Publications by authors named "Valérie Oesch"

5 Publications

  • Page 1 of 1

Rebound of Involuted Infantile Hemangioma After Administration of Salbutamol.

Pediatrics 2020 03 12;145(3). Epub 2020 Feb 12.

Pediatric Skin Center, Department of Dermatology.

Since the discovery of propranolol in the treatment of infantile hemangioma (IH), there has been emergent investigation of β-adrenergic receptor (β-AR) signaling in IH and the mechanisms of action for which β-AR blockers regulate hemangioma cell proliferation. However, β-AR agonists and antagonists are known to act antithetically via the same intracellular β-AR-driven proangiogenic pathways. We present the case of a patient with involuted IH treated with propranolol that showed a full and rapid regrowth during the intravenous administration of salbutamol, a selective β2-adrenergic agonist, for an episode of severe obstructive bronchitis. This observation brings forward the clinical implication of β-signaling effects in IH and raises awareness of the potential proliferative response of IH to β-AR agonists such as salbutamol.
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http://dx.doi.org/10.1542/peds.2019-1942DOI Listing
March 2020

Hematometra presenting as an acute abdomen in a 13-year-old postmenarchal girl: a case report.

J Med Case Rep 2012 Dec 12;6:419. Epub 2012 Dec 12.

Department of Pediatric Surgery, Inselspital, University of Berne, Berne, Switzerland.

Unlabelled:

Introduction: Most underlying diseases for abdominal pain in children are not dangerous. However some require rapid diagnosis and treatment, such as acute ovarian torsion or appendicitis. Since reaching a diagnosis can be difficult, and delayed treatment of potentially dangerous diseases might have significant consequences, exploratory laparoscopy is a diagnostic and therapeutic option for patients who have unclear and potentially hazardous abdominal diseases. Here we describe a case where the anomaly could not be identified using a laparoscopy in an adolescent girl with acute abdomen.

Case Presentation: A 13-year old postmenarchal caucasian female presented with an acute abdomen. Emergency sonography could not exclude ovarian torsion. Accurate diagnosis and treatment were achieved only after an initial laparoscopy followed by a laparotomy and after a magnetic resonance imaging scan a further laparotomy. The underlying disease was hematometra of the right uterine horn in a uterus didelphys in conjunction with an imperforate right cervix.

Conclusion: This report demonstrates that the usual approach for patients with acute abdominal pain may not be sufficient in emergency situations.
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http://dx.doi.org/10.1186/1752-1947-6-419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543215PMC
December 2012

Community-associated methicillin-resistant Staphylococcus aureus-infected chronic scalp wound with exposed dura in a 10-year-old boy: vacuum-assisted closure is a feasible option: case report.

Neurosurgery 2011 May;68(5):E1481-3; discussion E1484

Pediatric Surgery, Children's Hospital, University Zurich, Zurich, Switzerland.

Background And Importance: Since the introduction of vacuum-assisted closure (VAC) in 1997, it has been used successfully in treating difficult wounds, including spinal wounds and wounds in pediatric patients. There are no reports on VAC therapy in pediatric patients on the scalp, especially with exposed dura. This report describes a 10-year-old boy with a chronic wound of the scalp with exposed dura after multiple neurosurgical interventions who was treated successfully with VAC.

Clinical Presentation: A 10-year-old mentally disabled boy with Apert syndrome suffered from a chronic wound with community-associated methicillin-resistant Staphylococcus aureus (MRSA) infection after multiple neurosurgeon operations. For wound closure, VAC therapy was initiated on the bony defect with exposed dura. The wound healed successfully, and the MRSA disappeared.

Conclusion: The aims of VAC therapy are formation of new granulation tissue, wound cleansing, and bacterial clearance. In this case, the VAC device was excellent for temporary coverage of the defect and for wound cleaning, and it allowed a thick bed of granulation tissue to form over the dura, even with minimal constant negative pressure. The application and management were feasible even in a mentally disabled child. With this experience, we are encouraged to use the VAC device in difficult wounds, even in the head and neck area in children, and to bring this treatment into the outpatient clinic.
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http://dx.doi.org/10.1227/NEU.0b013e318210c7fbDOI Listing
May 2011

Sagittal craniosynostosis combined with ossified cephalhematoma--a tricky and demanding puzzle.

Childs Nerv Syst 2009 Jan 23;25(1):103-10. Epub 2008 Oct 23.

Department of Pediatric Surgery, Children's Hospital, Inselspital, University of Berne, 3010, Bern, Switzerland.

Introduction: Four cases of sagittal synostosis combined with ossified cephalhematoma prompted the authors to present the data and to discuss the implications. Large cephalhematoma of the vertex at birth with subsequent ossification occurred in all with final sizes of 6.5-10 by 4.0-5.5 by 0.8-1.8 cm. At surgery with 2-6 months, the mean skull index was 64.75, sagittal suture completely closed, and a disfiguring bony mass present in all.

Discussion: In three of the original cohort of 106 sagittal synostoses, ossified cephalhematoma was removed in one piece together with the suture. In contrast to pathogenesis of common parietal cephalhematomas, cephalhematoma in sagittal synostosis is rather induced by periosteal detachment of the midline by strong shearing forces because molding is hindered in the lateral direction. Frequent and fast complete ossification is possibly directed by the same local factors (e.g., Noggin) which lead to premature fusion of cranial sutures. Some treatment principles of ossified cephalhematoma in sagittal synostosis may be applied to surgery of common types.
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http://dx.doi.org/10.1007/s00381-008-0726-1DOI Listing
January 2009

Rapidly increasing stridor in a 12-week-old infant.

J Pediatr 2002 Jan;140(1):135

Department of Pediatrics and Department of Pediatric Surgery, University Children's Hospital Inselspital, CH-3010, Berne, Switzerland.

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http://dx.doi.org/10.1067/mpd.2002.119623DOI Listing
January 2002