Vaclav Kremen, M.Sc.Eng., PhD. - Mayo Clinic Minnesota - Assistant Professor, Principal Engineer, Research Fellow

Vaclav Kremen

M.Sc.Eng., PhD.

Mayo Clinic Minnesota

Assistant Professor, Principal Engineer, Research Fellow

Rochester, MN | United States

Main Specialties: Neurology, Sleep Medicine, Statistics

ORCID logohttps://orcid.org/0000-0001-9844-7617

Vaclav Kremen, M.Sc.Eng., PhD. - Mayo Clinic Minnesota - Assistant Professor, Principal Engineer, Research Fellow

Vaclav Kremen

M.Sc.Eng., PhD.

Introduction

Principal engineer, assistant professor of Neurology at College of Medicine Mayo Clinic and scientist with a demonstrated history of an employee in the hospital & healthcare industry. Skilled in Medical Devices, Biomedical Engineering, Healthcare, Product Development, and Research and Development (R&D). Main focus on development and application of analytics and approaches for 1-D multi-modal, multi-scale biomedical data as (PSG, ECG, and multi scale intracranial electrophysiology) using methods of advanced signal processing, machine learning, and artificial intelligence.

Primary Affiliation: Mayo Clinic Minnesota - Rochester, MN , United States

Specialties:

Education

Dec 2008
Czech Technical University in Prague
Ph.D. in Artificial Intelligence and Biocybernetics
Department of Cybernetics, Faculty of Electrical Engineering
Feb 2002
Czech Technical University in Prague
M.Sc.Eng. in Biomedical Engineering
Department of Cybernetics, Faculty of Electrical Engineering

Experience

Nov 2016 - Sep 2019
Mayo Clinic Minnesota
Assistant professor, senior engineer, research fellow
Neurology
Sep 2019
Mayo Clinic Minnesota
Assistant professor, principal engineer, research fellow
Neurology
Jan 2014 - Nov 2016
Mayo Clinic Minnesota
Research fellow
Cardiology, Neurology
Sep 2006 - Dec 2015
Czech Technical University in Prague
Assistant professor, researcher
Department of Cybernetics
Apr 2003 - Aug 2006
Vitatron Czechia s.r.o.
Field Clinical Monitor and Sales Representative

Publications

30Publications

476Reads

42Profile Views

30PubMed Central Citations

Noninvasive Assessment of Aortic Pulse Wave Velocity by the Brachial Occlusion-Cuff Technique: Comparative Study.

Sensors (Basel) 2019 Aug 8;19(16). Epub 2019 Aug 8.

2nd Department of Internal Medicine-Cardiology and Angiology of General University Hospital and 1st Medical Faculty of Charles University, 128 08 Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/s19163467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719951PMC
August 2019
2.245 Impact Factor

Deep-learning for seizure forecasting in canines with epilepsy.

J Neural Eng 2019 Jun 8;16(3):036031. Epub 2019 Apr 8.

Mayo Systems Electrophysiology Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, United States of America. International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. The Czech Academy of Sciences, Institute of Scientific Instruments, Brno, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1741-2552/ab172dDOI Listing
June 2019
25 Reads

Intracerebral EEG Artifact Identification Using Convolutional Neural Networks.

Neuroinformatics 2019 04;17(2):225-234

The Czech Academy of Sciences, Institute of Scientific Instruments, Brno, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12021-018-9397-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459786PMC
April 2019
3 Reads
2.830 Impact Factor

Cloud computing for seizure detection in implanted neural devices.

J Neural Eng 2019 Apr 18;16(2):026016. Epub 2018 Dec 18.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, United States of America. Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1741-2552/aaf92eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711163PMC
April 2019
6 Reads

Automated unsupervised behavioral state classification using intracranial electrophysiology.

J Neural Eng 2019 Apr 2;16(2):026004. Epub 2018 Oct 2.

Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States of America. Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague, Jugoslavskych Partyzanu 1580/3, 160 00 Prague 6, Czechia. Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1741-2552/aae5abDOI Listing
April 2019
5 Reads

Sample Entropy Analysis of Noisy Atrial Electrograms during Atrial Fibrillation.

Comput Math Methods Med 2018 13;2018:1874651. Epub 2018 Jun 13.

Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague, Czech Republic.

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/cmmm/2018/1874651/
Publisher Site
http://dx.doi.org/10.1155/2018/1874651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020546PMC
December 2018
36 Reads
0.770 Impact Factor

Visually validated semi-automatic high-frequency oscillation detection aides the delineation of epileptogenic regions during intra-operative electrocorticography.

Clin Neurophysiol 2018 10 20;129(10):2089-2098. Epub 2018 Jul 20.

Department of Neurology, Mayo Systems Electrophysiology Laboratory (MSEL), USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2018.06.030DOI Listing
October 2018
6 Reads
3.100 Impact Factor

Physiological and pathological high frequency oscillations in focal epilepsy.

Ann Clin Transl Neurol 2018 Sep 9;5(9):1062-1076. Epub 2018 Aug 9.

Mayo Systems Electrophysiology Laboratory Department of Neurology Mayo Clinic 200 First St SW Rochester Minnesota 55905.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/acn3.618
Publisher Site
http://dx.doi.org/10.1002/acn3.618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144446PMC
September 2018
3 Reads

Pupil size reflects successful encoding and recall of memory in humans.

Sci Rep 2018 03 21;8(1):4949. Epub 2018 Mar 21.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-23197-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862978PMC
March 2018
3 Reads
5.080 Impact Factor

Spatial variation in high-frequency oscillation rates and amplitudes in intracranial EEG.

Neurology 2018 02 24;90(8):e639-e646. Epub 2018 Jan 24.

From Mayo Systems Electrophysiology Laboratory, Department of Neurology (H.G., M.S., B.M.B., V.K., D.K.-J., J.B., G.A.W., B.H.B.), and Department of Physiology & Biomedical Engineering (B.M.B., V.K., G.A.W., B.H.B.), Mayo Clinic, Rochester, MN; International Clinical Research Center (J.C.), St. Anne's University Hospital, Brno, Czech Republic; The Krembil Neuroscience Centre (D.M.G.), Toronto, Canada; and Czech Institute of Informatics, Robotics, and Cybernetics (V.K.), Czech Technical University in Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818159PMC
February 2018
3 Reads
1 Citation
8.290 Impact Factor

Architectural T-Wave Analysis and Identification of On-Therapy Breakthrough Arrhythmic Risk in Type 1 and Type 2 Long-QT Syndrome.

Circ Arrhythm Electrophysiol 2017 Nov;10(11)

From the Division of Heart Rhythm Services, Department of Cardiovascular Diseases (A.S., P.A.N., V.K., B.Q., Z.I.A., P.B., S.J.A., P.A.F., M.J.A.), Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine (R.K.R., J.M.B., S.J.A., M.J.A.), and Department of Molecular Pharmacology and Experimental Therapeutics (J.M.B., M.J.A.), Windland Smith Rice Sudden Death Genomics Laboratory, and Division of Biomedical Statistics and Informatics (C.G.S.), Mayo Clinic, Rochester, MN; Czech Institute of Informatics, Robotics, and Cybernetics, Czech Technical University in Prague (V.K.); and Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer Sheva, Israel (Y.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.117.005648DOI Listing
November 2017
33 Reads

Automated T-wave analysis can differentiate acquired QT prolongation from congenital long QT syndrome.

Ann Noninvasive Electrocardiol 2017 Nov 21;22(6). Epub 2017 Apr 21.

Department of Cardiovascular Diseases, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/anec.12455DOI Listing
November 2017
21 Reads
1.440 Impact Factor

Dissecting gamma frequency activity during human memory processing.

Brain 2017 May;140(5):1337-1350

Mayo Clinic, Department of Neurology, Mayo Systems Electrophysiology Laboratory (MSEL), Rochester MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awx043DOI Listing
May 2017
23 Reads
9 Citations
9.200 Impact Factor

Behavioral state classification in epileptic brain using intracranial electrophysiology.

J Neural Eng 2017 04 4;14(2):026001. Epub 2017 Jan 4.

Department of Neurology, Mayo Systems Electrophysiology Laboratory, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. Czech Institute of Informatics, Robotics and Cybernetics, Czech Technical University in Prague, Zikova street 1903/4, 166 36 Prague 6, Czech Republic. Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1741-2552/aa5688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460075PMC
April 2017
22 Reads
3 Citations

Noninvasive assessment of cardiac output by brachial occlusion-cuff technique: comparison with the open-circuit acetylene washin method.

J Appl Physiol (1985) 2016 12 20;121(6):1319-1325. Epub 2016 Oct 20.

Department of Internal Medicine; Division of Cardiovascular Diseases, Mayo Clinic & Foundation, Rochester, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.00981.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206382PMC
December 2016
22 Reads

Identification of Concealed and Manifest Long QT Syndrome Using a Novel T Wave Analysis Program.

Circ Arrhythm Electrophysiol 2016 07;9(7)

From the Division of Internal Medicine (A.S.), Division of Cardiovascular Diseases (P.A.N., V.K., B.Q., R.K.R., Z.I.A., P.B., S.J.A., P.A.F., M.J.A.), Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology (J.M.B., S.J.A., M.J.A.), Mayo Clinic, Rochester, MN; Czech Institute of Informatics, Robotics, and Cybernetics, Czech Technical University in Prague, Czech Republic (V.K.); Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer Sheva, Israel (Y.S., Z.I.A.); Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN (J.M.B., M.J.A.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.115.003830DOI Listing
July 2016
35 Reads
2 Citations

Electrocardiographic predictors of coronary microvascular dysfunction in patients with non-obstructive coronary artery disease: Utility of a novel T wave analysis program.

Int J Cardiol 2016 Jan 1;203:601-6. Epub 2015 Nov 1.

Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2015.10.228DOI Listing
January 2016
24 Reads
4.040 Impact Factor

Comparison of JADE and canonical correlation analysis for ECG de-noising.

Conf Proc IEEE Eng Med Biol Soc 2014 ;2014:3857-60

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/EMBC.2014.6944465DOI Listing
November 2015
5 Reads
1 Citation

Independent component analysis and decision trees for ECG holter recording de-noising.

PLoS One 2014 6;9(6):e98450. Epub 2014 Jun 6.

Department of Cybernetics, FEE, CTU in Prague, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098450PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048160PMC
August 2015
5 Reads
3 Citations
3.234 Impact Factor

Top co-authors

Gregory A Worrell
Gregory A Worrell

Mayo Clinic

11
Benjamin H Brinkmann
Benjamin H Brinkmann

Mayo Clinic

9
Brent M Berry
Brent M Berry

Mayo Clinic Rochester

7
Alan Sugrue
Alan Sugrue

Galway University Hospital

6
Jan Cimbalnik
Jan Cimbalnik

St. Anne's University Hospital

6
Michal T Kucewicz
Michal T Kucewicz

Mayo Clinic

6
Peter A Noseworthy
Peter A Noseworthy

Mayo Clinic

6
Matt Stead
Matt Stead

Mayo Systems Electrophysiology Laboratory

6
Michael J Ackerman
Michael J Ackerman

Mayo Clinic

6