Vania Broccoli

Vania Broccoli

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Vania Broccoli

Vania Broccoli

Publications by authors named "Vania Broccoli"

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Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging.

Stem Cell Reports 2019 Nov 3;13(5):832-846. Epub 2019 Oct 3.

Proteomic of Iron Metabolism Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.09.002DOI Listing
November 2019

SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.

Neuron 2019 Oct 9;104(2):271-289.e13. Epub 2019 Sep 9.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; CNR Institute of Neuroscience, 20129 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.07.013DOI Listing
October 2019

Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors.

Front Neurosci 2019 26;13:283. Epub 2019 Mar 26.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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https://www.frontiersin.org/article/10.3389/fnins.2019.00283
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http://dx.doi.org/10.3389/fnins.2019.00283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445133PMC
March 2019

Recipes for Making Neurons using Combinatorial Forward Genetics.

Cell Stem Cell 2018 07;23(1):13-14

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183029
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http://dx.doi.org/10.1016/j.stem.2018.06.012DOI Listing
July 2018

Reprogramming of somatic cells: iPS and iN cells.

Authors:
Vania Broccoli

Prog Brain Res 2017 6;230:53-68. Epub 2017 Feb 6.

San Raffaele Scientific Institute, Milan, Italy; CNR-Institute of Neuroscience, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/bs.pbr.2016.12.009DOI Listing
May 2018

mSEL-1L deficiency affects vasculogenesis and neural stem cell lineage commitment.

J Cell Physiol 2018 04 12;233(4):3152-3163. Epub 2017 Sep 12.

Institute of Genetic and Biomedical Research (IRGB) of the National Research Council, Milano, Italy.

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http://dx.doi.org/10.1002/jcp.26153DOI Listing
April 2018

Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.

Sci Rep 2018 02 13;8(1):2942. Epub 2018 Feb 13.

Translational Cardiomyology Laboratory, Stem Cell Biology and Embryology Unit, Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41598-018-21103-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811493PMC
February 2018

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy.

Mol Ther 2017 Dec 10;25(12):2727-2742. Epub 2017 Aug 10.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; National Research Council (CNR), Institute of Neuroscience, 20129 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768559PMC
December 2017

The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways.

Cereb Cortex 2017 06;27(6):3378-3396

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1093/cercor/bhw270DOI Listing
June 2017

Human Endometrial Stromal Cells Are Highly Permissive To Productive Infection by Zika Virus.

Sci Rep 2017 03 10;7:44286. Epub 2017 Mar 10.

Viral Pathogens and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/srep44286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345097PMC
March 2017

Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy.

Stem Cells Transl Med 2017 02 16;6(2):352-368. Epub 2016 Sep 16.

San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Milan, Italy.

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http://dx.doi.org/10.5966/sctm.2015-0414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442804PMC
February 2017

Coenzyme A corrects pathological defects in human neurons of PANK2-associated neurodegeneration.

EMBO Mol Med 2016 10 4;8(10):1197-1211. Epub 2016 Oct 4.

Proteomics of Iron Metabolism Unit, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy Vita-Salute San Raffaele University, Milan, Italy

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http://dx.doi.org/10.15252/emmm.201606391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048368PMC
October 2016

Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo.

Acta Diabetol 2015 Dec 4;52(6):1025-35. Epub 2015 Mar 4.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

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http://dx.doi.org/10.1007/s00592-015-0726-zDOI Listing
December 2015

Histone modifications controlling native and induced neural stem cell identity.

Curr Opin Genet Dev 2015 Oct 24;34:95-101. Epub 2015 Oct 24.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.gde.2015.08.003DOI Listing
October 2015

Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients.

Neurobiol Dis 2015 Sep 30;81:144-53. Epub 2015 Mar 30.

San Raffaele Scientific Institute, Division of Neuroscience, 20132 Milano, Italy; University Vita-Salute San Raffaele, 20132 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642744PMC
September 2015

Overcoming the hurdles for a reproducible generation of human functionally mature reprogrammed neurons.

Exp Biol Med (Maywood) 2015 Jun 18;240(6):787-94. Epub 2015 Mar 18.

Neuroimmunology Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://dx.doi.org/10.1177/1535370215577585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935208PMC
June 2015

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.

Stem Cell Reports 2015 Jan 31;4(1):25-36. Epub 2014 Dec 31.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297873PMC
January 2015

Modeling physiological and pathological human neurogenesis in the dish.

Front Neurosci 2014 24;8:183. Epub 2014 Jul 24.

Stem Cells and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute Milan, Italy.

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http://dx.doi.org/10.3389/fnins.2014.00183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109586PMC
August 2014

Nuclear receptors: Oxysterols detour to neurodevelopment.

Nat Chem Biol 2013 Feb;9(2):70-1

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http://dx.doi.org/10.1038/nchembio.1165DOI Listing
February 2013

Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1.

Cereb Cortex 2012 Oct 17;22(10):2415-27. Epub 2011 Nov 17.

Neuroimmunology Unit, Institute of Experimental Neurology, Division of Neuroscience San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1093/cercor/bhr320DOI Listing
October 2012

Primary skin fibroblasts as a model of Parkinson's disease.

Mol Neurobiol 2012 Aug 19;46(1):20-7. Epub 2012 Feb 19.

Experimental Neurology, Department of Neurology, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s12035-012-8245-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443476PMC
August 2012

Setting a highway for converting skin into neurons.

J Mol Cell Biol 2011 Dec 21;3(6):322-3. Epub 2011 Oct 21.

San Raffaele Scientific Institute, Via Olgettina 58, Milan 20132, Italy.

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http://dx.doi.org/10.1093/jmcb/mjr029DOI Listing
December 2011

GABAergic neuronal precursor grafting: implications in brain regeneration and plasticity.

Neural Plast 2011 20;2011:384216. Epub 2011 Jun 20.

Department of Cell Therapy and Regenerative Medicine, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), 41092 Seville, Spain.

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http://dx.doi.org/10.1155/2011/384216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135013PMC
November 2011

A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells.

Stem Cells 2011 Nov;29(11):1684-95

Division of Neuroscience, Stem Cells and Neurogenesis Unit, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/stem.726DOI Listing
November 2011

Adult human Müller glia cells are a highly efficient source of rod photoreceptors.

Stem Cells 2011 Feb;29(2):344-56

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/stem.579DOI Listing
February 2011

Xenopus Bsx links daily cell cycle rhythms and pineal photoreceptor fate.

Proc Natl Acad Sci U S A 2010 Apr 22;107(14):6352-7. Epub 2010 Mar 22.

Unita' di Biologia Cellulare e dello Sviluppo, Dipartimento di Biologia, Universita' di Pisa, Pisa 56127, Italy.

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http://dx.doi.org/10.1073/pnas.1000854107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852004PMC
April 2010

The apical complex couples cell fate and cell survival to cerebral cortical development.

Neuron 2010 Apr;66(1):69-84

Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Division of Genetics, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.neuron.2010.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872122PMC
April 2010

CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery.

Hum Mol Genet 2009 Dec 9;18(23):4590-602. Epub 2009 Sep 9.

Division of Neuroscience, San Raffaele Rett Research Center, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://dx.doi.org/10.1093/hmg/ddp426DOI Listing
December 2009

Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity.

Dev Biol 2009 Oct 21;334(1):59-71. Epub 2009 Jul 21.

Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132, Milan, Italy.

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http://dx.doi.org/10.1016/j.ydbio.2009.07.014DOI Listing
October 2009

Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4.

Stem Cells Dev 2009 Jun;18(5):707-16

Stem Cell Research Department, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy.

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http://dx.doi.org/10.1089/scd.2008.0180DOI Listing
June 2009

CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail.

J Biol Chem 2008 Oct 13;283(44):30101-11. Epub 2008 Aug 13.

Department of Structural and Functional Biology, University of Insubria, Via Alberto da Giussano 12, 21052 Busto Arsizio (VA), Italy.

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http://dx.doi.org/10.1074/jbc.M804613200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662074PMC
October 2008

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons.

J Neurosci 2008 Oct;28(42):10674-86

Department of Biological and Technological Research, San Raffaele Scientific Institute, Stem Cell Research Institute, Vita e Salute San Raffaele University, 20132 Milan, Italy.

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http://dx.doi.org/10.1523/JNEUROSCI.1283-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844830PMC
October 2008

FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex.

Exp Cell Res 2007 Nov 7;313(19):3959-70. Epub 2007 Sep 7.

Department of Human Genetics, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 10, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.yexcr.2007.08.025DOI Listing
November 2007

Direct derivation of neural rosettes from cloned bovine blastocysts: a model of early neurulation events and neural crest specification in vitro.

Stem Cells 2006 Nov 24;24(11):2514-21. Epub 2006 Aug 24.

Laboratorio di Tecnologie della Riproduzione, Istituto Sperimentale Italiano Lazzaro Spallanzani, CIZ s.r.l., Cremona, Italy.

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http://dx.doi.org/10.1634/stemcells.2006-0149DOI Listing
November 2006

Embryonic stem-derived versus somatic neural stem cells: a comparative analysis of their developmental potential and molecular phenotype.

Stem Cells 2006 Apr 9;24(4):825-34. Epub 2005 Dec 9.

Stem Cell Research Department, Dipartmento di Biotecnologie, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.

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http://doi.wiley.com/10.1634/stemcells.2005-0313
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http://dx.doi.org/10.1634/stemcells.2005-0313DOI Listing
April 2006

Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage.

Hum Mol Genet 2005 Dec 13;14(23):3565-77. Epub 2005 Oct 13.

Institut de Neuropatologia, Hospital Universitari de Bellvitge, Department de Biologia Cel.lular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Spain.

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http://academic.oup.com/hmg/article/14/23/3565/559447/Inacti
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http://dx.doi.org/10.1093/hmg/ddi384DOI Listing
December 2005

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.

Development 2005 Jul 1;132(13):2969-80. Epub 2005 Jun 1.

Max-Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1242/dev.01870DOI Listing
July 2005

The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain.

J Comp Neurol 2005 Mar;483(3):292-303

Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94158-2611, USA.

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http://dx.doi.org/10.1002/cne.20405DOI Listing
March 2005

Neuroacanthocytosis: new developments in a neglected group of dementing disorders.

J Neurol Sci 2005 Mar 7;229-230:171-86. Epub 2005 Jan 7.

Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität Marchioninistr. 15 D-81366 Munich, Germany.

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http://dx.doi.org/10.1016/j.jns.2004.11.024DOI Listing
March 2005

Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons.

Dev Dyn 2004 Nov;231(3):631-9

Stem Cell Research Institute, DIBIT, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1002/dvdy.20164DOI Listing
November 2004

Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus.

Gene Expr Patterns 2004 Jan;4(1):47-51

Stem Cell Research Institute, DIBIT, San Raffaele Science Park Via Olgettina 58, Milan 20132, Italy.

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http://dx.doi.org/10.1016/s1567-133x(03)00151-0DOI Listing
January 2004

Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.

J Neurosci 2003 May;23(10):4199-207

Max-Planck-Institute of Psychiatry, 80804 Munich, Germany, and GSF-National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, 85758 Oberschleissheim, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741088PMC
May 2003

Role of citron kinase in dendritic morphogenesis of cortical neurons.

Brain Res Bull 2003 May;60(4):319-27

Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, 10126, Torino, Italy.

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http://dx.doi.org/10.1016/s0361-9230(03)00058-3DOI Listing
May 2003

Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors.

Proc Natl Acad Sci U S A 2003 Mar 7;100(6):3299-304. Epub 2003 Mar 7.

Histology and Embryology Section, Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, 35131 Padua, Italy.

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http://dx.doi.org/10.1073/pnas.0434590100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152286PMC
March 2003

Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system.

Development 2002 Apr;129(7):1633-44

Stem Cell Research Institute, H. S. Raffaele, Via Olgettina 58, Milan, I-20132, Italy.

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April 2002

Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain.

Mech Dev 2002 Jan;110(1-2):203-7

Department of Human Genetics, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/s0925-4773(01)00568-8DOI Listing
January 2002