Valerie Mizrahi

Valerie Mizrahi

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Valerie Mizrahi

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Renewing the Fight Against TB with an Old Vaccine.

Cell 2020 Mar;180(5):829-831

SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit and Institute of Infectious Disease and Molecular Medicine. Division of Medical Microbiology, Department of Pathology, University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.02.024DOI Listing
March 2020

Harnessing Biological Insight to Accelerate Tuberculosis Drug Discovery.

Acc Chem Res 2019 08 30;52(8):2340-2348. Epub 2019 Jul 30.

SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit and DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology and Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Observatory, Cape Town 7925 , South Africa.

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http://dx.doi.org/10.1021/acs.accounts.9b00275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704484PMC
August 2019

Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH.

Eur J Med Chem 2019 Jul 15;174:309-329. Epub 2019 Apr 15.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7925, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234193033
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http://dx.doi.org/10.1016/j.ejmech.2019.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990405PMC
July 2019

Transmission of drug-resistant tuberculosis in HIV-endemic settings.

Lancet Infect Dis 2019 03 13;19(3):e77-e88. Epub 2018 Dec 13.

Department of Infection and Immunity, University College London, London, UK; Africa Health Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30537-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474238PMC
March 2019

Expanding the anti-TB arsenal.

Science 2019 02;363(6426):457-458

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1126/science.aaw5224DOI Listing
February 2019

Priming the tuberculosis drug pipeline: new antimycobacterial targets and agents.

Curr Opin Microbiol 2018 10 23;45:39-46. Epub 2018 Feb 23.

SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2018.02.006DOI Listing
October 2018

Drug-resistant tuberculosis: challenges and opportunities for diagnosis and treatment.

Curr Opin Pharmacol 2018 10 6;42:7-15. Epub 2018 Jun 6.

SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research and Wellcome Centre for Clinical Infectious Diseases Research in Africa, University of Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine and Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2018.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219890PMC
October 2018

The Coming of Age of Drug-Susceptibility Testing for Tuberculosis.

N Engl J Med 2018 10 26;379(15):1474-1475. Epub 2018 Sep 26.

From the Institute of Infectious Disease and Molecular Medicine and the Department of Pathology, Wellcome Centre for Infectious Diseases Research in Africa (H.C., V.M.), and the South African Medical Research Council/National Health Laboratory Service/University of Cape Town Molecular Mycobacteriology Research Unit, University of Cape Town (V.M.), Cape Town, South Africa.

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http://dx.doi.org/10.1056/NEJMe1811861DOI Listing
October 2018

Death of by l-arginine starvation.

Proc Natl Acad Sci U S A 2018 09 6;115(39):9658-9660. Epub 2018 Sep 6.

South African Medical Research Council, National Health Laboratory Service, University of Cape Town Molecular Mycobacteriology Research Unit, University of Cape Town, 7925 Cape Town, South Africa.

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http://dx.doi.org/10.1073/pnas.1813587115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166815PMC
September 2018

Mycobacterium tuberculosis.

Trends Microbiol 2018 06 23;26(6):555-556. Epub 2018 Mar 23.

SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2018.02.012DOI Listing
June 2018

Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.

J Med Chem 2018 06 30;61(11):4739-4756. Epub 2018 May 30.

Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy , University of Houston , Health Building 2, 4849 Calhoun Road , Houston , Texas 77204 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166404PMC
June 2018

Detection of bacilli in bio-aerosols from untreated TB patients.

Gates Open Res 2017 8;1:11. Epub 2018 Jun 8.

Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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https://gatesopenresearch.org/articles/1-11/v1
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http://dx.doi.org/10.12688/gatesopenres.12758.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757796PMC
June 2018

Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.

J Med Chem 2018 04 23;61(7):2806-2822. Epub 2018 Mar 23.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900554PMC
April 2018

DNA Replication Fidelity in the Mycobacterium tuberculosis Complex.

Adv Exp Med Biol 2017 ;1019:247-262

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit and DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, P/Bag X3, Rondebosch, 7700, South Africa.

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http://dx.doi.org/10.1007/978-3-319-64371-7_13DOI Listing
March 2018

-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2017 11 24;61(11). Epub 2017 Oct 24.

Comenius University in Bratislava, Faculty of Natural Sciences, Department of Biochemistry, Bratislava, Slovakia

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http://dx.doi.org/10.1128/AAC.01310-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655080PMC
November 2017

Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.

Front Mol Biosci 2017 14;4:75. Epub 2017 Nov 14.

SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fmolb.2017.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694481PMC
November 2017

Susceptibility of Mycobacterium tuberculosis Cytochrome Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome .

Antimicrob Agents Chemother 2017 10 22;61(10). Epub 2017 Sep 22.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Department of Pathology, University of Cape Town, Cape Town, South Africa

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http://dx.doi.org/10.1128/AAC.01338-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610507PMC
October 2017

Correction for Arora et al., "Respiratory Flexibility in Response to Inhibition of Cytochrome Oxidase in ".

Antimicrob Agents Chemother 2017 09 24;61(9). Epub 2017 Aug 24.

Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/AAC.01429-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571366PMC
September 2017

The Influence of HIV on the Evolution of Mycobacterium tuberculosis.

Mol Biol Evol 2017 07;34(7):1654-1668

Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, and Department of Medicine, University of Cape Town, Cape Town, South Africa.

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https://academic.oup.com/mbe/article-lookup/doi/10.1093/molb
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http://dx.doi.org/10.1093/molbev/msx107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455964PMC
July 2017

Identification and validation of novel drug targets in Mycobacterium tuberculosis.

Drug Discov Today 2017 03 17;22(3):503-509. Epub 2016 Sep 17.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Anzio Road, Observatory 7925, South Africa.

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http://dx.doi.org/10.1016/j.drudis.2016.09.010DOI Listing
March 2017

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.

ACS Infect Dis 2017 01 8;3(1):5-17. Epub 2016 Sep 8.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town , Anzio Road, Observatory 7925, South Africa.

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http://dx.doi.org/10.1021/acsinfecdis.6b00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241705PMC
January 2017

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.

ACS Infect Dis 2016 12 5;2(12):958-968. Epub 2016 Oct 5.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town , Anzio Road, Observatory 7925, South Africa.

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http://dx.doi.org/10.1021/acsinfecdis.6b00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153693PMC
December 2016

Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery.

Antimicrob Agents Chemother 2016 11 21;60(11):6748-6757. Epub 2016 Oct 21.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Department of Pathology, University of Cape Town, Cape Town, South Africa

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http://dx.doi.org/10.1128/AAC.01178-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075082PMC
November 2016

Targeted gene knockout and essentiality testing by homologous recombination.

Methods Mol Biol 2015 ;1285:131-49

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit and DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://link.springer.com/content/pdf/10.1007%2F978-1-4939-24
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http://link.springer.com/10.1007/978-1-4939-2450-9_8
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http://dx.doi.org/10.1007/978-1-4939-2450-9_8DOI Listing
December 2015

The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis.

Front Microbiol 2015 4;6:812. Epub 2015 Aug 4.

South African Medical Research Council/National Health Laboratory Service/University of Cape Town Molecular Mycobacteriology Research Unit Cape Town, South Africa ; DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town Cape Town, South Africa.

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http://dx.doi.org/10.3389/fmicb.2015.00812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523840PMC
August 2015

bis-Molybdopterin guanine dinucleotide is required for persistence of Mycobacterium tuberculosis in guinea pigs.

Infect Immun 2015 Feb 17;83(2):544-50. Epub 2014 Nov 17.

DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa

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http://iai.asm.org/content/early/2014/11/11/IAI.02722-14.ful
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http://iai.asm.org/content/83/2/544.full.pdf
Web Search
http://iai.asm.org/lookup/doi/10.1128/IAI.02722-14
Publisher Site
http://dx.doi.org/10.1128/IAI.02722-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294236PMC
February 2015

Cleavage of the moaX-encoded fused molybdopterin synthase from Mycobacterium tuberculosis is necessary for activity.

BMC Microbiol 2015 Feb 6;15:22. Epub 2015 Feb 6.

DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory Service, P.O. Box 1038, Johannesburg, 2000, South Africa.

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http://dx.doi.org/10.1186/s12866-015-0355-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326299PMC
February 2015

Diversity and disease pathogenesis in Mycobacterium tuberculosis.

Trends Microbiol 2015 Jan 10;23(1):14-21. Epub 2014 Nov 10.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2014.10.005DOI Listing
January 2015

The complex mechanism of antimycobacterial action of 5-fluorouracil.

Chem Biol 2015 Jan 24;22(1):63-75. Epub 2014 Dec 24.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Rondebosch, Cape Town 7700, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.11.006DOI Listing
January 2015

Respiratory flexibility in response to inhibition of cytochrome C oxidase in Mycobacterium tuberculosis.

Antimicrob Agents Chemother 2014 Nov 25;58(11):6962-5. Epub 2014 Aug 25.

Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/AAC.03486-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249445PMC
November 2014

Shortening treatment for tuberculosis--to basics.

N Engl J Med 2014 Oct;371(17):1642-3

From the Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine, and Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1056/NEJMe1410977DOI Listing
October 2014

Nucleotide Metabolism and DNA Replication.

Microbiol Spectr 2014 Oct;2(5)

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Center of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine, and Division of Medical Microbiology, University of Cape Town, P/Bag X3 Rondebosch 7700, South Africa.

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http://dx.doi.org/10.1128/microbiolspec.MGM2-0001-2013DOI Listing
October 2014

DNA metabolism in mycobacterial pathogenesis.

Curr Top Microbiol Immunol 2013 ;374:27-51

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit and DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, P/Bag X3, Rondebosch, 7700, South Africa,

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http://www.springer.com/cda/content/document/cda_downloaddoc
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http://link.springer.com/10.1007/82_2013_328
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http://dx.doi.org/10.1007/82_2013_328DOI Listing
April 2014

Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.

Bioorg Med Chem 2014 Mar 23;22(5):1726-35. Epub 2014 Jan 23.

Center for Drug Design, University of Minnesota, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667779PMC
March 2014

The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?

Emerg Microbes Infect 2014 Mar 12;3(3):e17. Epub 2014 Mar 12.

Medical Research Council/National Health Laboratory Service/University of Cape Town Molecular Mycobacteriology Research Unit, Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Institute of Infectious Disease and Molecular Medicine and Department of Clinical Laboratory Sciences, University of Cape Town , Cape Town 7701, South Africa.

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http://dx.doi.org/10.1038/emi.2014.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975073PMC
March 2014

Molybdenum cofactor: a key component of Mycobacterium tuberculosis pathogenesis?

Crit Rev Microbiol 2014 Feb 15;40(1):18-29. Epub 2013 Jan 15.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Division of Medical Microbiology, Faculty of Health Sciences , University of Cape Town .

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http://dx.doi.org/10.3109/1040841X.2012.749211DOI Listing
February 2014

Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents.

Bioorg Med Chem Lett 2014 Jan 12;24(2):560-4. Epub 2013 Dec 12.

Department of Chemistry, University of Cape Town, Private Bag X3, Rondebosch 7701, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2013.12.022DOI Listing
January 2014

Vitamin B(12) metabolism in Mycobacterium tuberculosis.

Future Microbiol 2013 Nov;8(11):1405-18

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Center of Excellence for Biomedical TB Research, Institute of Infectious Disease & Molecular Medicine & Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa.

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http://dx.doi.org/10.2217/fmb.13.113DOI Listing
November 2013

Complex genetics of drug resistance in Mycobacterium tuberculosis.

Nat Genet 2013 Oct;45(10):1107-8

Medical Research Council (MRC)-National Health Laboratory Service (NHLS)-University of Cape Town Molecular Mycobacteriology Research Unit and Department of Science and Technology (DST)-National Research Foundation (NRF) Centre of Excellence for Biomedical Tuberculosis Research, Institute of Infectious Disease and Molecular Medicine, and the Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Rondebosch, South Africa.

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http://dx.doi.org/10.1038/ng.2769DOI Listing
October 2013

A vitamin B₁₂ transporter in Mycobacterium tuberculosis.

Open Biol 2013 Feb 13;3(2):120175. Epub 2013 Feb 13.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit and DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, University of Cape Town, Observatory, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1098/rsob.120175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603451PMC
February 2013

Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening.

Chem Biol 2012 Jul;19(7):844-54

Molecular Mycobacteriology Research Unit and DST/NRF Centre of Excellence for Biomedical TB Research, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1016/j.chembiol.2012.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421836PMC
July 2012

Approaches to target identification and validation for tuberculosis drug discovery: a UCT perspective.

S Afr Med J 2012 Mar 2;102(6):457-60. Epub 2012 Mar 2.

Institute of Infectious Disease and Molecular Medicine, University of Cape Town.

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http://dx.doi.org/10.7196/samj.5437DOI Listing
March 2012

A pseudokinase debut at the mycobacterial cell wall.

Sci Signal 2012 Jan 24;5(208):pe3. Epub 2012 Jan 24.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit and DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Institute of Infectious Disease and Molecular Medicine, and Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Private Bag X3, Rondebosch 7701, Cape Town, South Africa.

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http://dx.doi.org/10.1126/scisignal.2002785DOI Listing
January 2012

VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins.

PLoS One 2011 29;6(6):e21738. Epub 2011 Jun 29.

Medical Research Council, National Health Laboratory Service, University of the Witwatersrand Molecular Mycobacteriology Research Unit, Department of Science and Technology, National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021738PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126847PMC
December 2011

Functional analysis of molybdopterin biosynthesis in mycobacteria identifies a fused molybdopterin synthase in Mycobacterium tuberculosis.

J Bacteriol 2011 Jan 22;193(1):98-106. Epub 2010 Oct 22.

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa.

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http://dx.doi.org/10.1128/JB.00774-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019926PMC
January 2011

Making ends meet in mycobacteria.

Mol Microbiol 2011 Jan 24;79(2):283-7. Epub 2010 Nov 24.

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit and DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, PO Box 1038, Johannesburg 2000, South Africa.

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http://doi.wiley.com/10.1111/j.1365-2958.2010.07462.x
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http://dx.doi.org/10.1111/j.1365-2958.2010.07462.xDOI Listing
January 2011

Depletion of resuscitation-promoting factors has limited impact on the drug susceptibility of Mycobacterium tuberculosis.

J Antimicrob Chemother 2010 Aug 11;65(8):1583-5. Epub 2010 Jun 11.

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, University of the Witwatersrand, National Health Laboratory Service, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1093/jac/dkq199DOI Listing
August 2010

Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis.

Proc Natl Acad Sci U S A 2010 Jul 6;107(29):13093-8. Epub 2010 Jul 6.

Medical Research Council/National Health Laboratory Service/University of the Witwatersrand Molecular Mycobacteriology Research Unit and Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1073/pnas.1002614107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919956PMC
July 2010

Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis.

J Bacteriol 2010 Apr 5;192(8):2220-7. Epub 2010 Feb 5.

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, School of Pathology of the University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa.

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http://jb.asm.org/content/192/8/2220.full.pdf
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http://jb.asm.org/cgi/doi/10.1128/JB.01135-09
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http://dx.doi.org/10.1128/JB.01135-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849458PMC
April 2010

Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling.

FEMS Immunol Med Microbiol 2010 Feb 4;58(1):39-50. Epub 2009 Sep 4.

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa.

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http://dx.doi.org/10.1111/j.1574-695X.2009.00606.xDOI Listing
February 2010

Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria.

J Bacteriol 2009 Feb 21;191(3):985-95. Epub 2008 Nov 21.

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand, National Health Laboratory Service, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1128/JB.01409-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632068PMC
February 2009

IS1096-mediated DNA rearrangements play a key role in genome evolution of Mycobacterium smegmatis.

Tuberculosis (Edinb) 2008 Sep 24;88(5):399-409. Epub 2008 Apr 24.

IPH-Pasteur Institute of Brussels, Rue Engeland 642, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.tube.2008.02.003DOI Listing
September 2008

Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids.

J Bacteriol 2008 Jun 28;190(11):3886-95. Epub 2008 Mar 28.

Molecular Mycobacteriology Research Unit, University of the Witwatersrand and National Health Laboratory Service, P.O. Box 1038, Johannesburg 2000, South Africa.

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http://jb.asm.org/cgi/doi/10.1128/JB.01767-07
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http://dx.doi.org/10.1128/JB.01767-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395058PMC
June 2008

The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro.

Mol Microbiol 2008 Feb;67(3):672-84

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1111/j.1365-2958.2007.06078.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229633PMC
February 2008

In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis.

J Bacteriol 2007 Mar 15;189(5):2190-5. Epub 2006 Dec 15.

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, University of the Witwatersrand, Johannesburg 2000, South Africa.

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http://jb.asm.org/cgi/doi/10.1128/JB.01647-06
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http://dx.doi.org/10.1128/JB.01647-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855714PMC
March 2007

The survival kit of Mycobacterium tuberculosis.

Nat Med 2007 Mar;13(3):282-4

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March 2007

A derivative of Mycobacterium smegmatis mc(2)155 that lacks the duplicated chromosomal region.

Tuberculosis (Edinb) 2006 Nov 15;86(6):438-44. Epub 2005 Dec 15.

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, DST-NRF, School of Pathology of the University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/j.tube.2005.10.001DOI Listing
November 2006

The carbon starvation-inducible genes Rv2557 and Rv2558 of Mycobacterium tuberculosis are not required for long-term survival under carbon starvation and for virulence in SCID mice.

Tuberculosis (Edinb) 2006 Nov 22;86(6):430-7. Epub 2005 Dec 22.

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, DST/NRF, School of Pathology of the University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1016/j.tube.2005.11.001DOI Listing
November 2006

Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy.

Clin Microbiol Rev 2006 Jul;19(3):558-70

Molecular Mycobacteriology Research Unit, Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand and NHLS, P.O. Box 1038, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1128/CMR.00060-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539104PMC
July 2006

Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption.

J Bacteriol 2005 Sep;187(18):6300-8

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, DST/NRF/ Centre of Excellence in Biomedical TB Research, School of Pathology, National Health Laboratory Service, Johannesburg, South Africa.

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http://dx.doi.org/10.1128/JB.187.18.6300-6308.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236647PMC
September 2005

Mycobacterium tuberculosis and the host response.

J Exp Med 2005 Jun;201(11):1693-7

Max Plank Institute for Infection Biology, Berlin D10117, Germany.

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http://dx.doi.org/10.1084/jem.20050842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213264PMC
June 2005

TB tools to tell the tale-molecular genetic methods for mycobacterial research.

Int J Biochem Cell Biol 2005 Jan;37(1):54-68

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, School of Pathology, University of the Witwatersrand and National Health Laboratory Service, P.O. Box 1038, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1016/j.biocel.2004.06.012DOI Listing
January 2005

Mycobacterial genetics in target validation.

Drug Discov Today Technol 2004 Oct;1(2):93-8

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, School of Pathology of the University of the Witwatersrand and the National Health Laboratory Service, PO Box 1038, Johannesburg 2000, South Africa. Electronic

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http://dx.doi.org/10.1016/j.ddtec.2004.07.001DOI Listing
October 2004

Lack of mismatch correction facilitates genome evolution in mycobacteria.

Mol Microbiol 2004 Sep;53(6):1601-9

Institut für Medizinische Mikrobiologie, Universität Zürich, Gloriastrasse 30/32, CH-3028 Zürich, Switzerland.

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http://doi.wiley.com/10.1111/j.1365-2958.2004.04231.x
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http://dx.doi.org/10.1111/j.1365-2958.2004.04231.xDOI Listing
September 2004

Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines.

Tuberculosis (Edinb) 2004 ;84(1-2):63-75

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, National Health Laboratory Service and School of Pathology, University of the Witwatersrand, NHLS P.O. Box 1038, Room 311 James Gear Building, Johannesburg 2000, South Africa.

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June 2004

The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo.

Mol Microbiol 2004 Jun;52(6):1691-702

Department of Medicine, Division of Infectious Diseases, University of British Columbia, 2733 Heather St., Vancouver, British Columbia, Canada V5Z 3J5.

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June 2004

Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases.

Infect Immun 2003 Nov;71(11):6124-31

School of Pathology of the National Health Laboratory Service and Department of Molecular Medicine and Hematology, University of the Witwatersrand Medical School, Johannesburg 2000, South Africa.

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http://dx.doi.org/10.1128/iai.71.11.6124-6131.2003DOI Listing
November 2003

The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice.

Proc Natl Acad Sci U S A 2003 Aug 1;100(17):10026-31. Epub 2003 Aug 1.

Tuberculosis Research Section, National Institute of Allergy and Infectious Disease, 12441 Parklawn Drive, Rockville, MD 20852, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1631248100
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187750PMC
August 2003

DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis.

Cell 2003 Apr;113(2):183-93

Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1016/s0092-8674(03)00270-8DOI Listing
April 2003

DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis.

Infect Immun 2003 Feb;71(2):997-1000

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, School of Pathology, University of the Witwatersrand, and National Health Laboratory Service, Johannesburg, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC145403PMC
http://dx.doi.org/10.1128/iai.71.2.997-1000.2003DOI Listing
February 2003

Construction and phenotypic characterization of an auxotrophic mutant of Mycobacterium tuberculosis defective in L-arginine biosynthesis.

Infect Immun 2002 Jun;70(6):3080-4

MRC/NHLS/WITS Molecular Mycobacteriology Research Unit, School of Pathology, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127984PMC
http://dx.doi.org/10.1128/iai.70.6.3080-3084.2002DOI Listing
June 2002

Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.

J Bacteriol 2002 Apr;184(8):2167-72

Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134955PMC
http://dx.doi.org/10.1128/jb.184.8.2167-2172.2002DOI Listing
April 2002

Production of mutants in amino acid biosynthesis genes of Mycobacterium tuberculosis by homologous recombination.

Microbiology 1999 Dec;145 ( Pt 12):3497-3503

Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK 1.

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December 1999