Valerian E Kagan

Valerian E Kagan

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Valerian E Kagan

Publications by authors named "Valerian E Kagan"

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Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level.

Angew Chem Int Ed Engl 2019 Mar 14;58(10):3156-3161. Epub 2019 Feb 14.

Department of Chemistry, Pennsylvania State University, 209 Chemistry Bldg., University Park, PA, 16802, USA.

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http://dx.doi.org/10.1002/anie.201814256DOI Listing
March 2019

Aiming for the target: Mitochondrial drug delivery in traumatic brain injury.

Neuropharmacology 2019 02 30;145(Pt B):209-219. Epub 2018 Jul 30.

Department of Critical Care Medicine, Safar Center for Resuscitation Research, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA; Children's Neuroscience Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309489PMC
February 2019

Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members.

J Chem Inf Model 2019 Feb 28. Epub 2019 Feb 28.

Mol & Cell Cancer Biology , UPMC Hillman Cancer Center , Pittsburgh , Pennsylvania 15232 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jcim.9b00006
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http://dx.doi.org/10.1021/acs.jcim.9b00006DOI Listing
February 2019

Mitochondria modulate programmed neuritic retraction.

Proc Natl Acad Sci U S A 2019 01 24;116(2):650-659. Epub 2018 Dec 24.

Neuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;

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http://dx.doi.org/10.1073/pnas.1811021116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329959PMC
January 2019

Lipidomics Detection of Brain Cardiolipins in Plasma Is Associated With Outcome After Cardiac Arrest.

Crit Care Med 2019 Jan 11. Epub 2019 Jan 11.

Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1097/CCM.0000000000003636DOI Listing
January 2019

Disentangling oxidation/hydrolysis reactions of brain mitochondrial cardiolipins in pathogenesis of traumatic injury.

JCI Insight 2018 Nov 2;3(21). Epub 2018 Nov 2.

The Safar Center for Resuscitation Research and the Neuroscience Institute of Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

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https://insight.jci.org/articles/view/97677
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http://dx.doi.org/10.1172/jci.insight.97677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238757PMC
November 2018

Aberrant cardiolipin metabolism is associated with cognitive deficiency and hippocampal alteration in tafazzin knockdown mice.

Biochim Biophys Acta Mol Basis Dis 2018 Oct 25;1864(10):3353-3367. Epub 2018 Jul 25.

Department of Pharmacology & Therapeutics, Faculty of Health Sciences, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E OW3, Canada; The Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada; Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Center, Winnipeg, MB R3E 0Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.07.022DOI Listing
October 2018

Targeting myeloid regulators by paclitaxel-loaded enzymatically degradable nanocups.

Nanoscale 2018 Sep;10(37):17990-18000

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

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http://dx.doi.org/10.1039/c8nr04437fDOI Listing
September 2018

Oxidized phospholipid signaling in traumatic brain injury.

Free Radic Biol Med 2018 Aug 30;124:493-503. Epub 2018 Jun 30.

Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15224, United States; Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, United States; Children's Neuroscience Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, United States. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098726PMC
August 2018

Structural characterization of cardiolipin-driven activation of cytochrome c into a peroxidase and membrane perturbation.

Biochim Biophys Acta Biomembr 2018 May 6;1860(5):1057-1068. Epub 2018 Jan 6.

Division of Metabolic and Vascular Health, Medical School, University of Warwick, Coventry CV4 7AL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2018.01.009DOI Listing
May 2018

Regulation of lipid peroxidation and ferroptosis in diverse species.

Genes Dev 2018 05;32(9-10):602-619

Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

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http://dx.doi.org/10.1101/gad.314674.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004068PMC
May 2018

Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency.

Immunology 2018 03 26;153(3):342-356. Epub 2017 Oct 26.

Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders (TARGID), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/imm.12844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795189PMC
March 2018

NME4/nucleoside diphosphate kinase D in cardiolipin signaling and mitophagy.

Lab Invest 2018 02 16;98(2):228-232. Epub 2017 Oct 16.

Center for Free Radical and Antioxidant Health, Department of Environmental Health, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1038/labinvest.2017.113DOI Listing
February 2018

Necroptotic cell death in anti-cancer therapy.

Immunol Rev 2017 11;280(1):207-219

Cancer Research Institute Ghent (CRIG), Ghent, Belgium.

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http://dx.doi.org/10.1111/imr.12583DOI Listing
November 2017

Global assessment of oxidized free fatty acids in brain reveals an enzymatic predominance to oxidative signaling after trauma.

Biochim Biophys Acta Mol Basis Dis 2017 10 25;1863(10 Pt B):2601-2613. Epub 2017 Mar 25.

Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15224, United States; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, United States; Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, United States; Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA 15224, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612836PMC
October 2017

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

Cell 2017 Oct;171(3):628-641.e26

Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173113
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http://dx.doi.org/10.1016/j.cell.2017.09.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683852PMC
October 2017

Ins and Outs in Environmental and Occupational Safety Studies of Asthma and Engineered Nanomaterials.

ACS Nano 2017 08 24;11(8):7565-7571. Epub 2017 Jul 24.

Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Centers for Disease Control and Prevention , Morgantown, West Virginia 26505, United States.

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http://dx.doi.org/10.1021/acsnano.7b04916DOI Listing
August 2017

Defect-Induced Near-Infrared Photoluminescence of Single-Walled Carbon Nanotubes Treated with Polyunsaturated Fatty Acids.

J Am Chem Soc 2017 04 22;139(13):4859-4865. Epub 2017 Mar 22.

Departments of †Chemistry, ‡Mechanical Engineering and Materials Science, §Environmental and Occupational Health, and ∥Bioengineering, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.

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http://dx.doi.org/10.1021/jacs.7b00390DOI Listing
April 2017

A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage.

J Invest Dermatol 2017 03 26;137(3):576-586. Epub 2016 Oct 26.

Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.09.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466072PMC
March 2017

Known unknowns of cardiolipin signaling: The best is yet to come.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Jan 4;1862(1):8-24. Epub 2016 Aug 4.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323096PMC
January 2017

Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids.

Biochem Biophys Res Commun 2017 01 3;482(3):482-490. Epub 2017 Feb 3.

Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.bbrc.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319735PMC
January 2017

Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity.

Placenta 2016 11 14;47:86-95. Epub 2016 Sep 14.

Magee-Womens Research Institute, Department of OBGYN and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123854PMC
November 2016

Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications.

Toxicol Appl Pharmacol 2016 May 6;299:58-69. Epub 2016 Jan 6.

Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, United States; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, United States; Departments of Pharmacology and Chemical Biology and Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15260, United States. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2016.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811710PMC
May 2016

Peroxidase activation of cytoglobin by anionic phospholipids: Mechanisms and consequences.

Biochim Biophys Acta 2016 May 27;1861(5):391-401. Epub 2016 Feb 27.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Center for Free Radical and Antioxidant Health and Center for Medical Countermeasures against Radiation, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821708PMC
May 2016

Necrostatin-1 rescues mice from lethal irradiation.

Biochim Biophys Acta 2016 04 20;1862(4):850-856. Epub 2016 Jan 20.

Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, United States; Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh, United States; Children's Hospital of Pittsburgh, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788560PMC
April 2016

LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1.

J Cell Sci 2016 Jan 24;129(1):51-64. Epub 2015 Nov 24.

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA Department of Cell Biology and Physiology and Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA Medical Specialty Service Line, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA

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http://dx.doi.org/10.1242/jcs.176701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732295PMC
January 2016

Structural Changes and Proapoptotic Peroxidase Activity of Cardiolipin-Bound Mitochondrial Cytochrome c.

Biophys J 2015 Nov;109(9):1873-84

Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643272PMC
November 2015

Inhibition of Peroxidase Activity of Cytochrome c: De Novo Compound Discovery and Validation.

Mol Pharmacol 2015 Sep 15;88(3):421-7. Epub 2015 Jun 15.

Department of Computational and Systems Biology, School of Medicine (A.B., F.H., I.B.), and Department of Environmental and Occupational Health (A.A.K., H.B., V.E.K.), University of Pittsburgh, Pittsburgh, Pennsylvania

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http://molpharm.aspetjournals.org/content/early/2015/06/15/m
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http://molpharm.aspetjournals.org/content/88/3/421.full.pdf
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.115.09
Publisher Site
http://dx.doi.org/10.1124/mol.115.097816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551054PMC
September 2015

Cardiolipin Interactions with Proteins.

Biophys J 2015 Sep 20;109(6):1282-94. Epub 2015 Aug 20.

Division of Metabolic and Vascular Health, Medical School, University of Warwick, Coventry, United Kingdom; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.07.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576322PMC
September 2015

MDSC and TGFβ Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes.

Cancer Res 2015 Apr 5;75(8):1615-23. Epub 2015 Mar 5.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Department of Immunology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-2376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401633PMC
April 2015

Abnormalities in the male reproductive system after exposure to diesel and biodiesel blend.

Environ Mol Mutagen 2015 Mar 18;56(2):265-76. Epub 2014 Oct 18.

Pathology and Physiology Research Branch, and Exposure Assessment Branch, HELD, NIOSH, Morgantown, West Virginia.

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http://dx.doi.org/10.1002/em.21915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946425PMC
March 2015

Mitochondrial NM23-H4/NDPK-D: a bifunctional nanoswitch for bioenergetics and lipid signaling.

Naunyn Schmiedebergs Arch Pharmacol 2015 Feb 18;388(2):271-8. Epub 2014 Sep 18.

Laboratory of Fundamental and Applied Bioenergetics (LBFA) and SFR Environmental and Systems Biology (BEeSy), University Grenoble Alpes, Grenoble, France,

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http://dx.doi.org/10.1007/s00210-014-1047-4DOI Listing
February 2015

Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion.

J Cereb Blood Flow Metab 2015 Feb 19;35(2):319-28. Epub 2014 Nov 19.

1] Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA [2] Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA [3] Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA [4] Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA [5] Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1038/jcbfm.2014.204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426750PMC
February 2015

Nano-gold corking and enzymatic uncorking of carbon nanotube cups.

J Am Chem Soc 2015 Jan 7;137(2):675-84. Epub 2015 Jan 7.

Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.

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http://dx.doi.org/10.1021/ja511843wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308760PMC
January 2015

Quantification of selective phosphatidylserine oxidation during apoptosis.

Methods Mol Biol 2014 ;1105:603-11

Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Bridgeside Point, Pittsburgh, PA, 15219, USA,

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http://dx.doi.org/10.1007/978-1-62703-739-6_41DOI Listing
November 2014

Quantitative method of measuring phosphatidylserine externalization during apoptosis using electron paramagnetic resonance (EPR) spectroscopy and annexin-conjugated iron.

Methods Mol Biol 2014 ;1105:613-21

Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Bridgeside Point, Pittsburgh, PA, 15219, USA,

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http://link.springer.com/10.1007/978-1-62703-739-6_42
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http://dx.doi.org/10.1007/978-1-62703-739-6_42DOI Listing
November 2014

Molecular speciation and dynamics of oxidized triacylglycerols in lipid droplets: Mass spectrometry and coarse-grained simulations.

Free Radic Biol Med 2014 Nov 10;76:53-60. Epub 2014 Aug 10.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.07.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276254PMC
November 2014

Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate.

J Biol Chem 2014 Nov 2;289(47):32488-98. Epub 2014 Oct 2.

From the Center for Free Radical and Antioxidant Health, the Departments of Environmental and Occupational Health, Pharmacology and Chemical Biology, Radiation Oncology, and Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.

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http://dx.doi.org/10.1074/jbc.M114.601377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239604PMC
November 2014

Designing inhibitors of cytochrome c/cardiolipin peroxidase complexes: mitochondria-targeted imidazole-substituted fatty acids.

Free Radic Biol Med 2014 Jun 12;71:221-30. Epub 2014 Mar 12.

Center for Free Radical and Antioxidant Health and Center for Medical Countermeasures against Radiation, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Pharmacology and Chemical Biology, and University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849140010
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http://dx.doi.org/10.1016/j.freeradbiomed.2014.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216591PMC
June 2014

A mitochondrial pathway for biosynthesis of lipid mediators.

Nat Chem 2014 Jun 20;6(6):542-52. Epub 2014 Apr 20.

1] Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA [2] Department of Environmental Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1038/nchem.1924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201180PMC
June 2014

Lung macrophages "digest" carbon nanotubes using a superoxide/peroxynitrite oxidative pathway.

ACS Nano 2014 Jun 4;8(6):5610-21. Epub 2014 Jun 4.

Center for Free Radical and Antioxidant Health, △Acute Lung Injury Center of Excellence, ‡Departments of Environmental and Occupational Health, §Cell Biology and Physiology, ⊥Chemistry, and ⊗Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania, United States.

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http://dx.doi.org/10.1021/nn406484bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072413PMC
June 2014

Cardiolipin asymmetry, oxidation and signaling.

Chem Phys Lipids 2014 Apr 1;179:64-9. Epub 2013 Dec 1.

Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1016/j.chemphyslip.2013.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973441PMC
April 2014

Characterization of cardiolipins and their oxidation products by LC-MS analysis.

Chem Phys Lipids 2014 Apr 12;179:3-10. Epub 2013 Dec 12.

Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1016/j.chemphyslip.2013.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025908PMC
April 2014

Evaluation of the Pulmonary Toxicity of Cellulose Nanocrystals: A Renewable and Sustainable Nanomaterial of the Future.

ACS Sustain Chem Eng 2014;2(7):1691-1698. Epub 2014 Apr 18.

Pathology and Physiology Research Branch/NIOSH/CDC, Morgantown, West Virginia 26505, United States; Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, United States.

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http://dx.doi.org/10.1021/sc500153kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703331PMC
April 2014

Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.

J Biol Chem 2014 Apr 3;289(15):10668-79. Epub 2014 Mar 3.

From the Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.

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http://dx.doi.org/10.1074/jbc.M113.540260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036448PMC
April 2014

E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia.

Cell Rep 2014 Apr 3;7(2):476-487. Epub 2014 Apr 3.

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Medical Specialty Service Line, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.02.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085683PMC
April 2014

LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: implications for Parkinson disease.

Autophagy 2014 Feb 26;10(2):376-8. Epub 2013 Nov 26.

Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health; University of Pittsburgh School of Public Health; Pittsburgh, PA USA.

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http://www.researchgate.net/profile/Charleen_Chu/publication
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http://www.tandfonline.com/doi/full/10.4161/auto.27191
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http://dx.doi.org/10.4161/auto.27191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396091PMC
February 2014

Molecular modeling in structural nano-toxicology: interactions of nano-particles with nano-machinery of cells.

Adv Drug Deliv Rev 2013 Dec 28;65(15):2070-7. Epub 2013 May 28.

Pathology & Physiology Research Branch/NIOSH/CDC, Morgantown, WV, USA.

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http://dx.doi.org/10.1016/j.addr.2013.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819408PMC
December 2013

Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo.

Adv Drug Deliv Rev 2013 Dec 12;65(15):1921-32. Epub 2013 Jul 12.

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.addr.2013.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855904PMC
December 2013

LC/MS characterization of rotenone induced cardiolipin oxidation in human lymphocytes: implications for mitochondrial dysfunction associated with Parkinson's disease.

Mol Nutr Food Res 2013 Aug 3;57(8):1410-22. Epub 2013 May 3.

Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1002/mnfr.201200801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810210PMC
August 2013

Effect of antioxidants on enzyme-catalysed biodegradation of carbon nanotubes.

J Mater Chem B 2013 ;1(3):302-309

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1039/C2TB00047DDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634595PMC
January 2013

A natural vanishing act: the enzyme-catalyzed degradation of carbon nanomaterials.

Acc Chem Res 2012 Oct 23;45(10):1770-81. Epub 2012 Jul 23.

Department of Chemistry, University of Pittsburgh, Pennsylvania, United States.

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http://dx.doi.org/10.1021/ar300106hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473158PMC
October 2012