko Luoni Cinzia Cancellieri Alessandro Sessa Marco Bacigaluppi Stefano Taverna Letizia Leocani José L Lanciego Vania Broccoli

Mol Ther 2017 Dec 10;25(12):2727-2742. Epub 2017 Aug 10.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; National Research Council (CNR), Institute of Neuroscience, 20129 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.08.004	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768559	PMC

December 2017

The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

Authors:

Alessandro Sessa Ernesto Ciabatti Daniela Drechsel Luca Massimino Gaia Colasante Serena Giannelli Takashi Satoh Shizuo Akira Francois Guillemot Vania Broccoli

Cereb Cortex 2017 12;27(12):5715

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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https://academic.oup.com/cercor/article/27/12/5715/4091094	Publisher Site
http://dx.doi.org/10.1093/cercor/bhx209	DOI Listing

December 2017

A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential.

Cell 2017 Sep;171(1):229-241.e15

Humabs BioMed SA a subsidiary of Vir Biotechnology, Inc., Via Mirasole 1, 6500 Bellinzona, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.002	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673489	PMC

September 2017

The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

Authors:

Alessandro Sessa Ernesto Ciabatti Daniela Drechsel Luca Massimino Gaia Colasante Serena Giannelli Takashi Satoh Shizuo Akira Francois Guillemot Vania Broccoli

Cereb Cortex 2017 06;27(6):3378-3396

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1093/cercor/bhw270	DOI Listing

June 2017

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.

Authors:

Silvia Ghezzi Lynsay Cooper Alicia Rubio Isabel Pagani Maria Rosaria Capobianchi Giuseppe Ippolito Julien Pelletier Maria Cecilia Z Meneghetti Marcelo A Lima Mark A Skidmore Vania Broccoli Edwin A Yates Elisa Vicenzi

Antiviral Res 2017 04 5;140:13-17. Epub 2017 Jan 5.

San Raffaele Scientific Institute, Via Olgettina, Milano 20132, Italy.

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http://dx.doi.org/10.1016/j.antiviral.2016.12.023	DOI Listing

April 2017

Neuroprotection of Brain Cells by Lipoic Acid Treatment after Cellular Stress.

Authors:

Sara Paradells-Navarro María Soledad Benlloch-Navarro María Inmaculada Almansa Frias Ma Angeles Garcia-Esparza Vania Broccoli María Miranda José Miguel Soria

ACS Chem Neurosci 2017 03 9;8(3):569-577. Epub 2016 Dec 9.

San Raffaele Hospital , 20132 Milan, Italy.

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http://dx.doi.org/10.1021/acschemneuro.6b00306	DOI Listing

March 2017

Human Endometrial Stromal Cells Are Highly Permissive To Productive Infection by Zika Virus.

Authors:

Isabel Pagani Silvia Ghezzi Adele Ulisse Alicia Rubio Filippo Turrini Elisabetta Garavaglia Massimo Candiani Concetta Castilletti Giuseppe Ippolito Guido Poli Vania Broccoli Paola Panina-Bordignon Elisa Vicenzi

Sci Rep 2017 03 10;7:44286. Epub 2017 Mar 10.

Viral Pathogens and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/srep44286	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345097	PMC

March 2017

Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells.

Authors:

Pietro Giuseppe Mazzara Luca Massimino Marta Pellegatta Giulia Ronchi Alessandra Ricca Angelo Iannielli Serena Gea Giannelli Marco Cursi Cinzia Cancellieri Alessandro Sessa Ubaldo Del Carro Angelo Quattrini Stefano Geuna Angela Gritti Carla Taveggia Vania Broccoli

Nat Commun 2017 02 7;8:14088. Epub 2017 Feb 7.

Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1038/ncomms14088	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309703	PMC

February 2017

Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy.

Authors:

Vasco Meneghini Giacomo Frati Davide Sala Silvia De Cicco Marco Luciani Chiara Cavazzin Marianna Paulis Wieslawa Mentzen Francesco Morena Serena Giannelli Francesca Sanvito Anna Villa Alessandro Bulfone Vania Broccoli Sabata Martino Angela Gritti

Stem Cells Transl Med 2017 02 16;6(2):352-368. Epub 2016 Sep 16.

San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Milan, Italy.

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http://dx.doi.org/10.5966/sctm.2015-0414	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442804	PMC

February 2017

Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming.

Authors:

Alicia Rubio Mirko Luoni Serena G Giannelli Isabella Radice Angelo Iannielli Cinzia Cancellieri Claudia Di Berardino Giulia Regalia Giovanna Lazzari Andrea Menegon Stefano Taverna Vania Broccoli

Sci Rep 2016 11 18;6:37540. Epub 2016 Nov 18.

Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1038/srep37540	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114606	PMC

November 2016

Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration.

Authors:

Daniel I Orellana Paolo Santambrogio Alicia Rubio Latefa Yekhlef Cinzia Cancellieri Sabrina Dusi Serena G Giannelli Paola Venco Pietro G Mazzara Anna Cozzi Maurizio Ferrari Barbara Garavaglia Stefano Taverna Valeria Tiranti Vania Broccoli Sonia Levi

EMBO Mol Med 2016 10 4;8(10):1197-1211. Epub 2016 Oct 4.

Proteomics of Iron Metabolism Unit, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy Vita-Salute San Raffaele University, Milan, Italy

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http://dx.doi.org/10.15252/emmm.201606391	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048368	PMC

October 2016

MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis.

Authors:

Francisca F Vasconcelos Alessandro Sessa Cátia Laranjeira Alexandre A S F Raposo Vera Teixeira Daniel W Hagey Diogo M Tomaz Jonas Muhr Vania Broccoli Diogo S Castro

Cell Rep 2016 10;17(2):469-483

Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.024	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067283	PMC

October 2016

The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations.

Authors:

Clément A Gautier Zoi Erpapazoglou François Mouton-Liger Marie Paule Muriel Florence Cormier Stéphanie Bigou Sophie Duffaure Mathilde Girard Benjamin Foret Angelo Iannielli Vania Broccoli Carine Dalle Delphine Bohl Patrick P Michel Jean-Christophe Corvol Alexis Brice Olga Corti

Hum Mol Genet 2016 07 19;25(14):2972-2984. Epub 2016 May 19.

Bases moléculaires, physiopathologie et traitement des maladies neurodégénératives, Inserm, U1127, F-75013 Paris, France

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http://dx.doi.org/10.1093/hmg/ddw148	DOI Listing

July 2016

MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion.

Authors:

Sara Mariotti Ivana Barravecchia Carla Vindigni Angela Pucci Michele Balsamo Rosaliana Libro Vera Senchenko Alexey Dmitriev Emanuela Jacchetti Marco Cecchini Franco Roviello Michele Lai Vania Broccoli Massimiliano Andreazzoli Chiara M Mazzanti Debora Angeloni

Oncotarget 2016 Jan;7(2):1808-25

Institute of Life Sciences, Scuola Superiore Sant'Anna, 56124 Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.6577	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811499	PMC

January 2016

Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo.

Authors:

Silvia Pellegrini Federica Ungaro Alessia Mercalli Raffaella Melzi Guido Sebastiani Francesco Dotta Vania Broccoli Lorenzo Piemonti Valeria Sordi

Acta Diabetol 2015 Dec 4;52(6):1025-35. Epub 2015 Mar 4.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

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http://dx.doi.org/10.1007/s00592-015-0726-z	DOI Listing

December 2015

Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.

Cell Stem Cell 2015 Dec 29;17(6):719-734. Epub 2015 Oct 29.

Division of Neuroscience, Ospedale San Raffaele, 20132 Milan, Italy; CNR Institute of Neuroscience, 20129 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.09.002	DOI Listing

December 2015

Histone modifications controlling native and induced neural stem cell identity.

Authors:

Vania Broccoli Gaia Colasante Alessandro Sessa Alicia Rubio

Curr Opin Genet Dev 2015 Oct 24;34:95-101. Epub 2015 Oct 24.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.gde.2015.08.003	DOI Listing

October 2015

Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients.

Authors:

Paolo Santambrogio Sabrina Dusi Michela Guaraldo Luisa Ida Rotundo Vania Broccoli Barbara Garavaglia Valeria Tiranti Sonia Levi

Neurobiol Dis 2015 Sep 30;81:144-53. Epub 2015 Mar 30.

San Raffaele Scientific Institute, Division of Neuroscience, 20132 Milano, Italy; University Vita-Salute San Raffaele, 20132 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.02.030	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642744	PMC

September 2015

Overcoming the hurdles for a reproducible generation of human functionally mature reprogrammed neurons.

Authors:

Vania Broccoli Alicia Rubio Stefano Taverna Latefa Yekhlef

Exp Biol Med (Maywood) 2015 Jun 18;240(6):787-94. Epub 2015 Mar 18.

Neuroimmunology Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://dx.doi.org/10.1177/1535370215577585	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935208	PMC

June 2015

ARX regulates cortical intermediate progenitor cell expansion and upper layer neuron formation through repression of Cdkn1c.

Authors:

Gaia Colasante Jacqueline C Simonet Raffaele Calogero Stefania Crispi Alessandro Sessa Ginam Cho Jeffrey A Golden Vania Broccoli

Cereb Cortex 2015 Feb 22;25(2):322-35. Epub 2013 Aug 22.

Department of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://dx.doi.org/10.1093/cercor/bht222	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351425	PMC

February 2015

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.

Authors:

Massimiliano Caiazzo Serena Giannelli Pierluigi Valente Gabriele Lignani Annamaria Carissimo Alessandro Sessa Gaia Colasante Rosa Bartolomeo Luca Massimino Stefano Ferroni Carmine Settembre Fabio Benfenati Vania Broccoli

Stem Cell Reports 2015 Jan 31;4(1):25-36. Epub 2014 Dec 31.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.12.002	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297873	PMC

January 2015

Modeling physiological and pathological human neurogenesis in the dish.

Authors:

Vania Broccoli Serena G Giannelli Pietro G Mazzara

Front Neurosci 2014 24;8:183. Epub 2014 Jul 24.

Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute Milan, Italy.

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http://dx.doi.org/10.3389/fnins.2014.00183	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109586	PMC

August 2014

Remote control of induced dopaminergic neurons in parkinsonian rats.

Authors:

Maria Teresa Dell'Anno Massimiliano Caiazzo Damiana Leo Elena Dvoretskova Lucian Medrihan Gaia Colasante Serena Giannelli Ilda Theka Giovanni Russo Liudmila Mus Gianni Pezzoli Raul R Gainetdinov Fabio Benfenati Stefano Taverna Alexander Dityatev Vania Broccoli

J Clin Invest 2014 Jul 17;124(7):3215-29. Epub 2014 Jun 17.

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http://dx.doi.org/10.1172/JCI74664	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071410	PMC

July 2014

Zrf1 is required to establish and maintain neural progenitor identity.

Authors:

Luigi Aloia Bruno Di Stefano Alessandro Sessa Lluis Morey Alexandra Santanach Arantxa Gutierrez Luca Cozzuto Salvador Aznar Benitah Thomas Graf Vania Broccoli Luciano Di Croce

Genes Dev 2014 Jan;28(2):182-97

Centre for Genomic Regulation (CRG), Universitat Pompeu Fabra, 08003 Barcelona, Spain;

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http://dx.doi.org/10.1101/gad.228510.113	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909791	PMC

January 2014

Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome.

Authors:

Anna Cozzi Paolo Santambrogio Daniela Privitera Vania Broccoli Luisa Ida Rotundo Barbara Garavaglia Rudolf Benz Sandro Altamura Jeroen S Goede Martina U Muckenthaler Sonia Levi

J Exp Med 2013 Aug 12;210(9):1779-91. Epub 2013 Aug 12.

San Raffaele Scientific Institute, Division of Neuroscience and 2 University Vita-Salute San Raffaele, Milan, Italy.

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http://dx.doi.org/10.1084/jem.20130315	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754865	PMC

August 2013

Rapid generation of functional dopaminergic neurons from human induced pluripotent stem cells through a single-step procedure using cell lineage transcription factors.

Authors:

Ilda Theka Massimiliano Caiazzo Elena Dvoretskova Damiana Leo Federica Ungaro Sebastiano Curreli Francesca Managò Maria Teresa Dell'Anno Gianni Pezzoli Raul R Gainetdinov Alexander Dityatev Vania Broccoli

Stem Cells Transl Med 2013 Jun 8;2(6):473-9. Epub 2013 May 8.

Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.5966/sctm.2012-0133	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673759	PMC

June 2013

Nuclear receptors: Oxysterols detour to neurodevelopment.

Authors:

Vania Broccoli Massimiliano Caiazzo

Nat Chem Biol 2013 Feb;9(2):70-1

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http://dx.doi.org/10.1038/nchembio.1165	DOI Listing

February 2013

Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1.

Authors:

Cinzia Marinaro Maria Pannese Franziska Weinandy Alessandro Sessa Andrea Bergamaschi Makoto M Taketo Vania Broccoli Giancarlo Comi Magdalena Götz Gianvito Martino Luca Muzio

Cereb Cortex 2012 Oct 17;22(10):2415-27. Epub 2011 Nov 17.

Neuroimmunology Unit, Institute of Experimental Neurology, Division of Neuroscience San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1093/cercor/bhr320	DOI Listing

October 2012

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.

Authors:

Sara Ricciardi Federica Ungaro Melanie Hambrock Nils Rademacher Gilda Stefanelli Dario Brambilla Alessandro Sessa Cinzia Magagnotti Angela Bachi Elisa Giarda Chiara Verpelli Charlotte Kilstrup-Nielsen Carlo Sala Vera M Kalscheuer Vania Broccoli

Nat Cell Biol 2012 Sep 26;14(9):911-23. Epub 2012 Aug 26.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1038/ncb2566	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485419	PMC

September 2012

Primary skin fibroblasts as a model of Parkinson's disease.

Authors:

Georg Auburger Michael Klinkenberg Jessica Drost Katrin Marcus Blas Morales-Gordo Wolfram S Kunz Ulrich Brandt Vania Broccoli Heinz Reichmann Suzana Gispert Marina Jendrach

Mol Neurobiol 2012 Aug 19;46(1):20-7. Epub 2012 Feb 19.

Experimental Neurology, Department of Neurology, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s12035-012-8245-1	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443476	PMC

August 2012

Transplantation of genetically corrected human iPSC-derived progenitors in mice with limb-girdle muscular dystrophy.

Sci Transl Med 2012 Jun;4(140):140ra89

Department of Cell and Developmental Biology and Centre for Stem Cells and Regenerative Medicine, University College London, London, UK.

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http://dx.doi.org/10.1126/scitranslmed.3003541	DOI Listing

June 2012

Setting a highway for converting skin into neurons.

Authors:

Vania Broccoli Massimiliano Caiazzo Maria Teresa Dell'Anno

J Mol Cell Biol 2011 Dec 21;3(6):322-3. Epub 2011 Oct 21.

San Raffaele Scientific Institute, Via Olgettina 58, Milan 20132, Italy.

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http://dx.doi.org/10.1093/jmcb/mjr029	DOI Listing

December 2011

GABAergic neuronal precursor grafting: implications in brain regeneration and plasticity.

Authors:

Manuel Alvarez Dolado Vania Broccoli

Neural Plast 2011 20;2011:384216. Epub 2011 Jun 20.

Department of Cell Therapy and Regenerative Medicine, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), 41092 Seville, Spain.

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http://dx.doi.org/10.1155/2011/384216	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135013	PMC

November 2011

A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells.

Authors:

Bruno Di Stefano Sara Martina Maffioletti Bernhard Gentner Federica Ungaro Giulia Schira Luigi Naldini Vania Broccoli

Stem Cells 2011 Nov;29(11):1684-95

Division of Neuroscience, Stem Cells and Neurogenesis Unit, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/stem.726	DOI Listing

November 2011

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

Authors:

Chiara Verpelli Elena Dvoretskova Cinzia Vicidomini Francesca Rossi Michela Chiappalone Michael Schoen Bruno Di Stefano Renato Mantegazza Vania Broccoli Tobias M Böckers Alexander Dityatev Carlo Sala

J Biol Chem 2011 Oct 27;286(40):34839-50. Epub 2011 Jul 27.

Department of Pharmacology, CNR Institute of Neuroscience, University of Milan, Milan 20129, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.258384	Publisher Site
http://dx.doi.org/10.1074/jbc.M111.258384	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186429	PMC

October 2011

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

Authors:

Angelo Lombardo Daniela Cesana Pietro Genovese Bruno Di Stefano Elena Provasi Daniele F Colombo Margherita Neri Zulma Magnani Alessio Cantore Pietro Lo Riso Martina Damo Oscar M Pello Michael C Holmes Philip D Gregory Angela Gritti Vania Broccoli Chiara Bonini Luigi Naldini

Nat Methods 2011 Aug 21;8(10):861-9. Epub 2011 Aug 21.

San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Gene Therapy and Stem Cells, San Raffaele Institute, Milan, Italy.

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http://www.nature.com/nmeth/journal/v8/n10/pdf/nmeth.1674.pd	Web Search
http://www.nature.com/doifinder/10.1038/nmeth.1674	Publisher Site
http://dx.doi.org/10.1038/nmeth.1674	DOI Listing

August 2011

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts.

Authors:

Massimiliano Caiazzo Maria Teresa Dell'Anno Elena Dvoretskova Dejan Lazarevic Stefano Taverna Damiana Leo Tatyana D Sotnikova Andrea Menegon Paola Roncaglia Giorgia Colciago Giovanni Russo Piero Carninci Gianni Pezzoli Raul R Gainetdinov Stefano Gustincich Alexander Dityatev Vania Broccoli

Nature 2011 Jul 3;476(7359):224-7. Epub 2011 Jul 3.

Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1038/nature10284	DOI Listing

July 2011

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

Authors:

Sara Ricciardi Elena M Boggio Stefano Grosso Giuseppina Lonetti Greta Forlani Gilda Stefanelli Eleonora Calcagno Noemi Morello Nicoletta Landsberger Stefano Biffo Tommaso Pizzorusso Maurizio Giustetto Vania Broccoli

Hum Mol Genet 2011 Mar 6;20(6):1182-96. Epub 2011 Jan 6.

Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milano, Italy.

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http://hmg.oxfordjournals.org/content/early/2011/02/02/hmg.d	Web Search
http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddq563	Publisher Site
http://dx.doi.org/10.1093/hmg/ddq563	DOI Listing

March 2011

Adult human Müller glia cells are a highly efficient source of rod photoreceptors.

Authors:

Serena G Giannelli Gian Carlo Demontis Grazia Pertile Paolo Rama Vania Broccoli

Stem Cells 2011 Feb;29(2):344-56

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/stem.579	DOI Listing

February 2011

An ES-like pluripotent state in FGF-dependent murine iPS cells.

Authors:

Bruno Di Stefano Christa Buecker Federica Ungaro Alessandro Prigione Hsu-Hsin Chen Maaike Welling Maureen Eijpe Gustavo Mostoslavsky Paul Tesar James Adjaye Niels Geijsen Vania Broccoli

PLoS One 2010 Dec 30;5(12):e16092. Epub 2010 Dec 30.

Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016092	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012723	PMC

December 2010

Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons.

Authors:

Alessandro Sessa Chai-An Mao Gaia Colasante Alessandro Nini William H Klein Vania Broccoli

Genes Dev 2010 Aug;24(16):1816-26

Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://dx.doi.org/10.1101/gad.575410	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922508	PMC

August 2010

Long-term culture and differentiation of CNS precursors derived from anterior human neural rosettes following exposure to ventralizing factors.

Authors:

Silvia Colleoni Cesare Galli Serena G Giannelli Marie-Therese Armentero Fabio Blandini Vania Broccoli Giovanna Lazzari

Exp Cell Res 2010 Apr 17;316(7):1148-58. Epub 2010 Feb 17.

Laboratorio di Tecnologie della Riproduzione, Avantea, Cremona, Italy.

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http://dx.doi.org/10.1016/j.yexcr.2010.02.013	DOI Listing

April 2010

Xenopus Bsx links daily cell cycle rhythms and pineal photoreceptor fate.

Authors:

Silvia D'Autilia Vania Broccoli Giuseppina Barsacchi Massimiliano Andreazzoli

Proc Natl Acad Sci U S A 2010 Apr 22;107(14):6352-7. Epub 2010 Mar 22.

Unita' di Biologia Cellulare e dello Sviluppo, Dipartimento di Biologia, Universita' di Pisa, Pisa 56127, Italy.

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http://dx.doi.org/10.1073/pnas.1000854107	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852004	PMC

April 2010

The apical complex couples cell fate and cell survival to cerebral cortical development.

Authors:

Seonhee Kim Maria K Lehtinen Alessandro Sessa Mauro W Zappaterra Seo-Hee Cho Dilenny Gonzalez Brigid Boggan Christina A Austin Jan Wijnholds Michael J Gambello Jarema Malicki Anthony S LaMantia Vania Broccoli Christopher A Walsh

Neuron 2010 Apr;66(1):69-84

Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Division of Genetics, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.neuron.2010.03.019	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872122	PMC

April 2010

CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery.

Authors:

Sara Ricciardi Charlotte Kilstrup-Nielsen Thierry Bienvenu Aurélia Jacquette Nicoletta Landsberger Vania Broccoli

Hum Mol Genet 2009 Dec 9;18(23):4590-602. Epub 2009 Sep 9.

Division of Neuroscience, San Raffaele Rett Research Center, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://dx.doi.org/10.1093/hmg/ddp426	DOI Listing

December 2009

Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity.

Authors:

Gaia Colasante Alessandro Sessa Stefania Crispi Raffaele Calogero Ahmed Mansouri Patrick Collombat Vania Broccoli

Dev Biol 2009 Oct 21;334(1):59-71. Epub 2009 Jul 21.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.

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http://dx.doi.org/10.1016/j.ydbio.2009.07.014	DOI Listing

October 2009

Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4.

Authors:

Bruno Di Stefano Alessandro Prigione Vania Broccoli

Stem Cells Dev 2009 Jun;18(5):707-16

Stem Cell Research Department, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy.

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http://dx.doi.org/10.1089/scd.2008.0180	DOI Listing

June 2009

CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail.

Authors:

Laura Rusconi Lisa Salvatoni Laura Giudici Ilaria Bertani Charlotte Kilstrup-Nielsen Vania Broccoli Nicoletta Landsberger

J Biol Chem 2008 Oct 13;283(44):30101-11. Epub 2008 Aug 13.

Department of Structural and Functional Biology, University of Insubria, Via Alberto da Giussano 12, 21052 Busto Arsizio (VA), Italy.

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http://dx.doi.org/10.1074/jbc.M804613200	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662074	PMC

October 2008

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons.

Authors:

Gaia Colasante Patrick Collombat Valentina Raimondi Dario Bonanomi Carmelo Ferrai Mario Maira Kazuaki Yoshikawa Ahmed Mansouri Flavia Valtorta John L R Rubenstein Vania Broccoli

J Neurosci 2008 Oct;28(42):10674-86

Department of Biological and Technological Research, San Raffaele Scientific Institute, Stem Cell Research Institute, Vita e Salute San Raffaele University, 20132 Milan, Italy.

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http://dx.doi.org/10.1523/JNEUROSCI.1283-08.2008	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844830	PMC

October 2008

Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex.

Authors:

Alessandro Sessa Chai-An Mao Anna-Katerina Hadjantonakis William H Klein Vania Broccoli

Neuron 2008 Oct;60(1):56-69

Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.neuron.2008.09.028	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887762	PMC

October 2008

Magic-factor 1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis.

Authors:

Marco Cassano Stefano Biressi Amanda Finan Laura Benedetti Claudia Omes Renata Boratto Frank Martin Marcello Allegretti Vania Broccoli Gabriella Cusella De Angelis Paolo M Comoglio Cristina Basilico Yvan Torrente Paolo Michieli Giulio Cossu Maurilio Sampaolesi

PLoS One 2008 Sep 16;3(9):e3223. Epub 2008 Sep 16.

Translational Cardiomyology, Stem Cell Institute Leuven, KULeuven, Leuven, Belgium.

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http://discovery.ucl.ac.uk/1342599/1/1342599.pdf	Web Search
http://dx.plos.org/10.1371/journal.pone.0003223	Publisher Site
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003223	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528937	PMC

September 2008

FOXG1 is responsible for the congenital variant of Rett syndrome.

Authors:

Francesca Ariani Giuseppe Hayek Dalila Rondinella Rosangela Artuso Maria Antonietta Mencarelli Ariele Spanhol-Rosseto Marzia Pollazzon Sabrina Buoni Ottavia Spiga Sara Ricciardi Ilaria Meloni Ilaria Longo Francesca Mari Vania Broccoli Michele Zappella Alessandra Renieri

Am J Hum Genet 2008 Jul 19;83(1):89-93. Epub 2008 Jun 19.

Medical Genetics, Molecular Biology Department, University of Siena, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ajhg.2008.05.015	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443837	PMC

July 2008

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.

Authors:

Marius Wernig Jian-Ping Zhao Jan Pruszak Eva Hedlund Dongdong Fu Frank Soldner Vania Broccoli Martha Constantine-Paton Ole Isacson Rudolf Jaenisch

Proc Natl Acad Sci U S A 2008 Apr 7;105(15):5856-61. Epub 2008 Apr 7.

The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1073/pnas.0801677105	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311361	PMC

April 2008

FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex.

Authors:

Ilse Gosens Alessandro Sessa Anneke I den Hollander Stef J F Letteboer Valentina Belloni Maarten L Arends André Le Bivic Frans P M Cremers Vania Broccoli Ronald Roepman

Exp Cell Res 2007 Nov 7;313(19):3959-70. Epub 2007 Sep 7.

Department of Human Genetics, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 10, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.yexcr.2007.08.025	DOI Listing

November 2007

Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation.

Authors:

Daniela Deponti Stéphanie François Silvia Baesso Clara Sciorati Anna Innocenzi Vania Broccoli Françoise Muscatelli Raffaella Meneveri Emilio Clementi Giulio Cossu Silvia Brunelli

J Cell Biol 2007 Oct;179(2):305-19

Department of Histology and Medical Embryology, University of Roma-La Sapienza, 00161 Rome, Italy.

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http://dx.doi.org/10.1083/jcb.200701027	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064766	PMC

October 2007

Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation.

Authors:

Elena Colombo Patrick Collombat Gaia Colasante Marta Bianchi Jason Long Ahmed Mansouri John L R Rubenstein Vania Broccoli

J Neurosci 2007 Apr;27(17):4786-98

Stem Cell Research Department, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1523/JNEUROSCI.0417-07.2007	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916654	PMC

April 2007

Direct derivation of neural rosettes from cloned bovine blastocysts: a model of early neurulation events and neural crest specification in vitro.

Authors:

Giovanna Lazzari Silvia Colleoni Serena G Giannelli Dario Brunetti Elena Colombo Irina Lagutina Cesare Galli Vania Broccoli

Stem Cells 2006 Nov 24;24(11):2514-21. Epub 2006 Aug 24.

Laboratorio di Tecnologie della Riproduzione, Istituto Sperimentale Italiano Lazzaro Spallanzani, CIZ s.r.l., Cremona, Italy.

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http://dx.doi.org/10.1634/stemcells.2006-0149	DOI Listing

November 2006

Embryonic stem-derived versus somatic neural stem cells: a comparative analysis of their developmental potential and molecular phenotype.

Authors:

Elena Colombo Serena G Giannelli Rossella Galli Enrico Tagliafico Chiara Foroni Elena Tenedini Sergio Ferrari Stefano Ferrari Giorgio Corte Angelo Vescovi Giulio Cossu Vania Broccoli

Stem Cells 2006 Apr 9;24(4):825-34. Epub 2005 Dec 9.

Stem Cell Research Department, Dipartmento di Biotecnologie, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.

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http://doi.wiley.com/10.1634/stemcells.2005-0313	Publisher Site
http://dx.doi.org/10.1634/stemcells.2005-0313	DOI Listing

April 2006

Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage.

Authors:

Isidre Ferrer Josef P Kapfhammer Colette Hindelang Stephan Kemp Nathalie Troffer-Charlier Vania Broccoli Noëlle Callyzot Petra Mooyer Jacqueline Selhorst Peter Vreken Ronald J A Wanders Jean Louis Mandel Aurora Pujol

Hum Mol Genet 2005 Dec 13;14(23):3565-77. Epub 2005 Oct 13.

Institut de Neuropatologia, Hospital Universitari de Bellvitge, Department de Biologia Cel.lular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Spain.

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http://academic.oup.com/hmg/article/14/23/3565/559447/Inacti	Publisher Site
http://dx.doi.org/10.1093/hmg/ddi384	DOI Listing

December 2005

CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome.

Hum Mol Genet 2005 Jul 25;14(14):1935-46. Epub 2005 May 25.

Medical Genetics, University of Siena, Italy.

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http://dx.doi.org/10.1093/hmg/ddi198	DOI Listing

July 2005

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.

Authors:

Patrick Collombat Jacob Hecksher-Sørensen Vania Broccoli Jens Krull Ilaria Ponte Tabea Mundiger Julian Smith Peter Gruss Palle Serup Ahmed Mansouri

Development 2005 Jul 1;132(13):2969-80. Epub 2005 Jun 1.

Max-Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1242/dev.01870	DOI Listing

July 2005

The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain.

Authors:

Inma Cobos Vania Broccoli John L R Rubenstein

J Comp Neurol 2005 Mar;483(3):292-303

Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158-2611, USA.

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http://dx.doi.org/10.1002/cne.20405	DOI Listing

March 2005

Neuroacanthocytosis: new developments in a neglected group of dementing disorders.

Authors:

Adrian Danek Hans H Jung Mariarosa A B Melone Luca Rampoldi Vania Broccoli Ruth H Walker

J Neurol Sci 2005 Mar 7;229-230:171-86. Epub 2005 Jan 7.

Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität Marchioninistr. 15 D-81366 Munich, Germany.

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http://dx.doi.org/10.1016/j.jns.2004.11.024	DOI Listing

March 2005

Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons.

Authors:

Elena Colombo Rossella Galli Giulio Cossu Jozef Gécz Vania Broccoli

Dev Dyn 2004 Nov;231(3):631-9

Stem Cell Research Institute, DIBIT, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1002/dvdy.20164	DOI Listing

November 2004

Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus.

Authors:

Mattia Cremona Elena Colombo Massimiliano Andreazzoli Giulio Cossu Vania Broccoli

Gene Expr Patterns 2004 Jan;4(1):47-51

Stem Cell Research Institute, DIBIT, San Raffaele Science Park Via Olgettina 58, Milan 20132, Italy.

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http://dx.doi.org/10.1016/s1567-133x(03)00151-0	DOI Listing

January 2004

Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport.

Authors:

Fatima Ferreirinha Angelo Quattrini Marinella Pirozzi Valentina Valsecchi Giorgia Dina Vania Broccoli Alberto Auricchio Fiorella Piemonte Giulia Tozzi Laura Gaeta Giorgio Casari Andrea Ballabio Elena I Rugarli

J Clin Invest 2004 Jan;113(2):231-42

Telethon Institute of Genetics and Medicine, Naples, Italy.

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http://dx.doi.org/10.1172/JCI20138	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC311437	PMC

January 2004

Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.

Authors:

Claude Brodski Daniela M Vogt Weisenhorn Massimo Signore Inge Sillaber Matthias Oesterheld Vania Broccoli Dario Acampora Antonio Simeone Wolfgang Wurst

J Neurosci 2003 May;23(10):4199-207

Max-Planck-Institute of Psychiatry, 80804 Munich, Germany, and GSF-National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, 85758 Oberschleissheim, Germany.

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