Ursula B Kaiser

Ursula B Kaiser

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Ursula B Kaiser

Publications by authors named "Ursula B Kaiser"

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GnRH Transactivates Human AMH Receptor Gene via Egr1 and FOXO1 in Gonadotrope Cells.

Neuroendocrinology 2019 28;108(2):65-83. Epub 2018 Oct 28.

Physiologie de l'axe gonadotrope U1133, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Biologie Fonctionnelle et Adaptative UMR 8251, Sorbonne Paris Cité, Université Paris-Diderot, Paris,

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http://dx.doi.org/10.1159/000494890DOI Listing
December 2019

Evolutionary Conservation of MKRN3 and Other Makorins and Their Roles in Puberty Initiation and Endocrine Functions.

Semin Reprod Med 2019 Jul 23;37(4):166-173. Epub 2020 Jan 23.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1055/s-0039-3400965DOI Listing
July 2019

DLK1, Notch Signaling and the Timing of Puberty.

Semin Reprod Med 2019 Jul 23;37(4):174-181. Epub 2020 Jan 23.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1055/s-0039-3400963DOI Listing
July 2019

GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers.

Cell Rep 2019 Jun;27(12):3522-3532.e3

Division of Endocrinology, Diabetes and Hypertension, Departments of Medicine and BCMP, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.062DOI Listing
June 2019

Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints.

Endocr Rev 2019 02;40(1):17-65

Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1210/er.2018-00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270990PMC
February 2019

Central Precocious Puberty Caused by a Heterozygous Deletion in the MKRN3 Promoter Region.

Neuroendocrinology 2018 15;107(2):127-132. Epub 2018 May 15.

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1159/000490059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363361PMC
January 2019

GnRH-A Key Regulator of FSH.

Endocrinology 2019 01;160(1):57-67

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1210/en.2018-00889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304106PMC
January 2019

Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators.

Endocr Rev 2018 08;39(4):424-439

Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1210/er.2017-00246DOI Listing
August 2018

S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism.

J Sex Med 2018 05 30;15(5):654-661. Epub 2018 Mar 30.

Department of Urology, University of Miami, Miami, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsxm.2018.03.002DOI Listing
May 2018

High Frequency of MKRN3 Mutations in Male Central Precocious Puberty Previously Classified as Idiopathic.

Neuroendocrinology 2017 26;105(1):17-25. Epub 2016 May 26.

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1159/000446963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5195904PMC
March 2018

Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression.

Mol Cell Endocrinol 2018 03 2;463:131-141. Epub 2017 Nov 2.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812824PMC
March 2018

Endocrine dysfunction induced by immune checkpoint inhibitors: Practical recommendations for diagnosis and clinical management.

Cancer 2018 03 3;124(6):1111-1121. Epub 2018 Jan 3.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/cncr.31200
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http://dx.doi.org/10.1002/cncr.31200DOI Listing
March 2018

Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse.

Endocrinology 2017 07;158(7):2319-2329

Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/en.2016-1807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505212PMC
July 2017

Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors.

Endocrinology 2017 07;158(7):2284-2291

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/en.2016-1967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505210PMC
July 2017

Computational Analysis of Missense Variants of G Protein-Coupled Receptors Involved in the Neuroendocrine Regulation of Reproduction.

Neuroendocrinology 2016 18;103(3-4):230-9. Epub 2015 Jun 18.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass., USA.

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http://dx.doi.org/10.1159/000435884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684493PMC
May 2017

Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty.

J Clin Endocrinol Metab 2017 05;102(5):1557-1567

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo 01246-093, Brazil.

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http://dx.doi.org/10.1210/jc.2016-3677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443333PMC
May 2017

Time Course of Central Precocious Puberty Development Caused by an MKRN3 Gene Mutation: A Prismatic Case.

Horm Res Paediatr 2016 16;86(2):126-130. Epub 2016 Jul 16.

Departments of Pediatrics and Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061599PMC
http://dx.doi.org/10.1159/000447515DOI Listing
April 2017

Estrogens regulate glycosylation of IgG in women and men.

JCI Insight 2017 02 23;2(4):e89703. Epub 2017 Feb 23.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.89703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313059PMC
February 2017

Functional Gonadotroph Adenomas: Case Series and Report of Literature.

Neurosurgery 2016 Dec;79(6):823-831

*Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; ‡Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; §Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1227/NEU.0000000000001188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912468PMC
December 2016

Reproductive endocrinology: The emotional cost of contraception.

Nat Rev Endocrinol 2016 12;13(1):7-9

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrendo.2016.194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498822PMC
December 2016

GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER.

Mol Endocrinol 2016 Mar 2;30(3):348-60. Epub 2016 Feb 2.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/me.2015-1222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771696PMC
March 2016

Pubertal development and regulation.

Lancet Diabetes Endocrinol 2016 Mar 4;4(3):254-264. Epub 2016 Feb 4.

Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://www.thelancet.com/pdfs/journals/landia/PIIS2213-8587(
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http://linkinghub.elsevier.com/retrieve/pii/S221385871500418
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http://dx.doi.org/10.1016/S2213-8587(15)00418-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192018PMC
March 2016

Candidate gene analysis in a case of congenital absence of the endometrium.

Fertil Res Pract 2016 9;2. Epub 2016 Feb 9.

Department of Obstetrics and Gynecology, Boston University School of Medicine, 85 E. Concord St, 6th floor, Boston, MA 02118 USA.

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http://dx.doi.org/10.1186/s40738-016-0015-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424362PMC
February 2016

RF9 Acts as a KISS1R Agonist In Vivo and In Vitro.

Endocrinology 2015 Dec 29;156(12):4639-48. Epub 2015 Sep 29.

Division of Endocrinology, Diabetes and Hypertension (L.M., H.L., R.S.C., U.B.K.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; Department of Cell Biology, Physiology and Immunology (S.L., L.P., M.T.-S.), University of Córdoba; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, and Instituto Maimónides de Investigación Biomédica de Córdoba/Hospital Universitario Reina Sofia, Córdoba, 14004 Spain; and FiDiPro Program, Department of Physiology (M.T.-S.), University of Turku, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1210/en.2015-1635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655216PMC
December 2015

Decade in review-reproductive endocrinology: Understanding reproductive endocrine disorders.

Authors:
Ursula B Kaiser

Nat Rev Endocrinol 2015 Nov 13;11(11):640-1. Epub 2015 Oct 13.

Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/nrendo.2015.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691350PMC
November 2015

Corticosteroids and immune checkpoint blockade.

Aging (Albany NY) 2015 Aug;7(8):521-2

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA 02115 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586093PMC
http://dx.doi.org/10.18632/aging.100797DOI Listing
August 2015

Editorial: The Rise of the Asterisk: One Step to Facilitate Team Science.

Mol Endocrinol 2015 Jul;29(7):943-5

Divisions of Hematology (M.A.G.) and Endocrinology, Diabetes and Hypertension (U.B.K.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/me.2015-1140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484782PMC
July 2015

Substance p regulates puberty onset and fertility in the female mouse.

Endocrinology 2015 Jun 9;156(6):2313-22. Epub 2015 Apr 9.

Division of Endocrinology, Diabetes and Hypertension (S.S., I.R.T., C.A.M., J.C.G., R.S.C., U.B.K., V.M.N.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; and Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.

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http://dx.doi.org/10.1210/en.2014-2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430622PMC
June 2015

Cushing's disease: towards precision medicine.

Authors:
Ursula B Kaiser

Cell Res 2015 Jun 1;25(6):649-50. Epub 2015 May 1.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/cr.2015.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456621PMC
June 2015

A new pathway in the control of the initiation of puberty: the MKRN3 gene.

J Mol Endocrinol 2015 Jun;54(3):R131-9

Division of EndocrinologyDiabetes and Hypertension, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USAUnidade de Endocrinologia do DesenvolvimentoDisciplina de Endocrinologia e Metabologia, Laboratório de Hormônios e Genética Molecular, LIM 42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Avenida Dr Enéas de Carvalho Aguiar, 255, 7° andar, sala 7037, CEP: 05403-900, São Paulo, Brazil

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http://jme.endocrinology-journals.org/content/54/3/R131.full
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http://jme.endocrinology-journals.org/cgi/doi/10.1530/JME-14
Publisher Site
http://dx.doi.org/10.1530/JME-14-0315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573396PMC
June 2015

The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction.

Endocrinology 2015 Feb 25;156(2):627-37. Epub 2014 Nov 25.

Division of Endocrinology, Diabetes, and Hypertension (V.M.N., S.S., R.S.C., U.B.K.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Physiology and Pharmacology (M.A.B., O.K.R.), Oregon Health and Science University, Portland, Oregon 97239; Department of Cell Biology, Physiology, and Immunology (S.L., L.P., M.T.-S.), University of Córdoba; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (S.L., L.P., M.T.-S.), Instituto de Salud Carlos III; and Instituto Maimónides de Investigaciones Biomédicas and Hospital Universitario Reina Sofia (S.L., L.P., M.T.-S.), 14004 Córdoba, Spain; Department of Obstetrics and Gynecology (S.S.), Pamukkale University School of Medicine, Denizli, 20020 Turkey; and Massachusetts General Hospital and Harvard Medical School (C.T., S.B.S.), Boston, Massachusetts 02114.

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http://dx.doi.org/10.1210/en.2014-1651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298326PMC
February 2015

KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse.

Endocrinology 2014 Nov 22;155(11):4433-46. Epub 2014 Aug 22.

The Children's Health Research Institute (M.A., M.P., A.V.B.), London, Ontario, Canada; Lawson Health Research Institute (M.A., M.P., A.V.B.), London, Ontario, Canada; Departments of Obstetrics and Gynaecology (M.P., A.V.B.), Physiology and Pharmacology (M.A., M.B., A.V.B.), and Oncology (M.B.), The University of Western Ontario, London, Ontario, Canada N6C 2V5; Division of Endocrinology, Diabetes, and Hypertension (L.M., J.W., K.S., R.S.C., U.B.K.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Biomedical Sciences (C.N., S.A.T.), Colorado State University, Fort Collins, Colorado 80523; and Department of Reproductive Medicine (C.A.G.-K., P.L.M.), Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, California 92093.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2014-1304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197989PMC
November 2014

Editorial: advances in neuroscience: the BRAIN initiative and implications for neuroendocrinology.

Authors:
Ursula B Kaiser

Mol Endocrinol 2014 Oct;28(10):1589-91

Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/me.2014-1288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179630PMC
October 2014

Role of gonadotropin-releasing hormone receptor mutations in patients with a wide spectrum of pubertal delay.

Fertil Steril 2014 Sep 10;102(3):838-846.e2. Epub 2014 Jul 10.

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Disciplina de Endocrinologia e Metabologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.fertnstert.2014.05.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149947PMC
September 2014

Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3.

J Clin Endocrinol Metab 2014 Jun 14;99(6):E1097-103. Epub 2014 Mar 14.

Unidade de Endocrinologia do Desenvolvimento e Laboratório de Hormônios e Genética Molecular/LIM42, Disciplina de Endocrinologia (D.B.M., A.P.A., L.R.M., D.B., P.C., L.F.G.S., M.G.T., I.J.P.A., B.B.M., V.N.B., A.C.L.), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil, 05403-900; Departamento de Puericultura e Pediatria (A.C.S.R., M.C., A.C.M., C.E.M., S.R.A.), Faculdade de Medicina de Ribeirão Preto, da Universidade de São Paulo, Ribeirão Preto, SP, Brasil, 14049900; Division of Endocrinology, Diabetes, and Hypertension (A.P.A., R.S.C., U.B.K.), Brigham and Women's Hospital and Harvard Medical School and Division of Endocrinology, (A.D., J.N.H.) Boston Children's Hospital, Boston, Massachusetts 02115, Program in Medical and Population Genetics Broad Institute (A.D., J.N.H.), Cambridge, Massachusetts 02142; Unidade de Endocrinologia Pediátrica (G.G.J., G.G.F.), Universidade de Campinas, SP, Brasil, 13084-970; and Medical Faculty Skopje (Z.G.), 50 Divizija BB, 1000 Skopje, Macedonia.

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http://dx.doi.org/10.1210/jc.2013-3126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037732PMC
June 2014

TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients.

FASEB J 2014 Apr 27;28(4):1924-37. Epub 2013 Dec 27.

1Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115, USA.

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http://dx.doi.org/10.1096/fj.13-240630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963009PMC
April 2014

Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone.

J Neurosci 2014 Apr;34(17):6047-56

Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1523/JNEUROSCI.3003-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996222PMC
April 2014

GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression.

Mol Cell Endocrinol 2014 Mar 19;385(1-2):28-35. Epub 2013 Sep 19.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2013.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947649PMC
March 2014

Dynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signaling.

Mol Endocrinol 2014 Jan 2;28(1):16-27. Epub 2013 Dec 2.

Division of Endocrinology, Diabetes and Hypertension (L.M., K.S., A.C.S.R., S.X., W.K., M.J., R.S.C., U.B.K.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115; and School of Medicine of Ribeirao Preto (A.C.S.R.), University of Sao Paulo, Brazil 14040-900.

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http://dx.doi.org/10.1210/me.2013-1165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874457PMC
January 2014

A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells.

Math Biosci 2013 Nov 3;246(1):38-46. Epub 2013 Oct 3.

Physical Sciences Inc., 20 New England Business Center, Andover, MA 01810-1077, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mbs.2013.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096114PMC
November 2013

Molecular biology of the kisspeptin receptor: signaling, function, and mutations.

Adv Exp Med Biol 2013 ;784:133-58

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1007/978-1-4614-6199-9_7DOI Listing
August 2013

Metabolic influences on neuroendocrine regulation of reproduction.

Curr Opin Endocrinol Diabetes Obes 2013 Aug;20(4):335-41

Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1097/MED.0b013e32836318ceDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898855PMC
August 2013

GnRH pulse frequency-dependent stimulation of FSHβ transcription is mediated via activation of PKA and CREB.

Mol Endocrinol 2013 Apr 7;27(4):606-18. Epub 2013 Feb 7.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1210/me.2012-1281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607701PMC
April 2013

LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation.

Mol Cell 2013 Feb 20;49(3):558-70. Epub 2012 Dec 20.

Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Department of Biological Chemistry & Molecular Pharmacology, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625064PMC
February 2013

Single-cell analyses reveal that KISS1R-expressing cells undergo sustained kisspeptin-induced signaling that is dependent upon an influx of extracellular Ca2+.

Endocrinology 2012 Dec 15;153(12):5875-87. Epub 2012 Oct 15.

Children's Health Research Institute, The University of Western Ontario, London, Ontario, Canada N6C 2V5.

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http://dx.doi.org/10.1210/en.2012-1747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512071PMC
December 2012

Hyperprolactinemia and infertility: new insights.

Authors:
Ursula B Kaiser

J Clin Invest 2012 Oct;122(10):3467-8

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461927PMC
http://dx.doi.org/10.1172/jci64455DOI Listing
October 2012

When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR).

J Clin Endocrinol Metab 2012 Sep 28;97(9):E1798-807. Epub 2012 Jun 28.

Harvard Center for Reproductive Sciences and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, BHX 504, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1210/jc.2012-1264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431570PMC
September 2012

Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function.

Mol Endocrinol 2012 Aug 28;26(8):1417-27. Epub 2012 Jun 28.

Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1210/me.2012-1102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404297PMC
August 2012

G protein-coupled receptors involved in GnRH regulation: molecular insights from human disease.

Mol Cell Endocrinol 2011 Oct 29;346(1-2):91-101. Epub 2011 Jun 29.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.mce.2011.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185177PMC
October 2011

The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations.

Endocr Rev 2011 Apr 29;32(2):225-46. Epub 2010 Oct 29.

Harvard Center for Reproductive Endocrine Sciences, Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, 02114, USA.

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http://dx.doi.org/10.1210/er.2010-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365793PMC
April 2011

KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation.

Endocrinology 2011 Apr 1;152(4):1616-26. Epub 2011 Feb 1.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1210/en.2010-0903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060635PMC
April 2011

Clinical problem-solving. Lying low.

N Engl J Med 2011 Mar;364(9):871-5

Clinical Pathological Conference Series, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1056/NEJMcps0903869DOI Listing
March 2011

Interactive medical case. Lying low.

N Engl J Med 2011 Feb;364(6):e10

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http://www.nejm.org/doi/10.1056/NEJMimc1010297
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February 2011

Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons.

Neuroendocrinology 2010 7;92(2):81-99. Epub 2010 Jul 7.

Harvard Reproductive Endocrine Sciences Center of Excellence, Reproductive Endocrine Unit of the Department of Medicine of the Massachusetts General Hospital and Endocrine Division of the Brigham and Women's Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1159/000314193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214927PMC
December 2010

The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism.

Neuroendocrinology 2010 21;91(4):283-90. Epub 2010 May 21.

Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular, LIM/42, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.

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http://dx.doi.org/10.1159/000308880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2968764PMC
November 2010

Cushing's disease and idiopathic intracranial hypertension: case report and review of underlying pathophysiological mechanisms.

J Clin Endocrinol Metab 2010 Nov 25;95(11):4850-4. Epub 2010 Aug 25.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1210/jc.2010-0896DOI Listing
November 2010

Lymphocytic hypophysitis with diabetes insipidus in a young man.

Nat Rev Endocrinol 2010 Aug 29;6(8):464-70. Epub 2010 Jun 29.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/nrendo.2010.104DOI Listing
August 2010

Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

Mol Cell 2010 Jul;39(2):222-33

Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518444PMC
July 2010

Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice.

PLoS One 2010 Jul 30;5(7):e11911. Epub 2010 Jul 30.

Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912854PMC
July 2010

Deciphering genetic disease in the genomic era: the model of GnRH deficiency.

Sci Transl Med 2010 May;2(32):32rv2

Harvard Reproductive Endocrine Sciences Center, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.3000288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936248PMC
May 2010

Clinical problem-solving. Stalking the diagnosis.

N Engl J Med 2010 Mar;362(9):834-9

Clinical Pathological Conference Series, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcps0806157DOI Listing
March 2010

Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factors.

Mol Cell Biol 2010 Feb 14;30(4):1028-40. Epub 2009 Dec 14.

Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115, USA.

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http://dx.doi.org/10.1128/MCB.00848-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815570PMC
February 2010

The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism.

Nat Rev Endocrinol 2009 Oct 25;5(10):569-76. Epub 2009 Aug 25.

Department of Molecular and Cellular Pharmacology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.

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http://www.nature.com/doifinder/10.1038/nrendo.2009.177
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864719PMC
October 2009

The biology of gonadotroph regulation.

Curr Opin Endocrinol Diabetes Obes 2009 Aug;16(4):321-7

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.

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https://insights.ovid.com/crossref?an=01266029-200908000-000
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http://dx.doi.org/10.1097/MED.0b013e32832d88fbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862266PMC
August 2009

Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis.

Endocrinology 2009 Jul 12;150(7):3383-91. Epub 2009 Mar 12.

Harvard Medical School, Brigham and Women's Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1210/en.2008-1362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703545PMC
July 2009

The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice.

Endocrinology 2008 Sep 22;149(9):4596-604. Epub 2008 May 22.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1210/en.2008-0403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553368PMC
September 2008

A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta gene.

Mol Endocrinol 2008 Aug 11;22(8):1908-23. Epub 2008 Jun 11.

Brigham and Women's Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 0211, USA.

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http://dx.doi.org/10.1210/me.2007-0455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725769PMC
August 2008

Genetic labeling: new approaches to creating a gonadotroph "ID".

Authors:
Ursula B Kaiser

Endocrinology 2008 Jun;149(6):2699-700

Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1210/en.2008-0365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408798PMC
June 2008

A GPR54-activating mutation in a patient with central precocious puberty.

N Engl J Med 2008 Feb;358(7):709-15

Developmental Endocrinology Unit, Medical Investigation Laboratory, Clinicas Hospital, São Paulo University Medical School, São Paulo.

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http://dx.doi.org/10.1056/NEJMoa073443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859966PMC
February 2008

Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies.

Mol Endocrinol 2007 Dec 23;21(12):3013-27. Epub 2007 Aug 23.

Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20889, USA.

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http://dx.doi.org/10.1210/me.2005-0337DOI Listing
December 2007

Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function.

Semin Reprod Med 2007 Sep;25(5):368-78

Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada.

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http://dx.doi.org/10.1055/s-2007-984743DOI Listing
September 2007

Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice.

Am J Physiol Endocrinol Metab 2007 Feb 26;292(2):E523-32. Epub 2006 Sep 26.

Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1152/ajpendo.00372.2005DOI Listing
February 2007

GPR54 and KiSS-1: role in the regulation of puberty and reproduction.

Rev Endocr Metab Disord 2006 Dec;7(4):257-63

Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1007/s11154-006-9020-2DOI Listing
December 2006

Gonadotropin-releasing hormone pulse frequency-dependent activation of extracellular signal-regulated kinase pathways in perifused LbetaT2 cells.

Endocrinology 2005 Dec 1;146(12):5503-13. Epub 2005 Sep 1.

Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1210/en.2004-1317DOI Listing
December 2005

A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation.

Mol Endocrinol 2005 Apr 29;19(4):972-81. Epub 2004 Dec 29.

Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1210/me.2004-0192DOI Listing
April 2005

New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1.

Endocrinology 2005 Apr;146(4):1686-8

Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1210/en.2005-0070DOI Listing
April 2005

KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty.

Endocrine 2005 Apr;26(3):277-84

Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://link.springer.com/10.1385/ENDO:26:3:277
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http://dx.doi.org/10.1385/ENDO:26:3:277DOI Listing
April 2005

Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene.

Mol Endocrinol 2005 Jan 16;19(1):237-54. Epub 2004 Sep 16.

Brigham and Women's Hospital and Harvard Medical School, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1210/me.2003-0473DOI Listing
January 2005

Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcription.

Mol Endocrinol 2005 Jan 23;19(1):148-62. Epub 2004 Sep 23.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1210/me.2004-0025DOI Listing
January 2005