Uri Ben-David

Uri Ben-David

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Uri Ben-David

Uri Ben-David

Publications by authors named "Uri Ben-David"

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32Publications

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Context is everything: aneuploidy in cancer.

Nat Rev Genet 2019 Sep 23. Epub 2019 Sep 23.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41576-019-0171-xDOI Listing
September 2019

Genomic evolution of cancer models: perils and opportunities.

Nat Rev Cancer 2019 02;19(2):97-109

Broad Institute of Harvard and MIT, Cambridge, MA, USA.

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http://www.nature.com/articles/s41568-018-0095-3
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http://dx.doi.org/10.1038/s41568-018-0095-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493335PMC
February 2019

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer.

Cell Death Dis 2018 08 6;9(8):832. Epub 2018 Aug 6.

Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, IMRIC, Jerusalem, Israel.

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http://dx.doi.org/10.1038/s41419-018-0896-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079009PMC
August 2018

Patient-derived xenografts undergo mouse-specific tumor evolution.

Nat Genet 2017 Nov 9;49(11):1567-1575. Epub 2017 Oct 9.

Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659952PMC
November 2017

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Cancer Discov 2016 08 3;6(8):914-29. Epub 2016 Jun 3.

Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972686PMC
August 2016

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.

Nat Commun 2016 07 4;7:12160. Epub 2016 Jul 4.

Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/ncomms12160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932194PMC
July 2016

Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects.

Cell Stem Cell 2016 Feb 5;18(2):253-61. Epub 2015 Dec 5.

Department of Genetics, The Hebrew University, Jerusalem, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.11.003DOI Listing
February 2016

Flowing through the CRISPR-CAScade: Will genome editing boost cell therapies?

Authors:
Uri Ben-David

Mol Cell Ther 2013 6;1. Epub 2013 Nov 6.

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, 91904 Israel.

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http://dx.doi.org/10.1186/2052-8426-1-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448953PMC
June 2015

Genomic instability, driver genes and cell selection: Projections from cancer to stem cells.

Authors:
Uri Ben-David

Biochim Biophys Acta 2015 Apr 15;1849(4):427-35. Epub 2014 Aug 15.

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.08.005DOI Listing
April 2015

Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies.

Stem Cells Transl Med 2015 Apr 26;4(4):389-400. Epub 2015 Feb 26.

Medical Research Council Centre for Drug Safety Science, Division of Molecular & Clinical Pharmacology, Institute of Translational Medicine, and Institute of Integrative Biology, University of Liverpool, Liverpool, U.K.; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Pharmazentrum, University of Basel, Basel, Switzerland; Laboratorios Almirall, S.A. Laurea Miro, Sant Feliu de Llobregat, Spain; SANOFI-Research & Development, Disposition, Safety and Animal Research, Alfortville, France; Uppsala Biomedicinska Centrum BMC, Husarg, Uppsala University, Uppsala, Sweden; Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield, U.K.; Developmental & Regenerative Biomedicine, School of Biomedicine, Faculty of Human and Medical Sciences, University of Manchester, Manchester, U.K.; Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, U.K.; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; OakMore Solutions Ltd., Faversham, U.K.; ReNeuron Limited, Guildford, U.K.; Medicines and Healthcare Products Regulatory Agency, London, U.K.; Paul Ehrlich Institut, Langen, Germany; Faculty of Science, Leiden Academic Centre for Drug Research, Toxicology, Leiden, The Netherlands; Stem Cell Unit, Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat-Ram, Jerusalem, Israel; U.K. Stem Cell Bank, National Institute for Biological Standards and Control, Medicines and Healthcare Products Regulatory Agency, Potters Bar, U.K.; Cellectis AB, Göteborg, Sweden; GSK, David Jack Centre for Research & Development, Ware, U.K.; Personalised Healthcare and Biomarkers, AstraZeneca, Macclesfield, U.K.; CN-bio Innovations Limited, Centre for Innovation & Enterprise, Begbroke, U.K.; Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland; School of Bio Scien

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http://dx.doi.org/10.5966/sctm.2014-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367503PMC
April 2015

Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha.

Stem Cells 2015 Mar;33(3):1013-9

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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http://doi.wiley.com/10.1002/stem.1888
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http://dx.doi.org/10.1002/stem.1888DOI Listing
March 2015

Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells.

Cell Stem Cell 2014 Dec;15(6):687-91

Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909140046
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http://dx.doi.org/10.1016/j.stem.2014.10.018DOI Listing
December 2014

Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells.

Nat Commun 2014 Sep 8;5:4825. Epub 2014 Sep 8.

1] Department of Biomedical Sciences and Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1038/ncomms5825DOI Listing
September 2014

Elimination of undifferentiated cancer cells by pluripotent stem cell inhibitors.

J Mol Cell Biol 2014 Jun 27;6(3):267-9. Epub 2014 Mar 27.

Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel

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http://dx.doi.org/10.1093/jmcb/mju012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055828PMC
June 2014

Chemical ablation of tumor-initiating human pluripotent stem cells.

Nat Protoc 2014 Mar 27;9(3):729-40. Epub 2014 Feb 27.

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/nprot.2014.050DOI Listing
March 2014

Quality control: Genome maintenance in pluripotent stem cells.

J Cell Biol 2014 Jan;204(2):153-63

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1083/jcb.201310135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897183PMC
January 2014

Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells.

Nat Commun 2013 ;4:1992

Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/ncomms2992DOI Listing
December 2013

Virtual karyotyping of pluripotent stem cells on the basis of their global gene expression profiles.

Nat Protoc 2013 May 25;8(5):989-97. Epub 2013 Apr 25.

Department of Genetics, Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/nprot.2013.051DOI Listing
May 2013

New balance in pluripotency: reprogramming with lineage specifiers.

Cell 2013 May;153(5):939-40

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1016/j.cell.2013.04.051DOI Listing
May 2013

Expanding the boundaries of embryonic stem cells.

Cell Stem Cell 2012 Jun;10(6):666-677

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2012.05.003DOI Listing
June 2012

High prevalence of evolutionarily conserved and species-specific genomic aberrations in mouse pluripotent stem cells.

Stem Cells 2012 Apr;30(4):612-22

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1002/stem.1057DOI Listing
April 2012

Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells.

Cell Stem Cell 2011 Aug;9(2):97-102

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 91904, Israel.

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http://dx.doi.org/10.1016/j.stem.2011.06.013DOI Listing
August 2011

Assessing the safety of stem cell therapeutics.

Cell Stem Cell 2011 Jun;8(6):618-28

MRC Centre for Drug Safety Science, Division of Molecular & Clinical Pharmacology, The Institute of Translational Medicine, The University of Liverpool, Liverpool L69 3GE, UK.

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http://dx.doi.org/10.1016/j.stem.2011.05.012DOI Listing
June 2011

The tumorigenicity of human embryonic and induced pluripotent stem cells.

Nat Rev Cancer 2011 Apr 10;11(4):268-77. Epub 2011 Mar 10.

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://www.nature.com/articles/nrc3034
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http://dx.doi.org/10.1038/nrc3034DOI Listing
April 2011

Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.

Cell Stem Cell 2010 Oct;7(4):521-31

Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1016/j.stem.2010.07.017DOI Listing
October 2010