Publications by authors named "Vadim N Gladyshev"

100Publications

COVID-19 is an emergent disease of aging.

Aging Cell 2020 Oct 1;19(10):e13230. Epub 2020 Oct 1.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/acel.13230DOI Listing
October 2020

The Ground Zero of Organismal Life and Aging.

Trends Mol Med 2020 Sep 23. Epub 2020 Sep 23.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2020.08.012DOI Listing
September 2020

Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity.

Cell Rep 2020 Jul;32(4):107949

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107949DOI Listing
July 2020

Multifaceted deregulation of gene expression and protein synthesis with age.

Proc Natl Acad Sci U S A 2020 07 23;117(27):15581-15590. Epub 2020 Jun 23.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.2001788117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354943PMC
July 2020

CTELS: A Cell-Free System for the Analysis of Translation Termination Rate.

Biomolecules 2020 Jun 16;10(6). Epub 2020 Jun 16.

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.

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http://dx.doi.org/10.3390/biom10060911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356799PMC
June 2020

Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning.

iScience 2020 Jun 23;23(6):101199. Epub 2020 May 23.

Deep Longevity Inc, Hong Kong Science and Technology Park, Hong Kong; Insilico Medicine Ltd, Hong Kong Science and Technology Park, Hong Kong; Buck Institute for Research on Aging, Novato, CA, USA; Biogerontology Research Foundation, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.101199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298543PMC
June 2020

An NMR-Based Biosensor to Measure Stereospecific Methionine Sulfoxide Reductase Activities in Vitro and in Vivo.

Chemistry 2020 Jun 5. Epub 2020 Jun 5.

Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET-UNR), Ocampo y Esmeralda, 2000, Rosario, Argentina.

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http://dx.doi.org/10.1002/chem.202002645DOI Listing
June 2020

Systematic age-, organ-, and diet-associated ionome remodeling and the development of ionomic aging clocks.

Aging Cell 2020 05 23;19(5):e13119. Epub 2020 Apr 23.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/acel.13119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253066PMC
May 2020

Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities.

Ageing Res Rev 2020 07 6;60:101050. Epub 2020 Apr 6.

InSilico Medicine, Science Park, Hong Kong; Biogerontology Research Foundation, London, UK; Buck Institute for Research on Aging, Novato, USA. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2020.101050DOI Listing
July 2020

Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration.

Redox Biol 2020 05 16;32:101507. Epub 2020 Mar 16.

Department of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbrücke, 14558, Nuthetal, Germany; German Center for Diabetes Research (DZD), 85764, München-Neuherberg, Germany; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2020.101507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097524PMC
May 2020

Bioinformatics of Selenoproteins.

Antioxid Redox Signal 2020 Sep 23;33(7):525-536. Epub 2020 Apr 23.

Division of Genetics, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1089/ars.2020.8044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409585PMC
September 2020

Molecular signatures of aneuploidy-driven adaptive evolution.

Nat Commun 2020 01 30;11(1):588. Epub 2020 Jan 30.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-019-13669-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992709PMC
January 2020

Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality.

Cell Rep 2019 12;29(13):4276-4284.e3

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.091DOI Listing
December 2019

Tolerance to Selenoprotein Loss Differs between Human and Mouse.

Mol Biol Evol 2020 02;37(2):341-354

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/molbev/msz218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993852PMC
February 2020

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.

Cell Metab 2019 09 25;30(3):573-593.e8. Epub 2019 Jul 25.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907080PMC
September 2019

Selenium Deficiency Is Associated with Pro-longevity Mechanisms.

Cell Rep 2019 05;27(9):2785-2797.e3

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689410PMC
May 2019

svist4get: a simple visualization tool for genomic tracks from sequencing experiments.

BMC Bioinformatics 2019 Mar 6;20(1):113. Epub 2019 Mar 6.

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskiye gory 1, Moscow, 119234, Russia.

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http://dx.doi.org/10.1186/s12859-019-2706-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404320PMC
March 2019

Utilization of selenocysteine in early-branching fungal phyla.

Nat Microbiol 2019 05 11;4(5):759-765. Epub 2019 Feb 11.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41564-018-0354-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551623PMC
May 2019

Protein synthesis and quality control in aging.

Aging (Albany NY) 2018 12;10(12):4269-4288

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia.

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http://dx.doi.org/10.18632/aging.101721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326689PMC
December 2018

Reversibility of irreversible aging.

Ageing Res Rev 2019 01 1;49:104-114. Epub 2018 Dec 1.

Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119234, Russia; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2018.11.008DOI Listing
January 2019

A whole lifespan mouse multi-tissue DNA methylation clock.

Elife 2018 11 14;7. Epub 2018 Nov 14.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

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http://dx.doi.org/10.7554/eLife.40675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287945PMC
November 2018

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells.

Aging Cell 2019 02 22;18(1):e12841. Epub 2018 Oct 22.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/acel.12841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351832PMC
February 2019

A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts.

Stem Cell Res 2018 08 20;31:197-200. Epub 2018 Jun 20.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.06.010DOI Listing
August 2018

Selenoproteins in colon cancer.

Free Radic Biol Med 2018 11 22;127:14-25. Epub 2018 May 22.

Dept. of Biological Sciences, Towson University, 8000 York Rd, Towson, MD 21252, United States. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.05.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168369PMC
November 2018

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.

Cell Rep 2018 05;23(5):1387-1398

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.009DOI Listing
May 2018

Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation.

Free Radic Biol Med 2018 11 30;127:190-197. Epub 2018 Apr 30.

School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.577DOI Listing
November 2018

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity.

Aging Cell 2018 08 19;17(4):e12740. Epub 2018 Apr 19.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/acel.12740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052463PMC
August 2018

Mechanisms of cancer resistance in long-lived mammals.

Nat Rev Cancer 2018 07;18(7):433-441

University of Rochester, Department of Biology, Rochester, NY, USA.

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http://www.nature.com/articles/s41568-018-0004-9
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http://dx.doi.org/10.1038/s41568-018-0004-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015544PMC
July 2018

Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans.

Genome Biol Evol 2018 03;10(3):967-975

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, China.

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http://dx.doi.org/10.1093/gbe/evy062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952927PMC
March 2018

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction.

Aging Cell 2018 06 25;17(3):e12738. Epub 2018 Mar 25.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/acel.12738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946071PMC
June 2018

Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner.

Sci Rep 2018 01 17;8(1):1010. Epub 2018 Jan 17.

Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-017-15090-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798039PMC
January 2018

Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera.

Stem Cell Reports 2017 11 26;9(5):1706-1720. Epub 2017 Oct 26.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829328PMC
November 2017

Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage.

Arch Biochem Biophys 2017 11 3;634:69-75. Epub 2017 Oct 3.

Department of Biochemistry and Molecular Biology, Yeungnam University College of Medicine, Daegu 42415, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00039861173045
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http://dx.doi.org/10.1016/j.abb.2017.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807074PMC
November 2017

Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity.

Methods Mol Biol 2018 ;1661:285-299

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/978-1-4939-7258-6_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854162PMC
May 2018

Selenocysteine tRNA, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing.

Methods Mol Biol 2018 ;1661:43-60

Molecular Biology of Selenium Section, Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA.

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http://link.springer.com/10.1007/978-1-4939-7258-6_4
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http://dx.doi.org/10.1007/978-1-4939-7258-6_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836751PMC
May 2018

A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.

Antioxid Redox Signal 2018 10 17;29(10):1003-1017. Epub 2017 Oct 17.

3 Division of Genetics, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital , Boston, Massachusetts.

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http://dx.doi.org/10.1089/ars.2017.7105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104246PMC
October 2018

Molecular signatures of longevity: Insights from cross-species comparative studies.

Semin Cell Dev Biol 2017 10 8;70:190-203. Epub 2017 Aug 8.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; Laboratory of Systems Biology of Aging, Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119234, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807068PMC
October 2017

Cytochrome peroxidase facilitates the beneficial use of HO in prokaryotes.

Proc Natl Acad Sci U S A 2017 08 1;114(33):8678-8680. Epub 2017 Aug 1.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1710943114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565471PMC
August 2017

Gene expression signatures of human cell and tissue longevity.

NPJ Aging Mech Dis 2016 7;2:16014. Epub 2016 Jul 7.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/npjamd.2016.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514998PMC
July 2016

Translation fidelity coevolves with longevity.

Aging Cell 2017 10 13;16(5):988-993. Epub 2017 Jul 13.

Department of Biology, University of Rochester, Rochester, NY, USA.

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http://dx.doi.org/10.1111/acel.12628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595694PMC
October 2017

Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo.

Sci Rep 2017 07 11;7(1):5119. Epub 2017 Jul 11.

Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-017-05230-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506048PMC
July 2017

Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.

Sci Rep 2017 06 29;7(1):4391. Epub 2017 Jun 29.

Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, D-13353, Germany.

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http://dx.doi.org/10.1038/s41598-017-04586-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491492PMC
June 2017

Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.

Cell Metab 2017 Apr;25(4):954-960.e6

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578459PMC
April 2017

Non-enzymatic molecular damage as a prototypic driver of aging.

J Biol Chem 2017 04 6;292(15):6029-6038. Epub 2017 Mar 6.

the Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

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http://dx.doi.org/10.1074/jbc.R116.751164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391736PMC
April 2017

Age-associated molecular changes are deleterious and may modulate life span through diet.

Sci Adv 2017 Feb 17;3(2):e1601833. Epub 2017 Feb 17.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/sciadv.1601833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315447PMC
February 2017

Regulated methionine oxidation by monooxygenases.

Free Radic Biol Med 2017 08 14;109:141-155. Epub 2017 Feb 14.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540442PMC
August 2017

Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil.

Free Radic Biol Med 2017 03 17;104:249-261. Epub 2017 Jan 17.

Department of Biochemistry, 89 Beaumont Ave, Given Building Room B413, Burlington, VT 05405, United States. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328918PMC
March 2017

A Disease or Not a Disease? Aging As a Pathology.

Trends Mol Med 2016 12 25;22(12):995-996. Epub 2016 Oct 25.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540438PMC
December 2016

Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide.

Methods 2016 10 23;109:149-157. Epub 2016 Jun 23.

Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075500PMC
http://dx.doi.org/10.1016/j.ymeth.2016.06.022DOI Listing
October 2016

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.

Redox Biol 2016 10 26;9:22-31. Epub 2016 May 26.

Helmholtz Zentrum München, Institute for Developmental Genetics, Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900515PMC
October 2016

Ribonuclease selection for ribosome profiling.

Nucleic Acids Res 2017 01 15;45(2):e6. Epub 2016 Sep 15.

Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA

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http://nar.oxfordjournals.org/content/early/2016/09/15/nar.g
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http://dx.doi.org/10.1093/nar/gkw822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314788PMC
January 2017

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.

Proc Natl Acad Sci U S A 2016 09 1;113(38):E5562-71. Epub 2016 Sep 1.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Broad Institute of MIT and Harvard, Cambridge, MA 02142; Harvard Stem Cell Institute, Cambridge, MA 02138; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035897PMC
http://dx.doi.org/10.1073/pnas.1600204113DOI Listing
September 2016

Intrinsic Versus Extrinsic Cancer Risk Factors and Aging.

Trends Mol Med 2016 Oct 17;22(10):833-834. Epub 2016 Aug 17.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/trends/molecular-medicine/pdf/S1471-4914
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068914PMC
http://dx.doi.org/10.1016/j.molmed.2016.08.001DOI Listing
October 2016

Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.

Nat Commun 2016 08 12;7:12157. Epub 2016 Aug 12.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms12157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990632PMC
August 2016

Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum.

Mol Biol Evol 2016 11 8;33(11):2885-2889. Epub 2016 Aug 8.

School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland

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http://dx.doi.org/10.1093/molbev/msw166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062323PMC
November 2016

Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems.

Mol Biol Evol 2016 09 12;33(9):2441-53. Epub 2016 Jul 12.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1093/molbev/msw122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989117PMC
September 2016

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.

Aging Cell 2016 08 6;15(4):594-602. Epub 2016 Apr 6.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1111/acel.12480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933668PMC
August 2016

Methionine restriction and life-span control.

Ann N Y Acad Sci 2016 Jan 10;1363:116-24. Epub 2015 Dec 10.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.12973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008916PMC
January 2016

Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.

Cancers (Basel) 2015 Nov 10;7(4):2262-76. Epub 2015 Nov 10.

Molecular Biology of Selenium Section, Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/cancers7040889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695889PMC
November 2015

Convergent evolution of marine mammals is associated with distinct substitutions in common genes.

Sci Rep 2015 Nov 9;5:16550. Epub 2015 Nov 9.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.nature.com/articles/srep16550
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http://dx.doi.org/10.1038/srep16550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637874PMC
November 2015

Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.

Cell Rep 2015 Nov 5;13(7):1319-1326. Epub 2015 Nov 5.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771060PMC
November 2015

Selenium and Methionine Sulfoxide Reduction.

Free Radic Biol Med 2014 Oct 10;75 Suppl 1:S8-9. Epub 2014 Dec 10.

Brigham and Women׳s Hospital, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.848DOI Listing
October 2014

Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine.

PLoS One 2015 9;10(10):e0140353. Epub 2015 Oct 9.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140353PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599804PMC
June 2016

A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters.

Antioxid Redox Signal 2016 01 27;24(4):205-216. Epub 2015 Oct 27.

1 Worm Biology Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay .

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http://dx.doi.org/10.1089/ars.2015.6377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913166PMC
January 2016

Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.

Proc Natl Acad Sci U S A 2015 Aug 10;112(34):10685-90. Epub 2015 Aug 10.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1505315112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553801PMC
August 2015

Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.

Cell Metab 2015 Aug;22(2):332-43

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758382PMC
August 2015

Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization.

Genome Res 2015 Sep 20;25(9):1256-67. Epub 2015 Jul 20.

Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 08003 Barcelona, Catalonia, Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Catalonia, Spain; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona, Catalonia, Spain;

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http://dx.doi.org/10.1101/gr.190538.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561486PMC
September 2015

Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1.

Antioxid Redox Signal 2015 Oct 16;23(10):814-22. Epub 2015 Jul 16.

1 Division of Genetics, Department of Medicine, Brigham and Women's Hospital , Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1089/ars.2015.6385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589106PMC
October 2015