Publications by authors named "Vanesa Muncan"

41Publications

Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity.

Proc Natl Acad Sci U S A 2020 10 28;117(41):25560-25570. Epub 2020 Sep 28.

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Center, University of Amsterdam, 1105 BK Amsterdam, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1912772117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568276PMC
October 2020

A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine.

Front Cell Infect Microbiol 2020 9;10:272. Epub 2020 Jun 9.

Tytgat Institute for Intestinal and Liver Research, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fcimb.2020.00272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326037PMC
June 2020

A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration.

Cell Mol Gastroenterol Hepatol 2020 5;10(2):209-223. Epub 2020 Mar 5.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2020.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301200PMC
March 2020

MEX3A regulates Lgr5 stem cell maintenance in the developing intestinal epithelium.

EMBO Rep 2020 Apr 13;21(4):e48938. Epub 2020 Feb 13.

i3S - Institute for Research and Innovation in Health (Instituto de Investigação e Inovação em Saúde), University of Porto, Porto, Portugal.

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http://dx.doi.org/10.15252/embr.201948938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132344PMC
April 2020

ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.

Cell Mol Gastroenterol Hepatol 2020 17;10(1):23-42. Epub 2020 Jan 17.

Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology & Metabolism, Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jcmgh.2020.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210476PMC
January 2020

Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids.

J Vis Exp 2019 11 15(153). Epub 2019 Nov 15.

Department of Gastroenterology and Hepatology, Tytgat Institute for Intestinal and Liver Research, Amsterdam UMC, AG&M, University of Amsterdam;

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http://dx.doi.org/10.3791/60470DOI Listing
November 2019

Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling.

Cell Death Dis 2019 06 21;10(7):490. Epub 2019 Jun 21.

Amsterdam UMC, University of Amsterdam, Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Meibergdreef 71, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41419-019-1729-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588629PMC
June 2019

The P4-ATPase ATP9A is a novel determinant of exosome release.

PLoS One 2019 4;14(4):e0213069. Epub 2019 Apr 4.

Amsterdam University Medical Centers, university of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213069PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448858PMC
December 2019

Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth.

Cell Rep 2019 03;26(13):3698-3708.e5

Amsterdam UMC, University of Amsterdam, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology & Hepatology, Amsterdam Gastroenterology and Metabolism, Meibergdreef 69-71, Amsterdam, the Netherlands; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.celrep.2019.02.101DOI Listing
March 2019

Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning.

EMBO Rep 2019 02 10;20(2). Epub 2018 Dec 10.

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, AG&M, University of Amsterdam, Amsterdam, The Netherlands

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http://dx.doi.org/10.15252/embr.201846221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362357PMC
February 2019

Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation.

Cancer Res 2018 11 19;78(21):6098-6106. Epub 2018 Sep 19.

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3600DOI Listing
November 2018

Colorectal tumor prevention by the progestin medroxyprogesterone acetate is critically dependent on postmenopausal status.

Oncotarget 2018 Jul 17;9(55):30561-30567. Epub 2018 Jul 17.

Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.25703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078141PMC
July 2018

Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response.

Cell Mol Gastroenterol Hepatol 2018 5;5(1):67-82.e1. Epub 2017 Sep 5.

Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jcmgh.2017.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738458PMC
September 2017

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC.

Am J Physiol Gastrointest Liver Physiol 2016 06 5;310(11):G1138-46. Epub 2016 May 5.

Tytgat Institute for Gastrointestinal and Liver Research, Amsterdam, the Netherlands; Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands; and

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http://dx.doi.org/10.1152/ajpgi.00411.2015DOI Listing
June 2016

Esophageal development and epithelial homeostasis.

Am J Physiol Gastrointest Liver Physiol 2015 Aug 2;309(4):G216-28. Epub 2015 Jul 2.

Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands

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http://dx.doi.org/10.1152/ajpgi.00088.2015DOI Listing
August 2015

Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis.

World J Gastroenterol 2014 Nov;20(44):16683-9

Mattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.

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http://dx.doi.org/10.3748/wjg.v20.i44.16683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248212PMC
November 2014

Dichotomal effect of space flight-associated microgravity on stress-activated protein kinases in innate immunity.

Sci Rep 2014 Jun 27;4:5468. Epub 2014 Jun 27.

Department of Gastroenterology and Hepatology. Erasmus MC, University Medical Center Rotterdam, 's Gravendijkwal 230, NL-3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/srep05468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073167PMC
June 2014

ER stress induces epithelial differentiation in the mouse oesophagus.

Gut 2015 Feb 30;64(2):195-202. Epub 2014 Apr 30.

Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2013-306347
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http://dx.doi.org/10.1136/gutjnl-2013-306347DOI Listing
February 2015

Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.

Gut 2014 Feb 13;63(2):310-6. Epub 2013 Feb 13.

Tytgat Institute for Liver & Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, , Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2012-304216DOI Listing
February 2014

Rage mediated DAMP signaling in intestinal tumorigenesis.

Oncoimmunology 2012 Oct;1(7):1165-1166

Tytgat Institute for Liver and Intestal Research and Department of Gastroenterology; Academic Medical Center; Amsterdam, Netherlands.

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http://dx.doi.org/10.4161/onci.20929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494632PMC
October 2012

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.

Proc Natl Acad Sci U S A 2008 Dec 24;105(48):18919-23. Epub 2008 Nov 24.

School of Biosciences, University of Cardiff, Cardiff CF10 3AX, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0805778105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596219PMC
December 2008

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine.

EMBO Rep 2007 Oct 7;8(10):966-73. Epub 2007 Sep 7.

Netherlands Institute for Developmental Biology, Center for Biomedical Research, Hubrecht Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/sj.embor.7401071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002560PMC
October 2007

Myc deletion rescues Apc deficiency in the small intestine.

Nature 2007 Apr 21;446(7136):676-9. Epub 2007 Mar 21.

The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nature05674DOI Listing
April 2007

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.

Mol Cell Biol 2006 Nov 5;26(22):8418-26. Epub 2006 Sep 5.

Hubrecht Laboratory, Nederlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1128/MCB.00821-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636776PMC
November 2006

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.

J Biol Chem 2005 Aug 9;280(31):28463-7. Epub 2005 Jun 9.

School of Biosciences, University of Cardiff, Museum P. O. Box 911, Cardiff CF103US, Wales, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M500191200DOI Listing
August 2005