Publications by authors named "Valeria Filippi"

4 Publications

  • Page 1 of 1

An observed association between conjunctivitis and severity of COVID-19.

J Infect 2021 Jun 9. Epub 2021 Jun 9.

Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.

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http://dx.doi.org/10.1016/j.jinf.2021.06.006DOI Listing
June 2021

Central obesity, smoking habit, and hypertension are associated with lower antibody titres in response to COVID-19 mRNA vaccine.

Diabetes Metab Res Rev 2021 May 6:e3465. Epub 2021 May 6.

Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.

Aims: To explore variables associated with the serological response following COVID-19 mRNA vaccine.

Methods: Eighty-six healthcare workers adhering to the vaccination campaign against COVID-19 were enrolled in January-February 2021. All subjects underwent two COVID-19 mRNA vaccine inoculations (Pfizer/BioNTech) separated by 3 weeks. Blood samples were collected before the 1st and 1-4 weeks after the second inoculation. Clinical history, demographics, and vaccine side effects were recorded. Baseline anthropometric parameters were measured, and body composition was performed through dual-energy-X-ray absorptiometry.

Results: Higher waist circumference was associated with lower antibody (Ab) titres (R = -0.324, p = 0.004); smokers had lower levels compared to non-smokers [1099 (1350) vs. 1921 (1375), p = 0.007], as well as hypertensive versus normotensive [650 ± 1192 vs. 1911 (1364), p = 0.001] and dyslipideamic compared to those with normal serum lipids [534 (972) vs 1872 (1406), p = 0.005]. Multivariate analysis showed that higher waist circumference, smoking, hypertension, and longer time elapsed since second vaccine inoculation were associated with lower Ab titres, independent of BMI, age. and gender.

Conclusions: Central obesity, hypertension, and smoking are associated with lower Ab titres following COVID-19 vaccination. Although it is currently impossible to determine whether lower SARS-CoV-2 Abs lead to higher likelihood of developing COVID-19, it is well-established that neutralizing antibodies correlate with protection against several viruses including SARS-CoV-2. Our findings, therefore, call for a vigilant approach, as subjects with central obesity, hypertension, and smoking could benefit from earlier vaccine boosters or different vaccine schedules.
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http://dx.doi.org/10.1002/dmrr.3465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209952PMC
May 2021

Anaplastic astrocytoma during pregnancy: the importance of an effective multidisciplinary approach.

BMJ Case Rep 2021 Apr 1;14(4). Epub 2021 Apr 1.

Obstetrics and Gynecology, University Hospital Basel, Basel, Switzerland.

A 34-year-old pregnant woman at 28 gestational weeks was diagnosed with a brain tumor after experiencing a generalised seizure. After completion of antenatal fetal lung maturation, she underwent an osteoplastic craniotomy parietal on the left side and a microsurgical partial tumor resection under general anaesthesia. With a histology of a diffuse astrocytoma and the postoperative stable amount of residual tumor on follow-up imaging, the pregnancy proceeded until 37 gestational weeks. A healthy baby boy was delivered by elective caesarean section. An awake craniotomy for removal of the residual tumor was planned two weeks later, followed by adjuvant treatment (combined radio-/chemotherapy). A multidisciplinary approach, combined with appropriate timing and a transparent and empathic communication, was able to create the most effective tailored management and optimise maternal and neonatal outcomes.
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http://dx.doi.org/10.1136/bcr-2021-242135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021753PMC
April 2021

Unprecedented reversible coupling of alkynyl and phosphide ligands on a dinuclear platinum framework.

Chem Commun (Camb) 2005 Apr 7(16):2155-7. Epub 2005 Mar 7.

Dipartimento di Chimica e Chimica Industriale, Universita di Pisa, Via Risorgimento 35, I-56126 Pisa, Italy.

The reductive coupling of the bridging phosphide and the adjacent [sigma]-alkynyl moieties in [Pt2(mu-P(t)Bu2){mu,eta1:eta2-C(Ph)CH2}(C[triple bond]C-Ph)(CO)(P(t)Bu2H)(Br)] is promoted by bromide abstraction and is reversed by adding N(n)Bu4Br.
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http://dx.doi.org/10.1039/b418893dDOI Listing
April 2005
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