Publications by authors named "Valerie G Brunton"

86Publications

The fibrotic and immune microenvironments as targetable drivers of metastasis.

Br J Cancer 2020 Nov 26. Epub 2020 Nov 26.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1038/s41416-020-01172-1DOI Listing
November 2020

Characterisation of estrogen receptor alpha (ERα) expression in breast cancer cells and effect of drug treatment using targeted nanoparticles and SERS.

Analyst 2020 Nov;145(22):7225-7233

Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George Street, Glasgow, Scotland G1 1RD, UK.

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http://dx.doi.org/10.1039/d0an01532fDOI Listing
November 2020

Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells.

J Med Chem 2020 03 27;63(5):2028-2034. Epub 2019 Dec 27.

Edinburgh Cancer Research UK Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073915PMC
March 2020

HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies.

Breast Cancer Res Treat 2020 Feb 8;179(3):543-555. Epub 2019 Nov 8.

Edinburgh Cancer Research UK Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.

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http://dx.doi.org/10.1007/s10549-019-05489-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997276PMC
February 2020

Kinetic analysis of bioorthogonal reaction mechanisms using Raman microscopy.

Faraday Discuss 2019 12;220(0):71-85

EaStCHEM School of Chemistry, The University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.

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http://dx.doi.org/10.1039/c9fd00057gDOI Listing
December 2019

Alkyne-Tagged PLGA Allows Direct Visualization of Nanoparticles In Vitro and Ex Vivo by Stimulated Raman Scattering Microscopy.

Biomacromolecules 2019 10 29;20(10):4008-4014. Epub 2019 Aug 29.

EaStCHEM School of Chemistry , University of Edinburgh , David Brewster Road , Edinburgh , EH9 3FJ , United Kingdom.

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http://dx.doi.org/10.1021/acs.biomac.9b01092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794644PMC
October 2019

Inhibition of cyclin-dependent kinase activity exacerbates H O -induced DNA damage in Kindler syndrome keratinocytes.

Exp Dermatol 2019 09 31;28(9):1074-1078. Epub 2019 Jul 31.

Edinburgh Cancer Research UK Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1111/exd.14000DOI Listing
September 2019

Development of mouse models of angiosarcoma driven by p53.

Dis Model Mech 2019 07 9;12(7). Epub 2019 Jul 9.

Edinburgh Cancer Research UK Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK

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http://dx.doi.org/10.1242/dmm.038612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679377PMC
July 2019

Raman Imaging of Nanocarriers for Drug Delivery.

Nanomaterials (Basel) 2019 Mar 3;9(3). Epub 2019 Mar 3.

EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh EH9 3FJ, UK.

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https://www.mdpi.com/2079-4991/9/3/341
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http://dx.doi.org/10.3390/nano9030341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474004PMC
March 2019

Development of a fluorescence-based cellular apoptosis reporter.

Methods Appl Fluoresc 2018 Oct 24;7(1):015001. Epub 2018 Oct 24.

Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, United Kingdom.

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http://stacks.iop.org/2050-6120/7/i=1/a=015001?key=crossref.
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http://dx.doi.org/10.1088/2050-6120/aae6f8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372133PMC
October 2018

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.

Cell Chem Biol 2018 12 4;25(12):1456-1469.e6. Epub 2018 Oct 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183030
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http://dx.doi.org/10.1016/j.chembiol.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309505PMC
December 2018

Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopy.

Chem Sci 2017 Aug 24;8(8):5606-5615. Epub 2017 May 24.

EaStCHEM School of Chemistry , The University of Edinburgh , Joseph Black Building, David Brewster Road , Edinburgh , EH9 3FJ , UK . Email:

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http://dx.doi.org/10.1039/c7sc01837aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103005PMC
August 2017

Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening.

J Med Chem 2018 03 21;61(5):2104-2110. Epub 2018 Feb 21.

Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine , University of Edinburgh , Crewe Road South , Edinburgh EH4 2XR , U.K.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01605
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http://dx.doi.org/10.1021/acs.jmedchem.7b01605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851644PMC
March 2018

Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis.

Cancer Res 2018 03 12;78(6):1484-1496. Epub 2018 Jan 12.

Cancer Research UK Edinburgh Centre, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857359PMC
March 2018

Mouse models of metastasis: progress and prospects.

Dis Model Mech 2017 09;10(9):1061-1074

Edinburgh Cancer Research Centre, Institute for Genetics and Molecular Medicine, Edinburgh, EH4 2XR, UK

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http://dx.doi.org/10.1242/dmm.030403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611969PMC
September 2017

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Cancer Res 2017 10 14;77(19):5301-5312. Epub 2017 Aug 14.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126615PMC
October 2017

Kindlin-1 protects cells from oxidative damage through activation of ERK signalling.

Free Radic Biol Med 2017 07 10;108:896-903. Epub 2017 May 10.

Edinburgh Cancer Research UK Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.05.013DOI Listing
July 2017

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.

Nat Cell Biol 2017 05 17;19(5):518-529. Epub 2017 Apr 17.

Department of Experimental Medicine 1, Nikolaus-Fiebiger-Center for Molecular Medicine, FAU University Erlangen-Nürnberg, Glückstrasse 6, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1038/ncb3513DOI Listing
May 2017

Kindlin1 regulates microtubule function to ensure normal mitosis.

J Mol Cell Biol 2016 08 18;8(4):338-48. Epub 2016 Mar 18.

Edinburgh Cancer Research Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK

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http://dx.doi.org/10.1093/jmcb/mjw009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991666PMC
August 2016

Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer.

Dis Model Mech 2016 Feb 31;9(2):131-40. Epub 2015 Dec 31.

Edinburgh Cancer Research UK Centre, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK

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http://dx.doi.org/10.1242/dmm.023143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770148PMC
February 2016

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.

Cell Rep 2015 Dec 19;13(9):1949-64. Epub 2015 Nov 19.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)01245-0.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501245
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http://dx.doi.org/10.1016/j.celrep.2015.10.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678118PMC
December 2015

AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective.

J Med Chem 2016 04 20;59(8):3593-608. Epub 2015 Nov 20.

Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Crewe Road South, Edinburgh EH4 2XR, U.K.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b01273
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http://dx.doi.org/10.1021/acs.jmedchem.5b01273DOI Listing
April 2016

The role and therapeutic potential of the autotaxin-lysophosphatidate signalling axis in breast cancer.

Biochem J 2014 Oct;463(1):157-65

*Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, U.K.

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http://dx.doi.org/10.1042/BJ20140680DOI Listing
October 2014

Exploring mechanisms of acquired resistance to HER2 (human epidermal growth factor receptor 2)-targeted therapies in breast cancer.

Biochem Soc Trans 2014 Aug;42(4):822-30

*Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR.

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http://dx.doi.org/10.1042/BST20140109DOI Listing
August 2014

Cell biology. Where is PTEN?

Science 2013 Jul;341(6144):355-6

Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh EH14 4AS, UK.

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http://dx.doi.org/10.1126/science.1242541DOI Listing
July 2013

Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.

Nat Commun 2013 ;4:2056

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1038/ncomms3056DOI Listing
December 2013

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.

Cancer Res 2013 Aug 7;73(15):4674-86. Epub 2013 Jun 7.

The Beatson Institute for Cancer Research, Glasgow; Section of Dermatology, School of Medicine, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4545DOI Listing
August 2013

Dasatinib inhibits mammary tumour development in a genetically engineered mouse model.

J Pathol 2013 Aug;230(4):430-40

Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1002/path.4202DOI Listing
August 2013

E-cadherin-integrin crosstalk in cancer invasion and metastasis.

J Cell Sci 2013 Jan 22;126(Pt 2):393-401. Epub 2013 Mar 22.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1242/jcs.100115DOI Listing
January 2013

Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis.

J Bone Miner Res 2013 May;28(5):1229-42

Bone and Cancer Group, Edinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1002/jbmr.1847DOI Listing
May 2013

Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.

Carcinogenesis 2012 Dec 12;33(12):2369-76. Epub 2012 Sep 12.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1093/carcin/bgs284DOI Listing
December 2012

Diversity of matriptase expression level and function in breast cancer.

PLoS One 2012 13;7(4):e34182. Epub 2012 Apr 13.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034182PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325989PMC
August 2012

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery.

Drug Discov Today 2012 Mar;17(5-6):203-14

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.

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http://csmres.co.uk/cs.public.upd/article-downloads/Carraghe
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http://dx.doi.org/10.1016/j.drudis.2012.02.002DOI Listing
March 2012

Src kinase inhibitors: promising cancer therapeutics?

Crit Rev Oncog 2012 ;17(2):145-59

Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1615/critrevoncog.v17.i2.20DOI Listing
May 2012

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.

Nat Cell Biol 2011 Dec 4;14(1):51-60. Epub 2011 Dec 4.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1038/ncb2386DOI Listing
December 2011

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imaging.

Cell Adh Migr 2011 Jul-Aug;5(4):360-5. Epub 2011 Jul 1.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210304PMC
http://dx.doi.org/10.4161/cam.5.4.17290DOI Listing
December 2011

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells.

Int J Cancer 2012 Jul 30;131(2):287-97. Epub 2011 Aug 30.

Edinburgh Cancer Research Centre, Institute for Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1002/ijc.26351DOI Listing
July 2012

E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion.

BMC Cancer 2011 Jul 22;11:309. Epub 2011 Jul 22.

Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1186/1471-2407-11-309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154179PMC
July 2011

Live cell in vitro and in vivo imaging applications: accelerating drug discovery.

Pharmaceutics 2011 Apr 4;3(2):141-70. Epub 2011 Apr 4.

Advanced Science & Technology Laboratory, AstraZeneca R&D Charnwood, Loughborough LE11 5RH, UK.

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http://dx.doi.org/10.3390/pharmaceutics3020141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864231PMC
April 2011

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.

Cancer Res 2010 Nov 2;70(22):9413-22. Epub 2010 Nov 2.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079905PMC
November 2010

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.

Curr Biol 2010 Jun 20;20(12):1086-92. Epub 2010 May 20.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1016/j.cub.2010.04.042DOI Listing
June 2010

Two-color photoactivatable probe for selective tracking of proteins and cells.

J Biol Chem 2010 Apr 5;285(15):11607-16. Epub 2010 Feb 5.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.102392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857038PMC
April 2010

Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors.

Clin Cancer Res 2009 Oct 29;15(19):6232-40. Epub 2009 Sep 29.

Ludwig Center, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0224DOI Listing
October 2009

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.

Cell Adh Migr 2009 Oct-Dec;3(4):351-4. Epub 2009 Oct 7.

Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802745PMC
http://dx.doi.org/10.4161/cam.3.4.9460DOI Listing
March 2010

SRC family kinase activity is up-regulated in hormone-refractory prostate cancer.

Clin Cancer Res 2009 May 15;15(10):3540-9. Epub 2009 May 15.

Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, Glasgow Royal Infirmary, Glasgow, UK.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1857DOI Listing
May 2009

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.

Cancer Res 2009 Apr 24;69(7):2714-9. Epub 2009 Mar 24.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4308DOI Listing
April 2009

Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells.

Exp Hematol 2009 Feb 18;37(2):206-14. Epub 2008 Dec 18.

Section of Experimental Haematology, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1016/j.exphem.2008.10.013DOI Listing
February 2009

A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.

Carcinogenesis 2009 Feb 5;30(2):249-57. Epub 2008 Dec 5.

Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1093/carcin/bgn278DOI Listing
February 2009

Src and focal adhesion kinase as therapeutic targets in cancer.

Curr Opin Pharmacol 2008 Aug 22;8(4):427-32. Epub 2008 Jul 22.

Institute of Genetics & Molecular Medicine, Division of Cancer Biology, University of Edinburgh, Crewe Road South, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.coph.2008.06.012DOI Listing
August 2008

Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly.

Eur J Cell Biol 2008 Sep 17;87(8-9):569-79. Epub 2008 Jun 17.

The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1016/j.ejcb.2008.04.002DOI Listing
September 2008

The multi-FERM-domain-containing protein FrmA is required for turnover of paxillin-adhesion sites during cell migration of Dictyostelium.

J Cell Sci 2008 Apr 18;121(Pt 8):1159-64. Epub 2008 Mar 18.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1242/jcs.021725DOI Listing
April 2008

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.

Nat Cell Biol 2007 Sep 26;9(9):1046-56. Epub 2007 Aug 26.

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/ncb1626DOI Listing
September 2007

An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells.

Exp Cell Res 2007 Sep 24;313(15):3175-88. Epub 2007 May 24.

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, Scotland, UK.

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http://dx.doi.org/10.1016/j.yexcr.2007.04.037DOI Listing
September 2007

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.

J Cell Sci 2007 Aug 10;120(Pt 15):2555-64. Epub 2007 Jul 10.

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1242/jcs.003657DOI Listing
August 2007

Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib.

Mol Cancer Ther 2006 Dec 5;5(12):3014-22. Epub 2006 Dec 5.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0382DOI Listing
December 2006

Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex.

Cell Motil Cytoskeleton 2006 Jan;63(1):6-13

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1002/cm.20101DOI Listing
January 2006

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.

Nat Rev Cancer 2005 Jul;5(7):505-15

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom.

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http://www.nature.com/articles/nrc1647
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http://dx.doi.org/10.1038/nrc1647DOI Listing
July 2005

The SRC-induced mesenchymal state in late-stage colon cancer cells.

Cells Tissues Organs 2005 ;179(1-2):73-80

Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1159/000084511DOI Listing
September 2005

RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane.

Dev Cell 2004 Dec;7(6):855-69

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1016/j.devcel.2004.09.019DOI Listing
December 2004

FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity.

J Cell Sci 2004 Dec;117(Pt 25):6007-17

CR-UK Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1242/jcs.01519DOI Listing
December 2004

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.

J Biol Chem 2004 Oct 23;279(44):46113-21. Epub 2004 Aug 23.

Cancer Research UK Paterson Institute for Cancer Research, Manchester, and School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1074/jbc.M408550200DOI Listing
October 2004

Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition.

Mol Biol Cell 2004 Jun 9;15(6):2794-803. Epub 2004 Apr 9.

Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e03-12-0879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420103PMC
June 2004

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

Nat Cell Biol 2002 Aug;4(8):632-8

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/ncb829DOI Listing
August 2002

Advances in Rho-dependent actin regulation and oncogenic transformation.

Curr Opin Genet Dev 2002 Feb;12(1):36-43

The Beatson Institute for Cancer Research and Institute of Biomedical and Life Sciences, Cancer Research Campaign Beatson Laboratories, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1016/s0959-437x(01)00261-1DOI Listing
February 2002