NEW DELHI, New Delhi | India
Main Specialties: Hematology
Additional Specialties: Immunohematolgy, Component Therapy, Apheresis and Transfusion Medicine
Primary Affiliation: Artemis Hospital - NEW DELHI, New Delhi , India
PubMed Central Citations
6PubMed Central Citations
Dogra M, Doda V, Kotwal U, Arora S, Bhardwaj S, Aroskar GS. Whole blood donor with a history of jaun
journal of applied hematology
Asian J Transfus Sci 2015 Jul-Dec;9(2):115-6
Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Asian J Transfus Sci 2015 Jan-Jun;9(1):18-22
Department of Transfusion Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Asian J Transfus Sci 2015;9:18-22
Asian journal of Transfusion science
Abstract Aims: To evaluate the response rate of transfusion-transmissible infection (TTI)-reactive donors after notification of their abnormal test results for the year 2012. Materials and Methods: This study is an observational descriptive study performed in our department over a period of 1 year. We evaluated the response rate of TTI-reactive donors after notification of their abnormal test results over 1 year as per the existing strategy (three telephonic and two postal communications). Results: During the study period, among the annual donation of 15,322 units, 464 blood donors were found to be seroreactive. Of these 464 seroreactive cases, 47 were HIV positive, 284 were reactive for Hepatitis B surface antigen (HBsAg), 49 were Hepatitis C (HCV) positive and 84 were VDRL reactive. The TTI-reactive donors (464) for various markers were contacted: 229 (49.4%) telephonically and the remaining 235 (50.6%) not contacted on phone were informed by post. Of the 229 contacted donors, the response rate was 98.2% as only 225 donors reported (221 on the first, three on second and one on the third call) for one to one counseling. The remaining four non-responders were - one HIV and three HBsAg reactive. The remaining 235 (50.6%) reactive donors did not respond to any communication. Conclusion: Donor notification and post-donation counseling are an essential aspect of the blood bank that entails provision of information on serological status, assess the impact of test results on the donor and finally referral for medical care. As in our data only 49.4% of the blood donors could be contacted successfully, incomplete demographic details was the major limiting factor in communicating with rest. Of the 229 contacted donors, the response rate was 98.2%. A large majority (94.75%) of the notified donors in our study contacted their health care provider when given clear instructions to do so. These results are encouraging because they indicate that a major element of the notification message is acted upon when it is worded clearly. The very high response rate of the contacted donors ensured their concern for knowing their test result status.
Indian J Med Microbiol. 2015 Jan-Mar;33(1):181-2. doi: 10.4103/0255-0857.148425.
Indian J Med Microbiol.
Dear Editor, Transfusion of blood and blood products, although being a life-saving measure [Figure 1], still has far-reaching consequences as far as the morbidity and mortality resulting from the transfusion of infected blood is concerned. With every unit of blood, there is a 1% chance of a transfusion-associated problem including TTIs.  HIV, HBV and HCV have been known to coexist in an individual. These three viruses have similar mode of transmission, although efficiency of transmission differs. Concurrent infection with HBV or HCV in HIV-infected individuals leads to interaction between all these viruses thus altering the natural history and the treatment response of these diseases. At a molecular level also, interactions between HIV and hepatic viruses may potentiate HIV replication but clinical studies have been inconclusive.  Therefore, to assess the seroprevalence of these coinfections among healthy blood donors at potential risk is essential. Figure 1: Prevalence of coinfection Click here to view The present study was done in the Department of Transfusion Medicine, GMC Jammu, which is a tertiary health care centre over a period of 2 years (January 2010 to December 2011) to analyze the prevalence of coinfections among blood donors, both voluntary and replacement. During this period 50,446 blood donors were screened for the routine 5 TTI's as laid down by the drug and cosmetic act. Screening for HIV, hepatitis B, hepatitis C was done using III generation ELISA kit while syphilis and malaria were screened using rapid kits. The total number of seroreactive cases were noted and those with a combination of >=2 TTIs were labelled as coinfection. Among the total 50,446 blood donors 14279 (28.30%) were voluntary and 36167 (71.70%) were replacement. Total seropositive cases were 879 (1.74%) among 50,446 donations. Seroprevalence of coinfection (>=2 TTIs) was 0.68% among the 879 total seropositive cases and was 0.01% among the total blood donors screened for the 2 years, with maximum being in age group of 30-40 years. Four donors out of the total 6 donors (66.66%), who were seroreactive for 2 or more infections, were the replacement type of donors and thus, the difference with voluntary donors was significant. (P < 0.005). Similar results were shown by Kour et al.  Among HIV-seropositive donors, there was one seroreactive case for HCV (16.66%). Among HIV-seronegative donors, two donors were seroreactive for both HbsAg and HCV (33.33%) each, 2 for both HCV and VDRL (33.33%), 1 for both HbsAg and VDRL (16.66%). The prevalence of coinfection in replacement donors is always higher than voluntary donors (P < 0.005). Jain et al., estimated the seroprevalence of Hepatitis virus in patients infected with HIV and found that 9.9% of patients were HbsAg positive, 6.3% were HCV positive and 1% had dual infection with HCV and HBV.  Mathai found coinfection among 10 donors (0.03%) out of 31942 donors screened over a 6-year period.  In a similar study done by Kour et al., in 2010, 23 (0.05%) of the total 42 439 blood donors had coinfection.  Many factors favour coinfections including high degree of epidemiological similarity between HIV and hepatitis viruses with similar routes of transmission, risk factors and higher prevalence with other STDs such as syphilis. So testing for syphilis is used as a surrogate marker for lifestyles known to be associated with a high risk of transmitting HIV and hepatitis. Compared to those who are only infected with HIV, coinfected individuals are at greater risk of hepatic toxicity following treatment with antiviral drugs, and their survival is also much lower. A study in India showed that one-third of deaths in HIV infection are directly or indirectly related to HCV infection.  Therefore, it is of utmost importance to screen the donors for all the TTIs and to know the rates of these coinfections among otherwise healthy blood donors at risk of transmitting these TTIs.
Asian J Transfus Sci 2014 Jul;8(2):135-6
Blood Bank, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Journal Medical Thesis 2014 Jan-Apr; 2(1): 31-34
Journal of Medical Thesis
Background: Out of twenty nine Blood group systems discovered so far, ABO & Rh system is the most important with respect to Blood Transfusion, Hematopoietic Stem Cell Transplantation & Solid Organ Transplantation. Methods: It was a Cross-sectional, hospital based study involving blood donors over a period of one year. Blood donors were divided into five major ethnic groups and ABO & Rh D blood grouping was done by conventional tube technique. Results: Among the total 13,281Blood Donors97.51% donors were male &2.49% were females. 89.09% donors were below 40 years of age with mean age of the 29.87 years. Maximum Donors were Dogras (78.20%) followed by Non Gujjar Muslims (9.28%), Sikhs (5.92%), Gujjars (4.31%)& Kashmiri Pandits (2.30%). The most prevalent ABO phenotype among donors was B (34.85%) followed by O (30.64%), A (24.77%) &AB (9.73%). Out of the total 3291 A blood group, there were 30 cases of A2thus comprising of 0.91%.Among the study group 94.52% were positive for Rh D antigen &5.48% were Rh D negative. Prevalence of Weak D was 0.0075% and among the Rh (D) antigen Negative Blood Donors (728) it was 0.14%. The prevalence of Rh D negative blood donors was highest among Non-Gujjar muslim donors 10.06%, followed by Kashmiri pundits 9% Gujjars8.22%, Sikhs 6.62%& Dogras 4.60%. In Dogra (34.80%), sikhs(38.80%) and non gujjar muslims(34.98%) donors B blood group was commonest. In Kashmiri Pandits(32.45) and Gujjars(34.09%) the O phenotype was common. To conclude our region is having a blood group distribution trend B>O>A>AB, which does not follow the Asiatic trend of O > B > A > AB with marked differences of distribution among the ethnic groups especially with reference to Rh D antigen.