Publications by authors named "Ursula Matulonis"

100Publications

Clinical assays for assessment of homologous recombination DNA repair deficiency.

Gynecol Oncol 2020 Oct 2. Epub 2020 Oct 2.

Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2020.09.029DOI Listing
October 2020

Homologous recombination deficiency real-time clinical assays, ready or not?

Gynecol Oncol 2020 Sep 20. Epub 2020 Sep 20.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, United States of America.

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http://dx.doi.org/10.1016/j.ygyno.2020.08.035DOI Listing
September 2020

Combined pembrolizumab and pegylated liposomal doxorubicin in platinum resistant ovarian cancer: A phase 2 clinical trial.

Gynecol Oncol 2020 Oct 6;159(1):72-78. Epub 2020 Aug 6.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America; Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2020.07.028DOI Listing
October 2020

PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies.

Cancers (Basel) 2020 Jul 25;12(8). Epub 2020 Jul 25.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215-5450, USA.

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http://dx.doi.org/10.3390/cancers12082054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465003PMC
July 2020

Emerging drugs for the treatment of ovarian cancer: a focused review of PARP inhibitors.

Expert Opin Emerg Drugs 2020 06 22;25(2):165-188. Epub 2020 Jun 22.

Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA, USA.

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http://dx.doi.org/10.1080/14728214.2020.1773791DOI Listing
June 2020

Differential blood count as triage tool in evaluation of pelvic masses.

Int J Gynecol Cancer 2020 Jun 2. Epub 2020 Jun 2.

Dana Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/ijgc-2019-001103DOI Listing
June 2020

An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers.

BMC Cancer 2020 Mar 12;20(1):197. Epub 2020 Mar 12.

Department of Computer Science and Engineering, University of Connecticut, Institute of System Genomics, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12885-020-6605-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068944PMC
March 2020

Phase Ib study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer.

Gynecol Oncol 2020 05 18;157(2):379-385. Epub 2020 Feb 18.

Stephenson Cancer Center at the University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Sarah Cannon Research Institute, Nashville, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2020.01.037DOI Listing
May 2020

Prediagnosis and postdiagnosis smoking and survival following diagnosis with ovarian cancer.

Int J Cancer 2020 Aug 2;147(3):736-746. Epub 2019 Dec 2.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

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http://dx.doi.org/10.1002/ijc.32773DOI Listing
August 2020

Choosing wisely: Selecting PARP inhibitor combinations to promote anti-tumor immune responses beyond BRCA mutations.

Gynecol Oncol 2020 02 17;156(2):488-497. Epub 2019 Oct 17.

Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1016/j.ygyno.2019.09.021DOI Listing
February 2020

Outcomes of secondary cytoreductive surgery for patients with platinum-sensitive recurrent ovarian cancer.

Am J Obstet Gynecol 2019 12 14;221(6):625.e1-625.e14. Epub 2019 Jun 14.

Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA; Division of Gynecologic Oncology, Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.ajog.2019.06.009DOI Listing
December 2019

Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer.

N Engl J Med 2019 06;380(24):2317-2326

From Northwestern University (D. Matei) and Loyola University (W.S.) - both in Chicago; NRG Oncology Statistical and Data Center, Roswell Park Comprehensive Cancer Center, Buffalo, NY (V.F., H.Q.H.); University of Kentucky, Lexington (M.E.R.); Washington University School of Medicine, Siteman Cancer Center, St. Louis (D. Mutch, M.A.P.); Women and Infants Hospital in Rhode Island-The Warren Alpert Medical School of Brown University, Providence (M.M.S., P.A.D.); Stephenson Cancer Center Gynecologic Cancers Clinic, University of Oklahoma Health Sciences Center, Oklahoma City (K.M.M.); Asan Medical Center, University of Ulsan, Songpa-gu, Seoul, South Korea (Y.M.K.); Ohio State University, Columbus (D.M.O.); Women's Cancer Center of Nevada, Las Vegas (N.M.S.); University of California Irvine Medical Center, Irvine (K.S.T.); Lewis Cancer and Research Pavilion at St. Joseph's-Candler, Savannah, GA (W.E.R.); Case Western Reserve University Hospital, Cleveland (J.N.); Dana-Farber Cancer Institute, Boston (U.A.M.); and the University of Texas Southwestern Medical Center, Dallas (D.S.M.).

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http://dx.doi.org/10.1056/NEJMoa1813181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948006PMC
June 2019

Immunotherapy and radiation combinatorial trials in gynecologic cancer: A potential synergy?

Gynecol Oncol 2019 07 14;154(1):236-245. Epub 2019 Apr 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193049
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http://dx.doi.org/10.1016/j.ygyno.2019.03.255DOI Listing
July 2019

Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial.

Lancet Oncol 2019 05 1;20(5):636-648. Epub 2019 Apr 1.

Division of Gynecologic Oncology, Arizona Oncology (US Oncology Network), University of Arizona College of Medicine, Creighton University School of Medicine at St Joseph's Hospital, Phoenix, AZ, USA.

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http://dx.doi.org/10.1016/S1470-2045(19)30029-4DOI Listing
May 2019

Diagnosis and management of a recurrent polymerase-epsilon (POLE)-mutated endometrial cancer.

Gynecol Oncol 2019 06 29;153(3):471-478. Epub 2019 Mar 29.

Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America.

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http://dx.doi.org/10.1016/j.ygyno.2019.03.247DOI Listing
June 2019

-mutated clear cell cervical cancer associated with in-utero diethylstilbestrol exposure.

Gynecol Oncol Rep 2019 May 29;28:15-17. Epub 2019 Jan 29.

Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23525789193001
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http://dx.doi.org/10.1016/j.gore.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357694PMC
May 2019

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.

Cell Rep 2018 12;25(11):2972-2980.e5

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183181
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http://dx.doi.org/10.1016/j.celrep.2018.11.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366450PMC
December 2018

Ovarian Cancer.

Hematol Oncol Clin North Am 2018 12 25;32(6):xiii-xiv. Epub 2018 Sep 25.

Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08898588183079
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http://dx.doi.org/10.1016/j.hoc.2018.09.006DOI Listing
December 2018

Targeting DNA Damage Response and Repair as a Therapeutic Strategy for Ovarian Cancer.

Hematol Oncol Clin North Am 2018 12;32(6):997-1010

Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08898588183075
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http://dx.doi.org/10.1016/j.hoc.2018.07.006DOI Listing
December 2018

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer.

PLoS Biol 2018 08 29;16(8):e2005756. Epub 2018 Aug 29.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2005756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114281PMC
August 2018

Management of newly diagnosed or recurrent ovarian cancer.

Clin Adv Hematol Oncol 2018 Jun;16(6):426-437

Harvard Medical School and Dana-Farber Cancer Institute, Boston, Massachusetts.

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June 2018

Pre-diagnosis and post-diagnosis use of common analgesics and ovarian cancer prognosis (NHS/NHSII): a cohort study.

Lancet Oncol 2018 08 18;19(8):1107-1116. Epub 2018 Jul 18.

Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.

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http://dx.doi.org/10.1016/S1470-2045(18)30373-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242286PMC
August 2018

Durable response in a woman with recurrent low-grade endometrioid endometrial cancer and a germline BRCA2 mutation treated with a PARP inhibitor.

Gynecol Oncol 2018 08 22;150(2):219-226. Epub 2018 Jun 22.

Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.05.028DOI Listing
August 2018

PARP Inhibitors in Ovarian Cancer: A Trailblazing and Transformative Journey.

Clin Cancer Res 2018 09 5;24(17):4062-4065. Epub 2018 Jun 5.

Division of Gynecologic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1314DOI Listing
September 2018

Assessment of a Chemotherapy Response Score (CRS) System for Tubo-Ovarian High-Grade Serous Carcinoma (HGSC).

Int J Gynecol Pathol 2019 May;38(3):230-240

Department of Pathology, Women's and Perinatal Pathology Division (H.M.D., K.C.S., E.E.M., W.R.W., M.S.H., B.J.Q., K.R.L., C.P.C., G.L.M., M.R.N., B.E.H.) Division of Gynecologic Oncology and Reproductive Biology (M.G.M., J.F.L., C.F., N.H., R.S.B.), Brigham and Women's Hospital Department of Pathology, Beth Israel Deaconess Medical Center (M.G., J.L.H., D.I.L.) Medical Gynecologic Oncology Program, Dana-Farber Cancer Institute (E.S., P.A.K., U.A.M.), Harvard Medical School, Boston, Massachusetts Department of Pathology, Duke University Medical Center, Durham, North Carolina (K.C.S.) Department of Gynecology and Obstetrics, Odense University Hospital, University of Southern Denmark, Odense, Denmark (K.M.J.) Department of Pathology, Stanford University, Stanford, California (B.E.H.).

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http://dx.doi.org/10.1097/PGP.0000000000000513DOI Listing
May 2019

The poly (ADP ribose) polymerase inhibitor niraparib: Management of toxicities.

Gynecol Oncol 2018 04 4;149(1):214-220. Epub 2018 Feb 4.

Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.01.011DOI Listing
April 2018

Management of the toxicities of common targeted therapeutics for gynecologic cancers.

Gynecol Oncol 2018 03 1;148(3):591-600. Epub 2018 Feb 1.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.01.010DOI Listing
March 2018

The NCI-MATCH trial and precision medicine in gynecologic cancers.

Gynecol Oncol 2018 03 1;148(3):585-590. Epub 2018 Feb 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183004
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http://dx.doi.org/10.1016/j.ygyno.2018.01.008DOI Listing
March 2018

Targeted Next-Generation Sequencing Reveals Clinically Actionable and Mutations in Low-Grade Serous Ovarian Carcinoma.

JCO Precis Oncol 2018 8;2018. Epub 2018 Nov 8.

Elizabeth H. Stover, Ursula A. Matulonis, and Panagiotis A. Konstantinopoulos, Dana-Farber Cancer Institute, Harvard Medical School; and Colleen Feltmate, Ross S. Berkowitz, and Neal I. Lindeman, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/PO.18.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394870PMC
November 2018

A review of mirvetuximab soravtansine in the treatment of platinum-resistant ovarian cancer.

Future Oncol 2018 Jan 3;14(2):123-136. Epub 2017 Nov 3.

Gillette Center for Gynecologic Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.2217/fon-2017-0379DOI Listing
January 2018

Highlights in Ovarian Cancer From the 2017 American Society of Clinical Oncology Annual Meeting: Commentary.

Clin Adv Hematol Oncol 2017 Aug;15 Suppl 7(8):13-17

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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August 2017

PARP inhibitors in ovarian cancer: evidence, experience and clinical potential.

Ther Adv Med Oncol 2017 Apr 3;9(4):253-267. Epub 2017 Feb 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1177/1758834016687254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405993PMC
April 2017

Niraparib in Recurrent Ovarian Cancer.

N Engl J Med 2017 02;376(8):801-2

Dana–Farber Cancer Institute, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1616633DOI Listing
February 2017

Safety and Activity of Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, in Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer: A Phase I Expansion Study.

J Clin Oncol 2017 Apr 28;35(10):1112-1118. Epub 2016 Dec 28.

Kathleen N. Moore, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Lainie P. Martin, Fox Chase Cancer Center, Philadelphia, PA; David M. O'Malley, Ohio State University James Cancer Center, Columbus, OH; Ursula A. Matulonis, Dana-Farber Cancer Institute; Michael J. Birrer, Massachusetts General Hospital, Boston; Rodrigo Ruiz-Soto, ImmunoGen, Waltham, MA; Jason A. Konner, Memorial Sloan Kettering Cancer Center, New York, NY; Raymond P. Perez, University of Kansas, Fairway, KS; and Todd M. Bauer, Sarah Cannon Research Institute and Tennessee Oncology, Nashville, TN.

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http://dx.doi.org/10.1200/JCO.2016.69.9538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559878PMC
April 2017

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer.

N Engl J Med 2016 12 7;375(22):2154-2164. Epub 2016 Oct 7.

From the Nordic Society of Gynecological Oncology and Rigshospitalet-Copenhagen University Hospital, Copenhagen (M.R.M.), Odense University Hospital (J.H.) and European Network for Gynacological Oncological Trial and Research Unit of General Practice, Institute of Public Health, University of Southern Denmark, Odense (R.D.C.) - all in Denmark; University of Arizona and Creighton University-Phoenix, Phoenix (B.J.M.), and Arizona Oncology Associates, Tuscon (B.J.M., J.B.) - all in Arizona; Princess Margaret Consortium, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto (A.M.O.), British Columbia Cancer Agency, Vancouver (A.V.T.), and McGill University-McGill University Health Centre, Montreal (L.G.) - all in Canada; Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and the University of Munich, Munich (S.M.), and Kliniken Essen Mitte, Essen (A.B.) - both in Germany; Grupo Español de Investigación en Cáncer de Ovario (GEICO) and Hospital Universitario La Paz (A.R.), and GEICO and M.D. Anderson Cancer Center Madrid (A.G.-M.), Madrid; French Investigator Group for Ovarian and Breast Cancer (GINECO) and Institut du Cancer de Montpellier, Montpellier (M.F.), and GINECO and Centre Antoine Lacassagne, Nice (P.F.) - both in France; National Cancer Research Institute and UCL Cancer Institute, University College London, London (J.A.L.); Multicenter Italian Trials in Ovarian Cancer/Mario Negri Gynecologic Oncology Group, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan (D.L.); Belgium and Luxembourg Gynecological Oncology Group and University of Leuven, Leuven, Belgium (I.V.); Kaplan Medical Center, Rehovot, Israel (N.E.B.-B.); AGO-Austria and Medical University Innsbruck, Innsbruck, Austria (C.M.); Central and Eastern European Gynecologic Oncology Group and Uniwersytet Medyczny w Poznaniu, Poznan, Poland (R.M.); Stanford Comprehensive Cancer Institute, Stanford (J.S.B.), and Cedars-Sinai Medical Center, West Hollywood (B.J.R.) - both in California; Oslo University Hospital, Radiumhospitalet, Oslo (A.D.); Northside Hospital, Atlanta (B.B.); Universitetssjukhuset, Linköping, Sweden (P.R.); and Veristat, Southborough (J.P.B.), Tesaro, Waltham (S.A.), and Dana-Farber Cancer Institute, Boston (U.A.M.) - all in Massachusetts.

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http://dx.doi.org/10.1056/NEJMoa1611310DOI Listing
December 2016

Biomarkers of Response and Resistance to DNA Repair Targeted Therapies.

Clin Cancer Res 2016 Dec 27;22(23):5651-5660. Epub 2016 Sep 27.

University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0247DOI Listing
December 2016

Use and Effectiveness of Neoadjuvant Chemotherapy for Treatment of Ovarian Cancer.

J Clin Oncol 2016 11;34(32):3854-3863

Larissa A. Meyer, Charlotte C. Sun, and Charles F. Levenback, The University of Texas MD Anderson Cancer Center, Houston, TX; Angel M. Cronin, Ursula A. Matulonis, and Alexi A. Wright, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA; Kristin Bixel and David M. O'Malley, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Michael A. Bookman, US Oncology Research and Arizona Oncology, Tucson, AZ; Mihaela C. Cristea and Joyce C. Niland, City of Hope Comprehensive Cancer Center, Duarte, CA; Jennifer J. Griggs, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; Robert A. Burger, University of Pennsylvania; and Gina Mantia-Smaldone, Fox Chase Cancer Center, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2016.68.1239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477982PMC
November 2016

Next-Generation Sequencing: Role in Gynecologic Cancers.

J Natl Compr Canc Netw 2016 09;14(9):1165-73

From the Departments of Obstetrics and Gynecology, Division of Gynecologic Oncology, Brigham and Women's Hospital; and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.6004/jnccn.2016.0123DOI Listing
September 2016

Ovarian cancer.

Nat Rev Dis Primers 2016 08 25;2:16061. Epub 2016 Aug 25.

Women's Cancer Program, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nrdp.2016.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290868PMC
August 2016

Prognostic importance of human papillomavirus (HPV) and p16 positivity in squamous cell carcinoma of the vulva treated with radiotherapy.

Gynecol Oncol 2016 08 3;142(2):293-8. Epub 2016 Jun 3.

Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.ygyno.2016.05.019DOI Listing
August 2016

Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model.

Oncoimmunology 2016 Mar 10;5(3):e1090075. Epub 2015 Dec 10.

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1080/2162402X.2015.1090075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839340PMC
March 2016

Moving beyond the platinum sensitive/resistant paradigm for patients with recurrent ovarian cancer.

Gynecol Oncol 2016 06 8;141(3):405-409. Epub 2016 Apr 8.

Cancer Treatment Centers of America, Philadelphia, PA, United States.

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http://dx.doi.org/10.1016/j.ygyno.2016.03.005DOI Listing
June 2016