Publications by authors named "Ute M Moll"

83Publications

Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins.

Cell Death Dis 2020 04 24;11(4):274. Epub 2020 Apr 24.

Department of Pathology, Stony Brook University, Stony Brook, NY, USA.

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April 2020

Tissue-specific roles of p73 in development and homeostasis.

J Cell Sci 2019 10 3;132(19). Epub 2019 Oct 3.

Department of Pathology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8691, USA

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October 2019

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.

Cancer Cell 2018 08;34(2):298-314.e7

Institute of Molecular Oncology, University Medical Center Göttingen, Göttingen 37077, Germany; Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address:

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August 2018

Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target.

Cancers (Basel) 2018 Jun 7;10(6). Epub 2018 Jun 7.

Institute of Molecular Oncology, University of Göttingen, 37077 Göttingen, Germany.

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June 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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March 2018

Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism.

Cell Death Differ 2018 01 27;25(1):144-153. Epub 2017 Oct 27.

Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.

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January 2018

Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner.

Cell Death Dis 2017 03 16;8(3):e2683. Epub 2017 Mar 16.

Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.

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March 2017

Depleting stabilized GOF mutant p53 proteins by inhibiting molecular folding chaperones: a new promise in cancer therapy.

Cell Death Differ 2017 01 9;24(1):3-5. Epub 2016 Dec 9.

Department of Pathology, Stony Brook University, Stony Brook, NY, USA.

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January 2017

Mdm2 as a chromatin modifier.

J Mol Cell Biol 2017 02;9(1):74-80

Institute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany.

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February 2017

Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.

Cell Death Differ 2017 02 11;24(2):300-316. Epub 2016 Nov 11.

Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen D-37077, Germany.

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February 2017

A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems.

J Mol Biol 2016 10 8;428(20):4154-4167. Epub 2016 Aug 8.

Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address:

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October 2016

TAp73 is a central transcriptional regulator of airway multiciliogenesis.

Genes Dev 2016 06 2;30(11):1300-12. Epub 2016 Jun 2.

Institute of Molecular Oncology, Göttingen University, 37077 Göttingen, Germany; Clinic for Cardiology and Pneumology, Department of Pneumology, University Medical Center Göttingen, 37099 Göttingen, Germany.

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June 2016

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.

Mol Cell 2016 Jan 31;61(1):68-83. Epub 2015 Dec 31.

Institute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany. Electronic address:

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January 2016

TAp73 is essential for germ cell adhesion and maturation in testis.

J Cell Biol 2014 Mar 24;204(7):1173-90. Epub 2014 Mar 24.

Department of Molecular Oncology, University of Göttingen, 37077 Göttingen, Germany.

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March 2014

Cortical hypoplasia and ventriculomegaly of p73-deficient mice: Developmental and adult analysis.

J Comp Neurol 2014 Aug 3;522(11):2663-79. Epub 2014 Apr 3.

Departamento de Anatomía, Facultad de Medicina, Universidad de La Laguna, 38071 La Laguna, Tenerife, Spain.

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August 2014

p53 further extends its reach.

Oncoimmunology 2013 May;2(5):e24959

Department of Pathology; School of Medicine; Stony Brook University; Stony Brook, NY USA.

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May 2013

Targeting the heat shock protein 90: a rational way to inhibit macrophage migration inhibitory factor function in cancer.

Curr Opin Oncol 2014 Jan;26(1):108-13

aInstitute of Molecular Oncology, Göttingen Center of Molecular Biosciences, University of Göttingen, Göttingen, Germany bDepartment of Pathology, Stony Brook University, Stony Brook, New York, USA.

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January 2014

Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase.

Cell Cycle 2013 Sep 6;12(17):2781-93. Epub 2013 Aug 6.

Laboratoire de génétique et biologie cellulaire (LGBC); Université de Versailles St Quentin-en-Yvelines/Ecole Pratique des Hautes Etudes; UFR des Sciences de la Santé; Montigny-le-Bretonneux, France.

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September 2013

Direct reprogramming by oncogenic Ras and Myc.

Proc Natl Acad Sci U S A 2013 Mar 19;110(10):3937-42. Epub 2013 Feb 19.

Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

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March 2013

HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates.

Oncoimmunology 2012 Nov;1(8):1425-1426

Department of Molecular Oncology; Göttingen Center of Molecular Biosciences; University of Göttingen; Göttingen, Germany.

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November 2012

Generation of p53-deficient induced pluripotent stem cells from mouse embryo fibroblasts.

Methods Mol Biol 2013 ;962:157-64

Department of Pathology, Stony Brook University, Stony Brook, NY, USA.

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April 2013

Identification of p53 in mitochondria.

Methods Mol Biol 2013 ;962:75-84

Department of Pathology, Stony Brook University, Stony Brook, NY, USA.

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April 2013

p53 opens the mitochondrial permeability transition pore to trigger necrosis.

Cell 2012 Jun;149(7):1536-48

Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.

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June 2012

Role of p53 family members p73 and p63 in human hematological malignancies.

Leuk Lymphoma 2012 Nov 21;53(11):2116-29. Epub 2012 May 21.

Department of Pathology, Stony Brook University, Stony Brook, NY, USA.

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November 2012

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.

J Exp Med 2012 Feb 23;209(2):275-89. Epub 2012 Jan 23.

Department of Molecular Oncology, Göttingen Center of Molecular Biosciences, University of Göttingen, 37077 Göttingen, Germany.

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February 2012

Links between mutant p53 and genomic instability.

J Cell Biochem 2012 Feb;113(2):433-9

Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.

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February 2012

Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes.

Proc Natl Acad Sci U S A 2011 Mar 7;108(9):3624-9. Epub 2011 Feb 7.

Department of Molecular Oncology, Göttingen Center of Molecular Biosciences, University of Göttingen, D-37077 Göttingen, Germany.

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March 2011

Role of the p53 family in stabilizing the genome and preventing polyploidization.

Adv Exp Med Biol 2010 ;676:73-91

Department of Pathology, Health Science Center, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.

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August 2010

Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice.

J Clin Invest 2010 Jun 17;120(6):2070-80. Epub 2010 May 17.

Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.

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June 2010

p63 and canonical Wnt signaling.

Cell Cycle 2010 Feb 15;9(4):648-9. Epub 2010 Feb 15.

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February 2010

Brdm2 - an aberrant hypomorphic p63 allele.

Cell Death Differ 2010 Jan;17(1):184-186

Department of Pathology, Stony Brook University, Stony Brook, NY 11794-8691, USA.

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January 2010

BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain.

J Biol Chem 2010 Jan 2;285(5):3439-50. Epub 2009 Dec 2.

Department Chemistry, Center for Integrated Protein Science Munich, Technische UniversitätMünchen, 85747 Garching, Germany.

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January 2010

p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy.

Mutat Res 2009 Apr 4;663(1-2):1-6. Epub 2009 Feb 4.

Division of Molecular Medicine, Ruder Bosković Institute, Zagreb, Croatia.

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April 2009

The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.

Cell Cycle 2009 Jun 30;8(11):1711-9. Epub 2009 Jun 30.

Department of Pathology, Stony Brook University, Stony Brook, NY 11794-8691, USA.

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June 2009

p63 regulation by microRNAs.

Cell Cycle 2009 May 15;8(10):1466-7. Epub 2009 May 15.

Rome Oncogenomic Center, Regina Elena Cancer Institute, 00158 Rome, Italy.

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May 2009

p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest.

Cancer Res 2008 Dec;68(24):10094-104

Department of Molecular Oncology, Göttingen Center of Molecular Biosciences, University of Göttingen, Göttingen, Germany.

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December 2008

The mitochondrial p53 pathway.

Biochim Biophys Acta 2009 May 25;1787(5):414-20. Epub 2008 Oct 25.

Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.

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May 2009

Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model.

Cell Cycle 2008 Aug 7;7(16):2584-90. Epub 2008 Aug 7.

Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.

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August 2008

E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression.

Cell Cycle 2008 Jun 30;7(12):1776-81. Epub 2008 Jun 30.

Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.

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June 2008

A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model.

Cell Cycle 2008 May 11;7(9):1205-13. Epub 2008 Feb 11.

Department of Pathology, Stony Brook University, Stony Brook, New York, USA.

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May 2008

Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer.

Eur J Cancer 2008 Jan 26;44(1):131-41. Epub 2007 Nov 26.

Laboratory of Molecular Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

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January 2008

p73 suppresses polyploidy and aneuploidy in the absence of functional p53.

Mol Cell 2007 Aug;27(4):647-59

Department of Pathology, Health Science Center, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

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August 2007

The role of ubiquitination in the direct mitochondrial death program of p53.

Cell Cycle 2007 Jul 25;6(14):1718-23. Epub 2007 May 25.

Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.

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July 2007

Macrophage migration inhibitory factor coordinates DNA damage response with the proteasomal control of the cell cycle.

Cell Cycle 2007 May 20;6(9):1030-4. Epub 2007 May 20.

Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York, USA.

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May 2007

Classic and novel roles of p53: prospects for anticancer therapy.

Trends Mol Med 2007 May 23;13(5):192-9. Epub 2007 Mar 23.

Vascular Biology Unit, Instituto de Biomedicina de Valencia (IBV-CSIC), Spanish Council for Scientific Research, 46010 Valencia, Spain.

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May 2007

Impaired DNA damage checkpoint response in MIF-deficient mice.

EMBO J 2007 Feb 8;26(4):987-97. Epub 2007 Feb 8.

Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA, and University Hospital Cologne, Medical Clinic I, Hematology and Oncology, Germany.

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February 2007

Monoubiquitylation promotes mitochondrial p53 translocation.

EMBO J 2007 Feb 1;26(4):923-34. Epub 2007 Feb 1.

Department of Pathology, Stony Brook University, Stony Brook, New York, NY 11794-869, USA.

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February 2007

Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway.

Cancer Res 2006 Mar;66(6):3126-36

Reproductive Biology Unit and Division of Gynaecology Oncology, Department of Obstetrics and Gynaecology and Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada.

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March 2006

Mitochondrially targeted p53 has tumor suppressor activities in vivo.

Cancer Res 2005 Nov;65(21):9971-81

Department of Pathology, Stony Brook University, Stony Brook, New York 11794-869, USA.

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November 2005

Transcription-independent pro-apoptotic functions of p53.

Curr Opin Cell Biol 2005 Dec 13;17(6):631-6. Epub 2005 Oct 13.

Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.

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December 2005

Viral and cellular oncogenes induce rapid mitochondrial translocation of p53 in primary epithelial and endothelial cells early in apoptosis.

FEBS Lett 2005 Nov 6;579(27):6079-83. Epub 2005 Oct 6.

Department of Pathology, School of Medicine, Stony Brook University, Stony Brook, New York 11794-8691, USA.

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November 2005

Stress-induced p53 runs a transcription-independent death program.

Biochem Biophys Res Commun 2005 Jun;331(3):843-50

Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.

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June 2005

Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway.

Mol Cell 2005 Jan;17(2):225-36

Department of Pathology, Health Science Center, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

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January 2005

Stress-induced p53 runs a direct mitochondrial death program: its role in physiologic and pathophysiologic stress responses in vivo.

Cell Cycle 2004 Dec 18;3(12):1492-5. Epub 2004 Dec 18.

Department of Pathology Stony Brook University, Stony Brook, New York 11794-8691, USA.

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December 2004

Rational design of DNA sequences for nanotechnology, microarrays and molecular computers using Eulerian graphs.

Nucleic Acids Res 2004 27;32(15):4630-45. Epub 2004 Aug 27.

Department of Pathology, Stony Brook University, New York, NY 11794, USA.

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September 2004

p63 and p73: roles in development and tumor formation.

Mol Cancer Res 2004 Jul;2(7):371-86

Department of Pathology, State University of New York at Stony Brook, BST L9 R134, R132-136, Stony Brook, NY 11794-8691, USA.

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July 2004

The MDM2-p53 interaction.

Mol Cancer Res 2003 Dec;1(14):1001-8

Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY 11794-8691, USA.

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December 2003

deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo.

Mol Cell Biol 2003 Aug;23(16):5540-55

Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.

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August 2003

Mutational analysis of p53 in human tumors: immunocytochemistry.

Methods Mol Biol 2003 ;234:231-43

Department of Pathology, State University of New York at Stony Brook, USA.

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April 2004

Mutational analysis of p53 in human tumors: direct DNA sequencing and SSCP.

Methods Mol Biol 2003 ;234:219-30

Department of Pathology, State University of New York at Stony Brook, USA.

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April 2004

Analysis of nuclear and cytoplasmic degradation of p53 in cells after stress.

Methods Mol Biol 2003 ;234:211-7

Department of Pathology, State University of New York at Stony Brook, USA.

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April 2004

Detection of mitochondrial localization of p53.

Methods Mol Biol 2003 ;234:203-9

Department of Pathology, State University of New York at Stony Brook, USA.

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April 2004

p53 has a direct apoptogenic role at the mitochondria.

Mol Cell 2003 Mar;11(3):577-90

Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.

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March 2003

Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage.

FASEB J 2002 Mar 14;16(3):420-2. Epub 2002 Jan 14.

Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.

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March 2002

Disrupting the p53-mdm2 interaction as a potential therapeutic modality.

Drug Resist Updat 2000 Aug;3(4):217-221

Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY, 11794-8691, USA

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August 2000