Publications by authors named "Uri Ben-David"

40 Publications

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.

Proc Natl Acad Sci U S A 2020 12 17;117(48):30566-30576. Epub 2020 Nov 17.

David H. Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

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December 2020

Adding to the CASeload: unwarranted p53 signaling induced by Cas9.

Mol Cell Oncol 2020 14;7(5):1789419. Epub 2020 Jul 14.

Department of Human Molecular Genetics & Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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July 2020

Elevated expression of ACE2 in tumor-adjacent normal tissues of cancer patients.

Int J Cancer 2020 12 17;147(11):3264-3266. Epub 2020 Jul 17.

Department of Human Molecular Genetics and Biochemistry, School of Medicine, Tel Aviv University, Tel Aviv, Israel.

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December 2020

Context is everything: aneuploidy in cancer.

Nat Rev Genet 2020 01 23;21(1):44-62. Epub 2019 Sep 23.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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January 2020

Genomic evolution of cancer models: perils and opportunities.

Nat Rev Cancer 2019 02;19(2):97-109

Broad Institute of Harvard and MIT, Cambridge, MA, USA.

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February 2019

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer.

Cell Death Dis 2018 08 6;9(8):832. Epub 2018 Aug 6.

Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, IMRIC, Jerusalem, Israel.

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August 2018

Patient-derived xenografts undergo mouse-specific tumor evolution.

Nat Genet 2017 Nov 9;49(11):1567-1575. Epub 2017 Oct 9.

Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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November 2017

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.

Nat Commun 2016 07 4;7:12160. Epub 2016 Jul 4.

Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.

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July 2016

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Cancer Discov 2016 08 3;6(8):914-29. Epub 2016 Jun 3.

Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.

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August 2016

Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects.

Cell Stem Cell 2016 Feb 5;18(2):253-61. Epub 2015 Dec 5.

Department of Genetics, The Hebrew University, Jerusalem, Israel. Electronic address:

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February 2016

Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies.

Stem Cells Transl Med 2015 Apr 26;4(4):389-400. Epub 2015 Feb 26.

Medical Research Council Centre for Drug Safety Science, Division of Molecular & Clinical Pharmacology, Institute of Translational Medicine, and Institute of Integrative Biology, University of Liverpool, Liverpool, U.K.; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Pharmazentrum, University of Basel, Basel, Switzerland; Laboratorios Almirall, S.A. Laurea Miro, Sant Feliu de Llobregat, Spain; SANOFI-Research & Development, Disposition, Safety and Animal Research, Alfortville, France; Uppsala Biomedicinska Centrum BMC, Husarg, Uppsala University, Uppsala, Sweden; Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield, U.K.; Developmental & Regenerative Biomedicine, School of Biomedicine, Faculty of Human and Medical Sciences, University of Manchester, Manchester, U.K.; Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, U.K.; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; OakMore Solutions Ltd., Faversham, U.K.; ReNeuron Limited, Guildford, U.K.; Medicines and Healthcare Products Regulatory Agency, London, U.K.; Paul Ehrlich Institut, Langen, Germany; Faculty of Science, Leiden Academic Centre for Drug Research, Toxicology, Leiden, The Netherlands; Stem Cell Unit, Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat-Ram, Jerusalem, Israel; U.K. Stem Cell Bank, National Institute for Biological Standards and Control, Medicines and Healthcare Products Regulatory Agency, Potters Bar, U.K.; Cellectis AB, Göteborg, Sweden; GSK, David Jack Centre for Research & Development, Ware, U.K.; Personalised Healthcare and Biomarkers, AstraZeneca, Macclesfield, U.K.; CN-bio Innovations Limited, Centre for Innovation & Enterprise, Begbroke, U.K.; Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland; School of Bio Scien

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April 2015

Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells.

Cell Stem Cell 2014 Dec;15(6):687-91

Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address:

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December 2014

Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha.

Stem Cells 2015 Mar;33(3):1013-9

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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March 2015

Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells.

Nat Commun 2014 Sep 8;5:4825. Epub 2014 Sep 8.

1] Department of Biomedical Sciences and Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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September 2014

Genomic instability, driver genes and cell selection: Projections from cancer to stem cells.

Authors:
Uri Ben-David

Biochim Biophys Acta 2015 Apr 15;1849(4):427-35. Epub 2014 Aug 15.

Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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April 2015

Elimination of undifferentiated cancer cells by pluripotent stem cell inhibitors.

J Mol Cell Biol 2014 Jun 27;6(3):267-9. Epub 2014 Mar 27.

Stem Cell Unit, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel

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June 2014

Chemical ablation of tumor-initiating human pluripotent stem cells.

Nat Protoc 2014 Mar 27;9(3):729-40. Epub 2014 Feb 27.

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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March 2014

Quality control: Genome maintenance in pluripotent stem cells.

J Cell Biol 2014 Jan;204(2):153-63

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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January 2014

Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells.

Nat Commun 2013 ;4:1992

Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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December 2013

New balance in pluripotency: reprogramming with lineage specifiers.

Cell 2013 May;153(5):939-40

Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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May 2013