Vanessa C Wheeler

Vanessa C Wheeler

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Vanessa C Wheeler

Vanessa C Wheeler

Publications by authors named "Vanessa C Wheeler"

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Assessing average somatic CAG repeat instability at the protein level.

Sci Rep 2019 Dec 16;9(1):19152. Epub 2019 Dec 16.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-019-55202-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915696PMC
December 2019

Population-specific genetic modification of Huntington's disease in Venezuela.

PLoS Genet 2018 05 11;14(5):e1007274. Epub 2018 May 11.

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965898PMC
May 2018

Haplotype-based stratification of Huntington's disease.

Eur J Hum Genet 2017 11 23;25(11):1202-1209. Epub 2017 Aug 23.

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/ejhg.2017.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643960PMC
November 2017

A modifier of Huntington's disease onset at the MLH1 locus.

Hum Mol Genet 2017 10;26(19):3859-3867

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/hmg/ddx286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455020PMC
October 2017

Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.

Neuron 2017 Apr;94(1):48-57.e4

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479704PMC
April 2017

Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families.

Am J Hum Genet 2014 Jun;94(6):870-83

Molecular Neurogenetics Unit and Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; Departments of Neurology, Genetics, Psychiatry, and Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02141, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121471PMC
June 2014

Early alterations of brain cellular energy homeostasis in Huntington disease models.

J Biol Chem 2012 Jan 28;287(2):1361-70. Epub 2011 Nov 28.

INSERM UMR S975 and Assistance-Publique des Hôpitaux de Paris, Department of Genetics, Hôpital La Salpêtrière, 75013 Paris, France.

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http://dx.doi.org/10.1074/jbc.M111.309849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256882PMC
January 2012

Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.

PLoS Genet 2009 Dec 4;5(12):e1000749. Epub 2009 Dec 4.

Department of Neurobiology and Genetics, Institute of Genetics and Molecular and Cellular Biology, UMR 7104-CNRS/INSERM/UdS, Illkirch, France.

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http://dx.doi.org/10.1371/journal.pgen.1000749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778875PMC
December 2009

Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.

Hum Mol Genet 2009 Aug 23;18(16):3039-47. Epub 2009 May 23.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/hmg/ddp242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714728PMC
August 2009

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.

Neurobiol Dis 2006 Jul 12;23(1):190-7. Epub 2006 May 12.

Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA.

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http://dx.doi.org/10.1016/j.nbd.2006.02.011DOI Listing
July 2006

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.

Hum Mol Genet 2006 Jun 10;15(12):2015-24. Epub 2006 May 10.

Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/hmg/ddl125DOI Listing
June 2006

Huntington's disease.

Neuromolecular Med 2003 ;4(1-2):7-20

Molecular Neurogenetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1385/NMM:4:1-2:7DOI Listing
January 2004

Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice.

Hum Mol Genet 2003 Mar;12(5):497-508

Molecular Neurogenetics Unit, Massachusetts General Hospital, Building 149, 13th St, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/hmg/ddg046DOI Listing
March 2003

Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.

Hum Mol Genet 2003 Feb;12(3):273-81

Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/hmg/ddg056DOI Listing
February 2003

The HD mutation does not alter neuronal death in the striatum of Hdh(Q92) knock-in mice after mild focal ischemia.

Neurobiol Dis 2002 Oct;11(1):147-54

Stroke and Neurovascular Regulation, Massachusetts General Hospital, Charlestown, 02129, USA.

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http://dx.doi.org/10.1006/nbdi.2002.0532DOI Listing
October 2002

Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice.

Hum Mol Genet 2002 Sep;11(19):2233-41

Molecular Neurogenetics Unit, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/hmg/11.19.2233DOI Listing
September 2002