Vadim N Gladyshev

Vadim N Gladyshev

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Vadim N Gladyshev

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Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.

Cell Metab 2019 Sep 25;30(3):573-593.e8. Epub 2019 Jul 25.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.018DOI Listing
September 2019

Tolerance to selenoprotein loss differs between human and mouse.

Mol Biol Evol 2019 Sep 27. Epub 2019 Sep 27.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/molbev/msz218DOI Listing
September 2019

Utilization of selenocysteine in early-branching fungal phyla.

Nat Microbiol 2019 05 11;4(5):759-765. Epub 2019 Feb 11.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41564-018-0354-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551623PMC
May 2019

Selenium Deficiency Is Associated with Pro-longevity Mechanisms.

Cell Rep 2019 May;27(9):2785-2797.e3

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689410PMC
May 2019

svist4get: a simple visualization tool for genomic tracks from sequencing experiments.

BMC Bioinformatics 2019 Mar 6;20(1):113. Epub 2019 Mar 6.

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskiye gory 1, Moscow, 119234, Russia.

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http://dx.doi.org/10.1186/s12859-019-2706-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404320PMC
March 2019

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells.

Aging Cell 2019 Feb 22;18(1):e12841. Epub 2018 Oct 22.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/acel.12841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351832PMC
February 2019

Reversibility of irreversible aging.

Ageing Res Rev 2019 Jan 1;49:104-114. Epub 2018 Dec 1.

Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119234, Russia; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2018.11.008DOI Listing
January 2019

Protein synthesis and quality control in aging.

Aging (Albany NY) 2018 12;10(12):4269-4288

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia.

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http://dx.doi.org/10.18632/aging.101721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326689PMC
December 2018

Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation.

Free Radic Biol Med 2018 11 30;127:190-197. Epub 2018 Apr 30.

School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.577DOI Listing
November 2018

Selenoproteins in colon cancer.

Free Radic Biol Med 2018 11 22;127:14-25. Epub 2018 May 22.

Dept. of Biological Sciences, Towson University, 8000 York Rd, Towson, MD 21252, United States. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.05.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168369PMC
November 2018

A whole lifespan mouse multi-tissue DNA methylation clock.

Elife 2018 11 14;7. Epub 2018 Nov 14.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

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http://dx.doi.org/10.7554/eLife.40675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287945PMC
November 2018

A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.

Antioxid Redox Signal 2018 10 17;29(10):1003-1017. Epub 2017 Oct 17.

3 Division of Genetics, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital , Boston, Massachusetts.

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http://dx.doi.org/10.1089/ars.2017.7105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104246PMC
October 2018

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity.

Aging Cell 2018 08 19;17(4):e12740. Epub 2018 Apr 19.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/acel.12740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052463PMC
August 2018

A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts.

Stem Cell Res 2018 08 20;31:197-200. Epub 2018 Jun 20.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.06.010DOI Listing
August 2018

Mechanisms of cancer resistance in long-lived mammals.

Nat Rev Cancer 2018 07;18(7):433-441

University of Rochester, Department of Biology, Rochester, NY, USA.

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http://www.nature.com/articles/s41568-018-0004-9
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http://dx.doi.org/10.1038/s41568-018-0004-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015544PMC
July 2018

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction.

Aging Cell 2018 06 25;17(3):e12738. Epub 2018 Mar 25.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/acel.12738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946071PMC
June 2018

Selenocysteine tRNA, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing.

Methods Mol Biol 2018 ;1661:43-60

Molecular Biology of Selenium Section, Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA.

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http://link.springer.com/10.1007/978-1-4939-7258-6_4
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http://dx.doi.org/10.1007/978-1-4939-7258-6_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836751PMC
May 2018

Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity.

Methods Mol Biol 2018 ;1661:285-299

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/978-1-4939-7258-6_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854162PMC
May 2018

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.

Cell Rep 2018 05;23(5):1387-1398

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.009DOI Listing
May 2018

Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans.

Genome Biol Evol 2018 03;10(3):967-975

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, China.

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http://dx.doi.org/10.1093/gbe/evy062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952927PMC
March 2018

Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner.

Sci Rep 2018 01 17;8(1):1010. Epub 2018 Jan 17.

Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-017-15090-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798039PMC
January 2018

Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage.

Arch Biochem Biophys 2017 11 3;634:69-75. Epub 2017 Oct 3.

Department of Biochemistry and Molecular Biology, Yeungnam University College of Medicine, Daegu 42415, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00039861173045
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http://dx.doi.org/10.1016/j.abb.2017.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807074PMC
November 2017

Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera.

Stem Cell Reports 2017 11 26;9(5):1706-1720. Epub 2017 Oct 26.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829328PMC
November 2017

Translation fidelity coevolves with longevity.

Aging Cell 2017 10 13;16(5):988-993. Epub 2017 Jul 13.

Department of Biology, University of Rochester, Rochester, NY, USA.

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http://dx.doi.org/10.1111/acel.12628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595694PMC
October 2017

Molecular signatures of longevity: Insights from cross-species comparative studies.

Semin Cell Dev Biol 2017 10 8;70:190-203. Epub 2017 Aug 8.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; Laboratory of Systems Biology of Aging, Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 119234, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807068PMC
October 2017

Regulated methionine oxidation by monooxygenases.

Free Radic Biol Med 2017 08 14;109:141-155. Epub 2017 Feb 14.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540442PMC
August 2017

Cytochrome peroxidase facilitates the beneficial use of HO in prokaryotes.

Proc Natl Acad Sci U S A 2017 08 1;114(33):8678-8680. Epub 2017 Aug 1.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1710943114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565471PMC
August 2017

Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo.

Sci Rep 2017 07 11;7(1):5119. Epub 2017 Jul 11.

Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-017-05230-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506048PMC
July 2017

Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P.

Sci Rep 2017 06 29;7(1):4391. Epub 2017 Jun 29.

Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, D-13353, Germany.

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http://dx.doi.org/10.1038/s41598-017-04586-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491492PMC
June 2017

Non-enzymatic molecular damage as a prototypic driver of aging.

J Biol Chem 2017 04 6;292(15):6029-6038. Epub 2017 Mar 6.

the Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115

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http://dx.doi.org/10.1074/jbc.R116.751164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391736PMC
April 2017

Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.

Cell Metab 2017 Apr;25(4):954-960.e6

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578459PMC
April 2017

Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil.

Free Radic Biol Med 2017 03 17;104:249-261. Epub 2017 Jan 17.

Department of Biochemistry, 89 Beaumont Ave, Given Building Room B413, Burlington, VT 05405, United States. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328918PMC
March 2017

Age-associated molecular changes are deleterious and may modulate life span through diet.

Sci Adv 2017 Feb 17;3(2):e1601833. Epub 2017 Feb 17.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/sciadv.1601833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315447PMC
February 2017

Ribonuclease selection for ribosome profiling.

Nucleic Acids Res 2017 01 15;45(2):e6. Epub 2016 Sep 15.

Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA

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http://nar.oxfordjournals.org/content/early/2016/09/15/nar.g
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http://dx.doi.org/10.1093/nar/gkw822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314788PMC
January 2017

A Disease or Not a Disease? Aging As a Pathology.

Trends Mol Med 2016 12 25;22(12):995-996. Epub 2016 Oct 25.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540438PMC
December 2016

Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum.

Mol Biol Evol 2016 11 8;33(11):2885-2889. Epub 2016 Aug 8.

School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland

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http://dx.doi.org/10.1093/molbev/msw166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062323PMC
November 2016

Intrinsic Versus Extrinsic Cancer Risk Factors and Aging.

Trends Mol Med 2016 Oct 17;22(10):833-834. Epub 2016 Aug 17.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/trends/molecular-medicine/pdf/S1471-4914
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068914PMC
http://dx.doi.org/10.1016/j.molmed.2016.08.001DOI Listing
October 2016

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.

Redox Biol 2016 10 26;9:22-31. Epub 2016 May 26.

Helmholtz Zentrum München, Institute for Developmental Genetics, Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900515PMC
October 2016

Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide.

Methods 2016 10 23;109:149-157. Epub 2016 Jun 23.

Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075500PMC
http://dx.doi.org/10.1016/j.ymeth.2016.06.022DOI Listing
October 2016

Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems.

Mol Biol Evol 2016 09 12;33(9):2441-53. Epub 2016 Jul 12.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1093/molbev/msw122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989117PMC
September 2016

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.

Proc Natl Acad Sci U S A 2016 09 1;113(38):E5562-71. Epub 2016 Sep 1.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Broad Institute of MIT and Harvard, Cambridge, MA 02142; Harvard Stem Cell Institute, Cambridge, MA 02138; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035897PMC
http://dx.doi.org/10.1073/pnas.1600204113DOI Listing
September 2016

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes.

Aging Cell 2016 08 6;15(4):594-602. Epub 2016 Apr 6.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1111/acel.12480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933668PMC
August 2016

Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.

Nat Commun 2016 08 12;7:12157. Epub 2016 Aug 12.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms12157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990632PMC
August 2016

Gene expression signatures of human cell and tissue longevity.

NPJ Aging Mech Dis 2016 7;2:16014. Epub 2016 Jul 7.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/npjamd.2016.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514998PMC
July 2016

Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine.

PLoS One 2015 9;10(10):e0140353. Epub 2015 Oct 9.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140353PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599804PMC
June 2016

A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters.

Antioxid Redox Signal 2016 01 27;24(4):205-216. Epub 2015 Oct 27.

1 Worm Biology Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay .

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http://dx.doi.org/10.1089/ars.2015.6377DOI Listing
January 2016

Methionine restriction and life-span control.

Ann N Y Acad Sci 2016 Jan 10;1363:116-24. Epub 2015 Dec 10.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.12973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008916PMC
January 2016

Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.

Cell Rep 2015 Nov 5;13(7):1319-1326. Epub 2015 Nov 5.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771060PMC
November 2015

Convergent evolution of marine mammals is associated with distinct substitutions in common genes.

Sci Rep 2015 Nov 9;5:16550. Epub 2015 Nov 9.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.nature.com/articles/srep16550
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http://dx.doi.org/10.1038/srep16550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637874PMC
November 2015

Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy.

Cancers (Basel) 2015 Nov 10;7(4):2262-76. Epub 2015 Nov 10.

Molecular Biology of Selenium Section, Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/cancers7040889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695889PMC
November 2015

Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1.

Antioxid Redox Signal 2015 Oct 16;23(10):814-22. Epub 2015 Jul 16.

1 Division of Genetics, Department of Medicine, Brigham and Women's Hospital , Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1089/ars.2015.6385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589106PMC
October 2015

Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates.

NPJ Aging Mech Dis 2015;1. Epub 2015 Sep 28.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/npjamd.2015.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807016PMC
September 2015

Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization.

Genome Res 2015 Sep 20;25(9):1256-67. Epub 2015 Jul 20.

Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), 08003 Barcelona, Catalonia, Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Catalonia, Spain; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), 08003 Barcelona, Catalonia, Spain;

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http://dx.doi.org/10.1101/gr.190538.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561486PMC
September 2015

Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.

Cell Metab 2015 Aug;22(2):332-43

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758382PMC
August 2015

Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.

Proc Natl Acad Sci U S A 2015 Aug 10;112(34):10685-90. Epub 2015 Aug 10.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1505315112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553801PMC
August 2015

Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks.

Chem Biol 2015 Jul 9;22(7):965-75. Epub 2015 Jul 9.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515171PMC
July 2015

Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae.

Aging Cell 2015 Jun 22;14(3):366-71. Epub 2015 Feb 22.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://doi.wiley.com/10.1111/acel.12290
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http://dx.doi.org/10.1111/acel.12290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406665PMC
June 2015

Selenium utilization in thioredoxin and catalytic advantage provided by selenocysteine.

Biochem Biophys Res Commun 2015 Jun 23;461(4):648-52. Epub 2015 Apr 23.

Department of Biochemistry and Molecular Biology, Yeungnam University College of Medicine, Daegu 705-717, Republic of Korea. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094351PMC
June 2015

Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors.

Nat Chem Biol 2015 May 23;11(5):332-8. Epub 2015 Mar 23.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402147PMC
May 2015

Genome-wide association study of selenium concentrations.

Hum Mol Genet 2015 Mar 24;24(5):1469-77. Epub 2014 Oct 24.

Department of Epidemiology and Biostatistics, Indiana University at Bloomington, Bloomington, IN, USA.

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http://dx.doi.org/10.1093/hmg/ddu546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321444PMC
March 2015

Translation inhibitors cause abnormalities in ribosome profiling experiments.

Nucleic Acids Res 2014 23;42(17):e134. Epub 2014 Jul 23.

Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA

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http://dx.doi.org/10.1093/nar/gku671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176156PMC
February 2015

Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins.

J Biol Chem 2015 Feb 5;290(9):5685-95. Epub 2015 Jan 5.

From the Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342480PMC
February 2015

Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway.

Biochem Biophys Res Commun 2015 Jan 18;456(4):884-90. Epub 2014 Dec 18.

School of Biological Sciences, Seoul National University, Seoul 151-742, Republic of Korea; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-742, Republic of Korea; Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.12.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758352PMC
January 2015

Endogenous hydrogen sulfide production is essential for dietary restriction benefits.

Cell 2015 Jan 23;160(1-2):132-44. Epub 2014 Dec 23.

Department of Genetics and Complex Diseases, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297538PMC
January 2015

Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.

Genetics 2014 Nov 29;198(3):905-17. Epub 2014 Aug 29.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115

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http://dx.doi.org/10.1534/genetics.114.169243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224179PMC
November 2014

Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size.

Endocrinology 2014 Oct 8;155(10):4069-80. Epub 2014 Jul 8.

State Key Laboratory of Medical Genomics (C.G., X.C., H.S.), Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025 China; Thyroid Program of the Division of Endocrinology (C.G., X.C., H.S., M.A.M., R.H.J., N.Y.L., L.A.C., S.A.H.) and Clinical Research Center (H.A.F.), Boston Children's Hospital; Stem Cell Program and Division of Hematology/Oncology (Y.Z., J.J.G., D.W., L.I.Z.), Boston Children's Hospital, Harvard Stem Cell Institute, Harvard Medical School, and Howard Hughes Medical Institute; Department of Medicine (A.V.L., V.N.G., S.A.H.), Brigham and Women's Hospital; Dana Farber Cancer Institute (V.N.G., L.I.Z., S.A.H.), Boston, Massachusetts 02115; and Departments of Physiology and Pharmacology (T.S.S.), Oregon Health and Science University, Portland, Oregon 97239.

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http://dx.doi.org/10.1210/en.2013-2029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164935PMC
October 2014

The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal.

Aging (Albany NY) 2014 Oct;6(10):879-99

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.18632/aging.100699DOI Listing
October 2014

Selenium and Methionine Sulfoxide Reduction.

Free Radic Biol Med 2014 Oct 10;75 Suppl 1:S8-9. Epub 2014 Dec 10.

Brigham and Women׳s Hospital, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.848DOI Listing
October 2014

Selenoprotein S is involved in maintenance and transport of multiprotein complexes.

Biochem J 2014 Sep;462(3):555-65

*Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578454PMC
September 2014

Comparative genetics of longevity and cancer: insights from long-lived rodents.

Nat Rev Genet 2014 Aug 1;15(8):531-40. Epub 2014 Jul 1.

Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353926PMC
August 2014

Selenoproteins: molecular pathways and physiological roles.

Physiol Rev 2014 Jul;94(3):739-77

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and Molecular Biology of Selenium Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1152/physrev.00039.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101630PMC
July 2014

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation.

Elife 2014 Apr 29;3:e02077. Epub 2014 Apr 29.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States Broad Institute, Cambridge, United States

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003482PMC
http://dx.doi.org/10.7554/eLife.02077DOI Listing
April 2014