Publications by authors named "Valér Džupa"

34 Publications

CT analysis of femoral malrotation after intramedullary nailing of trochanteric fractures.

Arch Orthop Trauma Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Orthopaedics and Traumatology, Third Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, Prague, Czech Republic.

Purpose: Functional results after internal fixation of trochanteric femoral fractures may be negatively affected by healing in a non-physiological position. The aim of this study was to evaluate the occurrence and severity of femoral malrotation after nailing of trochanteric fractures.

Materials And Methods: The authors conducted a prospective study focused on a CT analysis of malrotation after intramedullary nailing of trochanteric fractures (AO 31A1-3) in 101 patients. We recorded the type of fracture, method of anesthesia, scheduled surgery vs. acute surgery, and the surgeon's experience as possible risk factors for limb malrotation after trochanteric fracture surgeries.

Results: The average extent of malrotation was 9° of internal rotation ranging from 29° of external to 48°of internal rotation. In 35% of patients, we observed a rotation greater than 15°, and in 15 patients (15%), the rotation was greater than 25°. The risk of significant internal malrotation was significantly higher than external malrotation (37 vs. 4 patients). None of the factors observed proved to be statistically significant. The effect of general anesthesia and the type of intertrochanteric fracture came closest to having a significant effect on rotational error.

Conclusion: Improper reduction of a trochanteric fracture is a common problem that can lead to femur malrotation. In our study, a rotational error greater than 15° occurred in 35% of the patients, but none of the monitored factors represented a statistically significant risk for this complication.
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http://dx.doi.org/10.1007/s00402-021-03902-3DOI Listing
April 2021

Multiple occurrence of premature polyarticular osteoarthritis in an early medieval Bohemian cemetery (Prague, Czech Republic).

Int J Paleopathol 2020 09 14;30:35-46. Epub 2020 May 14.

CNRS, UMR 5199 PACEA, Université de Bordeaux, Bât. B8, Allée Geoffroy St Hilaire, CS 50023, 33615 Pessac Cedex, France; Department of Archaeology, Durham University, South Road, Durham, DH1 3LE, United Kingdom. Electronic address:

Objectives: To highlight conditions that may cause early-onset degenerative joint disease, and to assess the possible impact of such diseases upon everyday life.

Material: Four adults aged under 50 years from a medieval skeletal collection of Prague (Czechia).

Methods: Visual, osteometric, X-ray, and histological examinations, stable isotope analysis of bone collagen.

Results: All four individuals showed multiple symmetrical degenerative changes, affecting the majority of joints of the postcranial skeleton. Associated dysplastic deformities were observed in all individuals, including bilateral hip dysplasia (n = 1), flattening of the femoral condyles (n = 3), and substantial deformation of the elbows (n = 3). The diet of the affected individuals differed from the contemporary population sample.

Conclusions: We propose the diagnosis of a mild form of skeletal dysplasia in these four individuals, with multiple epiphyseal dysplasia or type-II collagenopathy linked to premature osteoarthritis as the most probable causes.

Significance: Combining the skeletal findings with information from the medical literature, this paper defines several characteristic traits which may assist with the diagnosis of skeletal dysplasia in the archaeological record.

Limitations: As no genetic analysis was performed to confirm the possible kinship of the individuals, it is not possible to definitively assess whether the individuals suffered from the same hereditary condition or from different forms of skeletal dysplasia.

Suggestions For Further Research: Further studies on premature osteoarthritis in archaeological skeletal series are needed to correct the underrepresentation of these mild forms of dysplasia in past populations.
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http://dx.doi.org/10.1016/j.ijpp.2020.04.004DOI Listing
September 2020

A case of marked bilateral asymmetry in the sacral alae of the Neandertal specimen Regourdou 1 (Périgord, France).

Am J Phys Anthropol 2020 02 11;171(2):242-259. Epub 2019 Nov 11.

CNRS, Université de Bordeaux, MCC, UMR5199 PACEA, Université de Bordeaux, Pessac Cedex, France.

Objectives: A marked asymmetry was previously reported in the sacral alae and S1-L5 facets orientation of the Neandertal individual Regourdou 1. Here, we provide a detailed description and quantification of the morphology and degree of asymmetry of this sacrum.

Material And Methods: Regourdou 1 was compared to a modern human sample composed of 24 females and 17 males, and to other Neandertal individuals. Both traditional and geometric morphometric analyses were used in order to quantify the degree of sacral asymmetry of Regourdou 1.

Results: The asymmetry of both sacral alae and facets orientation substantially exceeds directional and absolute asymmetry of the healthy modern sample. Regourdou 1 shows a considerably shorter right ala, which is absolutely and relatively outside of the modern and Neandertal variations.

Conclusion: Regourdou 1 shows marked sacral asymmetry that probably originated in early ontogenetic development. An asymmetric sacrum reflects asymmetric load dissipation and could relate to other morphological abnormalities observed in the skeleton, especially the mild scoliosis of the spine and the asymmetry of the femoral diaphyses. Further investigation is necessary to elucidate the relationship between those morphologies as well as a potential impact on the life of the individual.
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http://dx.doi.org/10.1002/ajpa.23968DOI Listing
February 2020

Kinetic characteristics of propofol-induced inhibition of electron-transfer chain and fatty acid oxidation in human and rodent skeletal and cardiac muscles.

PLoS One 2019 4;14(10):e0217254. Epub 2019 Oct 4.

OXYLAB - Mitochondrial Physiology Lab: Charles University, 3rd Faculty of Medicine and FNKV University Hospital, Prague, Czech Republic.

Introduction: Propofol causes a profound inhibition of fatty acid oxidation and reduces spare electron transfer chain capacity in a range of human and rodent cells and tissues-a feature that might be related to the pathogenesis of Propofol Infusion Syndrome. We aimed to explore the mechanism of propofol-induced alteration of bioenergetic pathways by describing its kinetic characteristics.

Methods: We obtained samples of skeletal and cardiac muscle from Wistar rat (n = 3) and human subjects: vastus lateralis from hip surgery patients (n = 11) and myocardium from brain-dead organ donors (n = 10). We assessed mitochondrial functional indices using standard SUIT protocol and high resolution respirometry in fresh tissue homogenates with or without short-term exposure to a range of propofol concentration (2.5-100 μg/ml). After finding concentrations of propofol causing partial inhibition of a particular pathways, we used that concentration to construct kinetic curves by plotting oxygen flux against substrate concentration during its stepwise titration in the presence or absence of propofol. By spectrophotometry we also measured the influence of the same propofol concentrations on the activity of isolated respiratory complexes.

Results: We found that human muscle and cardiac tissues are more sensitive to propofol-mediated inhibition of bioenergetic pathways than rat's tissue. In human homogenates, palmitoyl carnitine-driven respiration was inhibited at much lower concentrations of propofol than that required for a reduction of electron transfer chain capacity, suggesting FAO inhibition mechanism different from downstream limitation or carnitine-palmitoyl transferase-1 inhibition. Inhibition of Complex I was characterised by more marked reduction of Vmax, in keeping with non-competitive nature of the inhibition and the pattern was similar to the inhibition of Complex II or electron transfer chain capacity. There was neither inhibition of Complex IV nor increased leak through inner mitochondrial membrane with up to 100 μg/ml of propofol. If measured in isolation by spectrophotometry, propofol 10 μg/ml did not affect the activity of any respiratory complexes.

Conclusion: In human skeletal and heart muscle homogenates, propofol in concentrations that are achieved in propofol-anaesthetized patients, causes a direct inhibition of fatty acid oxidation, in addition to inhibiting flux of electrons through inner mitochondrial membrane. The inhibition is more marked in human as compared to rodent tissues.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217254PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777831PMC
March 2020

Pavlik harness and Frejka pillow: compliance affects results of outpatient treatment.

Arch Orthop Trauma Surg 2019 Nov 1;139(11):1519-1524. Epub 2019 Apr 1.

Department of Orthopaedics and Traumatology, Third Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, Prague, Czech Republic.

Purpose Of The Study: Outpatient treatment of hip dysplasia in newborns has excellent results. A combination of general screening with early treatment with a functional abduction device works well. Treatment with the Frejka pillow and the Pavlik harness is frequently used in our region. The aim of the study is to compare efficiency and treatment duration, related to the brace used, and to prove that the choice of an abduction device implies parental compliance with the treatment protocol.

Materials And Methods: Data of 286 treated children were analyzed. The diagnosis was made in the first weeks of life by clinical and sonographic examinations during general screening. The choice of treatment device was expert dependent and was involved by many variables. The experience, type of clinical finding and sonographic pathology according to Graf, availability of a treating facility, and the potential cooperation of individual parents were major parameters. The Frejka pillow was used to treat 145 children and the Pavlik harness was used in 137 children. The treatment duration and percentage of infants lost from follow-up in relation to the device used was documented.

Results: The success rate of outpatient treatment was 98.6%. In six patients, the type of device had to be changed during the treatment period. Physiological sonographic findings were achieved in all hips by the end of the treatment. The Frejka pillow was used as the preferred device in milder stable dysplastic hips, while unstable and decentered hips were treated more frequently with the Pavlik harness. Treatment lasted, on average, 95 days and 119 days in the Frejka and in the Pavlik group, respectively; there was no statistical significance in treatment duration of comparable sonographic pathologies. We observed statistically greater parental non-compliance with the treatment protocol in the Pavlik harness group (p = 0.0279; OR 2.7; 95% CI 1.07; 8.5).

Conclusions: Neither of the abduction devices was inferior with regard to treatment efficiency. We found that parental cooperation was an important factor during screening and treatment. The treatment decision and the choice of the brace must be made with full consent of the parents, keeping in mind that comfort during the nursing care may have a significant influence on compliance with the treatment protocol.
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http://dx.doi.org/10.1007/s00402-019-03179-7DOI Listing
November 2019

Where and what arteries are most likely injured with pelvic fractures?: The Influence of Localization, Shape, and Fracture Dislocation on the Arterial Injury During Pelvic Fractures.

Clin Anat 2019 Jul 2;32(5):682-688. Epub 2019 Apr 2.

Department of Orthopedics and Traumatology, Third Faculty of Medicine, Charles University and University Hospital Královské Vinohrady, Prague, Czech Republic.

Blood vessels passing through pelvic region come into intimate contact with pelvic bone and can be injured by the sharp edges of the dislocated fracture fragments. The aim of the study was to evaluate the influence of localization, shape, and dislocation of individual pelvic ring bones' fractures on arterial injuries. The study group consisted of 474 patients enrolled in a 1-year prospective multicenter study. The pattern of pelvic fracture lines was characterized and recorded on a planar diagram of the subjected side of the pelvis. The diagram was subdivided into 11 designated areas. Frequency of injury at each 11 areas was recorded. The course of individual arteries in the 11 areas was also recorded in relation to each type of pelvic fractures. Out of the 474 investigated patients, the highest proportion of fractures occurred in the areas of the superior (62%) and inferior (59%) ramus of the pubis as well as in the lateral part of the sacrum (19%). These locations can be associated with injuries of the external iliac, obturator, internal iliac, and aberrant obturator arteries. The highest risk of arterial injuries was associated with vertically displaced fractures in the middle part of the superior and inferior pubic rami, along the ischial ramus, in the apex of the greater sciatic notch and in the vicinity of the ventral part of the sacroiliac joint, where the artery runs at a distance of less than 1 cm from the bone. Clin. Anat. 32:682-688, 2019. © 2019 Wiley Periodicals, Inc.
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http://dx.doi.org/10.1002/ca.23372DOI Listing
July 2019

A 1-year prospective monocentric study of limb, spinal and pelvic fractures: Can monitoring fracture epidemiology impact injury prevention programmes?

Cent Eur J Public Health 2018 Dec;26(4):298-304

Institute of Epidemiology and Biostatistics, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Objectives: The aim of this study was to assess fractures of extremities, spine and pelvis in patients with respect to mechanism, time of the incident and demography of patients in order to propose preventive measures.

Methods: A mono-centric (Level I Trauma Centre, predominantly urban population) prospective study was carried-out during the one-year period from 1 January to 31 December 2012. Patients with bone fractures of extremities, spine and pelvis were studied. Demography, mechanism and time of the injury were analysed.

Results: The study group consisted of 3,148 patients, 53% being women and treated for 3,909 fractures. The mean age of patients was 53 years. The most traumatised patients were of the 3rd and 4th decade, a further increase in the incidence of fractures was seen in the 7th and 9th decade. Multiple fractures were significantly higher in men (p = 0.002). A car crash or fall from a height was more common cause of spinal fracture or pelvic fracture than fracture to the upper or lower limbs (p < 0.001). Most of the fractures occurred during the day between 9 a.m. and 6 p.m., on Saturdays and during the winter season. The bones most often broken were the radius (739 patients, 18.5%) and femur (436 patients, 11.1%).

Conclusions: Our study highlights the need for injury prevention focused on sex, age and types of activities performed. Among younger individuals, such programmes should primarily be targeted toward men who, as observed in our sample, have a higher fracture frequency compared to women. Conversely, injury prevention programmes for individuals ≥ 60 years should primarily be targeted toward women, who have the highest fracture prevalence in this population.
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http://dx.doi.org/10.21101/cejph.a5161DOI Listing
December 2018

Secondary fracture prevention in hip fracture patients requires cooperation from general practitioners.

Arch Osteoporos 2017 May 18;12(1):49. Epub 2017 May 18.

Department of Orthopedics and Traumatology, Faculty Hospital Královské Vinohrady, Faculty of Medicine 3, Charles University, Prague, Czech Republic.

Despite individual recommendations on osteoporosis management in patients after hip fracture surgery, addressed by orthopedic surgeons to Czech general practitioners, the patients remained undiagnosed and untreated because of provider-level barriers to post-fracture secondary prevention.

Purpose: The goal of the study was to assess whether an individual recommendation on osteoporosis treatment addressed to a hip fracture patient's GP would lead to better osteoporosis management.

Methods: Two groups of patients who suffered hip fractures and were treated at the Orthopedic Department were evaluated. In 111 patients, general recommendations on osteoporosis treatment and fracture prevention were provided in a discharge report addressed to the GP. In the second group, 96 patients were provided individually with a detailed written set of recommendations on osteoporosis examination, treatment, and fracture prevention, which was also provided in the discharge report. A questionnaire to assess the provided care was mailed to the patients 5.3 ± 1.2 months of discharge. Those patients who did not return the questionnaires were contacted by phone.

Results: The questionnaires were received from 44% and 49% of patients from the general and detailed recommendation groups, respectively. Along with the phone call, we were able to contact 78 (70.3%) and 68 (70.8%) patients from the general and detailed recommendation groups, respectively. GPs secured osteoporosis evaluation in 14.6% of the patients. Calcium supplementation and vitamin D supplementation were newly provided in 42.7 and 36.4% of the patients, respectively. Anti-resorptive therapy was newly provided in 8.3% of the patients. No significant differences between the groups were observed in osteoporosis evaluation, calcium and vitamin D supplementation, and anti-osteoporosis treatments. Out of 207 patients, further examination or treatment was requested by 45 patients (21.7%); 75 patients (36.2%) declared no interest in further care.

Conclusion: Recommendations on osteoporosis management addressed to Czech GPs after surgical fracture management had little effect on treatment. As the anti-osteoporotic preparations can only be prescribed by specialists, the availability of necessary examinations and treatment is limited by the motivation of GPs. Consequently, the implementation of Fracture Liaison Services to help close the care gap may be limited in the absence of participation by Czech GPs.
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http://dx.doi.org/10.1007/s11657-017-0346-zDOI Listing
May 2017

Antithrombotic therapy of patients with atrial fibrillation discharged after major non-cardiac surgery. 1-year follow-up. Sub-analysis of PRAGUE 14 study.

PLoS One 2017 24;12(5):e0177519. Epub 2017 May 24.

University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic.

Background: The study investigated the discharge antithrombotic medication in patients with atrial fibrillation (AF) after major non-cardiac surgery and the impact on one-year outcomes.

Methods: A subgroup of 366 patients (mean age 75.9±10.5 years, women 42.3%, acute surgery 42.9%) undergoing major non-cardiac surgery and having any form of AF (30.6% of the total population enrolled in the PRAGUE-14 study) was followed for 1 year.

Results: Antithrombotics (interrupted due to surgery) were resumed until discharge in 51.8% of patients; less frequently in men (OR 0.6 (95% CI 0.95 to 0.35); p = 0.029), and in patients undergoing elective surgery (OR 0.6 (95% CI 0.91 to 0.33); p = 0.021). Dual antiplatelet therapy was resumed more often (91.7%) in comparison to aspirin monotherapy (57.3%; p = 0.047), and vitamin K antagonist (56.3%; p = 0.042). Patients with AF had significantly higher one-year mortality (22.1%) than patients without AF (14.1%, p = 0.001). The causes of death were: ischaemic events (32.6% of deaths), bleeding events (8.1%), others (N = 51; 59.3%, 20 of them died due to cancer). Non-reinstitution of aspirin until discharge was associated with higher one-year mortality (17.6% vs. 34.8%; p = 0.018).

Conclusion: Preoperatively interrupted antithrombotics were re-administrated at discharge only in half of patients with AF, less likely in male patients and those undergoing elective surgery. The presence of AF was recognized as a predictor of one-year mortality, especially if aspirin therapy was not resumed until discharge.

Trial Registration: ClinicalTrials.gov NCT01897220.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177519PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443499PMC
September 2017

Distal tibiofibular synostosis after surgically resolved ankle fractures: An epidemiological, clinical and morphological evaluation of a patient sample.

Injury 2016 Nov 7;47(11):2570-2574. Epub 2016 Sep 7.

Department of Health Care Studies, College of Polytechnics Jihlava, Jihlava, Czech Republic; Department of Anatomy, Third Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address:

Introduction: Ankle fractures comprise a highly morphologically and etiologically diverse group of injuries, which includes various degrees of impairment of bone and ligamentous structures. The complete synostosis and incomplete bony bridging of tibiofibular syndesmosis are among the local late complications after surgically treated ankle fractures.

Patients And Method: 269 patients were evaluated, including 203 patients with Weber type-B fractures, and 66 patients with Weber type-C fractures. All patients underwent ankle radiography at standard intervals (post-operatively, 6 and 12 weeks, 6 and 12 months). The final assessment one year after osteosynthesis was performed. The study analyzed age, sex, fracture morphology, the location and morphology of ossification, functional outcomes and subjective evaluations of patient status.

Results: As risk factors there were found male sex, tibiotalar dislocation, syndesmotic screw fixation and Weber type-C fractures. The severity of subjective difficulties and objective status were not dependent on the size of distal tibiofibular synostosis.

Discussion And Conclusion: Despite relatively extensive imaging findings of complete synostosis or incomplete bony bridging, they only limited functional outcomes to a minimal extent.
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http://dx.doi.org/10.1016/j.injury.2016.09.007DOI Listing
November 2016

Mitochondrial Function in an In Vitro Model of Skeletal Muscle of Patients With Protracted Critical Illness and Intensive Care Unit-Acquired Weakness.

JPEN J Parenter Enteral Nutr 2017 09 29;41(7):1213-1221. Epub 2016 Jun 29.

1 Laboratory of Bioenergetics, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Background: Functional mitochondria in skeletal muscle of patients with protracted critical illness and intensive care unit-acquired weakness are depleted, but remaining mitochondria have increased functional capacities of respiratory complexes II and III. This can be an adaptation to relative abundancy of fatty acid over glucose caused by insulin resistance. We hypothesized that the capacity of muscle mitochondria to oxidize fatty acid is increased in protracted critical illness.

Methods: We assessed fatty acid oxidation (FAO) and mitochondrial functional indices in vitro by using extracellular flux analysis in cultured myotubes obtained by isolating and culturing satellite cells from vastus lateralis muscle biopsy samples from patients with ICU-acquired weakness (n = 6) and age-matched healthy controls (n = 7). Bioenergetic measurements were performed at baseline and after 6 days of exposure to free fatty acids (FFAs).

Results: Mitochondrial density in myotubes from ICU patients was 69% of healthy controls ( P = .051). After adjustment to mitochondrial content, there were no differences in adenosine triphosphate (ATP) synthesis or the capacity and coupling of the respiratory chain. FAO capacity in ICU patients was 157% of FAO capacity in controls ( P = .015). In myotubes of ICU patients, unlike healthy controls, the exposure to FFA significantly ( P = .009) increased maximum respiratory chain capacity.

Conclusion: In an in vitro model of skeletal muscle of patients with protracted critical illness, we have shown signs of adaptation to increased FAO. Even in the presence of glucose and insulin, elevation of FFAs in the extracellular environment increased maximal capacity of the respiratory chain.
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http://dx.doi.org/10.1177/0148607116657649DOI Listing
September 2017

Distal locking in short hip nails: Cause or prevention of peri-implant fractures?

Injury 2016 Apr 23;47(4):887-92. Epub 2016 Feb 23.

Department of Orthopedics and Traumatology, Charles University 3rd Faculty of Medicine and Kralovske Vinohrady Teaching Hospital, Šrobárova 50, 10034 Prague, Czech Republic.

Objectives: The most common cause of femoral fractures after osteosynthesis of trochanteric fractures with short nails is weakening of the femoral cortex via distal locking and stress concentrations at the tip of the nail. The aim of the study was to verify whether the incidence of peri-implant fractures is dependent upon the distal locking technique.

Methods: We prospectively analysed a group of 849 pertrochanteric fractures (AO/ASIF 31-A1+2) managed with short nails from 2009 to 2013. Unlocked nailing was performed in 70.1% and distal dynamic locking was performed in 29.9%. The mean age was 82.0 years. Peri-implant fractures were divided into 3 groups according to the height of the fracture in relation to the tip of the nail.

Results: In total 17 fractures (2.0%) were detected. One peri-implant fracture occurred after locked nailing, whereas 16 cases occurred after unlocked nailing (p=0.037). Patients without distal locking had an 85.7% greater risk of peri-implant fracture. Fractures of the proximal femur (Type I) occurred significantly earlier than fractures at the tip of the nail (Type II) (p=0.028).

Conclusion: Unlocked nails do not guarantee sufficient stability. Distal locking serves to prevent postoperative femoral fractures. We recommend the routine use of distal locking when utilizing short nails.
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http://dx.doi.org/10.1016/j.injury.2016.02.009DOI Listing
April 2016

Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness.

Crit Care 2015 Dec 24;19:448. Epub 2015 Dec 24.

Laboratory of Bioenergetics, Third Faculty of Medicine, Charles University in Prague, Ruská 87, Prague, 100 00, Prague 10, Czech Republic.

Background: Mitochondrial damage occurs in the acute phase of critical illness, followed by activation of mitochondrial biogenesis in survivors. It has been hypothesized that bioenergetics failure of skeletal muscle may contribute to the development of ICU-acquired weakness. The aim of the present study was to determine whether mitochondrial dysfunction persists until protracted phase of critical illness.

Methods: In this single-centre controlled-cohort ex vivo proof-of-concept pilot study, we obtained vastus lateralis biopsies from ventilated patients with ICU-acquired weakness (n = 8) and from age and sex-matched metabolically healthy controls (n = 8). Mitochondrial functional indices were measured in cytosolic context by high-resolution respirometry in tissue homogenates, activities of respiratory complexes by spectrophotometry and individual functional capacities were correlated with concentrations of electron transport chain key subunits from respiratory complexes II, III, IV and V measured by western blot.

Results: The ability of aerobic ATP synthesis (OXPHOS) was reduced to ~54% in ICU patients (p<0.01), in correlation with the depletion of complexes III (~38% of control, p = 0.02) and IV (~26% of controls, p<0.01) and without signs of mitochondrial uncoupling. When mitochondrial functional indices were adjusted to citrate synthase activity, OXPHOS and the activity of complexes I and IV were not different, whilst the activities of complexes II and III were increased in ICU patients 3-fold (p<0.01) respectively 2-fold (p<0.01).

Conclusions: Compared to healthy controls, in ICU patients we have demonstrated a ~50% reduction of the ability of skeletal muscle to synthetize ATP in mitochondria. We found a depletion of complex III and IV concentrations and relative increases in functional capacities of complex II and glycerol-3-phosphate dehydrogenase/complex III.
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http://dx.doi.org/10.1186/s13054-015-1160-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699339PMC
December 2015

The importance of intramedullary hip nail positioning during implantation for stable pertrochanteric fractures: biomechanical analysis.

Surg Radiol Anat 2016 Jul 8;38(5):577-85. Epub 2015 Dec 8.

Department of Orthopaedy and Traumatology, Third Faculty of Medicine, Charles University in Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.

Purpose: Proximal femoral fractures are among the most commonly sustained fractures. The current treatment of stable proximal femoral fractures located in trochanteric region primarily involves the use of two systems: extramedullary dynamic hip screws and intramedullary hip nails. Given that these fractures are mainly found in the elderly population, the necessity of a repeat, due to failure of the first, may jeopardize the patient's life. Decisive factors contributing to the healing of a fracture (or the failure thereof) include fracture pattern, technical implementation of the operation (i.e., position of the implant), implant's properties and its changes in relation to the surrounding bone tissue during loading. Each screw insertion variant results in damage to various load-bearing bone structures, which can be expected to influence healing quality and stability of newly formed bone.

Method: With the aid of a numerical model and finite element methods, the authors analyzed several different positions of IMHN/PFH-nails in the proximal femur, with the objective of determining positions with an increased risk of failure.

Results And Conclusion: In model situations, it has been shown that in stable fractures results do not depend on absolutely precise positioning and small deflections in the nails and neck screws positions do not significantly increase the risk of failure for the entire fixation. Damage to load-bearing structures relative to various implant placements does not impact the resultant overall fixation stability. Therefore, it is not necessary to re-introduce implants in the ideal position, which can lead to reduced patient radiation doses during surgery.
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http://dx.doi.org/10.1007/s00276-015-1595-4DOI Listing
July 2016

The modified scarf osteotomy in the treatment of tailor's bunion: midterm follow-up.

Acta Orthop Belg 2015 Mar;81(1):57-64

The aim of this study was to present the midterm results of modified scarf osteotomy in the treatment of tailor's bunion. From 2004 to 2011, 23 modified scarf osteotomies (with the fifth metatarsal shortening) were performed in group of 18 patients for the treatment of tailor's bunion. The mean follow-up period was 58.8 (range: 24-89) months. Patients were evaluated retrospectively--clinically and radiographically, using the American Orthopaedic Foot & Ankle Society scoring system with weight-beared radiographs at the end of 2013. Five males and thirteen females (mean age: 46.5 years) were included in the study. Two males and three females were operated bilaterally. Average American Orthopaedic Foot & Ankle Society scores were 59.8 preoperatively and 92.3 at the final follow-up. Three patients had complications: delayed union, superficial wound infection and distal screw migration. The modified scarf osteotomy in the correction of tailor's bunion offers promising results in the midterm.
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March 2015

Assessing the function of mitochondria in cytosolic context in human skeletal muscle: adopting high-resolution respirometry to homogenate of needle biopsy tissue samples.

Mitochondrion 2015 Mar 17;21:106-12. Epub 2015 Feb 17.

Laboratory of Bioenergetics, 3rd Faculty of Medicine, Charles University in Prague, Czech Republic. Electronic address:

Using skeletal muscle homogenates for respirometry has many advantages, but the main challenge is avoiding the damage to outer mitochondrial membrane (OMM) and complex I. By optimising the amount of muscle and careful titration of substrates and inhibitors we developed a new protocol and compared it to isolated mitochondria. We found acceptable damage to OMM (~10-15% increment of oxygen flux after addition of cytochrome c) and to complex I (~70% of electron flux). Homogenate retained ~90% of phosphorylation capacity of isolated mitochondria. The use of fresh homogenate was crucial as mitochondrial function declined rapidly after 2-3h of cold storage.
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http://dx.doi.org/10.1016/j.mito.2015.02.002DOI Listing
March 2015

Subsequent contralateral hip fractures: can at-risk patients be identified? An observational study of 5,102 patients.

Int Orthop 2015 Apr 8;39(4):755-60. Epub 2015 Jan 8.

Department of Orthopaedics and Traumatology, Third Faculty of Medicine, Charles University, and University Hospital Kralovske Vinohrady, Šrobárova 50, 100 34, Prague, Czech Republic,

Purpose: The aim of this study was to evaluate a sample of patients who sustained hip fractures during the years 1997-2011 and identify risk factors for a subsequent contralateral hip fracture; one-year mortality rates were compared in both groups.

Methods: A total of 5,102 patients with hip fractures were prospectively studied to identify patients who had also suffered a subsequent, contralateral, hip fracture (SCHF). Those patients who had sustained a second fracture within 18 months of the initial fracture were then studied. All data were statistically processed.

Results: Within 18 months of the first fracture, a SCHF occurred in 105 patients (2.1 %). These patients were an average of three years older than those in the single fracture group. Risk factors for the development of a SCHF included: female gender, residing in a residential care facility, and limited mobility prior to injury. Trochanteric fractures did not represent a statistically significant risk factor for SCHF. More than three-quarters of patients with subsequent injuries suffered the same type of fractures on the opposite side. Patients with subsequent fractures had lower one-year mortality rates than patients with only one fracture.

Conclusion: Patients at greatest risk for a SCHF were women with limited mobility who resided in nursing homes for the elderly. The lower mortality rate associated with second fractures shows that the prognosis for such patients is good. Since the at-risk group is so well defined, prophylactic measures for these patients should be utilized in order to minimize the risk of additional fractures.
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http://dx.doi.org/10.1007/s00264-014-2646-xDOI Listing
April 2015

Anatomist and the pioneer of radiology Étienne Destot--95th anniversary of his death.

Clin Anat 2014 Apr;27(3):282-5

Destot was a leading pioneer in radiology, a pupil of Ollier, an anatomist, and researcher who followed in the experimental medicine tradition of Claude Bérnard. This work is an extensive, in depth, look at the life and work of Étienne Destot. On February 5, 1896, he began performing X-ray examinations, less than two months after Roentgen's discovery! His pioneering work described a space bordered by the hamate, capitate, triquetrum, and lunate; this space is now known as Destot's space. Tanton stated that Destot was the first to reveal the mechanism of fractures of the posterior margin of the distal tibia and to emphasize their clinical relevance; in honor of this contribution, Tanton named such a fracture the “fracture of Destot.” Moreover, Destot is credited with being the first physician to use the term “pilon” in the orthopedic literature. He first described fractures of the scaphoid in 1905. He also described superficial hematomas, Destot's sign, located above the inguinal ligament or in the scrotum or thigh. Such hematomas are indicative of pelvic fractures. Destot is credited with inventing or improving many pieces of medical equipment (e.g., Lambotte's screw plates, anastomotic boutons for the digestive tube, monopolar endocavital radiological tubes). He was also active in developing technical aspects of equipment (e.g., radioscopic examination of the heart, a prototype of the mobile radiological laboratory). Étienne Destot is best known as a radiologist; however, his influence extends well beyond this field. He was an anatomist and surgeon, the founder of radiology in Lyon, prosector, physician, electrician, researcher, and artist.
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http://dx.doi.org/10.1002/ca.22314DOI Listing
April 2014

Developmental malformations in the area of the lumbosacral transitional vertebrae and sacrum: differences in gender and left/right distribution.

Surg Radiol Anat 2014 Sep 27;36(7):689-93. Epub 2013 Dec 27.

Center for Integrated Studies of the Pelvis, Third Faculty of Medicine, Charles University in Prague, University Hospital Kralovske Vinohrady, Prague, Czech Republic,

Purpose: The aim of this study was to determine the incidence of congenital malformations of the lumbosacral transitional vertebrae in the general population, and the differences in their gender and left/right distributions.

Methods: The examined group comprised of all patients who underwent a pelvic X-ray during 2010 for any reason. The observed parameters included the following malformations: the presence of megatransversus at L5; sacralization of L5 or L6; a S1 lumbarization; the presence of six sacral vertebrae; or spina bifida at the level of L5, S1 or S2. In cases of megatransversus at L5, the lateral distribution was recorded. A total of 1,513 images were evaluated. Sex and lateral differences were evaluated using the Pearson's (χ (2)) test with a significance level of 5 %.

Results And Conclusions: A total of 478 malformations were found in 417 patients, which constituted 27.6 % of the entire group. Malformations occurred in 250 women (25.4 % of all women) and 167 men (31.6 % of all men) and the female to male ratio in affected individuals was 1.5:1. The predominance of the occurrence of malformations observed in men was statistically significant (p = 0.009). The most frequently occurring malformations were the presence of six sacral vertebrae (179 patients) and megatransversus at L5 (150 patients). The study confirmed a high incidence of congenital malformations in the area of the lumbosacral transitional vertebrae and demonstrated a higher incidence in males. Unilaterally occurring megatransversus at L5 was significantly more common on the left side.
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http://dx.doi.org/10.1007/s00276-013-1250-xDOI Listing
September 2014

Combined traumatic atlantooccipital and atlantoaxial articulation instability: a case report with survival.

Eur Spine J 2014 May 1;23 Suppl 2:242-7. Epub 2013 Dec 1.

Department of Orthopaedics and Traumatology, 3rd Faculty of Medicine, Charles University Prague, Šrobárova 50, 100 34, Prague, Czech republic.

Traumatic atlantooccipital dislocation is a rare injury in survivors with 15 % share in deaths due to spinal injury. The authors present a case of a patient with concurrent atlantooccipital and atlantoaxial instability of the upper cervical spine, which he suffered after a fall from height. Atlantooccipital dislocation in surviving patients is a rare injury, for which in some cases coincident bone injury is reported to upper cervical spine, such as occipital fracture or contingent odontoid (C2 dens) fracture. In our case, it is combined with atlantoaxial instability and this combined type of injury has not yet been described in the literature. We performed realignment of the dislocation and posterior occipitocervical (C0-C3) fusion. After the surgery, the patient manifested neurological improvement almost to a normal neurological outcome with persistent residual finding after subarachnoid hemorrhage.
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http://dx.doi.org/10.1007/s00586-013-3112-yDOI Listing
May 2014

Normalizing glutamine concentration causes mitochondrial uncoupling in an in vitro model of human skeletal muscle.

JPEN J Parenter Enteral Nutr 2015 Feb 29;39(2):180-9. Epub 2013 Nov 29.

Laboratory for Metabolism and Bioenergetics, Department of Nutrition, Third Faculty of Medicine, Charles University in Prague, Czech Republic

Background: Glutamine has been considered essential for rapidly dividing cells, but its effect on mitochondrial function is unknown.

Materials And Methods: Human myoblasts were isolated from skeletal muscle biopsy samples (n = 9) and exposed for 20 days to 6 different glutamine concentrations (0, 100, 200, 300, 500, and 5000 µM). Cells were trypsinized and manually counted every 5 days. Seven days before the end of exposure, half of these cells were allowed to differentiate to myotubes. Afterward, energy metabolism in both myotubes and myoblasts was assessed by extracellular flux analysis (Seahorse Biosciences, Billerica, MA). The protocol for myoblasts was optimized in preliminary experiments. To account for different mitochondrial density or cell count, data were normalized to citrate synthase activity.

Results: Fastest myoblast proliferation was observed at 300 µM glutamine, with a significant reduction at 0 and 100 µM. Glutamine did not influence basal oxygen consumption, anaerobic glycolysis or respiratory chain capacity. Glutamine significantly (P = .015) influenced the leak through the inner mitochondrial membrane. Efficiency of respiratory chain was highest at 200-300 µM glutamine (~90% of oxygen used for adenosine triphosphate synthesis). Increased glutamine concentration to 500 or 5000 µM caused mitochondrial uncoupling in myoblasts and myotubes, decreasing the efficiency of the respiratory chain to ~70%.

Conclusion: Glutamine concentrations, consistent with moderate clinical hypoglutaminemia (300 µM), bring about an optimal condition of myoblast proliferation and for efficiency of aerobic phosphorylation in an in vitro model of human skeletal muscle. These data support the hypothesis of hypoglutaminemia as an adaptive phenomenon in conditions leading to bioenergetic failure (eg, critical illness).
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http://dx.doi.org/10.1177/0148607113513801DOI Listing
February 2015

The correlation between muscles insertions and topography of break lines in pertrochanteric fractures: a comprehensive anatomical approach of complex proximal femur injuries.

Surg Radiol Anat 2013 Dec 30;35(10):957-62. Epub 2013 Apr 30.

Department of Orthopaedics and Traumatology, Third Faculty of Medicine and University Hospital Kralovske Vinohrady, Charles University, Prague, Czech Republic.

Purpose: The purpose of our work was to verify the hypothesis that muscle insertions and ligament attachments have an impact on the course of typical break lines in the area of the trochanteric massif, i.e., to provide a more detailed description of the origins and insertions of the musculo-ligamentous apparatus on the surface of the proximal femur, and to find a potential morphological correlate between muscle insertions and ligament attachments to the proximal femur and the course of the break line in a typical pertrochanteric fracture.

Methods: A detailed dissection of areas of trochanter major et minor, linea et crista intertrochanterica was performed in 50 anatomical preparations of the proximal femur, and the insertions of the muscular-ligamentous structures were described. The set of 600 radiographs were used to obtain projections of typical break lines on the proximal femur, and corresponding areas of exposed bone surface were identified in the anatomical preparations based on the projections and on 15 real specimens of patients after the pertrochanteric fracture osteosynthesis.

Results And Conclusion: Bone covered only with the periosteum, with no reinforcing elements of the origin or insertions of muscles or attachments of ligaments, represents the locus minoris resistentiae for beginning of fractures. Variability in the sizes and shapes of pertrochanteric fracture fragments also depends on variability of the locations and sizes of soft tissue attachment areas at specified sites on the proximal femur.
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http://dx.doi.org/10.1007/s00276-013-1124-2DOI Listing
December 2013

Pudendal nerve in pelvic bone fractures.

Injury 2013 Jul 4;44(7):952-6. Epub 2013 Feb 4.

Center for Integrated Study of Pelvis, Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Introduction: Pelvic ring injuries rank among the most serious skeletal injuries. According to published data, pelvic fractures constitute 3-8% of all fractures. There has been a threefold increase in the number of these fractures over the last 10 years. A significant factor determining the choice of the therapeutic procedure, timing and sequence of individual steps, and also the prognosis of the patient with a fractured pelvis, are associated injuries defined as injuries to the organs and anatomical structures found in the pelvic region. Published data describes the incidence of injury to neurogenic structures as ranging between 9 and 21%, to the urogenital tract between 5 and 11%, to the gastrointestinal tract in 3-17% and to the gynecologic organs up to 1%. The pathway of the pudendal nerve may be affected in types B and C fractures where the root fibers emerge from the foramina sacralia and plexus sacralis is formed, on the one hand, and in types A, B and C fractures during the nerve's course alongside the inferior pubic ramus.

Materials And Methods: In order to determine the frequency of potential injury to the pudendal nerve, a set of 225 pelvic fractures treated between 2007 and 2009 was assessed; 38 fixed hemipelves were also used to study the length of the course of the pudendal nerve alongside the inferior pubic ramus, on the one hand, and the distances from the symphysis pubica at the crossing of the branches of the n. pudendus-n. dorsalis penis and the branches for the muscles of the diaphragma urogenitale on the other hand.

Conclusion: The work elucidated the selected distances and discuss their possible clinical relevance for evaluation of the seriousness of pelvic fractures from the perspective of late sequelae in the region innervated by the pudendal nerve.
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http://dx.doi.org/10.1016/j.injury.2012.12.004DOI Listing
July 2013

[Present concept for management of severely injured patients in Trauma Centre Faculty Hospital Královské Vinohrady].

Cas Lek Cesk 2012 ;151(10):468-71

Traumatologicke Centrum, Srobarova, Praha.

Background: The implementation of standardized protocols for management of polytrauma, multiple injuries and complicated monotrauma has led to improvement in trauma care with decrease in posttraumatic morbidity and mortality. The introduction of algorithm "Definitive Surgical Trauma Care" (DSTC) with concept of "damage control" surgery assumed the principal role in care of polytrauma patients. It can be accomplished only in the trauma- centre with implementation of care system for severely injured patients. Analysis of severely injured patients treated in Trauma Centre Faculty Hospital Královské Vinohrady was performed in a retrospective study.

Methods And Results: 515 injured patients admitted to emergency unit of the Department of anaesthesiology and resuscitation in years 2009-2010 were evaluated. There were 385 men and 130 women. Average age of patients was 45 years. Primary trauma admissions were 482 (83%) victims. There were 248 (48%) polytrauma patients, 158 (31%) with craniocerebral injuries, 76 (15%) with associated injuries and 33 (6 %) injured with monotrauma. ISS > 16 were in 309 injured patients, average rate ISS was 26.5. Trauma care in emergency unit was provided with the team of specialists (general surgeon for visceral traumatology, orthopaedic surgeon for extremities trauma, specialist for intensive care, anaesthesiology and diagnostic radiology). 412 surgical or radio intervention procedures were performed. There were 313 (76%) urgent surgeries and 99 delayed (24%). The most frequent urgent surgery was for fractures of extremities, (36%) and neurotraumas (29%). Acute operations for thoracic and abdominal trauma were performed in 24% of patients. Delayed surgeries were mostly operations of extremities fractures (66%) and maxillofacial injuries (15%). Mortality was 18% (95 patients); being highest in group of patients with Injury Severity Score (ISS) > 40 (65%).

Conclusions: The implementation of trauma care system in severely injured patients brings increased numbers of primary trauma admissions to trauma centres. Polytraumas and craniocerebral injuries were the most frequently admitted patients to emergency unit. Implementation of standardized protocols with interdisciplinary cooperation in trauma management represents improvements of trauma care. Early indication and performance of urgent operations with control of bleeding and prevention of subsequent contamination belongs to principal steps in the management of severely injured patients. Definitive management with reoperation in polytrauma patients can be indicated after the stabilisation. ISS > 40 was connected with high mortality rate (65%).
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April 2013

Single-centre study of hip fractures in Prague, Czech Republic, 1997-2007.

Int Orthop 2011 Apr 9;35(4):587-93. Epub 2010 Mar 9.

Department of Orthopedics and Traumatology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.

This study examines the epidemiological data of patients with hip fractures from 1997-2007. Adult patients treated for hip fracture between the years 1997-2007 were included in the study. Retrospective statistical assessment of continually gathered data focussed on epidemiology and demographics. The study involved 3,683 patients (2,678 women and 1,005 men). Patients older than 70 years accounted for 82% of all cases. There were 2.7 times more women; in patients younger than 60 years men significantly outnumbered women (p < 0.001). The mean patient age was 77.9 years (SD ± 12.6; women, 80.3 years; men, 71.5 years). There was a slight increase in the average age in both sexes. Trochanteric fractures accounted for 54.7% and femoral neck fractures accounted for 45.3% of fractures. The ratio of men to women was the same in femoral neck (AO-31B) and trochanteric (AO-31A) fractures. The average year-to-year increase in the number of fractures was 5.9%. For femoral neck fractures (AO-31B), there was a statistically insignificant increase in the number of fractures (p = 0.63); for intertrochanteric factures (AO-31A3) there was a statistically insignificant decrease (p = 0.65). There was an increase in the number of hip fractures resulting in a significant increase in pertrochanteric fractures (AO-31A1+2) (p < 0.001). The ratio of trochanteric to neck fractures increased from 0.99 to 1.53. Continual monitoring of patients with hip fracture offers data which allows comparisons between regions and countries. There has been a continual increase in the number of patients with hip fractures.
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http://dx.doi.org/10.1007/s00264-010-0984-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066323PMC
April 2011

Poster presentations.

Authors:
Funda Aksu Hakan Topacoglu Candan Arman Aytul Atac Suleyman Tetik Aida Hasanovic Amela Kulenovic Zakira Mornjakovic Branko Pikula Aida Sarac-Hadzihalilovic Alma Voljevica Belgin Bamac Tuncay Colak Murat Alemdar Gulmine Dundar Macit Selekler Ozgur Dincer Enis Colak Aydin Ozbek Cenk Kilic Kivanc Kamburoglu Tuncer Ozen Vatan Kavak Yalcin Kirici Emin Oztas Handan Altinkaya Soysal Erdogan Unur Nihat Ekinci Omur Karaca Olga Malakhova Murat Kocaoglu Serdar Toker Figen Taser Volkan Kilincoglu Mustafa Fahri Yurtgun Cannur Dalcik Ali Zeybek Marc Baroncini Johann Peltier Patrice Jissendi Jean-Pierre Pruvo Jean-Paul Francke Vincent Prevot Rengin Kosif Yasin Arifoglu Murat Diramali Mustafa Sarsilmaz Evren Kose Murat Ogeturk Burhan Akpinar Ilter Kus Sedat Meydan Alev Kara Zeliha Kurtoglu Ibrahim Tekdemir Alaittin Elhan Orhan Bas Ersan Odaci Hakan Mollaoglu Kagan Ucok Suleyman Kaplan Mehmet Senoglu Vedat Nacitarhan Ergul Belge Kurutas Nimet Senoglu Idris Altun Yalcin Atli Davut Ozbag Sacide Karakas M Dincer Bilgin Ayfer Metin Tellioglu Sercin Ozlem Betul Akcanal Yuksel Yildiz Hakki Gunes Hayrullah Kose Ibrahim Uzum Umit Naci Gundogmus Cigdem Caglayan Velichka Pavlova Mashenka Dimitrova Lilia Georgieva Elena Nikolova Deniz Uzmansel Nail Can Ozturk Canan Yurttas Saylam Erkin Ozgiray Mustafa Orhan Sedat Cagli Mehmet Zileli Derya Ozkan Taylan Akkaya Ayhan Comert Nilgun Balikci Esra Ozdemir Haluk Gumus Zafer Ergul Oskay Kaya Serdar Altun R Erkin Unlu Hakan Orbay Deog-Im Kim Seung-Ho Han Yi-Suk Kim Ho-Jeong Kim Kyu-Seok Lee Omur Elcioglu Hilmi Ozden Gul Guven Nurcan Imre Bulent Yalcin Hasan Ozan Pinar Akyer Mustafa Guvencer Vasfi Karatosun Mandeep Gill Sagoo Rachel Claire Aland Derya Ustuner M Cengiz Ustuner Jafar Ai Seyed Reza Ghazi Seyed Hadi Mansouri Mehmet Cudi Tuncer Mehmet Ufuk Aluclu Ozlen Karabulut Eyup Savas Hatipoglu Hasan Nazaroglu Cigdem Icke Emrah Akbay Turkan Gunay Suleyman Icke Selda Yildiz Fatih Yazar Barcin Orhan Barlas Delia Elena Zahoi Ahmet Kavakli Ufuk Tas Durrin Ozlem Dabak Hilal Irmak Sapmaz Necdet Kocabiyik Cenk Murat Ozer Ayhan Ozcan Levent Elevli Kadir Desdicioglu Ibrahim Alanbay Figen Govsa Canan Y Saylam Ilgaz Akdogan Yilmaz Kiroglu Sule Onur Emine Hilal Evcil Neslihan Cankara Mehmet Ali Malas M Tayyar Kalcioglu Serdar Duman Tufan Ulcay Ahmet Uzun Zulfu Karabulut Cagatay Barut Ozdemir Sevinc Gamze Yurdakan Dundar Kacar Ali Riza Erdogan Hulyam Kurt Bunyamin Demir Mustafa Saltan Dilek Burukoglu Mehmet Cengiz Ustuner Irfan Degirmenci Aliriza Erdogan Ozlem Damar Merih Is Gokhan Bayramoglu Sahin Kabay Onur Uysal Hakan Senturk Aysegul Bayramoglu Cansu Ozbayar Ali Kutlu Mediha Canbek Salih Cenap Cevli Oguz Hancerlioglu Mustafa Koplay Elif Aksakalli Fatih Dikici Aysin Kale Ozcan Gayretli Ilke Ali Gurses Senem Turan Ozdemir Ilker Ercan Emel Bulbul Baskan Mediha Yilmaz Guven Ozkaya Hayriye Saricaoglu Mete Erturk Gulgun Kayalioglu Mehmet Uzel Guler Kahraman Ercan Tanyeli Ali Ihsan Soyluoglu Orhan Tacar Ayda Demirant Murat Bilgin Aziz Karadede Ayfer Aktas E Hilal Evcil Esra Koyuncu Osman Sulak Soner Albay Gulnur Ozguner Ahmet Ozbek Elvan Ozbek A Hakan Ozturk Tuba Demirci Engin Ciftcioglu Mehmet Tevfik Demir Cem Kopuz Esra Eroglu Semin Gedikli Hamit Ozyurek Mehmet Selim Nural Lutfi Incesu Gonul Ogur Engin Kara Baris Celebi Altan Yildiz B Zuhal Altunkaynak Samet Vasfi Kuvat Suleyman Murat Tagil Cumhur Ertekin Hilmi Uysal Fikret Bademkiran Nural Albayrak Ali Firat Esmer Nigar Keles Coskun Muzaffer Sindel Ferah Kizilay Sevket Yalin Nevin Karapinar Mehmet Tokdemir Lokman Karakurt Levent Tumkaya Adnan Korkmaz Bulent Ayas Nusret Ciftci Yuksel Terzi Ozlem Baran Yusuf Nergiz Murat Akkus Ufuk Aluclu Askin Ender Topal Dilek Yuksel Halil Ibrahim Acar Simel Kendir Emre Hekimoglu Deniz Basman Sunay Duman Baris Ozener Can Pelin Ragiba Zagyapan Ayla Kurkcuoglu Mustafa Koc Meral Erdinc Levent Erdinc Ilker Kelle Enver Sancakdar Nil Cetin Selcuk Tunik Ayse Yildirim Iskender Kaplanoglu Ercan Ayaz Necip Ilhan Mehmet Okumus Kasim Zafer Yuksel Harun Ciralik Zeki Yilmaz Yakup Gumusalan Mehmet Gamsizkan Mustafa Kazkayasi Nadire Unver Dogan Ismihan Ilknur Uysal Aylin Karalezli Zeliha Fazliogullari Mustafa Buyukmumcu Mehmet Cem Bozkurt Aynur Emine Cicekcibasi Deniz Demiryurek M Hakan Ozsoy Alp Bayramoglu Eray Tuccar Ozlem Pamukcu Baran Sevda Soker Selen Bahceci Yasemin Nasir Mehmet Tugrul Yilmaz Emine Aynur Cicekcibasi Mahinur Ulusoy Pervin Gunaslan Nuray Bilge Muzaffer Akkaya Abdurrahman Genc Sezer Akcer Yucel Gonul Emine Cosar Gulengul Koken Ilknur Ari Sinan Bakirci Ilker Mustafa Kafa Murat Uysal Ahmet Kagan Karabulut Bahar Keles Dilek Emlik Yavuz Uyar Kayhan Ozturk Neslihan Altuntas Yilmaz Ahmet Salbacak Burkay Kutluhan Kacira Mehmet Arazi Serafettin Demirci Demet Kiresi Serter Gumus Muzaffer Seker Mehmet Uyar Mohammad Ebrahim Astaneh Alireza Khorshid Ramazan Uygur Ahmet Songur Osman Fikret Sonmez Kamil Hakan Dogan Giray Kolcu Madalina Iliescu Petru Bordei Dan Iliescu Camelia Ciobotaru Viorel Lucescu Anatoli Covaleov Constantin Ionescu Miguel Guirao E Páramo R Mutuberria I Sánchez-Montesinos O Roda F Girón Miguel Lopez-Soler Olga Roda Raúl Campos-López Miguel Guirao-Piñeiro Maria Teresa Pascual-Morenilla Indalecio Sanchez-Montesinos Maria Teresa Pascual I Garzon D Serrato R Nieto-Aguilar I Sanchez-Montesinos M Sanchez-Quevedo M Bulent Ozdemir R Hakan Ozean Dilek Bagdatli Esat Adiguzel Zumrut Dogan Ozlem Aycan Nigar Vardi Haldun Sukru Erkal Hakan Ozturk S Mocanu C Stefanescu A Ionescu Raluca Talpes Elena Sapte Constantin Dina Loredana Surdu Ionut Bulbuc M T Medina J Medina M López-Soler Carlos Martin-Oviedo Alejandro Lowy-Benoliel Eva Maranillo Tomas Martinez-Guirado Jose Sañudo Bartolome Scola Teresa Vazquez L A Arráez-Aybar J L Conejo-Menor C C Gonzáles-Gómez A J Torres-García Hisayo Nasu Shoji Chiba M Gutierrez-Semillera Yahya Paksoy Ahmet Kalaycioglu Mehmet Yildirim Ali Ozyasar Omer Ozdogmus Yusuf Ozgur Cakmak Ural Verimli Safiye Cavdar Begum Yildizhan Z Asli Aktan Ikiz Hulya Ucerler Zuhal Ozgur Seher Yilmaz Abdullah Demirtas Ertugrul Mavili Mehtap Hacialiogullari Hatice Susar Seda Arslan Kenan Aycan Vecihi Ozkaya Mara Pilmane Sarmite Boka Gursel Ortug Carlos Ramirez Aran Pascual-Font Francisco Valderrama-Canales Abdulah Kucukalic Eldan Kapur Elvira Talovic Vaclav Baca Robert Grill Zdenek Horak David Kachlik Valer Dzupa Marek Konarik Jakub Knize Petr Veleminsky Tereza Smrzova Michal Otcenasek Jana Chmelova Michal Kheck Michal Kheck Tomas Cupka Lukas Hnatek Floris van der Meijs Pavel Cech Vladimir Musil H Mustafa Ozkan S Kivanc Muratli Hamid Tayefi Ipek Ergur Amac Kiray Muhsin Toktas Ozan Alkoc Tolgahan Acar Ibrahim Uzun Oguz Asian Ozen Abdullah Aycicek Ozan Alper Alkoc Mehmet Unlu Ufuk Corumlu Ihsaniye Coskun Ikiz I Hakan Oygucu Erdogan Sendemir Tuncay Kaner Veli Caglar Olcay Eser Mehmet T Demir Omer Iyigun Gokhan Pirzirenli Ahmet Hilmi Kaya Mennan Ece Aydin Fahrettin Celik Hakan True Sevket Ozkaya Bekir Ugur Ergur Gulsah Zeybek Kadir Bacakoglu Mina Tadjalli Aghdas Poostpasand Seid Hadi Mansouiri Ozra Allahvaisi Jafar Soleimanirad Bahram Nikkhoo Yasukazu Nagato Yasuo Haruki Komazo Yazawa Tutomu Okazaki Munetaka Haida Yutaka Imai Thmineh Peirouvi Mehrzad Mahzad-Sadaghiani Farahnaz Noroozinia Salami Siamak Gholamhosseine Farjah Sima Mola Ewa Biegaj Tymon Skadorwa Konrad Pawlewicz Robert Kapolka Agata Chachulska Joanna Zabicka Aleksandra Krasowska Alicja Prusik Grzegorz Jaczewski Adam Kolesnik M Mohsen Taghavi S Hasan Alavi S Adel Moallem Zahed Safikhani Marzieh Panahi Shahriar Dabiri Majid Asadi Shekaari Rafael Latorre Federico Soria Octavio Lopez-Albors Ricardo Sarria Inacio Ayala Inma Serrano Enrique Perez-Cuadrado Vladimir Musienko Dmitry Tkachenko Neriman Colakoglu Murat Abdulgani Kus Mahdi Jalali Mohammad Reza Nikravesh Abbas Ali Moeen Mohammad Hassan Karimfar Houshang Rafighdoost Shabnam Mohammadi Marina Korneeva Houshang Rafighdoust Kvetuse Lovasova Adriana Bolekova Darina Kluchova Igor Sulla Marina Yurievna Kapitonova Syed Baharom Syed Ahmad Fuad Flossie Jayakaran Ali Reza Shams Fereshteh Aghaee Zohreh Baqer Mohamad Faroki Srijit Das Normadiah Kassim Azian Latiff Frihah Suhaimi Norzana Ghafar Khin Pa Pa Hlaing Israa Maatoq Faizah Othman Muge Kiray Husnu Alper Bagriyanik Cetin Pekcetin Candan Ozogul Mustafa Fidan Farihah Suhaimi Fei Sun Francisco Sanchez-Margallo Francisco Gil Verónica Crisostomo Jesus Uson Gegorio Ramirez Ozan Turamanlar Oguz Kirpiko Alpay Haktanir Salvador Climent Sergio Losilla Maria Climent Levent Sarikcioglu Yesim Senol Fatos B Yildirim Arzu Utuk Jacek Kunicki Parichehr Pasbakhsh Negar Omidi Hamed Omidi Fatemeh Dehghani Nazhvani Seyed Razi Ghalebi Nima Javan Akrami Mohagery Ali Reza Ebrahimzadeh Bideskan Mohammad Mehdi Hassanzadeh Taheri Ali Reza Fazel Cesare Tiengo Veronica Macchi Carla Stecco Andrea Porzionato Franco Mazzoleni Raffaele De Caro Alberto Clemente Aldo Morra Pietro Greco Piero Pavan Arturo Natali Mehmet Demir Mehmet Dokur Niyazi Acer Ayfer Mavi Niki Matveeva Dobrila Lazarova Kostandina Korneti Svetlana Jovevska Dragica Jurkovik Meri Papazova Masoumeh Havasi Naeim Alboghobeish Ahmad Savari Negin Salamat Mozafar Sharifi Hyun-Ho Kwak Kyung-Seok Hu Gyoo-Cheon Kim Bong-Soo Park Hee-Jin Kim Ahmet Sinav Adarsh K Gulati Nidhi K Gulati Hussien Alshammary Seifollah Dehghani Nazhvani Amir Vafafar Tahereh Esmaeilpour Soghra Bahmanpour Leila Elyasi Ahmad Monabbati M Ghanadi Mohammad Reza Paryani Hassan Gilanpour Banino Amirsam Rodrigo Elizondo Omaña Santos Guzmán López Oscar De la Garza Castro Edgar Urrutia Vega Santos Guzman Lopez Freshteh Talebpour Rahim Golmohammadi Golamreza Dashti Mohammad Ali Atlasi Mehdi Mehdizadeh Mohammad Hadi Bahadori Mohammad Taghi Joghataei Leili Hatami Mandana Beigi Boroujeni Jasem Estakhr Ebrahim Esfandiary Mohsen Marzban Mehrdad Bakhtiary Navid Modiry Mokhtar Jafarpur Hassan Mofidpur S Hassan Alavi Alareza Mahmoudian Mohmmad Mohsen Taghavi Mokhtar Jafarpour Ali Reza Mahmoudian Nasrin Sanjarmousavi Ines Doassans Natalia Sorrenti German Decuadro Andres Saibene Marie Poumayrac Sebastian Laza Carina Almiron Maria Elena Vergara Victor Soria Sebastian Lasa Adolfo Perez Gabriela Castro Ana Santa Maria Mansoureh Soleimani Majid Katebi Masoomeh Bakhshayesh Mithat Oner Mehmet Halici Ali Yikilmaz Ahmet Guney Yildirim Turk Mete Edizer Umit Beden Nihal Icten Mohammad Afshar Mohammad Mehdi Hasanzadeh Taheri Adel Moalem Mohammad Jafar Golalipour Azadeh Tamizi Mohammad Ahi Shahram Mohammadpour Ardeshir Maiery Cengiz Acikel Ersin Ulkur Huseyin Karagoz Bahattin Celikoz Kuldip Bedi Partadiredja Ginus Mohammad Jafar Golalipoor Mohammad Reza Mohammadi Poya Jhand Azad Reza Mansourian Kanizreza Hosseinpoor Abbas Ali Keshtkar Raith Alsaffar Babak Kabiri Balajadeh Soraya Ghafari Ramin Azarhosh Seyyed Amirhossein Fazeli Mehrdad Jahanshahi Annen Mohammad Gharravi Banu Alicioglu Hakki Muammer Karakas Ahmet Harma Hun-Mu Yang Sung-Yoon Won Jae-Gi Lee Ju-Young Lee Jeong-Yong Lee Yoo-Ri Kim Wu-Chul Song Ki-Seok Koh Eu-Na Hwang Hyun-Gon Choi Soon-Heum Kim Soo-Young Kim Mi-Sun Hur Enis Ulucam Osman Celbis Da-Hye Kim Hee-Suk Hong Hyun-Joo Kim Jong-Hoon Choi Jong-Tae Park Hyeon-Cheol Kim Hamed Abbasi Seyed Mohammad Hosseinipanah Mohammad Hosseini A Amani H R Ashrafi Mohsen Sadeghimehr Hyun-Ju Kim Vadim Sheverdin Zahra Amani Alireza Ashrafi Ali Reza Ashrafi Hami Javad Mokhtar Jafarpoor Kachap Sebastián Laza Marie Catherine Poumayrac Inés Doassans María Elena Vergara Carina Almirón Víctor Soria Alvaro Rivara Angela Sirilo Diego Freire Angela Cirillo Maria Elena Veragara Vlado Krmek Nikola Krmek Ana Jo-Osvatic Vasilije Nikolic Radivoje Radic R Shane Tubbs Marios Loukas Quentin Fogg Neil Ashwood Serpil Cilingiroglu Cemal Ozbakir Tahereh Mazoochi Vedat Sabanciogullari Cesur Gumus F Hayat Erdil Mehmet Cimen Hesam Moodi Fateme Ghiasi Asghar Akbari Javad Hami Majid Khazei Elham Haghparast Ioannis Mitsakis Aikaterini Anastasiou Menelaos Mitsakis Kyriaki Sianou Roxani Hainoglou Margarida Francisco Charikleia Mitsaki Maria Konstantinidi Stamatia Prapa Igor Leksan Tomislav Mrcela Robert Selthofer Fatemeh Kermanian Alireza Mahmoudian Mahmood Erfanian Ahmadpoor Naser Dalili Amir Hossein Elian Ardesheer Moaiery Zahra Jamalpour Mohammad Reza Nourani Alireza Asgari Mohammad Mehdi Hassanzadeh Taheri Alireza Ebrahimzadeh Seyed Hasan Eftekharvaghefi Abbas Mohammadi Vahid Sheibani Seyed Noureddin Nematollahi-Mahani Mastafa Latifpour Masood Deilami Behzad Soroure-Azimzadeh Fatemeh Nabipour Hamid Najafipour Nouzar Nakhaee Mohammad Yaghoobi Rana Eftekharvaghefi Parvin Salehinejad Hasan Azizi Hamid Reza Riasi Maliheh Nobakht Sara Asalgoo Roshanak Rahbar Norooz Najafzadeh Kazem Moosavizadeh Massood Ezzatabadypour Masoud Majidi Reza Malekpor-Afshar Fariba Karimzade Mahmood Hoseini Mohamad Bayat Ali Gorgi Akram Nezhadi Mehrdad Bakhtiari Homa Rasooli Jazi Maryam Jafaryan Hosein Haghir Mahmood Hosseini Sadegh Rahimi Fatemeh Behnam Rassouli Ali Gorji Aliasghar Habibi Fatemeh Pouya Shahryar Dabiri A Mousavi Saeed Rajabalian A Abolidokht Neda Khanlarkhani Homayoun Naderian Nezamedin Berjis Mohamad Reza Namavar Tahereh Talaei Zohreh Mazaheri Ahmad Monabati Mehmet Ilkay Kosar Kezban Karacan Hamidreza Chegini Hossein Nikzad Egemen Ayhan Sinan Ustundag Salih Murat Akkin Tahir Ogut Parviz Rayegan Mohamad Ali Emami Meibodi Reza Montazer Ghaem Rosa Zargarpoor Seyd Hasan Eftekhar Vaghefi Ghazale Moshkdanian Fateme Poya Hamid Kohestani Roozbeh Rayegan Abarghoeai Parviz Rayegan Abarghoeai Seyed Hasan Eftekhar Vaghefi Abolghasem Amir Mahmodi Ali Poraboli Hamid Reza Kohestani Raena Eftekhar Vaghefi Seyed Hasan Eftekhar Vaghefy Raena Eftekhar Vaghefy Parviz Raygan Abarghoeai Mohamad Saba Anneh Mohammad Gharravi Fatemeh Javadnia Mohsen Zhaleh Dariush Bijan Nezhad Mohammad Reza Gholami Maria Piagkou Vassiliki Kouki Aikaterini Giannoulis Piagkos Stergios Douvetzemis Panagiotis Skandalakis Sophia Anagnostopoulou Nikolaos Papadopoulos H Hamdi Celik Ilkan Tatar Emel Cadalli Tatar Burce Ozgen Mocan Mustafa F Sargon C Cem Denk Homa Rasoolijazi Mohammad Taghi Joghataie Mehrdad Roghani Salin Murat Akkin Gulten Dinc Mustafa Kurklu Sener Ozboluk Mahmut Komurcu Jürgen Koebke Mehmet Bulent Balioglu Mehmet Akif Kaygusuz Ferdi Sefa Bozkus Ozgur Korkmaz Sule Biyik Bayram Mehmet Ali Can Ebrahim Nasiri Koroush Jafar-Kazemi Melina Hosseini Shahin Maghoul Mansooreh Soleimani Abdollah Amini Mohamad Mahdi Hassanzade Mohammad Hossein Davari Tom Van Hoof Germano T Gomes Emmanuel Audenaert Koenraad Verstraete Ingrid Kerckaert Katharina D'Herde Brion Benninger Gil Hedley Florin Mihail Filipoiu Eugen Tarta Mihali Enyedi Cosmin Pantu Razvan Stanciulescu Cezary Skobowiat Jaroslaw Calka Mariusz Majewski Maryam Rezaian Akbar Yaghoobfar Somayeh Hamedi T Shomali

Surg Radiol Anat 2009 Sep;31 Suppl 1:95-229

Division of Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.

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http://dx.doi.org/10.1007/BF03371486DOI Listing
September 2009

Platform presentations.

Authors:
Jaime Pereda Gen Niimi Jagat Mohini Kaul Sabita Mishra Babita Pangtey Daniele Peri Vincenza Cannella Giovanni Peri A Valentino Francesco Li Volsi Rosaria Lo Verde E Russo A Sciuto Annalisa Sunseri Giuseppe Modica Gianpiero Gravante Seok Ling Ong Matthew Metcalfe David Lloyd Ashley Dennison Veronica Macchi Andrea Porzionato Anna Parenti Raffaele De Caro Kawthar I F Al-Harmni Zohair I F Rahemo Hussain I A Al-Khan Vedat Bakan Gulen Demirpolat Mahmut Bozkurt Yakup Gumusalan Niyazi Acer Mehmet Demir Hulusi Taskoparan Akcan Akkaya Birdal Yildirim Mehmet Camurdanoglu Gul Guven Hilmi Ozden Sahin Kabay Cengiz Ustuner Dilek Burukoglu Derya Ustuner Irfan Degirmenci Fahrettin Akyuz Neslihan Tekin Fulya Kucuk Firdevs Gurer M Cengiz Ustuner Davut Ozbag Mesut Ozkaya Harun Ciralik Fatma Inanc Tolun Fatih Yuzbasioglu Seda Arslan Ghazaleh Moshkdanian Fatemeh Pouya Amirmahdi Nematollahi-Mahani Seyed Noureddin Nematollahi-Mahani Ralph Ger Jeremy Nikfarjam Kathy Dooley Shuwei Liu Zhenping Li Xiangtao Lin Haiwei Meng Cheng Liu Lei Feng Min Suk Chung Dong Sun Shin Eric Havet Anne-Claire Dujardin Fabrice Duparc Pierre Freger Anitha Oommen Christoph Stosch Jürgen Koebke Stefan Herzig Adam Jqbal Paul Gazzani Tim Rattay Birgit Fruhstorfer Anil Vohrah Richard M Wellings Stephen Brydges Gregory R Smith Jamie Roebuck Peter H Abrahams Vaclav Baca Michal Otcenasek Filip Svatos Tereza Smrzova Robert Grill David Kachlik Jan Skubal Valer Dzupa Alena Doubkova Ivo Klepacek Josef Stingl Muddathir Ali Yahya Bedir Günther Weber Karim Malek Amos Patrick Brent Rochambeau Phil Knickelbein Da-Yae Choi Mi-Sun Hur Kwan-Hyun Youn Kyung-Seok Hu Hee-Jin Kim Fadullah Aksoy Yavuz Selim Yildirim Orhan Ozturan Hurtan Acar Hasan Demirhan Bayram Veyseller Jean Michel Prades Andrei Timoshenko Alexander Asanau Marie Gavid Christian Martin Benoit Ayestaray Isabelle Auquit-Auckbur Pierre-Yves Millez Burcu Ercakmak Alp Bayramoglu Hakan Ozsoy Deniz Demiryurek Eray Tuccar Keiichi Akita Kumiko Yamaguchi Atsuo Kato Tomoyuki Mochizuki Julien Beldame Jean-Philippe Mure Benjamin Lefebvre David M Lloyd K J Karmand M G Norwood Aysin Kale Ozcan Gayretli Adnan Ozturk Ilke Ali Gurses Ahmet Usta Kayihan Sahinoglu Gokhan Kaynak Mustafa Bilgili Isik Akgun Tahir Ogut Mehmetcan Unlu Ibrahim Uzun Biagio Valentino Elvira Farina Tomoyasu Kato Stoyan Pavlov Maria Grosheva Andrey Irintchev Doychin Angelov Tulin Sen Ali Firat Esmer S Tuna Karahan Benoit Delas Jean Pierre Marie Jean Christophe Sabourin Anna Hebda Rachel Claire Aland Nihal Apaydin Alparslan Apan Aysun Uz Ayhan Comert Mehmet Arslan Halil Ibrahim Acar Mevci Ozdemir Alaittin Elhan Ibrahim Tekdemir R Shane Tubbs Ayhan Attar Hasan Caglar Ugur Zeliha Fazliogullari Ismihan Ilknur Uysal Ahmet Kagan Karabulut Nadire Unver Dogan Muzaffer Seker Neslihan Cankara Mehmet Ali Malas Emine Hilal Evcil Aysegul Firat Mine Erbil Figen Kaymaz Sinan Yuruker Semiha Sen Mina Tadjalli Seid Reza Ghazi Paria Parto Seyed Reza Ghazi Ceren Gunenc Beser Musturay Karcaaltincaba H Hamdi Celik Ruhgun Basar Serpil Cilingiroglu Cemal Ozbakir Kenan Kose Suleyman Tuna Karahan Gulnur Ozguner Osman Sulak Irwin Best Radovan Turyna Ismail Malkoc Huseyin Karagoz Bilal Firat Alp Cemal Gundogdu Samih Diyarbakir Firas Ghazi Panagiotis Karanis Sayee Rajangam Preetha Tilak Rema Devi Bita Seifi Naeem Earfani Majd Mehran Dorstghol Negar Niakan Behpour Yousefi Nooshin Bromand Saeed Haghighi Majid Malekzadeh Shafaroudi Craig Daly John Chris McGrath Reza Ahadi Mehrdad Bakhtiary Mohammad Taghi Joghataei Mehdi Mehdizadeh Samideh Khoei Mohsen Marzban Parvin Salehinejad Zahra Torshizi Maryam Mohit Nourjahan Banou Alithan Ali Adulmanaf Omar Abdulrahman Seyed Adel Moallem Bibi Ezzat Hosseini Mohammad Afshar Mohammad Mehdi Hasanzadeh Taheri Javad Hami Mohammad Hossein Davari Saeid Kalbasi Noroz Najafzade Malihe Nobakht Manoochehr Safari Sara Asalgoo Nahid Rahbar Roshandel Mohamad Taghi Joghataeei Mehrdad Bakhtiari Farid Safar Negin Salamat Naeem Alboghobeish Mahmood Hashemitabar Mehrzad Mesbah Ewa Biegaj Tymon Skadorwa Robert Kapolka Bogdan Ciszek Maria Piagkou Giannoulis Piagkos Vassiliki Kouki Aikaterini Stergios Douvetzemis Panagiotis Skandalakis Sophia Anagnostopoulou Mohamed Rashid Haffajee Mohamed Adoobaker Ebrahim J W Smith Peter Osmotherly Darren Rivett Susan Mercer Bin Yue Dai-Soon Kwak Yong-Seok Nam Je-Hun Lee U-Young Lee Xiaochun An Mi-Sun Lee Seung-Ho Han Ahmet Songur Olcay Eser Ozan Alkoc Muhsin Toktas Veli Caglar Tuncay Kaner Mehmet Tugrul Yilmaz Serter Gumus Isinman Ilknur Uysal Yahya Paksoy Mahinur Ulusoy Mehmet Bulent Balioglu Koray Savran Gazi Zorer Hitomi Fujishiro Takeshi Muneta Kenji Sato Joël Vernois Patrice Mertl Bo Sun Ge Haitao Tang Yuchun Zhonghe Zhang Gaojun Teng Hequn Geng Taifei Yu Umit S Sehirli Ural Verimli Emel Ulupinar Ferruh Yucel Lia Neto Edson Oliveira Daniel Neto Hugo Martins Inácio Reis Francisco Correia António Goncalves Ferreira Joana Regala Paula Fernandes Joana Teixeira G Nilufer Yonguc M Bulent Ozdemir Vural Kucukatay Melike Sahiner Raziye Kursunluoglu Esat Adiguzel Ilgaz Akdogan Yusuf Yilmaz Melek Bor Kucukatay Gulten Erken M Ayberk Kurt Ilker M Kafa Murat Uysal Sinan Bakirci Suraj Prakash Mahindra Kumar Anand Meena Verma Mohsen Basiri Ronald Doucette Yuchun Tang Lingzhong Fan Mehmet Dumlu Aydin Canan Atalay Sare Altas Ednan Bayram Bunyami Unal Sahin Asian Georg Feigl Friedrich Anderhuber Rainer Rienmuller Jean Phillippe Guyot Jean H D Fasel Izabel Kos Oguz Aslan Ozen Mustafa Sarsilmaz Gunnar Grant Mohammad Reza Nourani Zahra Jamali Hamid Reza Taghipour Yuji Owada Mohammad Ali Khalili Ben R Clower Morteza Anvari Fatemeh Sadeghian Farzaneh Fesahat Seyd Mohsen Miresmaili Bagher Pourheydar Mohammad Taghi Joghataeei Vahid Pirhajati Abolfazl Faghihi Fereshteh Mehraeen S Saeed Seyed Jafari Abbas Aliaghaei S Noureddin Nematollahi-Mahani Vahid Sheibani Majid Asadi Gholam Reza Kaka Taki Tiraihi Karol Budohoski Jacek Kunicki Ulrike Pilsl Can Pelin Baris Ozener Ayla Kurkcuoglu Ragiba Zagyapan Anna Zurada Jerzy Gielecki Hakan Ay Bruno Grignon Frederic Walter Toufik Batch Horatiu Varlam Iulian Iopincariu Mehdi Benkhadra Francois Lenfant Pierre Trouilloud Manuel Kastner Likar Rudolf

Surg Radiol Anat 2009 Sep;31 Suppl 1:49-93

Department of Anesthesiology, Hospital Klagenfurt, Klagenfurt, Austria.

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http://dx.doi.org/10.1007/BF03371485DOI Listing
September 2009

Comparison of an inhomogeneous orthotropic and isotropic material models used for FE analyses.

Med Eng Phys 2008 Sep 20;30(7):924-30. Epub 2008 Feb 20.

Department of Anatomy, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Finite element (FE) analysis has been widely used to study the behaviour of bone or implants in many clinical applications. One of the main factors in analyses is the realistic behaviour of the bone model, because the behaviour of the bone is strongly dependent on a realistic bone material property assignment. The objective of this study was to compare isotropic and orthotropic inhomogeneous material models used for FE analyses of the "global" proximal femur and "small" specimens of the bone (cancellous and cortical). Our hypothesis was that realistic material property assignment (orthotropy) is very important for the FE analyses of small bone specimens, whereas in global FE analyses of the proximal femur, this assignment can be omitted, if the inhomogeneous material model was used. The three-dimensional geometry of the "global" proximal femur was reconstructed using CT scans of a cadaveric femur. This model was implemented into an FE simulation tool and various bone material properties, dependant on bone density, were assigned to each element in the models. The "small" specimens of cortical and cancellous bone were created in the same way as the model of the proximal femur. The results obtained from FE analyses support our above described hypothesis.
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http://dx.doi.org/10.1016/j.medengphy.2007.12.009DOI Listing
September 2008

The unusual cause of recurrent abdominal pain in an 11-year-old boy.

Nucl Med Rev Cent East Eur 2006 ;9(1):77-80

Department of Nuclear Medicine, University Hospital Královské Vinohrady and 3rd School of Medicine, Charles University, Prague, Czech Republic.

The case of an 11-year-old boy with recurrent abdominal pain is presented. Physiological findings were found normal during a clinical investigation, as well as many laboratory tests, ultrasonography and CT of abdomen. Only a high level of sedimentation rate and the focus of increased activity in the sacral region on scintigraphy using 99mTc-HMPAO (hexamethypropyleneaminooxime) labelled leukocytes were found. The other findings on bone scintigraphy, X-ray and MRI led to a deflection of the correct diagnosis. The real culprit proved to be an ingested foreign body (a piece of a wooden skewer) that the patient failed to reveal.
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August 2006