Valerie I Brown

Valerie I Brown

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Valerie I Brown

Valerie I Brown

Publications by authors named "Valerie I Brown"

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Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622.

J Clin Oncol 2018 08 29;36(22):2306-2314. Epub 2018 May 29.

William B. Slayton, John A. Kairalla, Meenakshi Devidas, Xinlei Mi, and Sherri L. Mizrahy, University of Florida, Gainesville, FL; Kirk R. Schultz, BC Children's Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; Michael A. Pulsipher, Children's Hospital of Los Angeles, Los Angeles; Lance Sieger, University of California Los Angles-Harbor, Torrance; Mignon L. Loh, University of California San Francisco, San Francisco, CA; Bill H. Chang, Oregon Health and Science University, Portland, OR; Charles Mullighan, Ilaria Iacobucci, and Thomas Merchant, St Jude's Research Hospital, Memphis, TN; Lewis B. Silverman, Dana-Farber Cancer Institute, Boston, MA; Michael J. Borowitz, Johns Hopkins University, Baltimore, MD; Andrew J. Carroll, University of Alabama at Birmingham, Birmingham, AL; Nyla A. Heerema, Ohio State University; Julie M. Gastier-Foster, Nationwide Children's Hospital, Columbus, OH; Brent L. Wood, University of Washington Seattle, Seattle, WA; Valerie I. Brown, Penn State Health Children's Hospital, Hershey; Stephen P. Hunger, Children's Hospital of Philadelphia, Philadelphia, PA; Marilyn J. Siegel, Washington University School of Medicine, St Louis, MO; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; Naomi J. Winick, University of Texas Southwestern Medical Center, Dallas, TX; and William L. Carroll, New York University Langone Health Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2017.76.7228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067800PMC
August 2018

Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies.

Paediatr Drugs 2012 Oct;14(5):299-316

Department of Pediatrics, Division of Oncology, Childrens Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2165/11594740-000000000-00000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214862PMC
October 2012

Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies.

Br J Haematol 2009 Jun 16;145(5):569-80. Epub 2009 Mar 16.

Division of Paediatric Hematology, Children's Hospital of Philadelphia, 3615 Civic Centre Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07657.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784662PMC
June 2009

Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease.

Immunol Res 2008 ;42(1-3):84-105

Division of Oncology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, ARC 902, 3615 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s12026-008-8038-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890314PMC
March 2009

Targeting Notch signaling in autoimmune and lymphoproliferative disease.

Blood 2008 Jan 9;111(2):705-14. Epub 2007 Oct 9.

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104, USA.

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http://dx.doi.org/10.1182/blood-2007-05-087353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200835PMC
January 2008

Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling.

Cancer Res 2007 Oct;67(20):9963-70

Division of Oncology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, and Department of Pediatrics, Division of Hematology and Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4704DOI Listing
October 2007

The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL.

Blood 2006 Feb 29;107(3):1149-55. Epub 2005 Sep 29.

Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2005-05-1935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895910PMC
February 2006

Role of the BCR complex in B cell development, activation, and leukemic transformation.

Immunol Res 2003 ;27(2-3):309-30

Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1385/IR:27:2-3:309DOI Listing
March 2004

Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling.

Proc Natl Acad Sci U S A 2003 Dec 1;100(25):15113-8. Epub 2003 Dec 1.

Division of Oncology, Children's Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.2436348100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299917PMC
December 2003