Utz Herbig

Utz Herbig

UNVERIFIED PROFILE

Are you Utz Herbig?   Register this Author

Register author
Utz Herbig

Utz Herbig

Publications by authors named "Utz Herbig"

Are you Utz Herbig?   Register this Author

27Publications

391Reads

37Profile Views

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts.

Aging Cell 2018 Dec 22;17(6):e12838. Epub 2018 Sep 22.

New Jersey Medical School, Cancer Institute of New Jersey-Newark, Rutgers Biomedical and Health Sciences, Newark, New Jersey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.12838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260909PMC
December 2018

Detection of Dysfunctional Telomeres in Oncogene-Induced Senescence.

Methods Mol Biol 2017 ;1534:69-78

Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School-Cancer Center, Rutgers Biomedical and Health Sciences, 205 South Orange Avenue, Newark, NJ, 07103, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6670-7_6DOI Listing
January 2018

Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence.

Proc Natl Acad Sci U S A 2016 08 8;113(34):E5024-33. Epub 2016 Aug 8.

New Jersey Medical School-Cancer Center, Rutgers Biomedical and Health Sciences, Newark, NJ 07103; Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ 07103

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1602379113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003242PMC
August 2016

Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.

Aging Cell 2015 Jun 14;14(3):372-81. Epub 2015 Feb 14.

Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.12289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406666PMC
June 2015

The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses.

Aging Cell 2014 Oct 18;13(5):780-6. Epub 2014 Jul 18.

Department of Microbiology and Molecular Genetics, NJMS Cancer Center, Rm G1226 Rutgers Biomedical and Health Sciences, 205 South Orange Ave., Newark, NJ, 07103, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.12246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331758PMC
October 2014

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

Curr Opin Genet Dev 2014 Jun 11;26:89-95. Epub 2014 Aug 11.

IFOM Foundation - FIRC Institute of Molecular Oncology Foundation, Milan 20139, Italy; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia 27100, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gde.2014.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217147PMC
June 2014

Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage.

Nucleic Acids Res 2013 May 9;41(10):5321-40. Epub 2013 Apr 9.

Department of Pathology and Laboratory Medicine, UMDNJ - New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07042, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664817PMC
May 2013

Telomerase gene therapy: a novel approach to combat aging.

EMBO Mol Med 2012 Aug 15;4(8):685-7. Epub 2012 May 15.

Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/emmm.201200246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494068PMC
August 2012

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells.

Nat Cell Biol 2012 Feb 26;14(3):266-75. Epub 2012 Feb 26.

Institut Pasteur, Nuclear Organisation and Oncogenesis Unit, Department of Cell Biology and Infection, F-75015 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb2443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423543PMC
February 2012

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.

Nat Struct Mol Biol 2010 Dec 14;17(12):1461-9. Epub 2010 Nov 14.

Telomere and Genome Stability Group, The Cancer Research UK/Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.1943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998174PMC
December 2010

A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction.

Aging Cell 2010 Apr;9(2):203-19

Department of Pharmacology and Physiology, National Institute of Environmental and Health Sciences, 111 TW Alexander dr, MD F0-02, Durham, NC 27709, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1474-9726.2010.00551.xDOI Listing
April 2010

Accumulation of senescent cells in mitotic tissue of aging primates.

Mech Ageing Dev 2007 Jan 20;128(1):36-44. Epub 2006 Nov 20.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2006.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654105PMC
January 2007

Cellular senescence in aging primates.

Science 2006 Mar 2;311(5765):1257. Epub 2006 Feb 2.

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1122446DOI Listing
March 2006

Regulation of growth arrest in senescence: telomere damage is not the end of the story.

Mech Ageing Dev 2006 Jan 17;127(1):16-24. Epub 2005 Oct 17.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship Street, Box G-E438, Providence, RI 02903, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S004763740500219
Publisher Site
http://dx.doi.org/10.1016/j.mad.2005.09.002DOI Listing
January 2006

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).

Mol Cell 2004 May;14(4):501-13

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.

View Article

Download full-text PDF

Source
May 2004

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence.

Aging Cell 2003 12;2(6):295-304

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1474-9728.2003.00067.xDOI Listing
December 2003

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts.

EMBO Rep 2003 Nov 17;4(11):1061-6. Epub 2003 Oct 17.

Department of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, Rhode Island 02912, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.embor.embor7400001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326371PMC
November 2003