Utz Fischer

Utz Fischer

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Utz Fischer

Publications by authors named "Utz Fischer"

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Gene Knockdown in Zebrafish (Danio rerio) as a Tool to Model Photoreceptor Diseases.

Methods Mol Biol 2019 ;1834:209-219

Department of Biochemistry, Biocentre, University of Wuerzburg, Würzburg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-8669-9_15DOI Listing
April 2019

UsnRNP biogenesis: mechanisms and regulation.

Chromosoma 2017 10 1;126(5):577-593. Epub 2017 Aug 1.

Department of Biochemistry, University of Würzburg, Biozentrum, Am Hubland, D-97074, Würzburg, Germany.

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http://dx.doi.org/10.1007/s00412-017-0637-6DOI Listing
October 2017

Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation.

J Cell Biol 2017 08 21;216(8):2391-2407. Epub 2017 Jun 21.

Department of Biochemistry, Biocenter, University of Würzburg, Am Hubland, Würzburg, Germany

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http://dx.doi.org/10.1083/jcb.201611108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551706PMC
August 2017

Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation.

Trends Biochem Sci 2017 05 6;42(5):369-382. Epub 2017 Mar 6.

Theodor-Boveri Institute, University of Wuerzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2017.02.004DOI Listing
May 2017

Molding Photonic Boxes into Fluorescent Emitters by Direct Laser Writing.

Adv Mater 2017 Apr 16;29(16). Epub 2017 Feb 16.

Technische Physik, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.

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http://dx.doi.org/10.1002/adma.201605236DOI Listing
April 2017

The right pick: structural basis of snRNA selection by Gemin5.

Genes Dev 2016 11;30(21):2341-2344

Department of Biochemistry, University of Würzburg, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1101/gad.293084.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131775PMC
November 2016

The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs.

Cell Rep 2016 09;16(12):3103-3112

Department of Biochemistry, University of Wuerzburg, 97074 Wuerzburg, Germany; Department of Radiation Medicine and Applied Sciences, University of California at San Diego, San Diego, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.047DOI Listing
September 2016

A critical examination of the recently reported crystal structures of the human SMN protein.

Hum Mol Genet 2016 08;25(21):4717–4725

Departement of Biochemistry, Biocenter of the University, University of Wuerzburg, Würzburg, Germany.

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http://dx.doi.org/10.1093/hmg/ddw298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418738PMC
August 2016

Drug-Encoded Biomarkers for Monitoring Biological Therapies.

PLoS One 2015 8;10(9):e0137573. Epub 2015 Sep 8.

Department of Biochemistry, Biocenter, University of Würzburg, Würzburg, Germany; Department of Radiation Oncology, Moores Cancer Center, University of California San Diego, San Diego, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137573PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562523PMC
June 2016

Crystallizing the 6S and 8S spliceosomal assembly intermediates: a complex project.

Acta Crystallogr D Biol Crystallogr 2015 Oct 26;71(Pt 10):2040-53. Epub 2015 Sep 26.

Department of Biochemistry, Theodor Boveri Institute, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

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http://dx.doi.org/10.1107/S1399004715014832DOI Listing
October 2015

LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation.

RNA 2015 Jul 22;21(7):1294-305. Epub 2015 May 22.

Biozentrum Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany Rudolf-Virchow-Zentrum für Experimentelle Biomedizin, Universität Würzburg, D-97080 Würzburg, Germany Department of Radiation Medicine and Applied Sciences, University of California at San Diego, San Diego, California 92037, USA.

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http://dx.doi.org/10.1261/rna.051441.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478348PMC
July 2015

Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization.

EMBO J 2015 Jul 11;34(14):1925-41. Epub 2015 Jun 11.

Department of Biochemistry, Biocenter, University of Würzburg, Würzburg, Germany Department of Radiation Medicine and Applied Sciences, University of California, San Diego, San Diego, CA, USA

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http://dx.doi.org/10.15252/embj.201490350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547896PMC
July 2015

mRNA metabolism and neuronal disease.

FEBS Lett 2015 Jun 13;589(14):1598-606. Epub 2015 May 13.

Institute for Genetics, University of Cologne, Zülpicher Str. 47a, 50674 Köln, Germany.

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http://dx.doi.org/10.1016/j.febslet.2015.04.052DOI Listing
June 2015

Assembly of RNPs: help needed.

RNA 2015 Apr;21(4):613-4

Max-Planck-Institute for Biophysical Chemistry, D-37077 Goettingen, Germany.

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http://dx.doi.org/10.1261/rna.049791.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371304PMC
April 2015

The structure of apo ArnA features an unexpected central binding pocket and provides an explanation for enzymatic cooperativity.

Acta Crystallogr D Biol Crystallogr 2015 Mar 26;71(Pt 3):687-96. Epub 2015 Feb 26.

Department of Biochemistry, Biocenter of the University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

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http://dx.doi.org/10.1107/S1399004714026686DOI Listing
March 2015

The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization.

Mol Biol Cell 2015 Jan 12;26(2):161-71. Epub 2014 Nov 12.

Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Universität Heidelberg, D-69120 Heidelberg, Germany

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http://dx.doi.org/10.1091/mbc.E14-06-1151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294665PMC
January 2015

Phosphoregulation of the human SMN complex.

Eur J Cell Biol 2014 Mar 11;93(3):106-17. Epub 2014 Feb 11.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejcb.2014.01.006DOI Listing
March 2014

Analysis of photoreceptor degeneration in the zebrafish Danio rerio.

Methods Mol Biol 2013 ;935:127-37

Department of Biochemistry, Biocenter, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1007/978-1-62703-080-9_9DOI Listing
April 2013

Structural basis of assembly chaperone- mediated snRNP formation.

Mol Cell 2013 Feb 17;49(4):692-703. Epub 2013 Jan 17.

Department of Biochemistry, Theodor Boveri Institute, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.molcel.2012.12.009DOI Listing
February 2013

The 1D4 antibody labels outer segments of long double cone but not rod photoreceptors in zebrafish.

Invest Ophthalmol Vis Sci 2012 Jul 26;53(8):4943-51. Epub 2012 Jul 26.

Department of Biological Sciences and Centre for Bioimaging Sciences (CBIS), National University of Singapore, Singapore.

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http://dx.doi.org/10.1167/iovs.12-9511DOI Listing
July 2012

Biogenesis of spliceosomal small nuclear ribonucleoproteins.

Wiley Interdiscip Rev RNA 2011 Sep-Oct;2(5):718-31. Epub 2011 Apr 25.

Department of Biochemistry, University of Wuerzburg, Germany.

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http://dx.doi.org/10.1002/wrna.87DOI Listing
March 2012

Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2.

Genes Dev 2012 Jan;26(1):25-30

Department of Biochemistry, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1101/gad.177774.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258962PMC
January 2012

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins.

Nat Struct Mol Biol 2011 Nov 20;18(12):1414-20. Epub 2011 Nov 20.

Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.

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http://dx.doi.org/10.1038/nsmb.2185DOI Listing
November 2011

Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa.

Mol Neurodegener 2011 Jul 30;6:56. Epub 2011 Jul 30.

Department of Biological Sciences; National University of Singapore; 117543, Singapore.

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http://dx.doi.org/10.1186/1750-1326-6-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158551PMC
July 2011

Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa.

Hum Mol Genet 2011 Jan 3;20(2):368-77. Epub 2010 Nov 3.

Department of Biochemistry, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1093/hmg/ddq473DOI Listing
January 2011

Cellular strategies for the assembly of molecular machines.

Trends Biochem Sci 2010 Dec 19;35(12):676-83. Epub 2010 Aug 19.

Department of Biochemistry, Theodor-Boveri Institute, University of Wurzburg, Am Hubland, D-97074 Wurzburg, Germany.

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http://dx.doi.org/10.1016/j.tibs.2010.07.006DOI Listing
December 2010

A stimulatory role for the La-related protein 4B in translation.

RNA 2010 Aug 23;16(8):1488-99. Epub 2010 Jun 23.

Department of Biochemistry, Theodor Boveri-Institute, University of Wuerzburg, Wuerzburg D-97074, Germany.

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http://dx.doi.org/10.1261/rna.2146910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905749PMC
August 2010

A crystallization screen based on alternative polymeric precipitants.

Acta Crystallogr D Biol Crystallogr 2010 Jun 15;66(Pt 6):685-97. Epub 2010 May 15.

Lehrstuhl für Biochemie, Biozentrum der Universität Würzburg, 97074 Würzburg, Germany.

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http://dx.doi.org/10.1107/S0907444910009005DOI Listing
June 2010

LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication.

RNA 2010 Apr 24;16(4):817-27. Epub 2010 Feb 24.

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1261/rna.1712910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844628PMC
April 2010

When one plus one equals three: biochemistry and bioinformatics combine to answer complex questions.

Fly (Austin) 2009 Jul-Sep;3(3):210-2. Epub 2009 Jul 11.

Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.

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November 2009

Native purification of protein and RNA-protein complexes using a novel affinity procedure.

Fly (Austin) 2009 Jul-Sep;3(3):221-8. Epub 2009 Jul 20.

Department of Biochemistry, University of Würzburg, Theodor-Boveri-Institute, Biocenter, Würzburg, Germany.

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November 2009

Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates.

Proc Natl Acad Sci U S A 2009 Aug 23;106(32):13517-22. Epub 2009 Jul 23.

Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1073/pnas.0906413106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714764PMC
August 2009

The role of RNP biogenesis in spinal muscular atrophy.

Curr Opin Cell Biol 2009 Jun 13;21(3):387-93. Epub 2009 Mar 13.

Department of Biochemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.ceb.2009.02.004DOI Listing
June 2009

Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.

Hum Mol Genet 2008 Oct 28;17(20):3236-46. Epub 2008 Jul 28.

Department of Biochemistry, Theodor Boveri Institute, Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1093/hmg/ddn219DOI Listing
October 2008

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

Cell 2008 Oct;135(3):497-509

Department of Biochemistry, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.cell.2008.09.020DOI Listing
October 2008

Evolution of an RNP assembly system: a minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster.

Proc Natl Acad Sci U S A 2008 Jul 10;105(29):10045-50. Epub 2008 Jul 10.

Department of Biochemistry, Theodor Boveri Institute, Biocenter, Am Hubland, 97074 Würzburg, Germany.

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http://dx.doi.org/10.1073/pnas.0802287105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481332PMC
July 2008

Deciphering the assembly pathway of Sm-class U snRNPs.

FEBS Lett 2008 Jun 17;582(14):1997-2003. Epub 2008 Mar 17.

Theodor-Boveri Institute at the Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.febslet.2008.03.009DOI Listing
June 2008

The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes.

EMBO Rep 2008 Jun 16;9(6):569-75. Epub 2008 May 16.

Department of Biochemistry, Theodor-Boveri-Institute, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1038/embor.2008.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427381PMC
June 2008

A 5'-fluorosulfonylbenzoyladenosine-based method to identify physiological substrates of a Drosophila p21-activated kinase.

Anal Biochem 2007 Sep 26;368(2):178-84. Epub 2007 May 26.

Institute of Medical Radiation and Cell Research, University of Würzburg, D-97078 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.ab.2007.05.022DOI Listing
September 2007

A comprehensive interaction map of the human survival of motor neuron (SMN) complex.

J Biol Chem 2007 Feb 18;282(8):5825-33. Epub 2006 Dec 18.

Theodor-Boveri Institute at the Biocenter, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1074/jbc.M608528200DOI Listing
February 2007

Spinal muscular atrophy: the RNP connection.

Trends Mol Med 2006 Mar 13;12(3):113-21. Epub 2006 Feb 13.

Theodor Boveri Institute, Biocenter at the University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.molmed.2006.01.005DOI Listing
March 2006

Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.

J Biol Chem 2005 Oct 8;280(41):34435-40. Epub 2005 Aug 8.

Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.

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http://dx.doi.org/10.1074/jbc.M505077200DOI Listing
October 2005

Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization.

Hum Mol Genet 2005 Oct 13;14(20):3099-111. Epub 2005 Sep 13.

Department of Biochemistry, Theodor Boveri Institute, University of Würzburg, Germany.

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http://dx.doi.org/10.1093/hmg/ddi343DOI Listing
October 2005

Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy.

Genes Dev 2005 Oct;19(19):2320-30

Institute of Biochemistry and Institute of Physiological Chemistry, Biocenter of the University of Würzburg, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1101/gad.342005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240041PMC
October 2005

Phosphorylation regulates the activity of the SMN complex during assembly of spliceosomal U snRNPs.

EMBO Rep 2005 Jan;6(1):70-6

Institute of Biochemistry, Biocenter at the University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

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http://dx.doi.org/10.1038/sj.embor.7400301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299218PMC
January 2005

Epstein-Barr virus nuclear antigen 2 binds via its methylated arginine-glycine repeat to the survival motor neuron protein.

J Virol 2003 Apr;77(8):5008-13

Institut für Medizinische Mikrobiologie und Hygiene, Abteilung Virologie, Universitätskliniken des Saarlandes, 66421 Homburg/Saar, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152127PMC
http://dx.doi.org/10.1128/jvi.77.8.5008-5013.2003DOI Listing
April 2003

Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs.

EMBO J 2002 Nov;21(21):5853-63

Max-Planck Institute of Biochemistry, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC131082PMC
http://dx.doi.org/10.1093/emboj/cdf585DOI Listing
November 2002

SMN-mediated assembly of RNPs: a complex story.

Trends Cell Biol 2002 Oct;12(10):472-8

Max-Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152,., Martinsried, Germany.

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October 2002

Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death.

Proc Natl Acad Sci U S A 2002 Jul 28;99(15):10126-31. Epub 2002 Jun 28.

Institute of Clinical Neurobiology, Josef-Schneider Strasse 11, D-97080 Würzburg, Germany.

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http://dx.doi.org/10.1073/pnas.152318699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126635PMC
July 2002

Chemical Synthesis of a 5'-Terminal TMG-Capped Triribonucleotide m(3)(2,2,7)G(5)(')pppAmpUmpA of U1 RNA.

J Org Chem 1996 Jun;61(13):4412-4422

Institut für Molekularbiologie und Tumorforschung, Philipps-Universität Marburg, Emil-Mannkopff-Strasse 2, D-3550 Marburg, Germany.

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http://dx.doi.org/10.1021/jo952263vDOI Listing
June 1996