Publications by authors named "Valentina Svicher"

97 Publications

Poor CD4/CD8 ratio recovery in HBcAb-positive HIV patients with worse immune status is associated with significantly higher CD8 cell numbers.

Authors:
Vincenzo Malagnino Carlotta Cerva Elisabetta Teti Laura Campogiani Mirko Compagno Luca Foroghi Biland Laura Saderi Daniele Armenia Romina Salpini Valentina Svicher Giovanni Sotgiu Marco Iannetta Massimo Andreoni Loredana Sarmati

Sci Rep 2021 Feb 17;11(1):3965. Epub 2021 Feb 17.

Clinic of Infectious Diseases, Policlinico Tor Vergata, V. Montpelier 1, 00133, Rome, Italy.

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February 2021

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B.

Authors:
Valentina Svicher Romina Salpini Lorenzo Piermatteo Luca Carioti Arianna Battisti Luna Colagrossi Rossana Scutari Matteo Surdo Valeria Cacciafesta Andrea Nuccitelli Navjyot Hansi Francesca Ceccherini Silberstein Carlo Federico Perno Upkar S Gill Patrick T F Kennedy

Gut 2020 Dec 21. Epub 2020 Dec 21.

Barts Liver Cente, Immunobiology, Blizard Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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December 2020

Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control.

Authors:
Romina Salpini Mohammad Alkhatib Giosuè Costa Lorenzo Piermatteo Francesca Alessandra Ambrosio Velia Chiara Di Maio Rossana Scutari Leonardo Duca Giulia Berno Lavinia Fabeni Stefano Alcaro Francesca Ceccherini-Silberstein Anna Artese Valentina Svicher

J Antimicrob Chemother 2021 01;76(2):396-412

Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.

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January 2021

Long-Term SARS-CoV-2 Infection Associated with Viral Dissemination in Different Body Fluids Including Bile in Two Patients with Acute Cholecystitis.

Authors:
Rossana Scutari Lorenzo Piermatteo Matteo Ciancio Manuelli Marco Iannetta Romina Salpini Ada Bertoli Claudia Alteri Patrizia Saccomandi Maria Concetta Bellocchi Vincenzo Malagnino Elisabetta Teti Daniele Sforza Leandro Siragusa Michele Grande Loredana Sarmati Valentina Svicher Massimo Andreoni Francesca Ceccherini-Silberstein

Life (Basel) 2020 Nov 23;10(11). Epub 2020 Nov 23.

Department of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.

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November 2020

Cryptic HBV Replicative Activity Is Frequently Revealed in Anti-HBc-Positive/HBsAg-Negative Patients with HIV Infection by Highly Sensitive Molecular Assays, and Can Be Predicted by Integrating Classical and Novel Serological HBV Markers.

Authors:
Romina Salpini Vincenzo Malagnino Lorenzo Piermatteo Tiziana Mulas Mohammad Alkhatib Rossana Scutari Elisabetta Teti Carlotta Cerva Katia Yu La Rosa Marta Brugneti Ada Bertoli Benedetta Rossi Vera Holzmayer Jeffrey Gersch Mary Kuhns Gavin Cloherty Francesca Ceccherini-Silberstein Carlo-Federico Perno Marco Iannetta Massimo Andreoni Loredana Sarmati Valentina Svicher

Microorganisms 2020 Nov 18;8(11). Epub 2020 Nov 18.

Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

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November 2020

Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses.

Authors:
Anna Artese Valentina Svicher Giosuè Costa Romina Salpini Velia Chiara Di Maio Mohammad Alkhatib Francesca Alessandra Ambrosio Maria Mercedes Santoro Yehuda G Assaraf Stefano Alcaro Francesca Ceccherini-Silberstein

Drug Resist Updat 2020 12 26;53:100721. Epub 2020 Aug 26.

Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address:

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December 2020

Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages.

Authors:
Stefano Aquaro Ana Borrajo Michele Pellegrino Valentina Svicher

Virulence 2020 12;11(1):400-413

Department of Experimental Medicine, University of Rome Tor Vergata, Roma, Italy.

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December 2020

Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels , hinder HBsAg secretion and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection.

Authors:
Romina Salpini Arianna Battisti Lorenzo Piermatteo Luca Carioti Olympia E Anastasiou Upkar S Gill Domenico Di Carlo Luna Colagrossi Leonardo Duca Ada Bertoli Katia Yu La Rosa Lavinia Fabeni Alessandra Iuvara Vincenzo Malagnino Carlotta Cerva Miriam Lichtner Claudio M Mastroianni Giuseppe Maria De Sanctis Maurizio Paoloni Massimo Marignani Caterina Pasquazzi Nerio Iapadre Giustino Parruti Jacopo Vecchiet Loredana Sarmati Massimo Andreoni Mario Angelico Sandro Grelli Patrick T Kennedy Jens Verheyen Stefano Aquaro Francesca Ceccherini Silberstein Carlo Federico Perno Valentina Svicher

Emerg Microbes Infect 2020 Dec;9(1):928-939

Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

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December 2020

HHV-8 Genetic Diversification and Its Impact on Severe Clinical Presentation of Associated Diseases.

Authors:
Maria Concetta Bellocchi Valentina Svicher Francesca Ceccherini-Silberstein

J Infect Dis 2020 Sep;222(8):1250-1253

Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.

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September 2020

Identification of gp120 polymorphisms in HIV-1 B subtype potentially associated with resistance to fostemsavir.

Authors:
Yagai Bouba Giulia Berno Lavinia Fabeni Luca Carioti Romina Salpini Stefano Aquaro Valentina Svicher Carlo Federico Perno Francesca Ceccherini-Silberstein Maria Mercedes Santoro

J Antimicrob Chemother 2020 07;75(7):1778-1786

University of Rome 'Tor Vergata', Rome, Italy.

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July 2020

A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro.

Authors:
Romina Salpini Lorenzo Piermatteo Arianna Battisti Luna Colagrossi Marianna Aragri Katia Yu La Rosa Ada Bertoli Patrizia Saccomandi Miriam Lichtner Massimo Marignani Sarah Maylin Constance Delaugerre Filomena Morisco Nicola Coppola Aldo Marrone Nerio Iapadre Carlotta Cerva Stefano Aquaro Mario Angelico Loredana Sarmati Massimo Andreoni Jens Verheyen Francesca Ceccherini-Silberstein Massimo Levrero Carlo Federico Perno Laura Belloni Valentina Svicher

Viruses 2020 02 23;12(2). Epub 2020 Feb 23.

Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

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February 2020

Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report.

Authors:
Luca Foroghi Biland Ludovica Ferrari Vincenzo Malagnino Elisabetta Teti Carlotta Cerva Adele Gentile Marianna Aragri Romina Salpini Valentina Svicher Massimo Andreoni Loredana Sarmati

J Med Case Rep 2019 Sep 22;13(1):299. Epub 2019 Sep 22.

Infectious Diseases Clinic, Policlinico Tor Vergata, Rome, Italy.

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September 2019

New Markers in Monitoring the Reactivation of Hepatitis B Virus Infection in Immunocompromised Hosts.

Authors:
Valentina Svicher Romina Salpini Vincenzo Malagnino Lorenzo Piermatteo Mohammad Alkhatib Carlotta Cerva Loredana Sarmati

Viruses 2019 08 25;11(9). Epub 2019 Aug 25.

Clinic of Infectious Diseases, Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

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August 2019

HBcAb seropositivity is correlated with poor HIV viremia control in an Italian cohort of HIV/HBV-coinfected patients on first-line therapy.

Authors:
Vincenzo Malagnino Carlotta Cerva Gaetano Maffongelli Elisabetta Teti Luca Foroghi Biland Novella Cesta Margherita De Masi Christof Stingone Daniele Armenia Valentina Svicher Romina Salpini Massimo Andreoni Loredana Sarmati

Sci Rep 2019 08 16;9(1):11942. Epub 2019 Aug 16.

Clinic of Infectious Diseases, Policlinico Tor Vergata, Rome, Italy.

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August 2019

Establishment of a Seronegative Occult Infection With an Active Hepatitis B Virus Reservoir Enriched of Vaccine Escape Mutations in a Vaccinated Infant After Liver Transplantation.

Authors:
Romina Salpini Andrea Pietrobattista Lorenzo Piermatteo Maria Sole Basso Maria C Bellocchi Daniela Liccardo Luca Carioti Paola Francalanci Marianna Aragri Mohammed Alkhatib Rossana Scutari Manila Candusso Marco Ciotti Valentina Svicher

J Infect Dis 2019 11;220(12):1935-1939

Department of Experimental Medicine, University of Rome "Tor Vergata,", Rome, Italy.

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November 2019

Different Patterns of HIV-1 Replication in MACROPHAGES is Led by Co-Receptor Usage.

Authors:
Ana Borrajo Alessandro Ranazzi Michela Pollicita Maria Concetta Bellocchi Romina Salpini Maria Vittoria Mauro Francesca Ceccherini-Silberstein Carlo Federico Perno Valentina Svicher Stefano Aquaro

Medicina (Kaunas) 2019 Jun 21;55(6). Epub 2019 Jun 21.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.

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June 2019

Quantification of HIV-DNA and residual viremia in patients starting ART by droplet digital PCR: Their dynamic decay and correlations with immunological parameters and virological success.

Authors:
Claudia Alteri Rossana Scutari Christof Stingone Gaetano Maffongelli Marta Brugneti Francesca Falasca Salvatore Martini Ada Bertoli Ombretta Turriziani Loredana Sarmati Nicola Coppola Massimo Andreoni Maria Mercedes Santoro Carlo-Federico Perno Francesca Ceccherini-Silberstein Valentina Svicher

J Clin Virol 2019 08 14;117:61-67. Epub 2019 Jun 14.

Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.

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August 2019

A snapshot of virological presentation and outcome of immunosuppression-driven HBV reactivation from real clinical practice: Evidence of a relevant risk of death and evolution from silent to chronic infection.

Authors:
Romina Salpini Arianna Battisti Luna Colagrossi Domenico Di Carlo Lavinia Fabeni Lorenzo Piermatteo Carlotta Cerva Miriam Lichtner Claudio Mastroianni Massimo Marignani Sarah Maylin Constance Delaugerre Filomena Morisco Nicola Coppola Aldo Marrone Mario Angelico Loredana Sarmati Massimo Andreoni Carlo-Federico Perno Francesca Ceccherini-Silberstein Valentina Svicher

J Viral Hepat 2019 07 14;26(7):846-855. Epub 2019 May 14.

Department of Experimental Medicine, Tor Vergata University, Rome, Italy.

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July 2019

Integrase strand transfer inhibitor-based regimen is related with a limited HIV-1 V3 loop evolution in clinical practice.

Authors:
Claudia Alteri Rossana Scutari Ada Bertoli Daniele Armenia Caterina Gori Gabriele Fabbri Claudio Maria Mastroianni Carlotta Cerva Antonio Cristaudo Ilaria Vicenti Bianca Bruzzone Maurizio Zazzi Massimo Andreoni Andrea Antinori Valentina Svicher Francesca Ceccherini-Silberstein Carlo Federico Perno Maria Mercedes Santoro

Virus Genes 2019 Jun 22;55(3):290-297. Epub 2019 Feb 22.

Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.

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June 2019

CCR5/CXCR4 Dual Antagonism for the Improvement of HIV Infection Therapy.

Authors:
Fedora Grande Maria Antonietta Occhiuzzi Bruno Rizzuti Giuseppina Ioele Michele De Luca Paola Tucci Valentina Svicher Stefano Aquaro Antonio Garofalo

Molecules 2019 Feb 2;24(3). Epub 2019 Feb 2.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Ampliamento Polifunzionale, Via P. Bucci, 87036 Rende (CS), Italy.

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February 2019

Reactivation of Hepatitis B Virus With Immune-Escape Mutations After Ocrelizumab Treatment for Multiple Sclerosis.

Authors:
Maria R Ciardi Marco Iannetta Maria A Zingaropoli Romina Salpini Marianna Aragri Rosanna Annecca Simona Pontecorvo Marta Altieri Gianluca Russo Valentina Svicher Claudio M Mastroianni Vincenzo Vullo

Open Forum Infect Dis 2019 Jan 26;6(1):ofy356. Epub 2018 Dec 26.

Department of Public Health and Infectious Diseases, Sapienza, University of Rome, Rome, Italy.

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January 2019

Genetic divergence of HIV-1 B subtype in Italy over the years 2003-2016 and impact on CTL escape prevalence.

Authors:
Claudia Alteri Lavinia Fabeni Rossana Scutari Giulia Berno Domenico Di Carlo Caterina Gori Ada Bertoli Alessandra Vergori Ilaria Mastrorosa Rita Bellagamba Cristina Mussini Manuela Colafigli Francesco Montella Alfredo Pennica Claudio Maria Mastroianni Enrico Girardi Massimo Andreoni Andrea Antinori Valentina Svicher Francesca Ceccherini-Silberstein Carlo Federico Perno Maria Mercedes Santoro

Sci Rep 2018 10 24;8(1):15739. Epub 2018 Oct 24.

Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, 00133, Italy.

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October 2018

HDV Can Constrain HBV Genetic Evolution in HBsAg: Implications for the Identification of Innovative Pharmacological Targets.

Authors:
Luna Colagrossi Romina Salpini Rossana Scutari Luca Carioti Arianna Battisti Lorenzo Piermatteo Ada Bertoli Lavinia Fabeni Carmine Minichini Pascale Trimoulet Hervé Fleury Elena Nebuloso Maria De Cristofaro Giuseppina Cappiello Alberto Spanò Vincenzo Malagnino Terenzio Mari Angelo Barlattani Nerio Iapadre Miriam Lichtner Claudio Mastroianni Ilaria Lenci Caterina Pasquazzi Giuseppe Maria De Sanctis Alfonso Galeota Lanza Maria Stanzione Gianfranca Stornaiuolo Massimo Marignani Loredana Sarmati Massimo Andreoni Mario Angelico Francesca Ceccherini-Silberstein Carlo-Federico Perno Nicola Coppola Valentina Svicher

Viruses 2018 07 9;10(7). Epub 2018 Jul 9.

Department of Experimental Medicine and Surgery, Tor Vergata University, 00133 Rome, Italy.

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July 2018

Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.

Authors:
Luna Colagrossi Lucas E Hermans Romina Salpini Domenico Di Carlo Suzan D Pas Marta Alvarez Ziv Ben-Ari Greet Boland Bianca Bruzzone Nicola Coppola Carole Seguin-Devaux Tomasz Dyda Federico Garcia Rolf Kaiser Sukran Köse Henrik Krarup Ivana Lazarevic Maja M Lunar Sarah Maylin Valeria Micheli Orna Mor Simona Paraschiv Dimitros Paraskevis Mario Poljak Elisabeth Puchhammer-Stöckl François Simon Maja Stanojevic Kathrine Stene-Johansen Nijaz Tihic Pascale Trimoulet Jens Verheyen Adriana Vince Snjezana Zidovec Lepej Nina Weis Tülay Yalcinkaya Charles A B Boucher Annemarie M J Wensing Carlo F Perno Valentina Svicher

BMC Infect Dis 2018 06 1;18(1):251. Epub 2018 Jun 1.

Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy.

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June 2018

The degree of HIV-1 amino acid variability is strictly related to different disease progression rates.

Authors:
Rossana Scutari Monica Faieta Roberta D'Arrigo Lavinia Fabeni Cristina Mussini Andrea Cossarizza Claudio Casoli Carlo Federico Perno Valentina Svicher Claudia Alteri Stefano Aquaro

Virus Genes 2018 Aug 17;54(4):493-501. Epub 2018 May 17.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.

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August 2018

High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance.

Authors:
Vincenzo Malagnino Romina Salpini Gaetano Maffongelli Arianna Battisti Lavinia Fabeni Lorenzo Piermatteo Luna Colagrossi Vanessa Fini Alessandra Ricciardi Cesare Sarrecchia Carlo Federico Perno Massimo Andreoni Valentina Svicher Loredana Sarmati

PLoS One 2018 29;13(3):e0195045. Epub 2018 Mar 29.

Clinical Infectious Diseases, Department of System Medicine, Tor Vergata University, Rome, Italy.

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July 2018

Effects of Amprenavir on HIV-1 Maturation, Production and Infectivity Following Drug Withdrawal in Chronically-Infected Monocytes/Macrophages.

Authors:
Ana Borrajo Alessandro Ranazzi Michela Pollicita Rosalinda Bruno Andrea Modesti Claudia Alteri Carlo Federico Perno Valentina Svicher Stefano Aquaro

Viruses 2017 09 28;9(10). Epub 2017 Sep 28.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.

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September 2017

Novelties in Evaluation and Monitoring of Human Immunodeficiency Virus-1 Infection: Is Standard Virological Suppression Enough for Measuring Antiretroviral Treatment Success?

Authors:
Valentina Svicher Giulia Marchetti Adrianna Ammassari Francesca Ceccherini-Silberstein Loredana Sarmati

AIDS Rev 2017 Oct-Dec;19(3):119-133

Department of System Medicine, Clinic of Infectious Diseases, University Hospital "Tor Vergata", Rome, Italy.

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June 2018

Quantification of intrahepatic total HBV DNA in liver biopsies of HBV-infected patients by a modified version of COBAS Ampliprep/COBASTaqMan HBV test v2.0.

Authors:
Romina Salpini Lorenzo Piermatteo Upkar Gill Arianna Battisti Francesca Stazi Tania Guenci Sara Giannella Valentina Serafini Patrick T F Kennedy Carlo Federico Perno Valentina Svicher Marco Ciotti

Med Microbiol Immunol 2017 Aug 11;206(4):295-299. Epub 2017 Apr 11.

Laboratory of Molecular Virology, Polyclinic Tor Vergata Foundation, Viale Oxford 81, 00133, Rome, Italy.

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August 2017

The Role of HIV Infection in Neurologic Injury.

Authors:
Rossana Scutari Claudia Alteri Carlo Federico Perno Valentina Svicher Stefano Aquaro

Brain Sci 2017 Apr 6;7(4). Epub 2017 Apr 6.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende (CS) 87036, Italy.

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April 2017