Publications by authors named "Vanessa M Hayes"

65Publications

DNA methylation profiles unique to Kalahari KhoeSan individuals.

Epigenetics 2020 Sep 6:1-17. Epub 2020 Sep 6.

Genomic Functional Analysis Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health , Bethesda, MD, USA.

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http://dx.doi.org/10.1080/15592294.2020.1809852DOI Listing
September 2020

Shiny-SoSV: A web-based performance calculator for somatic structural variant detection.

PLoS One 2020 27;15(8):e0238108. Epub 2020 Aug 27.

Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238108PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451576PMC
October 2020

MethylToSNP: identifying SNPs in Illumina DNA methylation array data.

Epigenetics Chromatin 2019 12 20;12(1):79. Epub 2019 Dec 20.

Genomic Functional Analysis Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Dr., Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1186/s13072-019-0321-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923858PMC
December 2019

Human origins in a southern African palaeo-wetland and first migrations.

Nature 2019 11 28;575(7781):185-189. Epub 2019 Oct 28.

Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1038/s41586-019-1714-1DOI Listing
November 2019

Metagenomic analysis reveals a rich bacterial content in high-risk prostate tumors from African men.

Prostate 2019 11 27;79(15):1731-1738. Epub 2019 Aug 27.

Laboratory for Human Comparative and Prostate Cancer Genomics, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1002/pros.23897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790596PMC
November 2019

African KhoeSan ancestry linked to high-risk prostate cancer.

BMC Med Genomics 2019 06 4;12(1):82. Epub 2019 Jun 4.

Laboratory for Human Comparative and Prostate Cancer Genomics, Genomics and Epigenetics Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, NSW, 2010, Australia.

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http://dx.doi.org/10.1186/s12920-019-0537-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549381PMC
June 2019

Diagnosis of fusion genes using targeted RNA sequencing.

Nat Commun 2019 03 27;10(1):1388. Epub 2019 Mar 27.

Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, 2010, NSW, Australia.

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http://dx.doi.org/10.1038/s41467-019-09374-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437215PMC
March 2019

Prostate cancer genomics and racial health disparity.

Oncotarget 2018 Nov 30;9(94):36650-36651. Epub 2018 Nov 30.

Laboratory for Human Comparative and Prostate Cancer Genomics, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, University of New South Wales, Randwick, NSW, Australia; Central Clinical School, University of Sydney, Camperdown, NSW, Australia; School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa.

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http://dx.doi.org/10.18632/oncotarget.26399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291177PMC
November 2018

Prostate Cancer in Southern Africa: Does Africa Hold Untapped Potential to Add Value to the Current Understanding of a Common Disease?

J Glob Oncol 2018 09 21;4:1-7. Epub 2017 Mar 21.

Vanessa M. Hayes, University of Sydney, University of New South Wales, and Garvan Institute of Medical Research, Sydney, Australia; and University of Limpopo, Limpopo, South Africa and; Vanessa M. Hayes and M.S. Riana Bornman, University of Pretoria, Pretoria South Africa.

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http://dx.doi.org/10.1200/JGO.2016.008862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223485PMC
September 2018

Whole-Genome Sequencing Reveals Elevated Tumor Mutational Burden and Initiating Driver Mutations in African Men with Treatment-Naïve, High-Risk Prostate Cancer.

Cancer Res 2018 12 14;78(24):6736-6746. Epub 2018 Sep 14.

Laboratory for Human Comparative and Prostate Cancer Genomics, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0254DOI Listing
December 2018

Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer.

Genome Res 2018 05 4;28(5):726-738. Epub 2018 Apr 4.

Genomics and Epigenetics Division, Garvan Institute of Medical Research, New South Wales 2010, Australia.

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http://dx.doi.org/10.1101/gr.227975.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932612PMC
May 2018

Altered mitochondrial genome content signals worse pathology and prognosis in prostate cancer.

Prostate 2018 Jan 14;78(1):25-31. Epub 2017 Nov 14.

Laboratory for Human Comparative and Prostate Cancer Genomics, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1002/pros.23440DOI Listing
January 2018

Mitochondrial genome variation and prostate cancer: a review of the mutational landscape and application to clinical management.

Oncotarget 2017 Sep 4;8(41):71342-71357. Epub 2017 Aug 4.

Laboratory for Human Comparative and Prostate Cancer Genomics, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.18632/oncotarget.19926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642640PMC
September 2017

Next generation mapping reveals novel large genomic rearrangements in prostate cancer.

Oncotarget 2017 Apr;8(14):23588-23602

Laboratory for Human Comparative and Prostate Cancer Genomics, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, Australia.

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http://dx.doi.org/10.18632/oncotarget.15802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410329PMC
April 2017

Mutational load of the mitochondrial genome predicts pathological features and biochemical recurrence in prostate cancer.

Aging (Albany NY) 2016 10;8(11):2702-2712

Laboratory for Human Comparative and Prostate Cancer Genomics, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.18632/aging.101044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191864PMC
October 2016

Target Acquired: Progress and Promise of Targeted Therapeutics in the Treatment of Prostate Cancer.

Curr Cancer Drug Targets 2015 ;15(5):394-405

Department of Surgery, The University of Melbourne, 5th Floor Clinical Sciences Building, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria, Australia.

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http://dx.doi.org/10.2174/1568009615666150416113453DOI Listing
May 2016

Revised timeline and distribution of the earliest diverged human maternal lineages in southern Africa.

PLoS One 2015 25;10(3):e0121223. Epub 2015 Mar 25.

Laboratory for Human Comparative and Prostate Cancer Genomics, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia; Faculty of Medicine, University of New South Wales Australia, Randwick, NSW, Australia; J. Craig Venter Institute, 4120 Torrey Pines Road, La Jolla, California, 92037, United States of America; School of Health Systems and Public Health, University of Pretoria, Hatfield, South Africa; Central Clinical School, The University of Sydney, Camperdown, NSW, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121223PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373779PMC
February 2016

First ancient mitochondrial human genome from a prepastoralist southern African.

Genome Biol Evol 2014 Sep 10;6(10):2647-53. Epub 2014 Sep 10.

Laboratory for Human Comparative and Prostate Cancer Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia Genomeic Medicine Group, J. Craig Venter Institute, La Jolla, California Central Clinical School, The University of Sydney, Camperdown, New South Wales, Australia Department of Urology, University of Pretoria, South Africa Medical Faculty, University of New South Wales, Randwick, New South Wales, Australia

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http://gbe.oxfordjournals.org/content/early/2014/09/10/gbe.e
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http://pubman.mpdl.mpg.de/pubman/item/escidoc:2129597:2/comp
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http://gbe.oxfordjournals.org/cgi/doi/10.1093/gbe/evu202
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http://dx.doi.org/10.1093/gbe/evu202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224329PMC
September 2014

Performance of high-throughput sequencing for the discovery of genetic variation across the complete size spectrum.

G3 (Bethesda) 2014 Jan 10;4(1):63-5. Epub 2014 Jan 10.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1534/g3.113.008797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887540PMC
January 2014

Interleukin-6 promoter variants, prostate cancer risk, and survival.

Prostate 2012 Dec 10;72(16):1701-7. Epub 2012 Jul 10.

Cancer Genetics Group, Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Randwick, New South Wales, Australia.

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http://doi.wiley.com/10.1002/pros.22557
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http://dx.doi.org/10.1002/pros.22557DOI Listing
December 2012

Helping hand for genomics in Africa.

Nature 2011 Aug 10;476(7359):152. Epub 2011 Aug 10.

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http://dx.doi.org/10.1038/476152cDOI Listing
August 2011

Calling SNPs without a reference sequence.

BMC Bioinformatics 2010 Mar 15;11:130. Epub 2010 Mar 15.

Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, USA.

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http://dx.doi.org/10.1186/1471-2105-11-130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851604PMC
March 2010

The 4q27 locus and prostate cancer risk.

BMC Cancer 2010 Feb 25;10:69. Epub 2010 Feb 25.

Cancer Genetics Group, Children's Cancer Institute Australia for Medical Research, Sydney Children's Hospital, High St, Randwick, NSW, Australia.

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http://dx.doi.org/10.1186/1471-2407-10-69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841665PMC
February 2010

Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation.

BMC Res Notes 2010 Feb 22;3:39. Epub 2010 Feb 22.

Cancer Genetics Group, Children's Cancer Institute Australia for Medical Research, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia.

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http://dx.doi.org/10.1186/1756-0500-3-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848685PMC
February 2010

Comprehensive sequence analysis of the human IL23A gene defines new variation content and high rate of evolutionary conservation.

DNA Res 2010 Apr 12;17(2):117-22. Epub 2010 Feb 12.

Cancer Genetics Group, Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia.

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https://academic.oup.com/dnaresearch/article-lookup/doi/10.1
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http://dx.doi.org/10.1093/dnares/dsq003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853383PMC
April 2010

Inflammatory genetic markers of prostate cancer risk.

Cancers (Basel) 2010 Jun 8;2(2):1198-220. Epub 2010 Jun 8.

Cancer Genetics Group, Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, PO Box 81, Randwick, NSW 2031, Australia.

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http://www.mdpi.com/2072-6694/2/2/1198
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http://dx.doi.org/10.3390/cancers2021198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835126PMC
June 2010

Optimization methods for selecting founder individuals for captive breeding or reintroduction of endangered species.

Pac Symp Biocomput 2010 :43-53

Center for Comparative Genomics and Bioinformatics, Penn State, University Park, PA 16802, USA.

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http://dx.doi.org/10.1142/9789814295291_0006DOI Listing
November 2013

Genetic structure of a unique admixed population: implications for medical research.

Hum Mol Genet 2010 Feb 5;19(3):411-9. Epub 2009 Nov 5.

Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge Center, Cambridge, MA, USA.

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http://dx.doi.org/10.1093/hmg/ddp505DOI Listing
February 2010

Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations.

J Med Virol 2009 Nov;81(11):1847-51

Department of Molecular Animal Physiology, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour and Nijmegen Center for Molecular Life Sciences, Nijmegen 6525 GA , The Netherlands.

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http://dx.doi.org/10.1002/jmv.21601DOI Listing
November 2009

Assessing high-resolution melt curve analysis for accurate detection of gene variants in complex DNA fragments.

Hum Mutat 2009 Jun;30(6):876-83

Cancer Genetics Group, Children's Cancer Institute Australia for Medical Research, Sydney Children's Hospital, Randwick, Sydney, NSW, Australia.

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http://dx.doi.org/10.1002/humu.20919DOI Listing
June 2009

HSD17B4 overexpression, an independent biomarker of poor patient outcome in prostate cancer.

Mol Cell Endocrinol 2009 Mar 28;301(1-2):89-96. Epub 2008 Nov 28.

Cancer Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/j.mce.2008.11.021DOI Listing
March 2009

No association between common chemokine and chemokine receptor gene variants and prostate cancer risk.

Cancer Epidemiol Biomarkers Prev 2008 Dec;17(12):3615-7

Cancer Genetics Group, Children's Cancer Institute Australia, Level 1, Sydney Children's Hospital, P.O. Box 81, High Street, Randwick, New South Wales 2031, Australia.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-0
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http://dx.doi.org/10.1158/1055-9965.EPI-08-0896DOI Listing
December 2008

Mammographic density and candidate gene variants: a twins and sisters study.

Cancer Epidemiol Biomarkers Prev 2007 Jul;16(7):1479-84

Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 2/723 Swanston Street, Carlton, Victoria 3053, Australia.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-0107DOI Listing
July 2007

Erlotinib (OSI-774)-induced inhibition of transitional cell carcinoma of bladder cell line growth is enhanced by interferon-alpha.

BJU Int 2007 Jun 6;99(6):1539-45. Epub 2007 Mar 6.

Oncology Research Centre, Prince of Wales Hospital, Department of Clinical Medicine, University of New South Wales, Sydney, Australia.

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http://doi.wiley.com/10.1111/j.1464-410X.2007.06778.x
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http://dx.doi.org/10.1111/j.1464-410X.2007.06778.xDOI Listing
June 2007

Macrophage inhibitory cytokine-1 H6D polymorphism, prostate cancer risk, and survival.

Cancer Epidemiol Biomarkers Prev 2006 Jun;15(6):1223-5

Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia.

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http://dx.doi.org/10.1158/1055-9965.EPI-06-0063DOI Listing
June 2006

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.

J Biol Chem 2006 Jan 27;281(1):626-37. Epub 2005 Oct 27.

Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1074/jbc.M509567200DOI Listing
January 2006

Genetic variants in the vitamin D receptor gene and prostate cancer risk.

Cancer Epidemiol Biomarkers Prev 2005 Apr;14(4):997-9

Cancer Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia.

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http://dx.doi.org/10.1158/1055-9965.EPI-04-0660DOI Listing
April 2005

The E211 G>A androgen receptor polymorphism is associated with a decreased risk of metastatic prostate cancer and androgenetic alopecia.

Cancer Epidemiol Biomarkers Prev 2005 Apr;14(4):993-6

Cancer Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, NSW 2010, Australia.

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http://dx.doi.org/10.1158/1055-9965.EPI-04-0778DOI Listing
April 2005

Are polymorphic markers within the alpha-1-antitrypsin gene associated with risk of human immunodeficiency virus disease?

J Infect Dis 2003 Oct 30;188(8):1205-8. Epub 2003 Sep 30.

Department of Urology, University of Stellenbosch, Faculty of Health Sciences, Tygerberg, South Africa.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/3786
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http://dx.doi.org/10.1086/378641DOI Listing
October 2003

Genetic diversity of the alpha-1-antitrypsin gene in Africans identified using a novel genotyping assay.

Authors:
Vanessa M Hayes

Hum Mutat 2003 Jul;22(1):59-66

Genetics Laboratory, Department of Urology, University of Stellenbosch, Faculty of Health Sciences, Tygerberg, South Africa.

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http://dx.doi.org/10.1002/humu.10231DOI Listing
July 2003

Novel mutations and SNPs identified in CCR2 using a new comprehensive denaturing gradient gel electrophoresis assay.

Hum Mutat 2002 Oct;20(4):253-9

Department of Medical Virology, University of Stellenbosch, Tygerburg, South Africa.

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http://dx.doi.org/10.1002/humu.10111DOI Listing
October 2002