Publications by authors named "V Stolyar"

5 Publications

  • Page 1 of 1

ADIPOCYTOKINES LEPTIN AND ADIPONEСTIN AS PREDICTORS OF GENERALIZED PERIODONTITIS ASSOCIATED WITH OBESITY.

Georgian Med News 2021 Mar(312):42-46

Bogomolets National Medical University, Institute of Postgraduate Education, Department of Dentistry, Kyiv, Ukraine.

In recent years, according to the WHO, more than 1,9 billion people over the age of 18 are overweight, of whom more than 650 million are obese, with an annual trend. Studies in recent decades have shown that obese young people with generalized periodontitis have abnormalities in protein, fat and carbohydrate metabolism, which contributes to the early destruction of the periodontal tissue complex and rapid tooth loss. The aim of our study was to examine changes in serum leptin and adiponectin in patients with generalized periodontitis on the background of obesity. The study involved 94 people aged 19 to 35 years. Patients were divided into 3 groups: 32 patients with generalized periodontitis on the background of overweight, 40 patients with generalized periodontitis and obesity, and the control group - 22 healthy individuals of the same age category. The content of leptin and adiponectin in the serum was determined by enzyme-linked immunosorbent assay (ELISA) ELISA. The study was performed by analyzing venous blood (2 ml) in a BD Vacutainer tube and then centrifuging on LDN and Mediagnost GmbH analyzers and test systems (Germany). Studies allow us to conclude that in the serum of patients with generalized periodontitis on the background of overweight and obesity there is an imbalance of adipokines leptin and adiponectin. The obtained data are consistent with the literature, according to which, an increase in BMI is accompanied by an increase in leptin production and a decrease in adiponectin levels. These disorders were more pronounced in patients with generalized periodontitis on the background of obesity. Such an imbalance in adipose tissue may stimulate the production of pro-inflammatory cytokines and contribute to the progression of periodontal disease in such patients.
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March 2021

DIVERSITY OF TREATMENT OF GENERALIZED PERIODONTAL DISEASES IN PATIENTS WITH ANOREXIA NERVOSA.

Georgian Med News 2020 Sep(306):46-51

Bogomolets National Medical University, Institute Postgraduate Education, Department of Dentistry, Kyiv, Ukraine.

Generalized parodontal diseases (GPD) consistently occupy one of the leading places in the structure of dental diseases. Early diagnosis of the initial degree of generalized parodontitis (GP) is an effective way of secondary prevention. This is due to the complexity of understanding the etio-pathogenetic mechanisms of the development generalized parodontal diseases (GPD) and the high association of them with a number of diseases of the internal organs and systems with common points of contact between interdependence and mutual influence, in particular with anorexia nervosa (AN). The aim of this research was to develop a protocol for the treatment of GP in patients with AN. The object - 60 patients (mean age 26±3.8 years), with a diagnosis of GP, I-II degree, chronic, and AN, restrictive, which by simple randomization were divided into three groups (randomized by sex, age of patients, underlying and comorbidy diagnosis) to study the clinical effectiveness of our proposed method. Clinical, radiological, hygienic, immunological, biochemical, psychological and statistical methods were used. Conclusions. Thus, as a result of the proposed treatment protocol, the largest number of satisfactory treatment results was observed in group III patients (85.0±8.0%) with the inclusion of drugs that affect the pathogenetic mechanisms of the disease, including normalization of local immunity, markers of decline oxidative-antioxidant stress, radiological data of normalization of bone tissue of the alveolar process, a tendency to reduce microbial and tissue sensitization.
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September 2020

EARLY POSTOPERATIVE COMPLICATIONS IN DENTAL IMPLANT PATIENTS.

Georgian Med News 2020 May(302):23-28

Bohomolets National Medical University, Institute Post-graduate Education, Department of Therapeutic Stomatology; Department of Dentistry, Kyiv, Ukraine.

Generalized parodontitis and caries complications lead to tooth loss in individuals of different age groups. As a result of this often there is a violation of the integrity of the dentition, which leads to functional disorders of the muscular apparatus, temporomandibular joint and cosmetic defects. The effective method of restoration of the integrity of the dentition is dental implantation. With this in mind, the issue of dental implantation is of particular importance and requires further development including different age groups. Aim of the study is to improve the results of dental implantation and to avoid its complications based on identification of the causes of dental implantation complications and development of preventative measures in people of different age groups. 65 patients aged 35-60 years with secondary adentia were under observation. The main study group included 45 patients aged 35-60 years with secondary adentia caused by periodontal disease. The control group included 20 patients of the same age with secondary adentia due to caries complications. All patients of the main and control groups were subjected to a comprehensive examination of the condition of the periodontal and peri-implant area prior to the implantation in the shortest time after surgery. Microbiological study was conducted in 65 patients to study the dynamics of colonization of oral microflora. Complications after implantation were identified in 24 (53.33%) patients in the main group. The most frequent complications were: disruption of wound healing in 7 (15,56%) patients, pus in postoperative wound in 8 (17.78%), expressed pain and altered sensitivity after implantation in 4 patients (8.89%) patients, perforation of the mandible in 1 (2.22%) patient, divergence of the wound edges without exposure of the implant in 4 (8.89%) patients. A large number (53.33%) of postoperative complications in patients of the main group with secondary adentia was due to generalized periodontitis. In patients of the main group at the early stage of dental implantation were revealed qualitative and quantitative changes in the microflora of the implanted furrow with increasing aggressiveness were revealed.
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May 2020

[Personal e-cards for military personnel and military-medical information system].

Voen Med Zh 2015 Aug;336(8):4-10

The article presents main directions of activities of the medical service, dealing with implementation of personal electronic cards for military personnel, organizing the process of automation of medical service management, military and medical organizations and health care departments. The given article, reveals the on-going activity, concerning creation of the military-medical information system, which will unite all medical units, organizations, and governments into one information space.
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August 2015

Neural substrates of defensive reactivity in two subtypes of specific phobia.

Soc Cogn Affect Neurosci 2014 Nov 29;9(11):1668-75. Epub 2013 Oct 29.

Institute of Clinical Psychology and Psychotherapy and Neuroimaging Center, Technische Universität Dresden, D-01187 Dresden, Germany.

Depending on threat proximity, different defensive behaviours are mediated by a descending neural network involving forebrain (distal threat) vs midbrain areas (proximal threat). Compared to healthy subjects, it can be assumed that phobics are characterized by shortened defensive distances on a behavioural and neural level. This study aimed at characterizing defensive reactivity in two subtypes of specific phobia [snake (SP) and dental phobics (DP)]. Using functional magnetic resonance imaging (fMRI), n = 39 subjects (13 healthy controls, HC; 13 SP; 13 DP) underwent an event-related fMRI task employing an anticipation (5-10 s) and immediate perception phase (phobic pictures and matched neutral stimuli; 1250 ms) to modulate defensive distance. Although no differential brain activity in any comparisons was observed in DP, areas associated with defensive behaviours (e.g. amygdala, hippocampus, midbrain) were activated in SP. Decreasing defensive distance in SP was characterized by a shift to midbrain activity. Present findings substantiate differences between phobia types in their physiological and neural organization that can be expanded to early stages of defensive behaviours. Findings may contribute to a better understanding of the dynamic organization of defensive reactivity in different types of phobic fear.
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http://dx.doi.org/10.1093/scan/nst159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221204PMC
November 2014