Uwe Christians

Uwe Christians

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Temsirolimus Metabolic Pathways Revisited.

Xenobiotica 2019 Oct 9:1-30. Epub 2019 Oct 9.

iC42 Clinical Research and Development, Department of Anesthesiology, School of Medicine, University of Colorado Anschutz Medical Campus , Aurora , CO , USA.

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http://dx.doi.org/10.1080/00498254.2019.1678793DOI Listing
October 2019

Cyclophilin D knockout protects the mouse kidney against cyclosporin A-induced oxidative stress.

Am J Physiol Renal Physiol 2019 Sep 12;317(3):F683-F694. Epub 2019 Jun 12.

Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado.

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http://dx.doi.org/10.1152/ajprenal.00417.2018DOI Listing
September 2019

A SENSITIVE LC-MS/MS ASSAY FOR THE QUANTIFICATION OF METHADONE AND ITS METABOLITES IN DRIED BLOOD SPOTS: COMPARISON WITH PLASMA.

Ther Drug Monit 2019 Jul 15. Epub 2019 Jul 15.

Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States.

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http://dx.doi.org/10.1097/FTD.0000000000000674DOI Listing
July 2019

Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women.

J Appl Physiol (1985) 2019 Jun 21;126(6):1533-1540. Epub 2019 Mar 21.

Division of Geriatrics, Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, Colorado.

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http://dx.doi.org/10.1152/japplphysiol.00819.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620665PMC
June 2019

Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values.

Am J Transplant 2019 May 26;19(5):1410-1420. Epub 2018 Dec 26.

Division of Hematology and Oncology, Children's Hospital of Richmond, Richmond, Virginia.

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http://doi.wiley.com/10.1111/ajt.15199
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http://dx.doi.org/10.1111/ajt.15199DOI Listing
May 2019

A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition.

CPT Pharmacometrics Syst Pharmacol 2019 May 7;8(5):273-284. Epub 2019 Mar 7.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/psp4.12392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539708PMC
May 2019

Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development.

J Pediatr 2019 May 14;208:198-206.e2. Epub 2019 Mar 14.

Department of Psychiatry, University of Colorado Denver School of Medicine, Aurora, CO; Department of Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Aurora, CO.

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http://dx.doi.org/10.1016/j.jpeds.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707520PMC
May 2019

Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients.

Pharmacotherapy 2019 May 15;39(5):564-575. Epub 2019 Apr 15.

Department of Surgery, Division of Transplantation, University of Cincinnati, Cincinnati, OH.

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http://dx.doi.org/10.1002/phar.2260DOI Listing
May 2019

Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy.

Clin Toxicol (Phila) 2019 May 21:1-5. Epub 2019 May 21.

a Section of Emergency Medicine and Medical Toxicology, Department of Pediatrics , University of Colorado Anschutz Medical Campus, Children's Hospital Colorado , Aurora , CO , USA.

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http://dx.doi.org/10.1080/15563650.2019.1616093DOI Listing
May 2019

Improving Therapeutic Decisions: Pharmacodynamic Monitoring as an Integral Part of Therapeutic Drug Monitoring.

Ther Drug Monit 2019 04;41(2):111-114

iC42 Clinical Research and Development, Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1097/FTD.0000000000000627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481676PMC
April 2019

Depressed prostaglandins and leukotrienes in veterans with Gulf War illness.

J Environ Sci Health B 2019 29;54(8):623-639. Epub 2019 Apr 29.

Department of Medicine, University of Colorado , Aurora , CO , USA.

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http://dx.doi.org/10.1080/03601234.2019.1596001DOI Listing
April 2019

A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction.

Eur J Nutr 2018 Nov 7. Epub 2018 Nov 7.

Departamento de Fisiologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu 862, Vila Clementino, São Paulo, SP, 04023-062, Brazil.

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http://link.springer.com/10.1007/s00394-018-1851-6
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http://dx.doi.org/10.1007/s00394-018-1851-6DOI Listing
November 2018

and Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons.

Front Pharmacol 2018 30;9:808. Epub 2018 Jul 30.

Department of Mechanical Engineering, University of South Alabama, Mobile, AL, United States.

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https://www.frontiersin.org/article/10.3389/fphar.2018.00808
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http://dx.doi.org/10.3389/fphar.2018.00808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078047PMC
July 2018

Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons.

Cardiovasc Eng Technol 2018 06 1;9(2):240-250. Epub 2018 Mar 1.

Mechanical Engineering Department, University of South Alabama, Mobile, AL, 36688, USA.

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http://dx.doi.org/10.1007/s13239-018-0346-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990435PMC
June 2018

Regulation of kynurenine metabolism by a ketogenic diet.

J Lipid Res 2018 06 31;59(6):958-966. Epub 2018 Mar 31.

Department of Pharmaceutical Sciences, School of Pharmacy University of Colorado Denver, Aurora, CO 80045

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http://dx.doi.org/10.1194/jlr.M079251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983405PMC
June 2018

Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid.

Xenobiotica 2018 May 30;48(5):433-441. Epub 2017 May 30.

a iC42 Clinical Research and Development, Department of Anesthesiology , School of Medicine, University of Colorado Denver , Aurora , CO , USA and.

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http://dx.doi.org/10.1080/00498254.2017.1329567DOI Listing
May 2018

Morphine Pharmacokinetics in Children With Down Syndrome Following Cardiac Surgery.

Pediatr Crit Care Med 2018 05;19(5):459-467

The Heart Institute, Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Denver School of Medicine, Aurora, CO.

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http://dx.doi.org/10.1097/PCC.0000000000001537DOI Listing
May 2018

A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples.

J Chromatogr A 2018 Apr 7;1547:45-52. Epub 2018 Mar 7.

Institute for Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00219673183028
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http://dx.doi.org/10.1016/j.chroma.2018.03.010DOI Listing
April 2018

The pharmacokinetics of intravenous ketorolac in children aged 2 months to 16 years: A population analysis.

Paediatr Anaesth 2018 02 21;28(2):80-86. Epub 2017 Dec 21.

Department of Anaesthesiology, Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1111/pan.13302DOI Listing
February 2018

An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine.

Ther Drug Monit 2017 10;39(5):556-564

*Department of Anesthesiology, University of Colorado, Aurora; †Division of Substance Dependence, Department of Psychiatry, University of Colorado, Aurora; ‡Department of Neurology, University of Colorado, Aurora; §Department of Pediatrics, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora; ¶Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora; and ‖Division of Pulmonary Medicine, National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.1097/FTD.0000000000000427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600652PMC
October 2017

A High-throughput HPLC-MS/MS Assay for the Detection, Quantification and Simultaneous Structural Confirmation of 136 Drugs and Metabolites in Human Urine.

Ther Drug Monit 2017 10;39(5):565-574

Department of Anesthesiology, iC42 Clinical Research and Development, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1097/FTD.0000000000000429DOI Listing
October 2017

Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart.

J Cell Biochem 2017 09 12;118(9):2933-2940. Epub 2017 Apr 12.

Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1002/jcb.25947DOI Listing
September 2017

The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans.

Can J Physiol Pharmacol 2017 Sep 3;95(9):1009-1018. Epub 2017 May 3.

i Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1139/cjpp-2016-0635DOI Listing
September 2017

A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition.

Physiol Rep 2017 Sep;5(17)

Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

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http://dx.doi.org/10.14814/phy2.13409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599867PMC
September 2017

The use of an occlusion perfusion catheter to deliver paclitaxel to the arterial wall.

Cardiovasc Ther 2017 Aug;35(4)

Mechanical Engineering Department, University of South Alabama, Mobile, AL, USA.

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http://dx.doi.org/10.1111/1755-5922.12269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511576PMC
August 2017

Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy.

Clin Transplant 2017 06 2;31(6). Epub 2017 May 2.

Division of Nephrology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1111/ctr.12975DOI Listing
June 2017

Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group.

Br J Clin Pharmacol 2017 05 20;83(5):1097-1107. Epub 2016 Dec 20.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1111/bcp.13181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401981PMC
May 2017

The Immunosuppressant Mycophenolic Acid Alters Nucleotide and Lipid Metabolism in an Intestinal Cell Model.

Sci Rep 2017 03 22;7:45088. Epub 2017 Mar 22.

Department of Anesthesiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Bioscience 2, 12705 East Montview Boulevard, Suite 200, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/srep45088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361167PMC
March 2017

Everolimus does not prevent Lafora body formation in murine Lafora disease.

Neurol Genet 2017 Feb 9;3(1):e127. Epub 2017 Jan 9.

Department of Paediatrics (Neurology) (N.M., B.A.M.) and Program in Genetics and Genome Biology (P.W., D.G., X.Z., Y.X., B.A.M.), The Hospital for Sick Children and University of Toronto, Canada; and iC42 Clinical Research and Development (U.C.), Department of Anesthesiology, University of Colorado, Denver.

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http://dx.doi.org/10.1212/NXG.0000000000000127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224705PMC
February 2017

Inhalation of two putative Gulf War toxins by mice.

J Environ Sci Health B 2016 7;51(6):366-73. Epub 2016 Mar 7.

b Department of Chemistry and Biochemistry , University of Denver , Denver , Colorado , USA.

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http://dx.doi.org/10.1080/03601234.2016.1142318DOI Listing
December 2016

Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches.

Respir Med 2016 12 21;121:59-66. Epub 2016 Oct 21.

Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, USA.

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http://dx.doi.org/10.1016/j.rmed.2016.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516646PMC
December 2016

Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent?

Clin Biochem 2016 Sep 8;49(13-14):955-61. Epub 2016 Jun 8.

iC42 Clinical Research and Development, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

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http://dx.doi.org/10.1016/j.clinbiochem.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047903PMC
September 2016

Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants.

CPT Pharmacometrics Syst Pharmacol 2016 08 8;5(8):411-7. Epub 2016 Aug 8.

Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/psp4.12096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999604PMC
August 2016

Remifentanil and propofol undergo separation and layering when mixed in the same syringe for total intravenous anesthesia.

Paediatr Anaesth 2016 Jul 5;26(7):703-9. Epub 2016 May 5.

Department of Anesthesiology, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1111/pan.12917DOI Listing
July 2016

Biomarkers in Transplantation--Proteomics and Metabolomics.

Ther Drug Monit 2016 Apr;38 Suppl 1:S70-4

iC42 Clinical Research and Development, University of Colorado, Aurora.

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http://dx.doi.org/10.1097/FTD.0000000000000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769975PMC
April 2016

Analytical Aspects of the Implementation of Biomarkers in Clinical Transplantation.

Ther Drug Monit 2016 Apr;38 Suppl 1:S80-92

*Klinikum Stuttgart, Zentralinstitut für Klinische Chemie und Laboratoriumsmedizin, Stuttgart, Germany; †Pharmacology and Toxicology, Biomedical Diagnostic Center, Hospital Clinic of Barcelona, University of Barcelona, Spain; ‡CHU Limoges, Department of Pharmacology, Toxicology and Pharmacovigilance, Limoges, France; §Servicio de Enfermedades Hepáticas Centro Nacional de Trasplante Hepático, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay; ¶Department of Nephrology, University Hospital Heidelberg, Germany; and ‖iC42 Clinical Research & Development, University of Colorado, Aurora.

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http://dx.doi.org/10.1097/FTD.0000000000000230DOI Listing
April 2016

Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation.

Ther Drug Monit 2016 Apr;38 Suppl 1:S1-20

*Pharmacology and Toxicology Laboratory, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Spain; †Klinikum Stuttgart, ZentralInstitut für Klinische Chemie und Laboratoriumsmedizin, Stuttgart, Germany; ‡Departments of Internal Medicine and Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, the Netherlands; §Department of Nephrology, University of Heidelberg, University Hospital Heidelberg and Mannheim, Heidelberg; ¶Medizinische Klinik mit Schwerpunkt Nephrologie, Charité Universitätsmedizin Berlin, Germany; ‖Louvain Centre for Toxicology and Applied Pharmacology, Institut de Recherche Expérimentale et Clinique and Clinical Chemistry Department, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium; **C42 Clinical Research & Development, Department of Anesthesiology, University of Colorado, Aurora; ††Immunology Laboratory, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain; ‡‡Department of Cardiovascular Surgery, University Heart Center Hamburg, Germany; §§Department of Pharmacology, Oslo University Hospital, Norway; ¶¶U850 INSERM, Université de Limoges, CHU Limoges, France; ‖‖Division of Nephrology and Renal Transplantation, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands; ***Liver Diseases Department, National Center for Liver Transplantation, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay; †††Department of Drug Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Poland; and ‡‡‡Department of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.

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http://dx.doi.org/10.1097/FTD.0000000000000287DOI Listing
April 2016

Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee.

Ther Drug Monit 2016 Apr;38(2):170-89

*Risch Laboratories Group, Schaan, Principality of Liechtenstein; †Klinikum Stuttgart, Zentralinstitut für Klinische Chemie und Laboratoriumsmedizin, Stuttgart, Germany; ‡iC42 Clinical Research and Development, University of Colorado, Anschutz Medical Campus, Denver; §Pharmacology, APHP, Hôpital Européen G Pompidou, Paris Descartes University, France; ¶Department of Pathology and Genomic Medicine, Houston Methodist Hospital, TX; ‖ASI Ltd, St George's-University of London, United Kingdom; **Pharmacology and Toxicology Laboratory, Biomedical Diagnostic Center (CDB), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain; ††Clinical Pharmacology Unit, Institute of Cardiology, Medical University of Warsaw, Poland; ‡‡Department of Drug Chemistry, Medical University of Warsaw, Poland; §§Department of Laboratory Medicine and Pathology, Mayo Clinic, College of Medicine, Rochester, NY; ¶¶UMR 850 INSERM, University Limoges, CHU Limoges, France; ‖‖Department of Clinical Pharmacology, Georg-August University, University Medical Center Göttingen, Germany; and ***Clinical Chemistry Department, Université Catholique de Louvain, LTAP, Cliniques Universitaires St Luc, Brussels, Belgium.

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http://dx.doi.org/10.1097/FTD.0000000000000269DOI Listing
April 2016

Memory-updating abrogates extinction of learned immunosuppression.

Brain Behav Immun 2016 Feb 18;52:40-48. Epub 2015 Sep 18.

Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2015.09.009DOI Listing
February 2016

Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs.

Ther Drug Monit 2015 Dec;37(6):718-24

*iC42 Clinical Research and Development, University of Colorado, Aurora; †Department of Pediatrics, Division of Clinical Pharmacology, Cincinnati Children's Hospital and Medical Center, College of Medicine, University of Cincinnati, Ohio; ‡Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota; §Department of Clinical Toxicology, Johns Hopkins School of Medicine, Baltimore, Maryland; ¶Department of Pharmacology, Toxicology and Pharmacovigilance, University Hospital of Limoges, France; ‖Cliniques Universitaires St. Luc, UCL, Brussels, Belgium; **Departments of Hospital Pharmacy and Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands; ††Navigant Consulting Inc, New York, New York; and ‡‡Novartis Pharmaceutical Corp, East Hanover, New Jersey.

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http://pdfs.journals.lww.com/drug-monitoring/2015/12000/Impa
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FTD.0000000000000205DOI Listing
December 2015

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS.

J Vis Exp 2015 Nov 8(105):e52424. Epub 2015 Nov 8.

iC42 Clinical Research and Development, University of Colorado, Anschutz Medical Campus;

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http://dx.doi.org/10.3791/52424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692696PMC
November 2015

Neurobehavioral consequences of small molecule-drug immunosuppression.

Neuropharmacology 2015 Sep 19;96(Pt A):83-93. Epub 2014 Dec 19.

Institute of Medical Psychology and Behavioral Immunobiology, University Hospital, Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.12.008DOI Listing
September 2015

Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease.

Clin J Am Soc Nephrol 2015 Sep 29;10(9):1534-41. Epub 2015 Jul 29.

Division of Renal Diseases and Hypertension, Department of Pediatrics, University of Colorado, Aurora, Colorado.

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http://dx.doi.org/10.2215/CJN.11331114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559520PMC
September 2015

Everolimus and sirolimus in transplantation-related but different.

Expert Opin Drug Saf 2015 Jul 26;14(7):1055-70. Epub 2015 Apr 26.

University of Colorado, iC42 Clinical Research and Development , Anschutz Medical Campus, 1999 North Fitzsimons Parkway, Suite 100, Aurora, CO 80045-7503 , USA +1 303 724 5665 ; +1 303 724 5662 ;

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http://dx.doi.org/10.1517/14740338.2015.1040388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053318PMC
July 2015

Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.

Ther Drug Monit 2015 Jun;37(3):395-9

*Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center; †Department of Pediatrics, College of Medicine, University of Cincinnati, OH; ‡iC42 Integrated Solutions in Clinical Research and Development, University of Colorado, Aurora; §Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD; ¶Division of Oncology, The Children's Hospital of Philadelphia; ‖Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia; **Division of Oncology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center; and ††Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, OH.

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http://dx.doi.org/10.1097/FTD.0000000000000130DOI Listing
June 2015

A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine.

Clin Chim Acta 2015 Jun 11;446:43-53. Epub 2015 Apr 11.

iC42 Clinical Research and Development, Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1016/j.cca.2015.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028022PMC
June 2015

Long-term cross-validation of everolimus therapeutic drug monitoring assays: the Zortracker study.

Ther Drug Monit 2015 Jun;37(3):296-303

*Department of Anesthesiology, iC42 Clinical Research and Development, University of Colorado Anschutz Medical Campus, Aurora; †Department of Pathology, University of Utah Health Sciences Center; ‡ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah; and §Novartis Pharmaceutical Corp, East Hanover, New Jersey.

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http://dx.doi.org/10.1097/FTD.0000000000000191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820066PMC
June 2015

Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects.

Anal Bioanal Chem 2014 Oct 13;406(25):6399-408. Epub 2014 Aug 13.

iC42 Integrated Solutions in Systems Biology, University of Colorado, Aurora, CO, 80045-7503, USA,

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http://dx.doi.org/10.1007/s00216-014-8020-4DOI Listing
October 2014

Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs.

Anesthesiology 2014 Sep;121(3):469-81

From the Department of Anesthesiology and Webb-Waring Center, University of Colorado School of Medicine, Aurora, Colorado (A.F.-B.); Department of Anesthesiology and iC42 Integrated Solutions in Systems Biology, University of Colorado School of Medicine, Aurora, Colorado (J.K., U.C.); Department of Medicine and Webb-Waring Center, University of Colorado School of Medicine, Aurora, Colorado (J.E.R.); Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado (A.A., T.S.); Department of Pathobiology and Lerner Research Institute (NC22), the Cleveland Clinic Foundation and Case Western Reserve University School of Medicine, Cleveland, Ohio (A.J.J., S.C.E.); Case Western Reserve University School of Medicine, Cleveland, Ohio (C.S.); Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado (M.M., I.S.D.); and Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, Colorado (Z.V.T.).

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http://dx.doi.org/10.1097/ALN.0000000000000301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165799PMC
September 2014

Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes.

Transpl Immunol 2014 Jun 24;31(1):22-32. Epub 2014 May 24.

University of Arizona College of Medicine, Tucson, AZ, USA.

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http://dx.doi.org/10.1016/j.trim.2014.05.002DOI Listing
June 2014

Genetic and structure-function studies of missense mutations in human endothelial lipase.

PLoS One 2013 25;8(3):e55716. Epub 2013 Mar 25.

Division of Cardiology, Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055716PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607615PMC
December 2013

Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats.

Inflammation 2013 Oct;36(5):1030-40

Department of Anesthesiology, University of Colorado SOM, AO-1, MS 8202, 12631 E 17th Ave, Aurora, CO, 80045, USA,

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http://dx.doi.org/10.1007/s10753-013-9635-xDOI Listing
October 2013

Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Oct 28;937:79-83. Epub 2013 Aug 28.

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2013.08.014DOI Listing
October 2013

Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients.

Clin Pharmacokinet 2013 Sep;52(9):751-62

Clinical Pharmacokinetics Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA.

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http://dx.doi.org/10.1007/s40262-013-0069-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755037PMC
September 2013

Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry.

J Pharm Biomed Anal 2013 Sep 16;83:1-9. Epub 2013 Apr 16.

iC42 Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, and The Children's Hospital of Colorado, Aurora, CO 80045-7503 , USA.

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http://dx.doi.org/10.1016/j.jpba.2013.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991461PMC
September 2013

Proteomics and metabolomics in renal transplantation-quo vadis?

Transpl Int 2013 Mar 21;26(3):225-41. Epub 2012 Nov 21.

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO, USA.

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http://dx.doi.org/10.1111/tri.12003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006577PMC
March 2013

Neurobehavioural activation during peripheral immunosuppression.

Int J Neuropsychopharmacol 2013 Feb 5;16(1):137-49. Epub 2012 Jan 5.

Swiss Federal Institute of Technology Zurich, Physiology and Behaviour Laboratory, Zurich, Switzerland.

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http://dx.doi.org/10.1017/S1461145711001799DOI Listing
February 2013

Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy.

Cardiovasc Res 2013 Jan 26;97(1):66-76. Epub 2012 Sep 26.

Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, 1999 N. Fitzsimons Parkway Bioscience East, Suite 100, Aurora, CO 80045-7503, USA.

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http://dx.doi.org/10.1093/cvr/cvs302DOI Listing
January 2013

Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin.

J Clin Pharmacol 2012 Nov 14;52(11):1725-38. Epub 2011 Dec 14.

PharmD, Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, 12850 East Montview Blvd, Mail Stop C238, Room V20-4103, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1177/0091270011427907DOI Listing
November 2012

Mass Spectrometry-Based Multiplexing for the Analysis of Biomarkers in Drug Development and Clinical Diagnostics- How Much is too Much?

Microchem J 2012 Nov;105:32-38

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado, Aurora, Colorado 80045, United States.

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http://dx.doi.org/10.1016/j.microc.2012.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640576PMC
November 2012

MF101: a multi-component botanical selective estrogen receptor beta modulator for the treatment of menopausal vasomotor symptoms.

Expert Opin Investig Drugs 2012 Jul 23;21(7):1031-42. Epub 2012 May 23.

University of California, Department of Nutritional Science and Toxicology, 44 Morgan Hall Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1517/13543784.2012.685652DOI Listing
July 2012

A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children.

J Sep Sci 2011 Dec 13;34(24):3568-77. Epub 2011 Sep 13.

iC42 Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045-7503, USA.

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http://dx.doi.org/10.1002/jssc.201100422DOI Listing
December 2011

How unbiased is non-targeted metabolomics and is targeted pathway screening the solution?

Curr Pharm Biotechnol 2011 Jul;12(7):1053-66

iC42 Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado 80045-7503, USA.

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http://dx.doi.org/10.2174/138920111795909078DOI Listing
July 2011

Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns.

J Mass Spectrom 2011 Jul;46(7):615-24

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Denver, Aurora, Colorado 80045-7503, USA.

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http://doi.wiley.com/10.1002/jms.1930
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http://dx.doi.org/10.1002/jms.1930DOI Listing
July 2011

A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry.

Anal Bioanal Chem 2011 May 12;400(3):715-28. Epub 2011 Mar 12.

iC42 Clinical Research & Development, Department of Anesthesiology, University of Colorado Denver, Aurora, 80045-7503, USA.

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http://dx.doi.org/10.1007/s00216-011-4775-zDOI Listing
May 2011

Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared.

Rapid Commun Mass Spectrom 2011 Feb;25(4):463-8

Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045-7503, USA.

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http://dx.doi.org/10.1002/rcm.4871DOI Listing
February 2011

Liquid chromatography and mass spectrometry in food allergen detection.

J Food Prot 2011 Feb;74(2):316-45

Section of Chemistry, Department of Feed and Food Safety, National Veterinary Institute, P.O. Box 750 Sentrum, Oslo N-0106, Norway.

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http://dx.doi.org/10.4315/0362-028X.JFP-10-336DOI Listing
February 2011