Publications by authors named "V Dalmo Correia Filho"

131 Publications

MUSIC INTERVENTIONS IN PEDIATRIC ONCOLOGY: Systematic review and meta-analysis.

Complement Ther Med 2021 Jun 5;59:102725. Epub 2021 May 5.

Pediatrics Department of the University of São Paulo, Av. Dr Enéas Carvalho Aguiar No. 647, Cerqueira Cesar, São Paulo, CEP: 05403-901, Brazil. Electronic address:

Background: Pain is a disagreeable and distressing feeling that affects human beings in multi-dimensional ways. A number of non-pharmacological interventions have had varying degrees of success in treating cancer-related pain, such as breathing and relaxation techniques, and music therapy, which have been identified as beneficial therapies for alleviating pain and anxiety.

Objective: Identify the therapeutic effects of music interventions in psychological and physiological terms and on the quality of life of children undergoing cancer treatment.

Method: Systematic review of effectiveness based on the methodology of the Joanna Briggs Institute.

Results: Eleven articles were included with a total of 429 children, whose ages ranged from 0 to 18 years. The mean duration of the music intervention was 30.6 (±SD 9.8) min. In a combined estimate of five studies for pain and anxiety outcomes, there were benefits to using music when compared with the control group (SMD -1.05; CI 95 % -1.70 - 0.40 N = 453 I = 90 %). A combined analysis of five studies to assess quality of life showed that the use of music was favorable when compared with the control (SMD -0.80; CI 95 % -1.17-0.43 N = 457= I = 71 %).

Conclusion: After completing this review, it was determined that there is evidence to support the use of music to reduce pain and anxiety and improve the quality of life of children undergoing cancer treatment.
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http://dx.doi.org/10.1016/j.ctim.2021.102725DOI Listing
June 2021

IS PET/MRI A RELIABLE TOOL FOR DETECTING VASCULAR ACTIVITY IN TREATED CHILDHOOD-ONSET TAKAYASU'S ARTERITIS (C-TA)? A MULTICENTER STUDY.

Rheumatology (Oxford) 2021 Mar 15. Epub 2021 Mar 15.

Paediatric Rheumatology Unit, Paediatrics Department, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.

Objectives: To assess whether 18F-fluordeoxiglucose-positron emission tomography/magnetic resonance imaging (18F-FDG-PET/MRI) with angiographic sequences can contribute to detecting vessel wall inflammation in patients with childhood-onset Takayasu's arteritis (c-TA) under immunosuppressive therapy.

Methods: Three-centre cross-sectional study was conducted. 18F-FDG-PET/MRI scans were performed in c-TA patients and in oncologic patients, who served as the control group. Clinical and laboratorial characteristics were also analysed.

Results: Seventeen c-TA patients (65% females) between the ages of 6 and 21 years, mean disease duration of 9.4 years were recruited. Only one patient presented clinical disease activity, and six (35.6%) had increased erythrocyte sedimentation rate (ESR) and/or C-reactive protein (CRP) levels. The most frequent magnetic resonance angiography (MRA) findings were stenosis and thickening, observed in 82.4% and 70.6% of c-TA patients, respectively. 18F-FDG-PET revealed 18F-FDG uptake higher than the liver in at least one arterial segment in 15 (88.2%) patients in a qualitative analysis and median standardized uptake value (SUVmax) of 3.22 (2.76-3.69) in a semi-quantitative analysis. c-TA patients presented significantly higher SUVmax than oncologic patients (p < 0.001). A positive correlation between SUVmax and CRP levels (Rho=0.528; p=0.029) was evidenced.

Conclusion: A state-of-the-art imaging modality was used in c-TA patients and revealed a strong arterial FDG uptake even in patients in apparent remission. We suppose that this finding may represent a silent activity in the vessel wall; however, we cannot exclude the possibility of arterial remodelling. Importantly, a negative imaging scan may help in immunosuppression withdrawal in daily clinical practice.
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http://dx.doi.org/10.1093/rheumatology/keab255DOI Listing
March 2021

Scaling up of Eco-Bio-Social Strategy to Control in Highly Vulnerable Areas in Fortaleza, Brazil: A Cluster, Non-Randomized Controlled Trial Protocol.

Int J Environ Res Public Health 2021 01 31;18(3). Epub 2021 Jan 31.

Collective Health Postgraduate Program, State University of Ceará, Fortaleza 60714-903, Brazil.

is a cosmopolitan vector for arboviruses dengue, Zika and chikungunya, disseminated in all Brazilian states. The Eco-Bio-Social (EBS) strategy is vital in control as it mobilizes stakeholders (government, professionals, society, and academics) to promote healthy environments. This paper describes the rationale and methods of expanding the EBS strategy for control in Fortaleza, Northeast Brazil. A cluster, non-randomized controlled clinical trial was developed to analyze the strategy's effectiveness in vulnerable territories (high incidence of dengue and violent deaths; low HDI; substandard urban infrastructure, high population density, and water scarcity). We selected two intervention and two control groups, resulting in a sample of approximately 16,000 properties. The intervention consisted of environmental management by sealing large elevated water tanks, introduction of beta fish in waterholes, elimination of potential breeding sites, and mobilization and training of schoolchildren, endemic disease workers, health workers, social mobilizers, and community leaders; community surveillance of arboviruses; construction and validation of a booklet for the prevention of arboviruses in pregnant women. We analyzed the costs of arboviruses to government and households, the intervention cost-effectiveness, chikungunya's chronicity, and acceptance, sustainability, and governance of vector control actions. The primary outcome (infestation) was analyzed using the house, container, and Breteau indices. We hope that this study will help us understand how to scale up strategies to fight in vulnerable areas.
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http://dx.doi.org/10.3390/ijerph18031278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908398PMC
January 2021

(Var. amazonica Ducke) Essential Oil: Chemical Composition, Antibacterial, Antioxidant and Antitrypanosomal Activity.

Antibiotics (Basel) 2020 Dec 30;10(1). Epub 2020 Dec 30.

Laboratório de Imunomodulação e Protozoologia, Instituto Oswaldo Cruz, Fiocruz, 21040-900 Rio de Janeiro, Brazil.

is one of the most widely used plants in the perfumery industry, being used as medicinal plant in the Brazilian Amazon. This work aimed to evaluate the chemical composition of essential oil and its biological activities. essential oil presented linalool (93.60%) as its major compound. The essential oil and linalool showed activity against all the bacteria strains tested, standard strains and marine environment bacteria, with the lower minimum inhibitory concentration being observed for . An efficient antioxidant activity of essential oil and linalool (EC: 15.46 and 6.78 µg/mL, respectively) was evidenced by the inhibition of the 2,2-azinobis- (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical. The antitrypanosomal activity of essential oil and linalool was observed at high concentrations against epimatigote forms (inhibitory concentration for 50% of parasites (IC): 150.5 ± 1.08 and 198.6 ± 1.12 µg/mL, respectively), and even higher against intracellular amastigotes of (IC: 911.6 ± 1.15 and 249.6 ± 1.18 µg/mL, respectively). Both essential oil and linalool did not exhibit a cytotoxic effect in BALB/c peritoneal macrophages, and both reduced nitrite levels in unstimulated cells revealing a potential effect in NO production. These data revealed the pharmacological potential of essential oil and linalool, encouraging further studies.
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http://dx.doi.org/10.3390/antibiotics10010024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824638PMC
December 2020

MEG3 and MEG8 aberrant methylation in an infant with neuroblastoma.

Pediatr Blood Cancer 2020 09 15;67(9):e28328. Epub 2020 Jul 15.

Instituto de Tratamento de Câncer Infantil, Instituto da Criança, HC/FMUSP, São Paulo, Brazil.

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http://dx.doi.org/10.1002/pbc.28328DOI Listing
September 2020