Publications by authors named "Urmi Dhagat"

27Publications

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.

MAbs 2018 10 12;10(7):1018-1029. Epub 2018 Sep 12.

a St. Vincent's Institute of Medical Research , Australian Cancer Research Foundation Rational Drug Discovery Centre , Fitzroy , Victoria , Australia.

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http://dx.doi.org/10.1080/19420862.2018.1494107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204844PMC
October 2018

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.

Structure 2016 08 7;24(8):1271-1281. Epub 2016 Jul 7.

ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.05.017DOI Listing
August 2016

The βc receptor family - Structural insights and their functional implications.

Cytokine 2015 Aug 14;74(2):247-58. Epub 2015 May 14.

Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S10434666150006
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http://dx.doi.org/10.1016/j.cyto.2015.02.005DOI Listing
August 2015

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

Acta Crystallogr F Struct Biol Commun 2014 Mar 19;70(Pt 3):358-61. Epub 2014 Feb 19.

Australian Cancer Research Foundation Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.1107/S2053230X14002593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944702PMC
March 2014

Signalling by the βc family of cytokines.

Cytokine Growth Factor Rev 2013 Jun 25;24(3):189-201. Epub 2013 Mar 25.

The Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1016/j.cytogfr.2013.03.002DOI Listing
June 2013

Activation of aldo-keto reductase family member 1B14 (AKR1B14) by bile acids: Activation mechanism and bile acid-binding site.

Biochimie 2011 Sep 10;93(9):1476-86. Epub 2011 May 10.

Laboratory of Biochemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan.

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http://dx.doi.org/10.1016/j.biochi.2011.04.022DOI Listing
September 2011

Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis.

Bioorg Med Chem Lett 2011 Apr 22;21(8):2564-7. Epub 2011 Jan 22.

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2011.01.076DOI Listing
April 2011

Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis.

Bioorg Med Chem Lett 2011 Jan 24;21(2):801-4. Epub 2010 Nov 24.

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2010.11.086DOI Listing
January 2011

Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1).

J Steroid Biochem Mol Biol 2011 May 2;125(1-2):105-11. Epub 2010 Nov 2.

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.jsbmb.2010.10.006DOI Listing
May 2011

Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors.

Eur J Med Chem 2010 Nov 17;45(11):5309-17. Epub 2010 Sep 17.

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.ejmech.2010.08.052DOI Listing
November 2010

Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme.

Bioorg Med Chem Lett 2010 Sep 1;20(17):5274-6. Epub 2010 Jul 1.

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2010.06.137DOI Listing
September 2010

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

Acta Crystallogr D Biol Crystallogr 2010 Feb 22;66(Pt 2):198-204. Epub 2010 Jan 22.

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1107/S0907444909051464DOI Listing
February 2010

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

Acta Crystallogr D Biol Crystallogr 2009 Mar 20;65(Pt 3):257-65. Epub 2009 Feb 20.

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

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http://scripts.iucr.org/cgi-bin/paper?S0907444908044028
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http://dx.doi.org/10.1107/S0907444908044028DOI Listing
March 2009

Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4).

Arch Biochem Biophys 2009 Jan 21;481(2):183-90. Epub 2008 Nov 21.

Laboratory of Biochemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.

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http://dx.doi.org/10.1016/j.abb.2008.11.014DOI Listing
January 2009

Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid.

J Med Chem 2008 Aug 12;51(15):4844-8. Epub 2008 Jul 12.

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1021/jm8003575DOI Listing
August 2008

Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.

Bioorg Med Chem 2008 Mar 15;16(6):3245-54. Epub 2007 Dec 15.

Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Vic. 3052, Australia.

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http://dx.doi.org/10.1016/j.bmc.2007.12.016DOI Listing
March 2008

A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase.

Med Chem 2007 Nov;3(6):546-50

Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.2174/157340607782360399DOI Listing
November 2007

Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Oct 19;63(Pt 10):825-30. Epub 2007 Sep 19.

Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1107/S1744309107040985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2339726PMC
October 2007