Publications by authors named "Ursula R Kees"

65Publications

Molecular-genetic profiling and high-throughput drug screening in NUT midline carcinoma-an aggressive and fatal disease.

Oncotarget 2017 Dec 2;8(68):112313-112329. Epub 2017 Dec 2.

Leukaemia and Cancer Genetics Program, Telethon Kids Institute, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.18632/oncotarget.22862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762512PMC
December 2017

Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia.

Oncotarget 2016 09;7(37):58728-42

Leukaemia Biology Program, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.18632/oncotarget.11233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312271PMC
September 2016

The role of CCN family genes in haematological malignancies.

J Cell Commun Signal 2015 Sep 31;9(3):267-78. Epub 2015 May 31.

Telethon Kids Institute, The University of Western Australia, PO Box 855 West Perth, Perth, Western Australia, 6872, Australia.

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http://dx.doi.org/10.1007/s12079-015-0296-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580684PMC
September 2015

Rare childhood cancers--an increasing entity requiring the need for global consensus and collaboration.

Cancer Med 2015 Jun 9;4(6):819-24. Epub 2015 Feb 9.

Department of Haematology and Oncology, Princess Margaret Hospital for Children, GPO Box D184, Perth, Western Australia, 6840, Australia.

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http://dx.doi.org/10.1002/cam4.426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472204PMC
June 2015

Gene expression analyses of the spatio-temporal relationships of human medulloblastoma subgroups during early human neurogenesis.

PLoS One 2014 20;9(11):e112909. Epub 2014 Nov 20.

Brain Tumour Research Program, Telethon Kids Institute, University of Western Australia, Subiaco, Western Australia, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112909PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239019PMC
December 2015

Aberrant expression of aldehyde dehydrogenase 1A (ALDH1A) subfamily genes in acute lymphoblastic leukaemia is a common feature of T-lineage tumours.

Br J Haematol 2015 Jan 11;168(2):246-57. Epub 2014 Sep 11.

Division of Children's Leukaemia and Cancer Research, Telethon Kids Institute, University of Western Australia, Perth, WA, 6008, Australia.

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http://dx.doi.org/10.1111/bjh.13120DOI Listing
January 2015

Deregulated expression of connective tissue growth factor (CTGF/CCN2) is linked to poor outcome in human cancer.

Int J Cancer 2015 Aug 30;137(3):504-11. Epub 2014 May 30.

Leukaemia and Cancer Division, Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1002/ijc.28972DOI Listing
August 2015

Bioenergetic modulation overcomes glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia.

Br J Haematol 2014 Apr 23;165(1):57-66. Epub 2014 Jan 23.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1111/bjh.12727DOI Listing
April 2014

Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia.

Br J Haematol 2013 Aug 15;162(4):537-41. Epub 2013 Jun 15.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1111/bjh.12417DOI Listing
August 2013

Drug-gene modeling in pediatric T-cell acute lymphoblastic leukemia highlights importance of 6-mercaptopurine for outcome.

Cancer Res 2013 May 22;73(9):2749-59. Epub 2013 Feb 22.

Division of Children's Leukaemia and Cancer Research, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3852DOI Listing
May 2013

FusionFinder: a software tool to identify expressed gene fusion candidates from RNA-Seq data.

PLoS One 2012 27;7(6):e39987. Epub 2012 Jun 27.

Division of Bioinformatics and Biostatistics, Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039987PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384600PMC
January 2013

Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins with acute lymphoblastic leukemia.

Haematologica 2012 Sep 11;97(9):1447-50. Epub 2012 May 11.

Department of Haematology and Oncology, Princess Margaret Hospital for Children, GPO Box D184, Perth, Western Australia.

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http://dx.doi.org/10.3324/haematol.2012.065730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436250PMC
September 2012

Interactions between acute lymphoblastic leukemia and bone marrow stromal cells influence response to therapy.

Leuk Res 2012 Mar 1;36(3):299-306. Epub 2011 Sep 1.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1016/j.leukres.2011.08.001DOI Listing
March 2012

Influence of wild-type MLL on glucocorticoid sensitivity and response to DNA-damage in pediatric acute lymphoblastic leukemia.

Mol Cancer 2010 Oct 28;9:284. Epub 2010 Oct 28.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, University of Western Australia Centre for Child Health Research, Perth, Australia.

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http://dx.doi.org/10.1186/1476-4598-9-284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987983PMC
October 2010

Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia.

Mol Cancer 2010 Jun 24;9:163. Epub 2010 Jun 24.

Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand.

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http://dx.doi.org/10.1186/1476-4598-9-163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224738PMC
June 2010

Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study.

Mol Cancer 2010 May 12;9:105. Epub 2010 May 12.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Perth, Australia.

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http://dx.doi.org/10.1186/1476-4598-9-105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879253PMC
May 2010

Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia.

BMC Genomics 2010 Apr 21;11:256. Epub 2010 Apr 21.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Perth, Western Australia.

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http://dx.doi.org/10.1186/1471-2164-11-256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876122PMC
April 2010

Effective adenovirus-mediated gene transfer into neural stem cells derived from human embryonic stem cells.

Stem Cells Dev 2010 Apr;19(4):569-78

Brain Tumour Research Program, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1089/scd.2009.0183DOI Listing
April 2010

MEIS proteins as partners of the TLX1/HOX11 oncoprotein.

Leuk Res 2010 Mar 25;34(3):358-63. Epub 2009 Jun 25.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, WA 6008, Australia.

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http://dx.doi.org/10.1016/j.leukres.2009.06.003DOI Listing
March 2010

Classic and desmoplastic medulloblastoma: complete case reports and characterizations of two new cell lines.

Neuropathology 2009 Aug 11;29(4):398-409. Epub 2008 Dec 11.

Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1111/j.1440-1789.2008.00989.xDOI Listing
August 2009

Receptor mutation is not a common mechanism of naturally occurring glucocorticoid resistance in leukaemia cell lines.

Leuk Res 2009 Feb 11;33(2):321-5. Epub 2008 Sep 11.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, University of Western Australia Centre for Child Health Research, Perth, Australia.

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http://dx.doi.org/10.1016/j.leukres.2008.08.007DOI Listing
February 2009

The role of BSG (CD147) in acute lymphoblastic leukaemia and relapse.

Br J Haematol 2008 Sep 30;142(6):1000-2. Epub 2008 Jul 30.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07296.xDOI Listing
September 2008

Mechanism of relapse in pediatric acute lymphoblastic leukemia.

Cell Cycle 2008 May 29;7(10):1315-20. Epub 2008 Feb 29.

Children's Cancer Institute Australiafor Medical Research, Experimental Therapeutics Program, PO Box 81 (HighSt), Randwick, Sydney, NSW 2031 Australia.

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http://dx.doi.org/10.4161/cc.7.10.5885DOI Listing
May 2008

Prediction of relapse in paediatric pre-B acute lymphoblastic leukaemia using a three-gene risk index.

Br J Haematol 2008 Mar;140(6):656-64

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Centre for Child Health Research, Unviersity of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2008.06981.xDOI Listing
March 2008

Overexpression of stem cell associated ALDH1A1, a target of the leukemogenic transcription factor TLX1/HOX11, inhibits lymphopoiesis and promotes myelopoiesis in murine hematopoietic progenitors.

Leuk Res 2008 Jun 21;32(6):873-83. Epub 2007 Dec 21.

School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, South Street, Murdoch, Perth WA 6150, Australia.

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http://dx.doi.org/10.1016/j.leukres.2007.11.001DOI Listing
June 2008

Transcriptional regulation of FHL1 by TLX1/HOX11 is dosage, cell-type and promoter context-dependent.

Biochem Biophys Res Commun 2008 Mar 10;367(3):707-13. Epub 2007 Dec 10.

School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, Perth, WA 6150, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0702623
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http://dx.doi.org/10.1016/j.bbrc.2007.12.005DOI Listing
March 2008

High expression of connective tissue growth factor in pre-B acute lymphoblastic leukaemia.

Br J Haematol 2007 Sep;138(6):740-8

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, West Perth, WA, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06739.xDOI Listing
September 2007

TLX1/HOX11 transcription factor inhibits differentiation and promotes a non-haemopoietic phenotype in murine bone marrow cells.

Br J Haematol 2007 Jul;138(1):54-67

School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, Murdoch, Western Australia, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06626.xDOI Listing
July 2007

Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.

Cancer Res 2007 May;67(9):4482-90

Children's Cancer Institute Australia for Medical Research, The University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4244DOI Listing
May 2007

Identification of novel molecular prognostic markers for paediatric T-cell acute lymphoblastic leukaemia.

Br J Haematol 2007 May;137(4):319-28

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06576.xDOI Listing
May 2007

Aberrant over-expression of a forkhead family member, FOXO1A, in a brain tumor cell line.

BMC Cancer 2007 Apr 19;7:67. Epub 2007 Apr 19.

Division of Children's Leukemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1186/1471-2407-7-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1878494PMC
April 2007

In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia.

Br J Haematol 2007 Apr;137(2):109-16

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, and Centre for Child Health Research, University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06527.xDOI Listing
April 2007

A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene.

Gene 2007 Apr 20;391(1-2):223-32. Epub 2007 Jan 20.

School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, Perth WA 6150, Australia.

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http://dx.doi.org/10.1016/j.gene.2006.12.034DOI Listing
April 2007

The role of MYCN in the failure of MYCN amplified neuroblastoma cell lines to G1 arrest after DNA damage.

Cell Cycle 2006 Nov 15;5(22):2639-47. Epub 2006 Nov 15.

Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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https://www.tandfonline.com/doi/full/10.4161/cc.5.22.3443
Publisher Site
http://dx.doi.org/10.4161/cc.5.22.3443DOI Listing
November 2006

Translating microarray data for diagnostic testing in childhood leukaemia.

BMC Cancer 2006 Sep 26;6:229. Epub 2006 Sep 26.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1186/1471-2407-6-229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1609180PMC
September 2006

Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse.

Cancer Res 2006 Feb;66(4):2138-45

Northern Institute for Cancer Research, University of Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2623DOI Listing
February 2006

Is there a folate-related gene-environment interaction in the etiology of childhood acute lymphoblastic leukemia?

Int J Cancer 2006 Jul;119(1):229-32

Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, WA, Australia.

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http://dx.doi.org/10.1002/ijc.21803DOI Listing
July 2006

The gene expression signature of relapse in paediatric acute lymphoblastic leukaemia: implications for mechanisms of therapy failure.

Br J Haematol 2005 Nov;131(4):447-56

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1111/j.1365-2141.2005.05785.xDOI Listing
November 2005

Genomic deletions in cell lines derived from primitive neuroectodermal tumors of the central nervous system.

Cancer Genet Cytogenet 2005 Jun;159(2):105-13

Division of Children's Leukemia and Cancer Research, Telethon Institute for Child Health Research and Center for Child Health Research, The University of Western Australia, P. O. Box 855, West Perth, WA 6872, Australia.

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http://dx.doi.org/10.1016/j.cancergencyto.2004.11.007DOI Listing
June 2005

Gene expression levels assessed by oligonucleotide microarray analysis and quantitative real-time RT-PCR -- how well do they correlate?

BMC Genomics 2005 Apr 27;6:59. Epub 2005 Apr 27.

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1186/1471-2164-6-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142514PMC
April 2005

Gene expression levels in small specimens from patients detected using oligonucleotide arrays.

Mol Biotechnol 2005 Jan;29(1):31-8

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research, P.O.Box 855, West Perth WA 6872, Australia.

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http://dx.doi.org/10.1385/MB:29:1:31DOI Listing
January 2005

Detection of hemizygous deletions in genomic DNA from leukaemia specimens for the diagnosis of patients.

Leuk Res 2005 Feb;29(2):165-71

Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1016/j.leukres.2004.05.021DOI Listing
February 2005

A microarray model system identifies potential new target genes of the proto-oncogene HOX11.

Genes Chromosomes Cancer 2004 Dec;41(4):309-20

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, P.O. Box 855, West Perth WA 6872 Australia.

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http://dx.doi.org/10.1002/gcc.20104DOI Listing
December 2004

Deletion of one copy of the p16INK4A tumor suppressor gene is implicated as a predisposing factor in pediatric leukemia.

Biochem Biophys Res Commun 2004 Jun;318(4):852-5

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2004.04.104DOI Listing
June 2004

Regions syntenic to human 17q are gained in mouse and rat neuroblastoma.

Genes Chromosomes Cancer 2004 Jun;40(2):158-63

Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/gcc.20031DOI Listing
June 2004

Gene expression signatures in lymphoid tumours.

Authors:
Ursula R Kees

Immunol Cell Biol 2004 Apr;82(2):154-60

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1046/j.0818-9641.2004.01236.xDOI Listing
April 2004

The functional mapping of long-range transcription control elements of the HOX11 proto-oncogene.

Biochem Biophys Res Commun 2004 Jan;313(2):327-35

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, West Perth, WA 6872, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2003.11.117DOI Listing
January 2004

Specific alternative HOX11 transcripts are expressed in paediatric neural tumours and T-cell acute lymphoblastic leukaemia.

Gene 2003 Dec;323:89-99

Division of Children's Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, P O Box 855,Western Australia 6872, West Perth, Australia.

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http://dx.doi.org/10.1016/j.gene.2003.09.001DOI Listing
December 2003

Gene expression profiles in a panel of childhood leukemia cell lines mirror critical features of the disease.

Mol Cancer Ther 2003 Jul;2(7):671-7

Telethon Institute for Child Health Research, The University of Western Australia, Perth, Australia and National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.

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July 2003

The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells.

Leuk Res 2003 Jan;27(1):79-84

Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, 27157, Winston-Salem, NC, USA

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http://dx.doi.org/10.1016/s0145-2126(02)00077-2DOI Listing
January 2003

Enforced expression of HOX11 is associated with an immature phenotype in J2E erythroid cells.

Br J Haematol 2002 Sep;118(3):909-17

Division of Children's Leukaemia and Cancer Research, TVW Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, West Perth, Australia.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03704.xDOI Listing
September 2002

Expression and purification of the human homeodomain oncoprotein HOX11.

Protein Expr Purif 2002 Jul;25(2):313-8

Division of Veterinary and Biomedical Sciences, Western Australian Biomedical Research Institute, Murdoch University, Murdoch, WA 6150, Australia.

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http://dx.doi.org/10.1016/s1046-5928(02)00014-1DOI Listing
July 2002