Uwe-Karsten Hanisch

Uwe-Karsten Hanisch

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Uwe-Karsten Hanisch

Uwe-Karsten Hanisch

Publications by authors named "Uwe-Karsten Hanisch"

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Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli.

J Neuroinflammation 2020 Jan 17;17(1):24. Epub 2020 Jan 17.

Institute of Neuropathology, University Medical Center Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1186/s12974-020-1700-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969464PMC
January 2020

Treatment with 5-azacitidine delay growth of glioblastoma xenografts: a potential new treatment approach for glioblastomas.

J Cancer Res Clin Oncol 2018 May 9;144(5):809-819. Epub 2018 Feb 9.

Max Delbrueck Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1007/s00432-018-2600-1DOI Listing
May 2018

Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever.

Cell Host Microbe 2017 Sep 17;22(3):354-365.e5. Epub 2017 Aug 17.

Department of Biomedicine - Haus Petersplatz, Division of Experimental Virology, University of Basel, 4009 Basel, Switzerland; Department of Pathology and Immunology, University of Geneva, 1211 Geneva 4, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.07.008DOI Listing
September 2017

A presumed antagonistic LPS identifies distinct functional organization of TLR4 in mouse microglia.

Glia 2017 07 4;65(7):1176-1185. Epub 2017 May 4.

Institute of Neuropathology, University Medical Center Göttingen, Göttingen, 37075, Germany.

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http://dx.doi.org/10.1002/glia.23151DOI Listing
July 2017

Thioredoxins and Methionine Sulfoxide Reductases in the Pathophysiology of Pneumococcal Meningitis.

J Infect Dis 2016 09 1;214(6):953-61. Epub 2016 Jul 1.

Department Genetics of Microorganisms, Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University of Greifswald, Germany.

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http://dx.doi.org/10.1093/infdis/jiw268DOI Listing
September 2016

Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling.

Neurol Neuroimmunol Neuroinflamm 2016 Jun 17;3(3):e233. Epub 2016 May 17.

Institute of Neuropathology (N.K., L.M., U.-K.H., W.B.), University Medical Center Göttingen, Germany; and Teva Pharmaceutical Industries (L.H.), Netanya, Israel.

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http://dx.doi.org/10.1212/NXI.0000000000000233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871804PMC
June 2016

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ.

Proc Natl Acad Sci U S A 2016 Jan 22;113(1):212-7. Epub 2015 Dec 22.

Institute of Physiology and Pathophysiology, University of Heidelberg, D-69120 Heidelberg, Germany; Interdisciplinary Center for Neurosciences, University of Heidelberg, D-69120 Heidelberg, Germany;

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http://dx.doi.org/10.1073/pnas.1513853113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711883PMC
January 2016

Erythropoietin dampens injury-induced microglial motility.

J Cereb Blood Flow Metab 2015 Aug 13;35(8):1233-6. Epub 2015 May 13.

1] Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany [2] Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany.

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http://dx.doi.org/10.1038/jcbfm.2015.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527993PMC
August 2015

Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions.

Oncotarget 2014 Dec;5(24):12573-92

Institute of Neuropathology, University Medical Center Göttingen, 37075 Göttingen, Germany. Department of Geriatrics, Evangelisches Krankenhaus Göttingen-Weende, 37075 Göttingen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350342PMC
http://dx.doi.org/10.18632/oncotarget.2709DOI Listing
December 2014

Microglial diversity by responses and responders.

Front Cell Neurosci 2014 1;8:101. Epub 2014 Apr 1.

Institute of Neuropathology, University of Göttingen Göttingen, Germany.

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http://dx.doi.org/10.3389/fncel.2014.00101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978327PMC
April 2014

Linking STAT and TLR signaling in microglia: a new role for the histone demethylase Jmjd3.

J Mol Med (Berl) 2014 Mar;92(3):197-200

Institute of Neuropathology, University of Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany,

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http://dx.doi.org/10.1007/s00109-014-1122-9DOI Listing
March 2014

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.

Neuro Oncol 2013 Nov 5;15(11):1457-68. Epub 2013 Sep 5.

Corresponding Author: Prof Dr Helmut Kettenmann, PhD, Cellular Neurosciences, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1093/neuonc/not115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813418PMC
November 2013

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP).

Cancer Immunol Immunother 2013 Oct 6;62(10):1587-97. Epub 2013 Aug 6.

Institute of Human Genetics, University Medical Center, Heinrich-Düker-Weg 12, 37073, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00262-013-1444-4DOI Listing
October 2013

Coculture system with an organotypic brain slice and 3D spheroid of carcinoma cells.

J Vis Exp 2013 Oct 9(80). Epub 2013 Oct 9.

Department of Hematology and Oncology, University of Göttingen.

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http://dx.doi.org/10.3791/50881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939073PMC
October 2013

Histone deacetylase inhibitors suppress immune activation in primary mouse microglia.

J Neurosci Res 2013 Sep 17;91(9):1133-42. Epub 2013 May 17.

Department of Neuroscience, Section of Medical Physiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://doi.wiley.com/10.1002/jnr.23221
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http://dx.doi.org/10.1002/jnr.23221DOI Listing
September 2013

Functional diversity of microglia - how heterogeneous are they to begin with?

Front Cell Neurosci 2013 14;7:65. Epub 2013 May 14.

Institute of Neuropathology, University of Göttingen Göttingen, Germany.

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http://dx.doi.org/10.3389/fncel.2013.00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653062PMC
May 2013

Proteins in microglial activation--inputs and outputs by subsets.

Curr Protein Pept Sci 2013 Feb;14(1):3-15

Institute of Neuropathology, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.2174/1389203711314010003DOI Listing
February 2013

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin.

J Neuroinflammation 2012 Jul 9;9:166. Epub 2012 Jul 9.

Dept. of Medical Neurobiology, IMRIC, Hebrew University Faculty of Medicine, Ein-Kerem, 12272, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1186/1742-2094-9-166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418574PMC
July 2012

Expression of coagulation factors and their receptors in tumor tissue and coagulation factor upregulation in peripheral blood of patients with cerebral carcinoma metastases.

J Cancer Res Clin Oncol 2012 Jan 8;138(1):141-51. Epub 2011 Nov 8.

Department of Neurosurgery, Medical Center of Friedrich-Schiller-University, University Hospital Jena, Erlanger Allee 101, 07747, Jena, Germany.

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http://dx.doi.org/10.1007/s00432-011-1078-xDOI Listing
January 2012

Physiology of microglia.

Physiol Rev 2011 Apr;91(2):461-553

Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany.

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http://www.physiology.org/doi/10.1152/physrev.00011.2010
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http://dx.doi.org/10.1152/physrev.00011.2010DOI Listing
April 2011

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis.

J Cell Sci 2011 Feb;124(Pt 3):447-58

Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str., D-37075 Göttingen, Germany.

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http://dx.doi.org/10.1242/jcs.074088DOI Listing
February 2011

Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

J Neuroimmunol 2010 Dec 9;229(1-2):169-79. Epub 2010 Sep 9.

Institut für Biologie II, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1016/j.jneuroim.2010.08.005DOI Listing
December 2010

Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

J Neurochem 2010 Sep 16;114(5):1511-26. Epub 2010 Jun 16.

Institut für Biologie II, RWTH Aachen University, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06867.xDOI Listing
September 2010

The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells.

Neurosci Lett 2010 Sep 3;482(1):17-20. Epub 2010 Jul 3.

Institute of Neuropathology, University of Göttingen, Robert Koch Str. 40, D-37075 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.neulet.2010.06.078DOI Listing
September 2010

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.

Proc Natl Acad Sci U S A 2010 Mar 15;107(13):6058-63. Epub 2010 Mar 15.

Department of Neurology, Deutsches Zentrum für Neurodegenerative Erkrankungen, University of Bonn, 53105 Bonn, Germany.

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http://dx.doi.org/10.1073/pnas.0909586107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851853PMC
March 2010

Fibronectin stimulates Escherichia coli phagocytosis by microglial cells.

Glia 2010 Feb;58(3):367-76

Department of Neurology, University of Göttingen, Robert-Koch-Strasse 40, Göttingen, Germany.

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http://doi.wiley.com/10.1002/glia.20929
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http://dx.doi.org/10.1002/glia.20929DOI Listing
February 2010

FK506 protects against various immune responses and secondary degeneration following cerebral ischemia.

Anat Rec (Hoboken) 2009 Dec;292(12):1993-2001

Institute of Experimental and Clinical Pharmacology, University Hospital of Schleswig-Holstein, Campus Kiel, Hospitalstrasse 4, Kiel, Germany.

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http://doi.wiley.com/10.1002/ar.20994
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http://dx.doi.org/10.1002/ar.20994DOI Listing
December 2009

Thrombin regulates CD40 expression in microglial cells.

Neuroreport 2008 May;19(7):757-60

Department of Neurology, School of Medicine, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1097/WNR.0b013e3282fdf4e7DOI Listing
May 2008

Toll-like receptors: roles in neuroprotection?

Trends Neurosci 2008 Apr 10;31(4):176-82. Epub 2008 Mar 10.

Institute of Neuropathology, University of Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.tins.2008.01.005DOI Listing
April 2008

Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype.

Glia 2008 Feb;56(3):271-83

Institute for Neuropathology, University of Göttingen, D-37075, Göttingen, Germany.

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http://dx.doi.org/10.1002/glia.20611DOI Listing
February 2008

Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors.

Glia 2008 Jan;56(1):16-26

Department of Neurology, School of Medicine, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1002/glia.20585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926344PMC
January 2008

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions.

Nat Neurosci 2007 Dec 18;10(12):1544-53. Epub 2007 Nov 18.

Institute of Neuropathology, Georg August University, Göttingen, Germany.

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http://dx.doi.org/10.1038/nn2015DOI Listing
December 2007

Microglia: active sensor and versatile effector cells in the normal and pathologic brain.

Nat Neurosci 2007 Nov;10(11):1387-94

Institute of Neuropathology, University of Göttingen, D-37075 Göttingen, Germany.

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http://dx.doi.org/10.1038/nn1997DOI Listing
November 2007

Fibronectin is elevated in the cerebrospinal fluid of patients suffering from bacterial meningitis and enhances inflammation caused by bacterial products in primary mouse microglial cell cultures.

J Neurochem 2007 Sep 11;102(6):2049-2060. Epub 2007 Jun 11.

Department of Neurology, Georg-August-University, Göttingen, GermanyDepartment of Neuropathology, Georg-August-University, Göttingen, GermanyDade Behring, Eschborn, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04683.xDOI Listing
September 2007

A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components.

Neurosurg Rev 2007 Apr 27;30(2):143-9; discussion 149. Epub 2007 Feb 27.

Department of Neurosurgery, Medical Centre, Friedrich-Schiller-University, Erlanger Allee 101, 07747 Jena, Germany.

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http://dx.doi.org/10.1007/s10143-007-0069-5DOI Listing
April 2007

Activation of microglial cells by thrombin: past, present, and future.

Semin Thromb Hemost 2006 Apr;32 Suppl 1:69-76

Department of Neurology, School of Medicine, University of Washington, Seattle, Washington 98195, USA.

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https://www.thieme-connect.com/products/ejournals/pdf/10.105
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http://www.thieme-connect.de/DOI/DOI?10.1055/s-2006-939556
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http://dx.doi.org/10.1055/s-2006-939556DOI Listing
April 2006

Microglial phenotype: is the commitment reversible?

Trends Neurosci 2006 Feb 6;29(2):68-74. Epub 2006 Jan 6.

The Weizmann Institute of Science, POB 26, Rehovot, 76100, Israel.

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http://linkinghub.elsevier.com/retrieve/pii/S016622360500323
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http://dx.doi.org/10.1016/j.tins.2005.12.005DOI Listing
February 2006

The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines.

J Biol Chem 2004 Dec 27;279(50):51880-7. Epub 2004 Sep 27.

Department of Cellular Neurosciences, Max Delbrück Center for Molecular Medicine, D-13092 Berlin, Germany.

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http://dx.doi.org/10.1074/jbc.M408318200DOI Listing
December 2004

Microglia.

Metab Brain Dis 2004 Dec;19(3-4):393-411

Institute for Neuropathology, University of Göttingen, D-37075 Göttingen, Germany.

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http://dx.doi.org/10.1023/b:mebr.0000043984.73063.d8DOI Listing
December 2004

Expression of proteinase-activated receptors in mouse microglial cells.

Neuroreport 2003 Dec;14(18):2373-7

Department of Neurosurgery, University of Washington, Seattle, 98195, USA.

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http://dx.doi.org/10.1097/00001756-200312190-00017DOI Listing
December 2003

Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro.

Eur J Neurosci 2003 Jun;17(11):2267-76

Max Delbrück Center for Molecular Medicine, Cellular Neuroscience, Robert-Rössle-Strasse10, D-13092, Berlin, Germany.

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http://dx.doi.org/10.1046/j.1460-9568.2003.02663.xDOI Listing
June 2003

Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages.

Eur J Neurosci 2002 Dec;16(11):2113-22

Max Delbrück Center for Molecular Medicine, Cellular Neurosciences, Robert-Rössle-Strasse 10, D-13092 Berlin, Germany.

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http://dx.doi.org/10.1046/j.1460-9568.2002.02287.xDOI Listing
December 2002

Microglia as a source and target of cytokines.

Glia 2002 Nov;40(2):140-55

Department of Cellular Neurosciences, Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.

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http://dx.doi.org/10.1002/glia.10161DOI Listing
November 2002