Unnur Thorsteinsdottir

Unnur Thorsteinsdottir

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Unnur Thorsteinsdottir

Unnur Thorsteinsdottir

Publications by authors named "Unnur Thorsteinsdottir"

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100Publications

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Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.

Authors:
Unnur Styrkarsdottir Sigrun H Lund Gudmar Thorleifsson Florian Zink Olafur A Stefansson Jon K Sigurdsson Kristinn Juliusson Kristbjörg Bjarnadottir Sara Sigurbjornsdottir Stefan Jonsson Kristjan Norland Lilja Stefansdottir Asgeir Sigurdsson Gardar Sveinbjornsson Asmundur Oddsson Gyda Bjornsdottir Reynir L Gudmundsson Gisli H Halldorsson Thorunn Rafnar Ingileif Jonsdottir Eirikur Steingrimsson Gudmundur L Norddahl Gisli Masson Patrick Sulem Helgi Jonsson Thorvaldur Ingvarsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2018 Dec 29;50(12):1681-1687. Epub 2018 Oct 29.

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.

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December 2018

Multiple transmissions of de novo mutations in families.

Authors:
Hákon Jónsson Patrick Sulem Gudny A Arnadottir Gunnar Pálsson Hannes P Eggertsson Snaedis Kristmundsdottir Florian Zink Birte Kehr Kristjan E Hjorleifsson Brynjar Ö Jensson Ingileif Jonsdottir Sigurdur Einar Marelsson Sigurjon Axel Gudjonsson Arnaldur Gylfason Adalbjorg Jonasdottir Aslaug Jonasdottir Simon N Stacey Olafur Th Magnusson Unnur Thorsteinsdottir Gisli Masson Augustine Kong Bjarni V Halldorsson Agnar Helgason Daniel F Gudbjartsson Kari Stefansson

Nat Genet 2018 Dec 5;50(12):1674-1680. Epub 2018 Nov 5.

deCODE genetics/Amgen Inc., Reykjavik, Iceland.

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December 2018

Author Correction: The rate of meiotic gene conversion varies by sex and age.

Authors:
Bjarni V Halldorsson Marteinn T Hardarson Birte Kehr Unnur Styrkarsdottir Arnaldur Gylfason Gudmar Thorleifsson Florian Zink Adalbjorg Jonasdottir Aslaug Jonasdottir Patrick Sulem Gisli Masson Unnur Thorsteinsdottir Agnar Helgason Augustine Kong Daniel F Gudbjartsson Kari Stefansson

Nat Genet 2018 Nov;50(11):1616

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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November 2018

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.

Authors:
Anubha Mahajan Daniel Taliun Matthias Thurner Neil R Robertson Jason M Torres N William Rayner Anthony J Payne Valgerdur Steinthorsdottir Robert A Scott Niels Grarup James P Cook Ellen M Schmidt Matthias Wuttke Chloé Sarnowski Reedik Mägi Jana Nano Christian Gieger Stella Trompet Cécile Lecoeur Michael H Preuss Bram Peter Prins Xiuqing Guo Lawrence F Bielak Jennifer E Below Donald W Bowden John Campbell Chambers Young Jin Kim Maggie C Y Ng Lauren E Petty Xueling Sim Weihua Zhang Amanda J Bennett Jette Bork-Jensen Chad M Brummett Mickaël Canouil Kai-Uwe Ec Kardt Krista Fischer Sharon L R Kardia Florian Kronenberg Kristi Läll Ching-Ti Liu Adam E Locke Jian'an Luan Ioanna Ntalla Vibe Nylander Sebastian Schönherr Claudia Schurmann Loïc Yengo Erwin P Bottinger Ivan Brandslund Cramer Christensen George Dedoussis Jose C Florez Ian Ford Oscar H Franco Timothy M Frayling Vilmantas Giedraitis Sophie Hackinger Andrew T Hattersley Christian Herder M Arfan Ikram Martin Ingelsson Marit E Jørgensen Torben Jørgensen Jennifer Kriebel Johanna Kuusisto Symen Ligthart Cecilia M Lindgren Allan Linneberg Valeriya Lyssenko Vasiliki Mamakou Thomas Meitinger Karen L Mohlke Andrew D Morris Girish Nadkarni James S Pankow Annette Peters Naveed Sattar Alena Stančáková Konstantin Strauch Kent D Taylor Barbara Thorand Gudmar Thorleifsson Unnur Thorsteinsdottir Jaakko Tuomilehto Daniel R Witte Josée Dupuis Patricia A Peyser Eleftheria Zeggini Ruth J F Loos Philippe Froguel Erik Ingelsson Lars Lind Leif Groop Markku Laakso Francis S Collins J Wouter Jukema Colin N A Palmer Harald Grallert Andres Metspalu Abbas Dehghan Anna Köttgen Goncalo R Abecasis James B Meigs Jerome I Rotter Jonathan Marchini Oluf Pedersen Torben Hansen Claudia Langenberg Nicholas J Wareham Kari Stefansson Anna L Gloyn Andrew P Morris Michael Boehnke Mark I McCarthy

Nat Genet 2018 Nov 8;50(11):1505-1513. Epub 2018 Oct 8.

Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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November 2018

Insights into imprinting from parent-of-origin phased methylomes and transcriptomes.

Authors:
Florian Zink Droplaug N Magnusdottir Olafur T Magnusson Nicolas J Walker Tiffany J Morris Asgeir Sigurdsson Gisli H Halldorsson Sigurjon A Gudjonsson Pall Melsted Helga Ingimundardottir Snædis Kristmundsdottir Kristjan F Alexandersson Anna Helgadottir Julius Gudmundsson Thorunn Rafnar Ingileif Jonsdottir Hilma Holm Gudmundur Ingi Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Gisli Masson Daniel F Gudbjartsson Unnur Thorsteinsdottir Bjarni V Halldorsson Simon N Stacey Kari Stefansson

Nat Genet 2018 Nov 22;50(11):1542-1552. Epub 2018 Oct 22.

deCODE genetics/AMGEN, Reykjavik, Iceland.

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November 2018

Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.

Authors:
Julius Gudmundsson Jon K Sigurdsson Lilja Stefansdottir Bjarni A Agnarsson Helgi J Isaksson Olafur A Stefansson Sigurjon A Gudjonsson Daniel F Gudbjartsson Gisli Masson Michael L Frigge Simon N Stacey Patrick Sulem Gisli H Halldorsson Vinicius Tragante Hilma Holm Gudmundur I Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Thorvaldur Jonsson Eirikur Jonsson Rosa B Barkardottir Rafn Hilmarsson Folkert W Asselbergs Gudmundur Geirsson Unnur Thorsteinsdottir Thorunn Rafnar Gudmar Thorleifsson Kari Stefansson

Nat Commun 2018 Nov 8;9(1):4568. Epub 2018 Nov 8.

deCODE genetics/AMGEN, 101, Reykjavik, Iceland.

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November 2018

Sequence variants associating with urinary biomarkers.

Authors:
Stefania Benonisdottir Ragnar P Kristjansson Asmundur Oddsson Valgerdur Steinthorsdottir Evgenia Mikaelsdottir Birte Kehr Brynjar O Jensson Gudny A Arnadottir Gerald Sulem Gardar Sveinbjornsson Snaedis Kristmundsdottir Erna V Ivarsdottir Lotte K Vogel Tragante Vinicius Bjarni Gunnarsson Hrafnhildur Linnet Runolfsdottir Joseph G Arthur Aimee M Deaton Gudmundur I Eyjolfsson Olafur B Davidsson Folkert W Asselbergs Astradur B Hreidarsson Thorunn Rafnar Gudmar Thorleifsson Vidar Edvardsson Gunnar Sigurdsson Anna Helgadottir Bjarni V Halldorsson Gisli Masson Hilma Holm Pall T Onundarson Olafur S Indridason Rafn Benediktsson Runolfur Palsson Daniel F Gudbjartsson Isleifur Olafsson Unnur Thorsteinsdottir Patrick Sulem Kari Stefansson

Hum Mol Genet 2018 Nov 24. Epub 2018 Nov 24.

deCODE genetics/Amgen Inc., Reykjavik, Iceland.

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November 2018

Genome-wide association meta-analysis yields 20 loci associated with gallstone disease.

Authors:
Egil Ferkingstad Asmundur Oddsson Solveig Gretarsdottir Stefania Benonisdottir Gudmar Thorleifsson Aimee M Deaton Stefan Jonsson Olafur A Stefansson Gudmundur L Norddahl Florian Zink Gudny A Arnadottir Bjarni Gunnarsson Gisli H Halldorsson Anna Helgadottir Brynjar O Jensson Ragnar P Kristjansson Gardar Sveinbjornsson David A Sverrisson Gisli Masson Isleifur Olafsson Gudmundur I Eyjolfsson Olof Sigurdardottir Hilma Holm Ingileif Jonsdottir Sigurdur Olafsson Thora Steingrimsdottir Thorunn Rafnar Einar S Bjornsson Unnur Thorsteinsdottir Daniel F Gudbjartsson Patrick Sulem Kari Stefansson

Nat Commun 2018 Nov 30;9(1):5101. Epub 2018 Nov 30.

deCODE Genetics/Amgen, Inc., Reykjavik, 101, Iceland.

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November 2018

A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease.

Authors:
Gudny A Arnadottir Gudmundur L Norddahl Steinunn Gudmundsdottir Arna B Agustsdottir Snaevar Sigurdsson Brynjar O Jensson Kristbjorg Bjarnadottir Fannar Theodors Stefania Benonisdottir Erna V Ivarsdottir Asmundur Oddsson Ragnar P Kristjansson Gerald Sulem Kristjan F Alexandersson Thorhildur Juliusdottir Kjartan R Gudmundsson Jona Saemundsdottir Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Paolo Manzanillo Sigurjon A Gudjonsson Gudmundur A Thorisson Olafur Th Magnusson Gisli Masson Kjartan B Orvar Hilma Holm Sigurdur Bjornsson Reynir Arngrimsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Ingileif Jonsdottir Asgeir Haraldsson Patrick Sulem Kari Stefansson

Nat Commun 2018 10 25;9(1):4447. Epub 2018 Oct 25.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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October 2018

A rare missense mutation in MYH6 associates with non-syndromic coarctation of the aorta.

Authors:
Thorsteinn Bjornsson Rosa B Thorolfsdottir Gardar Sveinbjornsson Patrick Sulem Gudmundur L Norddahl Anna Helgadottir Solveig Gretarsdottir Audur Magnusdottir Ragnar Danielsen Emil L Sigurdsson Berglind Adalsteinsdottir Sverrir I Gunnarsson Ingileif Jonsdottir David O Arnar Hrodmar Helgason Tomas Gudbjartsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Hilma Holm Kari Stefansson

Eur Heart J 2018 Sep;39(34):3243-3249

deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik, Iceland.

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September 2018

Association of BRCA2 K3326* With Small Cell Lung Cancer and Squamous Cell Cancer of the Skin.

Authors:
Thorunn Rafnar Gudbjorg R Sigurjonsdottir Simon N Stacey Gisli Halldorsson Patrick Sulem Luba M Pardo Hannes Helgason Stefan T Sigurdsson Thorkell Gudjonsson Laufey Tryggvadottir Gudridur H Olafsdottir Jon G Jonasson Kristin Alexiusdottir Asgeir Sigurdsson Julius Gudmundsson Jona Saemundsdottir Jon K Sigurdsson Hrefna Johannsdottir Andre Uitterlinden Sita H Vermeulen Tessel E Galesloot Dawn C Allain Martin Lacko Bardur Sigurgeirsson Kristin Thorisdottir Oskar T Johannsson Fridbjorn Sigurdsson Gunnar B Ragnarsson Helgi Isaksson Hronn Hardardottir Tomas Gudbjartsson Daniel F Gudbjartsson Gisli Masson Lambertus A M L Kiemeney Amanda Ewart Toland Tamar Nijsten Wilbert H M Peters Jon H Olafsson Steinn Jonsson Unnur Thorsteinsdottir Gudmar Thorleifsson Kari Stefansson

J Natl Cancer Inst 2018 Sep;110(9):967-974

deCODE Genetics/Amgen, Reykjavik, Iceland.

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September 2018

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.

Authors:
Jonas B Nielsen Rosa B Thorolfsdottir Lars G Fritsche Wei Zhou Morten W Skov Sarah E Graham Todd J Herron Shane McCarthy Ellen M Schmidt Gardar Sveinbjornsson Ida Surakka Michael R Mathis Masatoshi Yamazaki Ryan D Crawford Maiken E Gabrielsen Anne Heidi Skogholt Oddgeir L Holmen Maoxuan Lin Brooke N Wolford Rounak Dey Håvard Dalen Patrick Sulem Jonathan H Chung Joshua D Backman David O Arnar Unnur Thorsteinsdottir Aris Baras Colm O'Dushlaine Anders G Holst Xiaoquan Wen Whitney Hornsby Frederick E Dewey Michael Boehnke Sachin Kheterpal Bhramar Mukherjee Seunggeun Lee Hyun M Kang Hilma Holm Jacob Kitzman Jordan A Shavit José Jalife Chad M Brummett Tanya M Teslovich David J Carey Daniel F Gudbjartsson Kari Stefansson Gonçalo R Abecasis Kristian Hveem Cristen J Willer

Nat Genet 2018 Sep 30;50(9):1234-1239. Epub 2018 Jul 30.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.

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September 2018

Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.

Authors:
Kerrin S Small Marijana Todorčević Mete Civelek Julia S El-Sayed Moustafa Xiao Wang Michelle M Simon Juan Fernandez-Tajes Anubha Mahajan Momoko Horikoshi Alison Hugill Craig A Glastonbury Lydia Quaye Matt J Neville Siddharth Sethi Marianne Yon Calvin Pan Nam Che Ana Vinuela Pei-Chien Tsai Abhishek Nag Alfonso Buil Gudmar Thorleifsson Avanthi Raghavan Qiurong Ding Andrew P Morris Jordana T Bell Unnur Thorsteinsdottir Kari Stefansson Markku Laakso Ingrid Dahlman Peter Arner Anna L Gloyn Kiran Musunuru Aldons J Lusis Roger D Cox Fredrik Karpe Mark I McCarthy

Nat Genet 2018 Sep;50(9):1342

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.

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September 2018

Relatedness disequilibrium regression estimates heritability without environmental bias.

Authors:
Alexander I Young Michael L Frigge Daniel F Gudbjartsson Gudmar Thorleifsson Gyda Bjornsdottir Patrick Sulem Gisli Masson Unnur Thorsteinsdottir Kari Stefansson Augustine Kong

Nat Genet 2018 Sep 13;50(9):1304-1310. Epub 2018 Aug 13.

deCODE genetics/Amgen Inc., Reykjavik, Iceland.

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September 2018

Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.

Authors:
Thorunn Rafnar Bjarni Gunnarsson Olafur A Stefansson Patrick Sulem Andres Ingason Michael L Frigge Lilja Stefansdottir Jon K Sigurdsson Vinicius Tragante Valgerdur Steinthorsdottir Unnur Styrkarsdottir Simon N Stacey Julius Gudmundsson Gudny A Arnadottir Asmundur Oddsson Florian Zink Gisli Halldorsson Gardar Sveinbjornsson Ragnar P Kristjansson Olafur B Davidsson Anna Salvarsdottir Asgeir Thoroddsen Elisabet A Helgadottir Katrin Kristjansdottir Orri Ingthorsson Valur Gudmundsson Reynir T Geirsson Ragnheidur Arnadottir Daniel F Gudbjartsson Gisli Masson Folkert W Asselbergs Jon G Jonasson Karl Olafsson Unnur Thorsteinsdottir Bjarni V Halldorsson Gudmar Thorleifsson Kari Stefansson

Nat Commun 2018 09 7;9(1):3636. Epub 2018 Sep 7.

deCODE Genetics/Amgen, Sturlugata 8, 101, Reykjavik, Iceland.

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September 2018

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.

Authors:
Molly Went Amit Sud Asta Försti Britt-Marie Halvarsson Niels Weinhold Scott Kimber Mark van Duin Gudmar Thorleifsson Amy Holroyd David C Johnson Ni Li Giulia Orlando Philip J Law Mina Ali Bowang Chen Jonathan S Mitchell Daniel F Gudbjartsson Rowan Kuiper Owen W Stephens Uta Bertsch Peter Broderick Chiara Campo Obul R Bandapalli Hermann Einsele Walter A Gregory Urban Gullberg Jens Hillengass Per Hoffmann Graham H Jackson Karl-Heinz Jöckel Ellinor Johnsson Sigurður Y Kristinsson Ulf-Henrik Mellqvist Hareth Nahi Douglas Easton Paul Pharoah Alison Dunning Julian Peto Federico Canzian Anthony Swerdlow Rosalind A Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan Jolanta Nickel Markus M Nöthen Thorunn Rafnar Fiona M Ross Miguel Inacio da Silva Filho Hauke Thomsen Ingemar Turesson Annette Vangsted Niels Frost Andersen Anders Waage Brian A Walker Anna-Karin Wihlborg Annemiek Broyl Faith E Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Hartmut Goldschmidt Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J Morgan Kari Hemminki Björn Nilsson Richard S Houlston

Nat Commun 2018 09 13;9(1):3707. Epub 2018 Sep 13.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.

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September 2018

Corrigendum to "Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency" [J. Chromatogr. B 1036-1037 (2016) 170-177].

Authors:
Margret Thorsteinsdottir Unnur A Thorsteinsdottir Finnur F Eiriksson Hrafnhildur L Runolfsdottir Inger M Sch Agustsdottir Steinunn Oddsdottir Baldur B Sigurdsson Hordur K Hardarson Nilesh R Kamble Snorri Th Sigurdsson Vidar O Edvardsson Runolfur Palsson

J Chromatogr B Analyt Technol Biomed Life Sci 2018 08 1;1092:530. Epub 2018 Jun 1.

University of Iceland, Reykjavik, Iceland; Division of Nephrology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.

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August 2018

Variants in NKX2-5 and FLNC Cause Dilated Cardiomyopathy and Sudden Cardiac Death.

Authors:
Gardar Sveinbjornsson Eva F Olafsdottir Rosa B Thorolfsdottir Olafur B Davidsson Anna Helgadottir Adalbjorg Jonasdottir Aslaug Jonasdottir Eythor Bjornsson Brynjar O Jensson Gudny A Arnadottir Hallfridur Kristinsdottir Sigurdur S Stephensen Gylfi Oskarsson Tomas Gudbjartsson Emil L Sigurdsson Karl Andersen Ragnar Danielsen David O Arnar Ingileif Jonsdottir Unnur Thorsteinsdottir Patrick Sulem Gudmundur Thorgeirsson Daniel F Gudbjartsson Hilma Holm Kari Stefansson

Circ Genom Precis Med 2018 Aug;11(8):e002151

Adalbjorg Jonasdottir, Aslaug Jonasdottir, E.B., B.O.J., G.A.A., D.O.A., I.J., U.T., P.S., G.T., D.F.G., H.H., K.S.).

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August 2018

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Authors:
Bram P Prins Timothy J Mead Jennifer A Brody Gardar Sveinbjornsson Ioanna Ntalla Nathan A Bihlmeyer Marten van den Berg Jette Bork-Jensen Stefania Cappellani Stefan Van Duijvenboden Nikolai T Klena George C Gabriel Xiaoqin Liu Cagri Gulec Niels Grarup Jeffrey Haessler Leanne M Hall Annamaria Iorio Aaron Isaacs Ruifang Li-Gao Honghuang Lin Ching-Ti Liu Leo-Pekka Lyytikäinen Jonathan Marten Hao Mei Martina Müller-Nurasyid Michele Orini Sandosh Padmanabhan Farid Radmanesh Julia Ramirez Antonietta Robino Molly Schwartz Jessica van Setten Albert V Smith Niek Verweij Helen R Warren Stefan Weiss Alvaro Alonso David O Arnar Michiel L Bots Rudolf A de Boer Anna F Dominiczak Mark Eijgelsheim Patrick T Ellinor Xiuqing Guo Stephan B Felix Tamara B Harris Caroline Hayward Susan R Heckbert Paul L Huang J W Jukema Mika Kähönen Jan A Kors Pier D Lambiase Lenore J Launer Man Li Allan Linneberg Christopher P Nelson Oluf Pedersen Marco Perez Annette Peters Ozren Polasek Bruce M Psaty Olli T Raitakari Kenneth M Rice Jerome I Rotter Moritz F Sinner Elsayed Z Soliman Tim D Spector Konstantin Strauch Unnur Thorsteinsdottir Andrew Tinker Stella Trompet André Uitterlinden Ilonca Vaartjes Peter van der Meer Uwe Völker Henry Völzke Melanie Waldenberger James G Wilson Zhijun Xie Folkert W Asselbergs Marcus Dörr Cornelia M van Duijn Paolo Gasparini Daniel F Gudbjartsson Vilmundur Gudnason Torben Hansen Stefan Kääb Jørgen K Kanters Charles Kooperberg Terho Lehtimäki Henry J Lin Steven A Lubitz Dennis O Mook-Kanamori Francesco J Conti Christopher H Newton-Cheh Jonathan Rosand Igor Rudan Nilesh J Samani Gianfranco Sinagra Blair H Smith Hilma Holm Bruno H Stricker Sheila Ulivi Nona Sotoodehnia Suneel S Apte Pim van der Harst Kari Stefansson Patricia B Munroe Dan E Arking Cecilia W Lo Yalda Jamshidi

Genome Biol 2018 07 17;19(1):87. Epub 2018 Jul 17.

Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London, SW17 0RE, UK.

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July 2018

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Authors:
Jessica van Setten Jennifer A Brody Yalda Jamshidi Brenton R Swenson Anne M Butler Harry Campbell Fabiola M Del Greco Daniel S Evans Quince Gibson Daniel F Gudbjartsson Kathleen F Kerr Bouwe P Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M Nolte Sandosh Padmanabhan Marylyn D Ritchie Antonietta Robino Albert V Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O Arnar Folkert W Asselbergs Joel S Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M Buckley Mina K Chung Dana Crawford Marcel den Hoed Josh C Denny Anna F Dominiczak Georg B Ehret Mark Eijgelsheim Patrick T Ellinor Stephan B Felix Oscar H Franco Lude Franke Tamara B Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A Kors Edward G Lakatta Lenore J Launer Honghuang Lin Henry J Lin Ruth J F Loos Steven A Lubitz Peter W Macfarlane Jared W Magnani Irene Mateo Leach Thomas Meitinger Braxton D Mitchell Thomas Munzel George J Papanicolaou Annette Peters Arne Pfeufer Peter P Pramstaller Olli T Raitakari Jerome I Rotter Igor Rudan Nilesh J Samani David Schlessinger Claudia T Silva Aldana Moritz F Sinner Jonathan D Smith Harold Snieder Elsayed Z Soliman Timothy D Spector David J Stott Konstantin Strauch Kirill V Tarasov Unnur Thorsteinsdottir Andre G Uitterlinden David R Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S Wild Tanja Zeller Alvaro Alonso Christy L Avery Stefania Bandinelli Emelia J Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R Heckbert Andrew A Hicks J Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B Munroe Afshin Parsa Ozren Polasek Bruce M Psaty Dan M Roden Renate B Schnabel Gianfranco Sinagra Kari Stefansson Bruno H Stricker Pim van der Harst Cornelia M van Duijn James F Wilson Sina A Gharib Paul I W de Bakker Aaron Isaacs Dan E Arking Nona Sotoodehnia

Nat Commun 2018 07 25;9(1):2904. Epub 2018 Jul 25.

Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA.

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July 2018

Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease.

Authors:
Anna Helgadottir Patrick Sulem Gudmundur Thorgeirsson Solveig Gretarsdottir Gudmar Thorleifsson Brynjar Ö Jensson Gudny A Arnadottir Isleifur Olafsson Gudmundur I Eyjolfsson Olof Sigurdardottir Unnur Thorsteinsdottir Daniel F Gudbjartsson Hilma Holm Kari Stefansson

Eur Heart J 2018 Jun;39(23):2172-2178

deCODE Genetics/Amgen, Inc., Sturlugata 8, 101 Reykjavik, Iceland.

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June 2018

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Authors:
Viktoria Gusarova Colm O'Dushlaine Tanya M Teslovich Peter N Benotti Tooraj Mirshahi Omri Gottesman Cristopher V Van Hout Michael F Murray Anubha Mahajan Jonas B Nielsen Lars Fritsche Anders Berg Wulff Daniel F Gudbjartsson Marketa Sjögren Connor A Emdin Robert A Scott Wen-Jane Lee Aeron Small Lydia C Kwee Om Prakash Dwivedi Rashmi B Prasad Shannon Bruse Alexander E Lopez John Penn Anthony Marcketta Joseph B Leader Christopher D Still H Lester Kirchner Uyenlinh L Mirshahi Amr H Wardeh Cassandra M Hartle Lukas Habegger Samantha N Fetterolf Teresa Tusie-Luna Andrew P Morris Hilma Holm Valgerdur Steinthorsdottir Patrick Sulem Unnur Thorsteinsdottir Jerome I Rotter Lee-Ming Chuang Scott Damrauer David Birtwell Chad M Brummett Amit V Khera Pradeep Natarajan Marju Orho-Melander Jason Flannick Luca A Lotta Cristen J Willer Oddgeir L Holmen Marylyn D Ritchie David H Ledbetter Andrew J Murphy Ingrid B Borecki Jeffrey G Reid John D Overton Ola Hansson Leif Groop Svati H Shah William E Kraus Daniel J Rader Yii-Der I Chen Kristian Hveem Nicholas J Wareham Sekar Kathiresan Olle Melander Kari Stefansson Børge G Nordestgaard Anne Tybjærg-Hansen Goncalo R Abecasis David Altshuler Jose C Florez Michael Boehnke Mark I McCarthy George D Yancopoulos David J Carey Alan R Shuldiner Aris Baras Frederick E Dewey Jesper Gromada

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

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June 2018

Coding variants in and increase risk of atrial fibrillation.

Authors:
Rosa B Thorolfsdottir Gardar Sveinbjornsson Patrick Sulem Jonas B Nielsen Stefan Jonsson Gisli H Halldorsson Pall Melsted Erna V Ivarsdottir Olafur B Davidsson Ragnar P Kristjansson Gudmar Thorleifsson Anna Helgadottir Solveig Gretarsdottir Gudmundur Norddahl Sridharan Rajamani Bjarni Torfason Atli S Valgardsson Jon T Sverrisson Vinicius Tragante Oddgeir L Holmen Folkert W Asselbergs Dan M Roden Dawood Darbar Terje R Pedersen Marc S Sabatine Cristen J Willer Maja-Lisa Løchen Bjarni V Halldorsson Ingileif Jonsdottir Kristian Hveem David O Arnar Unnur Thorsteinsdottir Daniel F Gudbjartsson Hilma Holm Kari Stefansson

Commun Biol 2018 12;1:68. Epub 2018 Jun 12.

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.

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June 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Authors:
Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Grabe Struan F A Grant Niels Grarup Helen L Griffiths Megan L Grove Vilmundur Gudnason Stefan Gustafsson Jeff Haessler Hakon Hakonarson Anke R Hammerschlag Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Christian T Have Caroline Hayward Liang He Nancy L Heard-Costa Andrew C Heath Iris M Heid Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Yao Hu Paul L Huang Jennifer E Huffman M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Yucheng Jia Stefan Johansson Marit E Jørgensen Torben Jørgensen J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Sekar Kathiresan Frank Kee Lambertus A Kiemeney Eric Kim Hidetoshi Kitajima Pirjo Komulainen Jaspal S Kooner Charles Kooperberg Tellervo Korhonen Peter Kovacs Helena Kuivaniemi Zoltán Kutalik Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo A Lakka David Lamparter Ethan M Lange Leslie A Lange Claudia Langenberg Eric B Larson Nanette R Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Keng-Hung Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Ching-Ti Liu Dajiang J Liu Yongmei Liu Ken S Lo Artitaya Lophatananon Andrew J Lotery Anu Loukola Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen Satu Männistö Gaëlle Marenne Angela L Mazul Mark I McCarthy Roberta McKean-Cowdin Sarah E Medland Karina Meidtner Lili Milani Vanisha Mistry Paul Mitchell Karen L Mohlke Leena Moilanen Marie Moitry Grant W Montgomery Dennis O Mook-Kanamori Carmel Moore Trevor A Mori Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Narisu Narisu Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Dale R Nyholt Jeffrey R O'Connel Michelle L O'Donoghue Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Nicholette D Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Tune H Pers Thomas N Person Annette Peters Eva R B Petersen Patricia A Peyser Ailith Pirie Ozren Polasek Tinca J Polderman Hannu Puolijoki Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Frida Renström Myriam Rheinberger Paul M Ridker John D Rioux Manuel A Rivas David J Roberts Neil R Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Yadav Sapkota Naveed Sattar Robert E Schoen Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati H Shah Wayne H-H Sheu Xueling Sim Andrew J Slater Kerrin S Small Albert V Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kari Stefansson Valgerdur Steinthorsdottir Kathleen E Stirrups Konstantin Strauch Heather M Stringham Michael Stumvoll Liang Sun Praveen Surendran Amy J Swift Hayato Tada Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Matti Uusitupa Sander W Laan Cornelia M Duijn Nienke Leeuwen Jessica van Setten Mauno Vanhala Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Giovanni Veronesi Henrik Vestergaard Veronique Vitart Thomas F Vogt Uwe Völker Dragana Vuckovic Lynne E Wagenknecht Mark Walker Lars Wallentin Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Erin B Ware Nicholas J Wareham Helen R Warren Dawn M Waterworth Jennifer Wessel Harvey D White Cristen J Willer James G Wilson Daniel R Witte Andrew R Wood Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhou Krina T Zondervan Jerome I Rotter John A Pospisilik Fernando Rivadeneira Ingrid B Borecki Panos Deloukas Timothy M Frayling Guillaume Lettre Kari E North Cecilia M Lindgren Joel N Hirschhorn Ruth J F Loos

Nat Genet 2018 May;50(5):765-766

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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May 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Authors:
Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Grabe Struan F A Grant Niels Grarup Helen L Griffiths Megan L Grove Vilmundur Gudnason Stefan Gustafsson Jeff Haessler Hakon Hakonarson Anke R Hammerschlag Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Christian T Have Caroline Hayward Liang He Nancy L Heard-Costa Andrew C Heath Iris M Heid Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Yao Hu Paul L Huang Jennifer E Huffman M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Yucheng Jia Stefan Johansson Marit E Jørgensen Torben Jørgensen J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Sekar Kathiresan Frank Kee Lambertus A Kiemeney Eric Kim Hidetoshi Kitajima Pirjo Komulainen Jaspal S Kooner Charles Kooperberg Tellervo Korhonen Peter Kovacs Helena Kuivaniemi Zoltán Kutalik Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo A Lakka David Lamparter Ethan M Lange Leslie A Lange Claudia Langenberg Eric B Larson Nanette R Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Keng-Hung Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Ching-Ti Liu Dajiang J Liu Yongmei Liu Ken S Lo Artitaya Lophatananon Andrew J Lotery Anu Loukola Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen Satu Männistö Gaëlle Marenne Angela L Mazul Mark I McCarthy Roberta McKean-Cowdin Sarah E Medland Karina Meidtner Lili Milani Vanisha Mistry Paul Mitchell Karen L Mohlke Leena Moilanen Marie Moitry Grant W Montgomery Dennis O Mook-Kanamori Carmel Moore Trevor A Mori Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Narisu Narisu Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Dale R Nyholt Jeffrey R O'Connel Michelle L O'Donoghue Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Nicholette D Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Tune H Pers Thomas N Person Annette Peters Eva R B Petersen Patricia A Peyser Ailith Pirie Ozren Polasek Tinca J Polderman Hannu Puolijoki Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Frida Renström Myriam Rheinberger Paul M Ridker John D Rioux Manuel A Rivas David J Roberts Neil R Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Yadav Sapkota Naveed Sattar Robert E Schoen Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati H Shah Wayne H-H Sheu Xueling Sim Andrew J Slater Kerrin S Small Albert V Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kari Stefansson Valgerdur Steinthorsdottir Kathleen E Stirrups Konstantin Strauch Heather M Stringham Michael Stumvoll Liang Sun Praveen Surendran Amy J Swift Hayato Tada Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Matti Uusitupa Sander W Laan Cornelia M Duijn Nienke Leeuwen Jessica van Setten Mauno Vanhala Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Giovanni Veronesi Henrik Vestergaard Veronique Vitart Thomas F Vogt Uwe Völker Dragana Vuckovic Lynne E Wagenknecht Mark Walker Lars Wallentin Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Erin B Ware Nicholas J Wareham Helen R Warren Dawn M Waterworth Jennifer Wessel Harvey D White Cristen J Willer James G Wilson Daniel R Witte Andrew R Wood Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao Wei Zhou Krina T Zondervan Jerome I Rotter John A Pospisilik Fernando Rivadeneira Ingrid B Borecki Panos Deloukas Timothy M Frayling Guillaume Lettre Kari E North Cecilia M Lindgren Joel N Hirschhorn Ruth J F Loos

Nat Genet 2018 May;50(5):766-767

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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May 2018

A truncating mutation in EPOR leads to hypo-responsiveness to erythropoietin with normal haemoglobin.

Authors:
Gudjon R Oskarsson Ragnar P Kristjansson Amy L Lee Gardar Sveinbjornsson Magnus K Magnusson Erna V Ivarsdottir Stefania Benonisdottir Asmundur Oddsson Olafur B Davidsson Jona Saemundsdottir Gisli H Halldorsson Joseph Arthur Gudny A Arnadottir Gisli Masson Brynjar O Jensson Hilma Holm Isleifur Olafsson Pall T Onundarson Daniel F Gudbjartsson Gudmundur L Norddahl Unnur Thorsteinsdottir Patrick Sulem Kari Stefansson

Commun Biol 2018 17;1:49. Epub 2018 May 17.

deCODE genetics/Amgen, Inc, 101 Reykjavik, Iceland.

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May 2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Najaf Amin Hugo S Aparicio Donna K Arnett John Attia Alexa S Beiser Claudine Berr Julie E Buring Mariana Bustamante Valeria Caso Yu-Ching Cheng Seung Hoan Choi Ayesha Chowhan Natalia Cullell Jean-François Dartigues Hossein Delavaran Pilar Delgado Marcus Dörr Gunnar Engström Ian Ford Wander S Gurpreet Anders Hamsten Laura Heitsch Atsushi Hozawa Laura Ibanez Andreea Ilinca Martin Ingelsson Motoki Iwasaki Rebecca D Jackson Katarina Jood Pekka Jousilahti Sara Kaffashian Lalit Kalra Masahiro Kamouchi Takanari Kitazono Olafur Kjartansson Manja Kloss Peter J Koudstaal Jerzy Krupinski Daniel L Labovitz Cathy C Laurie Christopher R Levi Linxin Li Lars Lind Cecilia M Lindgren Vasileios Lioutas Yong Mei Liu Oscar L Lopez Hirata Makoto Nicolas Martinez-Majander Koichi Matsuda Naoko Minegishi Joan Montaner Andrew P Morris Elena Muiño Martina Müller-Nurasyid Bo Norrving Soichi Ogishima Eugenio A Parati Leema Reddy Peddareddygari Nancy L Pedersen Joanna Pera Markus Perola Alessandro Pezzini Silvana Pileggi Raquel Rabionet Iolanda Riba-Llena Marta Ribasés Jose R Romero Jaume Roquer Anthony G Rudd Antti-Pekka Sarin Ralhan Sarju Chloe Sarnowski Makoto Sasaki Claudia L Satizabal Mamoru Satoh Naveed Sattar Norie Sawada Gerli Sibolt Ásgeir Sigurdsson Albert Smith Kenji Sobue Carolina Soriano-Tárraga Tara Stanne O Colin Stine David J Stott Konstantin Strauch Takako Takai Hideo Tanaka Kozo Tanno Alexander Teumer Liisa Tomppo Nuria P Torres-Aguila Emmanuel Touze Shoichiro Tsugane Andre G Uitterlinden Einar M Valdimarsson Sven J van der Lee Henry Völzke Kenji Wakai David Weir Stephen R Williams Charles D A Wolfe Quenna Wong Huichun Xu Taiki Yamaji Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2018 Apr 12;50(4):524-537. Epub 2018 Mar 12.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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April 2018

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.

Authors:
Eleni Zengini Konstantinos Hatzikotoulas Ioanna Tachmazidou Julia Steinberg Fernando P Hartwig Lorraine Southam Sophie Hackinger Cindy G Boer Unnur Styrkarsdottir Arthur Gilly Daniel Suveges Britt Killian Thorvaldur Ingvarsson Helgi Jonsson George C Babis Andrew McCaskie Andre G Uitterlinden Joyce B J van Meurs Unnur Thorsteinsdottir Kari Stefansson George Davey Smith Jeremy M Wilkinson Eleftheria Zeggini

Nat Genet 2018 Apr 20;50(4):549-558. Epub 2018 Mar 20.

Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

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April 2018

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.

Authors:
Kerrin S Small Marijana Todorčević Mete Civelek Julia S El-Sayed Moustafa Xiao Wang Michelle M Simon Juan Fernandez-Tajes Anubha Mahajan Momoko Horikoshi Alison Hugill Craig A Glastonbury Lydia Quaye Matt J Neville Siddharth Sethi Marianne Yon Calvin Pan Nam Che Ana Viñuela Pei-Chien Tsai Abhishek Nag Alfonso Buil Gudmar Thorleifsson Avanthi Raghavan Qiurong Ding Andrew P Morris Jordana T Bell Unnur Thorsteinsdottir Kari Stefansson Markku Laakso Ingrid Dahlman Peter Arner Anna L Gloyn Kiran Musunuru Aldons J Lusis Roger D Cox Fredrik Karpe Mark I McCarthy

Nat Genet 2018 Apr 9;50(4):572-580. Epub 2018 Apr 9.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.

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April 2018

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

Authors:
Anubha Mahajan Jennifer Wessel Sara M Willems Wei Zhao Neil R Robertson Audrey Y Chu Wei Gan Hidetoshi Kitajima Daniel Taliun N William Rayner Xiuqing Guo Yingchang Lu Man Li Richard A Jensen Yao Hu Shaofeng Huo Kurt K Lohman Weihua Zhang James P Cook Bram Peter Prins Jason Flannick Niels Grarup Vassily Vladimirovich Trubetskoy Jasmina Kravic Young Jin Kim Denis V Rybin Hanieh Yaghootkar Martina Müller-Nurasyid Karina Meidtner Ruifang Li-Gao Tibor V Varga Jonathan Marten Jin Li Albert Vernon Smith Ping An Symen Ligthart Stefan Gustafsson Giovanni Malerba Ayse Demirkan Juan Fernandez Tajes Valgerdur Steinthorsdottir Matthias Wuttke Cécile Lecoeur Michael Preuss Lawrence F Bielak Marielisa Graff Heather M Highland Anne E Justice Dajiang J Liu Eirini Marouli Gina Marie Peloso Helen R Warren Saima Afaq Shoaib Afzal Emma Ahlqvist Peter Almgren Najaf Amin Lia B Bang Alain G Bertoni Cristina Bombieri Jette Bork-Jensen Ivan Brandslund Jennifer A Brody Noël P Burtt Mickaël Canouil Yii-Der Ida Chen Yoon Shin Cho Cramer Christensen Sophie V Eastwood Kai-Uwe Eckardt Krista Fischer Giovanni Gambaro Vilmantas Giedraitis Megan L Grove Hugoline G de Haan Sophie Hackinger Yang Hai Sohee Han Anne Tybjærg-Hansen Marie-France Hivert Bo Isomaa Susanne Jäger Marit E Jørgensen Torben Jørgensen Annemari Käräjämäki Bong-Jo Kim Sung Soo Kim Heikki A Koistinen Peter Kovacs Jennifer Kriebel Florian Kronenberg Kristi Läll Leslie A Lange Jung-Jin Lee Benjamin Lehne Huaixing Li Keng-Hung Lin Allan Linneberg Ching-Ti Liu Jun Liu Marie Loh Reedik Mägi Vasiliki Mamakou Roberta McKean-Cowdin Girish Nadkarni Matt Neville Sune F Nielsen Ioanna Ntalla Patricia A Peyser Wolfgang Rathmann Kenneth Rice Stephen S Rich Line Rode Olov Rolandsson Sebastian Schönherr Elizabeth Selvin Kerrin S Small Alena Stančáková Praveen Surendran Kent D Taylor Tanya M Teslovich Barbara Thorand Gudmar Thorleifsson Adrienne Tin Anke Tönjes Anette Varbo Daniel R Witte Andrew R Wood Pranav Yajnik Jie Yao Loïc Yengo Robin Young Philippe Amouyel Heiner Boeing Eric Boerwinkle Erwin P Bottinger Rajiv Chowdhury Francis S Collins George Dedoussis Abbas Dehghan Panos Deloukas Marco M Ferrario Jean Ferrières Jose C Florez Philippe Frossard Vilmundur Gudnason Tamara B Harris Susan R Heckbert Joanna M M Howson Martin Ingelsson Sekar Kathiresan Frank Kee Johanna Kuusisto Claudia Langenberg Lenore J Launer Cecilia M Lindgren Satu Männistö Thomas Meitinger Olle Melander Karen L Mohlke Marie Moitry Andrew D Morris Alison D Murray Renée de Mutsert Marju Orho-Melander Katharine R Owen Markus Perola Annette Peters Michael A Province Asif Rasheed Paul M Ridker Fernando Rivadineira Frits R Rosendaal Anders H Rosengren Veikko Salomaa Wayne H-H Sheu Rob Sladek Blair H Smith Konstantin Strauch André G Uitterlinden Rohit Varma Cristen J Willer Matthias Blüher Adam S Butterworth John Campbell Chambers Daniel I Chasman John Danesh Cornelia van Duijn Josée Dupuis Oscar H Franco Paul W Franks Philippe Froguel Harald Grallert Leif Groop Bok-Ghee Han Torben Hansen Andrew T Hattersley Caroline Hayward Erik Ingelsson Sharon L R Kardia Fredrik Karpe Jaspal Singh Kooner Anna Köttgen Kari Kuulasmaa Markku Laakso Xu Lin Lars Lind Yongmei Liu Ruth J F Loos Jonathan Marchini Andres Metspalu Dennis Mook-Kanamori Børge G Nordestgaard Colin N A Palmer James S Pankow Oluf Pedersen Bruce M Psaty Rainer Rauramaa Naveed Sattar Matthias B Schulze Nicole Soranzo Timothy D Spector Kari Stefansson Michael Stumvoll Unnur Thorsteinsdottir Tiinamaija Tuomi Jaakko Tuomilehto Nicholas J Wareham James G Wilson Eleftheria Zeggini Robert A Scott Inês Barroso Timothy M Frayling Mark O Goodarzi James B Meigs Michael Boehnke Danish Saleheen Andrew P Morris Jerome I Rotter Mark I McCarthy

Nat Genet 2018 Apr 9;50(4):559-571. Epub 2018 Apr 9.

Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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April 2018

Genome-wide analysis yields new loci associating with aortic valve stenosis.

Authors:
Anna Helgadottir Gudmar Thorleifsson Solveig Gretarsdottir Olafur A Stefansson Vinicius Tragante Rosa B Thorolfsdottir Ingileif Jonsdottir Thorsteinn Bjornsson Valgerdur Steinthorsdottir Niek Verweij Jonas B Nielsen Wei Zhou Lasse Folkersen Andreas Martinsson Mahyar Heydarpour Siddharth Prakash Gylfi Oskarsson Tomas Gudbjartsson Arnar Geirsson Isleifur Olafsson Emil L Sigurdsson Peter Almgren Olle Melander Anders Franco-Cereceda Anders Hamsten Lars Fritsche Maoxuan Lin Bo Yang Whitney Hornsby Dongchuan Guo Chad M Brummett Gonçalo Abecasis Michael Mathis Dianna Milewicz Simon C Body Per Eriksson Cristen J Willer Kristian Hveem Christopher Newton-Cheh J Gustav Smith Ragnar Danielsen Gudmundur Thorgeirsson Unnur Thorsteinsdottir Daniel F Gudbjartsson Hilma Holm Kari Stefansson

Nat Commun 2018 03 7;9(1):987. Epub 2018 Mar 7.

deCODE genetics/Amgen Inc., Reykjavik, 101, Iceland.

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March 2018

Comparison of the effect of allopurinol and febuxostat on urinary 2,8-dihydroxyadenine excretion in patients with Adenine phosphoribosyltransferase deficiency (APRTd): A clinical trial.

Authors:
Vidar O Edvardsson Hrafnhildur L Runolfsdottir Unnur A Thorsteinsdottir Inger M Sch Agustsdottir G Steinunn Oddsdottir Finnur Eiriksson David S Goldfarb Margret Thorsteinsdottir Runolfur Palsson

Eur J Intern Med 2018 02 12;48:75-79. Epub 2017 Dec 12.

Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Division of Nephrology, Internal Medicine Services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. Electronic address:

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February 2018

A rare missense variant in associates with lower cholesterol levels.

Authors:
Aimee M Deaton Patrick Sulem Paul Nioi Stefania Benonisdottir Lucas D Ward Olafur B Davidsson Socheata Lao Anna Helgadottir Fan Fan Brynjar O Jensson Gudmundur L Norddahl Aslaug Jonasdottir Adalbjorg Jonasdottir Asgeir Sigurdsson Ragnar P Kristjansson Asmundur Oddsson Gudny A Arnadottir Hakon Jonsson Isleifur Olafsson Gudmundur I Eyjolfsson Olof Sigurdardottir Einar S Bjornsson Sigurdur Olafsson Thora Steingrimsdottir Thorunn Rafnar Gudmundur Thorgeirsson Gisli Masson Gudmar Thorleifsson Daniel F Gudbjartsson Hilma Holm Unnur Thorsteinsdottir Kari Stefansson

Commun Biol 2018 8;1:14. Epub 2018 Feb 8.

deCODE Genetics/Amgen, Inc., Reykjavik, 101 Iceland.

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February 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 Jan 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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January 2018

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Authors:
Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Grabe Struan F A Grant Niels Grarup Helen L Griffiths Megan L Grove Vilmundur Gudnason Stefan Gustafsson Jeff Haessler Hakon Hakonarson Anke R Hammerschlag Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Christian T Have Caroline Hayward Liang He Nancy L Heard-Costa Andrew C Heath Iris M Heid Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Yao Hu Paul L Huang Jennifer E Huffman M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Yucheng Jia Stefan Johansson Marit E Jørgensen Torben Jørgensen J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Sekar Kathiresan Frank Kee Lambertus A Kiemeney Eric Kim Hidetoshi Kitajima Pirjo Komulainen Jaspal S Kooner Charles Kooperberg Tellervo Korhonen Peter Kovacs Helena Kuivaniemi Zoltán Kutalik Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo A Lakka David Lamparter Ethan M Lange Leslie A Lange Claudia Langenberg Eric B Larson Nanette R Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Keng-Hung Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Ching-Ti Liu Dajiang J Liu Yongmei Liu Ken S Lo Artitaya Lophatananon Andrew J Lotery Anu Loukola Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen Satu Männistö Gaëlle Marenne Angela L Mazul Mark I McCarthy Roberta McKean-Cowdin Sarah E Medland Karina Meidtner Lili Milani Vanisha Mistry Paul Mitchell Karen L Mohlke Leena Moilanen Marie Moitry Grant W Montgomery Dennis O Mook-Kanamori Carmel Moore Trevor A Mori Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Narisu Narisu Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Dale R Nyholt Jeffrey R O'Connel Michelle L O'Donoghue Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Nicholette D Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Tune H Pers Thomas N Person Annette Peters Eva R B Petersen Patricia A Peyser Ailith Pirie Ozren Polasek Tinca J Polderman Hannu Puolijoki Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Frida Renström Myriam Rheinberger Paul M Ridker John D Rioux Manuel A Rivas David J Roberts Neil R Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Yadav Sapkota Naveed Sattar Robert E Schoen Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati H Shah Wayne H-H Sheu Xueling Sim Andrew J Slater Kerrin S Small Albert V Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kari Stefansson Valgerdur Steinthorsdottir Kathleen E Stirrups Konstantin Strauch Heather M Stringham Michael Stumvoll Liang Sun Praveen Surendran Amy J Swift Hayato Tada Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Matti Uusitupa Sander W Laan Cornelia M Duijn Nienke Leeuwen Jessica van Setten Mauno Vanhala Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Giovanni Veronesi Henrik Vestergaard Veronique Vitart Thomas F Vogt Uwe Völker Dragana Vuckovic Lynne E Wagenknecht Mark Walker Lars Wallentin Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Erin B Ware Nicholas J Wareham Helen R Warren Dawn M Waterworth Jennifer Wessel Harvey D White Cristen J Willer James G Wilson Daniel R Witte Andrew R Wood Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao Wei Zhou Krina T Zondervan Jerome I Rotter John A Pospisilik Fernando Rivadeneira Ingrid B Borecki Panos Deloukas Timothy M Frayling Guillaume Lettre Kari E North Cecilia M Lindgren Joel N Hirschhorn Ruth J F Loos

Nat Genet 2018 Jan 22;50(1):26-41. Epub 2017 Dec 22.

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

View Article
January 2018

The nature of nurture: Effects of parental genotypes.

Authors:
Augustine Kong Gudmar Thorleifsson Michael L Frigge Bjarni J Vilhjalmsson Alexander I Young Thorgeir E Thorgeirsson Stefania Benonisdottir Asmundur Oddsson Bjarni V Halldorsson Gisli Masson Daniel F Gudbjartsson Agnar Helgason Gyda Bjornsdottir Unnur Thorsteinsdottir Kari Stefansson

Science 2018 Jan;359(6374):424-428

deCODE genetics/Amgen, 101 Reykjavik, Iceland.

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January 2018

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

Authors:
Robert A Scott Laura J Scott Reedik Mägi Letizia Marullo Kyle J Gaulton Marika Kaakinen Natalia Pervjakova Tune H Pers Andrew D Johnson John D Eicher Anne U Jackson Teresa Ferreira Yeji Lee Clement Ma Valgerdur Steinthorsdottir Gudmar Thorleifsson Lu Qi Natalie R Van Zuydam Anubha Mahajan Han Chen Peter Almgren Ben F Voight Harald Grallert Martina Müller-Nurasyid Janina S Ried Nigel W Rayner Neil Robertson Lennart C Karssen Elisabeth M van Leeuwen Sara M Willems Christian Fuchsberger Phoenix Kwan Tanya M Teslovich Pritam Chanda Man Li Yingchang Lu Christian Dina Dorothee Thuillier Loic Yengo Longda Jiang Thomas Sparso Hans A Kestler Himanshu Chheda Lewin Eisele Stefan Gustafsson Mattias Frånberg Rona J Strawbridge Rafn Benediktsson Astradur B Hreidarsson Augustine Kong Gunnar Sigurðsson Nicola D Kerrison Jian'an Luan Liming Liang Thomas Meitinger Michael Roden Barbara Thorand Tõnu Esko Evelin Mihailov Caroline Fox Ching-Ti Liu Denis Rybin Bo Isomaa Valeriya Lyssenko Tiinamaija Tuomi David J Couper James S Pankow Niels Grarup Christian T Have Marit E Jørgensen Torben Jørgensen Allan Linneberg Marilyn C Cornelis Rob M van Dam David J Hunter Peter Kraft Qi Sun Sarah Edkins Katharine R Owen John R B Perry Andrew R Wood Eleftheria Zeggini Juan Tajes-Fernandes Goncalo R Abecasis Lori L Bonnycastle Peter S Chines Heather M Stringham Heikki A Koistinen Leena Kinnunen Bengt Sennblad Thomas W Mühleisen Markus M Nöthen Sonali Pechlivanis Damiano Baldassarre Karl Gertow Steve E Humphries Elena Tremoli Norman Klopp Julia Meyer Gerald Steinbach Roman Wennauer Johan G Eriksson Satu Mӓnnistö Leena Peltonen Emmi Tikkanen Guillaume Charpentier Elodie Eury Stéphane Lobbens Bruna Gigante Karin Leander Olga McLeod Erwin P Bottinger Omri Gottesman Douglas Ruderfer Matthias Blüher Peter Kovacs Anke Tonjes Nisa M Maruthur Chiara Scapoli Raimund Erbel Karl-Heinz Jöckel Susanne Moebus Ulf de Faire Anders Hamsten Michael Stumvoll Panagiotis Deloukas Peter J Donnelly Timothy M Frayling Andrew T Hattersley Samuli Ripatti Veikko Salomaa Nancy L Pedersen Bernhard O Boehm Richard N Bergman Francis S Collins Karen L Mohlke Jaakko Tuomilehto Torben Hansen Oluf Pedersen Inês Barroso Lars Lannfelt Erik Ingelsson Lars Lind Cecilia M Lindgren Stephane Cauchi Philippe Froguel Ruth J F Loos Beverley Balkau Heiner Boeing Paul W Franks Aurelio Barricarte Gurrea Domenico Palli Yvonne T van der Schouw David Altshuler Leif C Groop Claudia Langenberg Nicholas J Wareham Eric Sijbrands Cornelia M van Duijn Jose C Florez James B Meigs Eric Boerwinkle Christian Gieger Konstantin Strauch Andres Metspalu Andrew D Morris Colin N A Palmer Frank B Hu Unnur Thorsteinsdottir Kari Stefansson Josée Dupuis Andrew P Morris Michael Boehnke Mark I McCarthy Inga Prokopenko

Diabetes 2017 11 31;66(11):2888-2902. Epub 2017 May 31.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.

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November 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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November 2017

COPA syndrome in an Icelandic family caused by a recurrent missense mutation in COPA.

Authors:
Brynjar O Jensson Sif Hansdottir Gudny A Arnadottir Gerald Sulem Ragnar P Kristjansson Asmundur Oddsson Stefania Benonisdottir Hakon Jonsson Agnar Helgason Jona Saemundsdottir Olafur T Magnusson Gisli Masson Gudmundur A Thorisson Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Ingileif Jonsdottir Vigdis Petursdottir Jon R Kristinsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Reynir Arngrimsson Patrick Sulem Gunnar Gudmundsson Kari Stefansson

BMC Med Genet 2017 11 14;18(1):129. Epub 2017 Nov 14.

deCODE Genetics/Amgen, Inc, Sturlugata 8, 101, Reykjavik, Iceland.

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November 2017

Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus.

Authors:
Sophie Hackinger Katerina Trajanoska Unnur Styrkarsdottir Eleni Zengini Julia Steinberg Graham R S Ritchie Konstantinos Hatzikotoulas Arthur Gilly Evangelos Evangelou John P Kemp David Evans Thorvaldur Ingvarsson Helgi Jonsson Unnur Thorsteinsdottir Kari Stefansson Andrew W McCaskie Roger A Brooks Jeremy M Wilkinson Fernando Rivadeneira Eleftheria Zeggini

Hum Mol Genet 2017 10;26(19):3850-3858

Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK.

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October 2017

Compound heterozygous mutations in UBA5 causing early-onset epileptic encephalopathy in two sisters.

Authors:
Gudny A Arnadottir Brynjar O Jensson Sigurdur E Marelsson Gerald Sulem Asmundur Oddsson Ragnar P Kristjansson Stefania Benonisdottir Sigurjon A Gudjonsson Gisli Masson Gudmundur A Thorisson Jona Saemundsdottir Olafur Th Magnusson Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Reynir Arngrimsson Patrick Sulem Kari Stefansson

BMC Med Genet 2017 10 2;18(1):103. Epub 2017 Oct 2.

deCODE Genetics/Amgen, Inc., Sturlugata 8, 101, Reykjavik, Iceland.

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October 2017

A Missense Variant in PLEC Increases Risk of Atrial Fibrillation.

Authors:
Rosa B Thorolfsdottir Gardar Sveinbjornsson Patrick Sulem Anna Helgadottir Solveig Gretarsdottir Stefania Benonisdottir Audur Magnusdottir Olafur B Davidsson Sridharan Rajamani Dan M Roden Dawood Darbar Terje R Pedersen Marc S Sabatine Ingileif Jonsdottir David O Arnar Unnur Thorsteinsdottir Daniel F Gudbjartsson Hilma Holm Kari Stefansson

J Am Coll Cardiol 2017 Oct;70(17):2157-2168

deCODE genetics/Amgen, Inc., Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Electronic address:

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October 2017

Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability.

Authors:
Erna V Ivarsdottir Valgerdur Steinthorsdottir Maryam S Daneshpour Gudmar Thorleifsson Patrick Sulem Hilma Holm Snaevar Sigurdsson Astradur B Hreidarsson Gunnar Sigurdsson Ragnar Bjarnason Arni V Thorsson Rafn Benediktsson Gudmundur Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Sirous Zeinali Fereidoun Azizi Unnur Thorsteinsdottir Daniel F Gudbjartsson Kari Stefansson

Nat Genet 2017 Sep 7;49(9):1398-1402. Epub 2017 Aug 7.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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September 2017

Whole genome characterization of sequence diversity of 15,220 Icelanders.

Authors:
Hákon Jónsson Patrick Sulem Birte Kehr Snaedis Kristmundsdottir Florian Zink Eirikur Hjartarson Marteinn T Hardarson Kristjan E Hjorleifsson Hannes P Eggertsson Sigurjon Axel Gudjonsson Lucas D Ward Gudny A Arnadottir Einar A Helgason Hannes Helgason Arnaldur Gylfason Adalbjorg Jonasdottir Aslaug Jonasdottir Thorunn Rafnar Soren Besenbacher Michael L Frigge Simon N Stacey Olafur Th Magnusson Unnur Thorsteinsdottir Gisli Masson Augustine Kong Bjarni V Halldorsson Agnar Helgason Daniel F Gudbjartsson Kari Stefansson

Sci Data 2017 09 21;4:170115. Epub 2017 Sep 21.

deCODE genetics/Amgen Inc., Sturlugata 8, Reykjavik 101, Iceland.

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September 2017

Parental influence on human germline de novo mutations in 1,548 trios from Iceland.

Authors:
Hákon Jónsson Patrick Sulem Birte Kehr Snaedis Kristmundsdottir Florian Zink Eirikur Hjartarson Marteinn T Hardarson Kristjan E Hjorleifsson Hannes P Eggertsson Sigurjon Axel Gudjonsson Lucas D Ward Gudny A Arnadottir Einar A Helgason Hannes Helgason Arnaldur Gylfason Adalbjorg Jonasdottir Aslaug Jonasdottir Thorunn Rafnar Mike Frigge Simon N Stacey Olafur Th Magnusson Unnur Thorsteinsdottir Gisli Masson Augustine Kong Bjarni V Halldorsson Agnar Helgason Daniel F Gudbjartsson Kari Stefansson

Nature 2017 09 20;549(7673):519-522. Epub 2017 Sep 20.

deCODE genetics/Amgen Inc., 101 Reykjavik, Iceland.

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September 2017

Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.

Authors:
Florian Zink Simon N Stacey Gudmundur L Norddahl Michael L Frigge Olafur T Magnusson Ingileif Jonsdottir Thorgeir E Thorgeirsson Asgeir Sigurdsson Sigurjon A Gudjonsson Julius Gudmundsson Jon G Jonasson Laufey Tryggvadottir Thorvaldur Jonsson Agnar Helgason Arnaldur Gylfason Patrick Sulem Thorunn Rafnar Unnur Thorsteinsdottir Daniel F Gudbjartsson Gisli Masson Augustine Kong Kari Stefansson

Blood 2017 08 8;130(6):742-752. Epub 2017 May 8.

deCODE genetics/AMGEN, Reykjavik, Iceland.

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August 2017

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

Authors:
Ralph McGinnis Valgerdur Steinthorsdottir Nicholas O Williams Gudmar Thorleifsson Scott Shooter Sigrun Hjartardottir Suzannah Bumpstead Lilja Stefansdottir Lucy Hildyard Jon K Sigurdsson John P Kemp Gabriela B Silva Liv Cecilie V Thomsen Tiina Jääskeläinen Eero Kajantie Sally Chappell Noor Kalsheker Ashley Moffett Susan Hiby Wai Kwong Lee Sandosh Padmanabhan Nigel A B Simpson Vivien A Dolby Eleonora Staines-Urias Stephanie M Engel Anita Haugan Lill Trogstad Gulnara Svyatova Nodira Zakhidova Dilbar Najmutdinova Anna F Dominiczak Håkon K Gjessing Juan P Casas Frank Dudbridge James J Walker Fiona Broughton Pipkin Unnur Thorsteinsdottir Reynir T Geirsson Debbie A Lawlor Ann-Charlotte Iversen Per Magnus Hannele Laivuori Kari Stefansson Linda Morgan

Nat Genet 2017 Aug 19;49(8):1255-1260. Epub 2017 Jun 19.

School of Life Sciences, University of Nottingham, Nottingham, UK.

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August 2017

Identification of sequence variants influencing immunoglobulin levels.

Authors:
Stefan Jonsson Gardar Sveinbjornsson Aitzkoa Lopez de Lapuente Portilla Bhairavi Swaminathan Rosina Plomp Gillian Dekkers Ram Ajore Mina Ali Arthur E H Bentlage Evelina Elmér Gudmundur I Eyjolfsson Sigurjon A Gudjonsson Urban Gullberg Arnaldur Gylfason Bjarni V Halldorsson Markus Hansson Hilma Holm Åsa Johansson Ellinor Johnsson Aslaug Jonasdottir Bjorn R Ludviksson Asmundur Oddsson Isleifur Olafsson Sigurgeir Olafsson Olof Sigurdardottir Asgeir Sigurdsson Lilja Stefansdottir Gisli Masson Patrick Sulem Manfred Wuhrer Anna-Karin Wihlborg Gudmar Thorleifsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Gestur Vidarsson Ingileif Jonsdottir Björn Nilsson Kari Stefansson

Nat Genet 2017 Aug 19;49(8):1182-1191. Epub 2017 Jun 19.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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August 2017

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations.

Authors:
Sigurgeir Olafsson Pernilla Stridh Steffan Daniël Bos Andres Ingason Jack Euesden Patrick Sulem Gudmar Thorleifsson Omar Gustafsson Ari Johannesson Arni J Geirsson Arni V Thorsson Bardur Sigurgeirsson Bjorn Runar Ludviksson Elias Olafsson Helga Kristjansdottir Jon G Jonasson Jon Hjaltalin Olafsson Kjartan B Orvar Rafn Benediktsson Ragnar Bjarnason Sjofn Kristjansdottir Thorarinn Gislason Trausti Valdimarsson Evgenia Mikaelsdottir Snaevar Sigurdsson Stefan Jonsson Thorunn Rafnar Dag Aarsland Srdjan Djurovic Tormod Fladby Gun Peggy Knudsen Elisabeth G Celius Kjell-Morten Myhr Gerdur Grondal Kristjan Steinsson Helgi Valdimarsson Sigurdur Bjornsson Unnur S Bjornsdottir Einar S Bjornsson Bjorn Nilsson Ole A Andreassen Lars Alfredsson Jan Hillert Ingrid Skelton Kockum Gisli Masson Unnur Thorsteinsdottir Daniel F Gudbjartsson Hreinn Stefansson Haukur Hjaltason Hanne F Harbo Tomas Olsson Ingileif Jonsdottir Kari Stefansson

NPJ Genom Med 2017 8;2:24. Epub 2017 Aug 8.

deCODE genetics/Amgen, Reykjavik, Iceland.

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August 2017

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

Authors:
Tin Aung Mineo Ozaki Mei Chin Lee Ursula Schlötzer-Schrehardt Gudmar Thorleifsson Takanori Mizoguchi Robert P Igo Aravind Haripriya Susan E Williams Yury S Astakhov Andrew C Orr Kathryn P Burdon Satoko Nakano Kazuhiko Mori Khaled Abu-Amero Michael Hauser Zheng Li Gopalakrishnan Prakadeeswari Jessica N Cooke Bailey Alina Popa Cherecheanu Jae H Kang Sarah Nelson Ken Hayashi Shin-Ichi Manabe Shigeyasu Kazama Tomasz Zarnowski Kenji Inoue Murat Irkec Miguel Coca-Prados Kazuhisa Sugiyama Irma Järvelä Patricio Schlottmann S Fabian Lerner Hasnaa Lamari Yildirim Nilgün Mukharram Bikbov Ki Ho Park Soon Cheol Cha Kenji Yamashiro Juan C Zenteno Jost B Jonas Rajesh S Kumar Shamira A Perera Anita S Y Chan Nino Kobakhidze Ronnie George Lingam Vijaya Tan Do Deepak P Edward Lourdes de Juan Marcos Mohammad Pakravan Sasan Moghimi Ryuichi Ideta Daniella Bach-Holm Per Kappelgaard Barbara Wirostko Samuel Thomas Daniel Gaston Karen Bedard Wenda L Greer Zhenglin Yang Xueyi Chen Lulin Huang Jinghong Sang Hongyan Jia Liyun Jia Chunyan Qiao Hui Zhang Xuyang Liu Bowen Zhao Ya-Xing Wang Liang Xu Stéphanie Leruez Pascal Reynier George Chichua Sergo Tabagari Steffen Uebe Matthias Zenkel Daniel Berner Georg Mossböck Nicole Weisschuh Ursula Hoja Ulrich-Christoph Welge-Luessen Christian Mardin Panayiota Founti Anthi Chatzikyriakidou Theofanis Pappas Eleftherios Anastasopoulos Alexandros Lambropoulos Arkasubhra Ghosh Rohit Shetty Natalia Porporato Vijayan Saravanan Rengaraj Venkatesh Chandrashekaran Shivkumar Narendran Kalpana Sripriya Sarangapani Mozhgan R Kanavi Afsaneh Naderi Beni Shahin Yazdani Alireza Lashay Homa Naderifar Nassim Khatibi Antonio Fea Carlo Lavia Laura Dallorto Teresa Rolle Paolo Frezzotti Daniela Paoli Erika Salvi Paolo Manunta Yosai Mori Kazunori Miyata Tomomi Higashide Etsuo Chihara Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Makoto Aihara Masaru Inatani Masahiro Miyake Norimoto Gotoh Fumihiko Matsuda Nagahisa Yoshimura Yoko Ikeda Morio Ueno Chie Sotozono Jin Wook Jeoung Min Sagong Kyu Hyung Park Jeeyun Ahn Marisa Cruz-Aguilar Sidi M Ezzouhairi Abderrahman Rafei Yaan Fun Chong Xiao Yu Ng Shuang Ru Goh Yueming Chen Victor H K Yong Muhammad Imran Khan Olusola O Olawoye Adeyinka O Ashaye Idakwo Ugbede Adeola Onakoya Nkiru Kizor-Akaraiwe Chaiwat Teekhasaenee Yanin Suwan Wasu Supakontanasan Suhanya Okeke Nkechi J Uche Ifeoma Asimadu Humaira Ayub Farah Akhtar Ewa Kosior-Jarecka Urszula Lukasik Ignacio Lischinsky Vania Castro Rodolfo Perez Grossmann Gordana Sunaric Megevand Sylvain Roy Edward Dervan Eoin Silke Aparna Rao Priti Sahay Pablo Fornero Osvaldo Cuello Delia Sivori Tamara Zompa Richard A Mills Emmanuelle Souzeau Paul Mitchell Jie Jin Wang Alex W Hewitt Michael Coote Jonathan G Crowston Sergei Y Astakhov Eugeny L Akopov Anton Emelyanov Vera Vysochinskaya Gyulli Kazakbaeva Rinat Fayzrakhmanov Saleh A Al-Obeidan Ohoud Owaidhah Leyla Ali Aljasim Balram Chowbay Jia Nee Foo Raphael Q Soh Kar Seng Sim Zhicheng Xie Augustine W O Cheong Shi Qi Mok Hui Meng Soo Xiao Yin Chen Su Qin Peh Khai Koon Heng Rahat Husain Su-Ling Ho Axel M Hillmer Ching-Yu Cheng Francisco A Escudero-Domínguez Rogelio González-Sarmiento Frederico Martinon-Torres Antonio Salas Kessara Pathanapitoon Linda Hansapinyo Boonsong Wanichwecharugruang Naris Kitnarong Anavaj Sakuntabhai Hip X Nguyn Giang T T Nguyn Trình V Nguyn Werner Zenz Alexander Binder Daniela S Klobassa Martin L Hibberd Sonia Davila Stefan Herms Markus M Nöthen Susanne Moebus Robyn M Rautenbach Ari Ziskind Trevor R Carmichael Michele Ramsay Lydia Álvarez Montserrat García Héctor González-Iglesias Pedro P Rodríguez-Calvo Luis Fernández-Vega Cueto Çilingir Oguz Nevbahar Tamcelik Eray Atalay Bilge Batu Dilek Aktas Burcu Kasım M Roy Wilson Anne L Coleman Yutao Liu Pratap Challa Leon Herndon Rachel W Kuchtey John Kuchtey Karen Curtin Craig J Chaya Alan Crandall Linda M Zangwill Tien Yin Wong Masakazu Nakano Shigeru Kinoshita Anneke I den Hollander Eija Vesti John H Fingert Richard K Lee Arthur J Sit Bradford J Shingleton Ningli Wang Daniele Cusi Raheel Qamar Peter Kraft Margaret A Pericak-Vance Soumya Raychaudhuri Steffen Heegaard Tero Kivelä André Reis Friedrich E Kruse Robert N Weinreb Louis R Pasquale Jonathan L Haines Unnur Thorsteinsdottir Fridbert Jonasson R Rand Allingham Dan Milea Robert Ritch Toshiaki Kubota Kei Tashiro Eranga N Vithana Shazia Micheal Fotis Topouzis Jamie E Craig Michael Dubina Periasamy Sundaresan Kari Stefansson Janey L Wiggs Francesca Pasutto Chiea Chuen Khor

Nat Genet 2017 07 29;49(7):993-1004. Epub 2017 May 29.

Singapore Eye Research Institute, Singapore.

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July 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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July 2017

Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.

Authors:
Unnur Styrkarsdottir Hannes Helgason Asgeir Sigurdsson Gudmundur L Norddahl Arna B Agustsdottir Louise N Reynard Amanda Villalvilla Gisli H Halldorsson Aslaug Jonasdottir Audur Magnusdottir Asmundur Oddson Gerald Sulem Florian Zink Gardar Sveinbjornsson Agnar Helgason Hrefna S Johannsdottir Anna Helgadottir Hreinn Stefansson Solveig Gretarsdottir Thorunn Rafnar Ina S Almdahl Anne Brækhus Tormod Fladby Geir Selbæk Farhad Hosseinpanah Fereidoun Azizi Jung Min Koh Nelson L S Tang Maryams Danesphour Jose I Mayordomo Corrine Welt Peter S Braund Nilesh J Samani Lambertus A Kiemeney L Stefan Lohmander Claus Christiansen Ole A Andreassen arcOGEN Consortium Olafur Magnusson Gisli Masson Augustine Kong Ingileif Jonsdottir Daniel Gudbjartsson Patrick Sulem Helgi Jonsson John Loughlin Thorvaldur Ingvarsson Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2017 07;49(8):1286

View Article
July 2017

A rare splice donor mutation in the haptoglobin gene associates with blood lipid levels and coronary artery disease.

Authors:
Eythor Bjornsson Hannes Helgason Gisli Halldorsson Anna Helgadottir Arnaldur Gylfason Birte Kehr Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Asmundur Oddsson Gudmar Thorleifsson Olafur Th Magnusson Solveig Gretarsdottir Florian Zink Ragnar P Kristjansson Margret Asgeirsdottir Dorine W Swinkels Lambertus A Kiemeney Gudmundur I Eyjolfsson Olof Sigurdardottir Gisli Masson Isleifur Olafsson Gudmundur Thorgeirsson Hilma Holm Unnur Thorsteinsdottir Daniel F Gudbjartsson Patrick Sulem Kari Stefansson

Hum Mol Genet 2017 06;26(12):2364-2376

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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June 2017

Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.

Authors:
Snaevar Sigurdsson Kristjan F Alexandersson Patrick Sulem Bjarke Feenstra Steinunn Gudmundsdottir Gisli H Halldorsson Sigurgeir Olafsson Asgeir Sigurdsson Thorunn Rafnar Thorgeir Thorgeirsson Erik Sørensen Andreas Nordholm-Carstensen Jakob Burcharth Jens Andersen Henrik Stig Jørgensen Emma Possfelt-Møller Henrik Ullum Gudmar Thorleifsson Gisli Masson Unnur Thorsteinsdottir Mads Melbye Daniel F Gudbjartsson Tryggvi Stefansson Ingileif Jonsdottir Kari Stefansson

Nat Commun 2017 06 6;8:15789. Epub 2017 Jun 6.

deCODE Genetics/Amgen Inc., Sturlugata 8, 101 Reykjavik, Iceland.

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June 2017

Sequence variant at 4q25 near PITX2 associates with appendicitis.

Authors:
Ragnar P Kristjansson Stefania Benonisdottir Asmundur Oddsson Tessel E Galesloot Gudmar Thorleifsson Katja K Aben Olafur B Davidsson Stefan Jonsson Gudny A Arnadottir Brynjar O Jensson G Bragi Walters Jon K Sigurdsson Snaevar Sigurdsson Hilma Holm David O Arnar Gudmundur Thorgeirsson Kristin Alexiusdottir Ingileif Jonsdottir Unnur Thorsteinsdottir Lambertus A Kiemeney Thorvaldur Jonsson Daniel F Gudbjartsson Thorunn Rafnar Patrick Sulem Kari Stefansson

Sci Rep 2017 Jun 8;7(1):3119. Epub 2017 Jun 8.

deCODE genetics/Amgen, Inc, Reykjavik, 101, Iceland.

View Article
June 2017

Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.

Authors:
Unnur Styrkarsdottir Hannes Helgason Asgeir Sigurdsson Gudmundur L Norddahl Arna B Agustsdottir Louise N Reynard Amanda Villalvilla Gisli H Halldorsson Aslaug Jonasdottir Audur Magnusdottir Asmundur Oddson Gerald Sulem Florian Zink Gardar Sveinbjornsson Agnar Helgason Hrefna S Johannsdottir Anna Helgadottir Hreinn Stefansson Solveig Gretarsdottir Thorunn Rafnar Ina S Almdahl Anne Brækhus Tormod Fladby Geir Selbæk Farhad Hosseinpanah Fereidoun Azizi Jung Min Koh Nelson L S Tang Maryam S Daneshpour Jose I Mayordomo Corrine Welt Peter S Braund Nilesh J Samani Lambertus A Kiemeney L Stefan Lohmander Claus Christiansen Ole A Andreassen Olafur Magnusson Gisli Masson Augustine Kong Ingileif Jonsdottir Daniel Gudbjartsson Patrick Sulem Helgi Jonsson John Loughlin Thorvaldur Ingvarsson Unnur Thorsteinsdottir Kari Stefansson

Nat Genet 2017 May 20;49(5):801-805. Epub 2017 Mar 20.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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May 2017

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.

Authors:
Yadav Sapkota Valgerdur Steinthorsdottir Andrew P Morris Amelie Fassbender Nilufer Rahmioglu Immaculata De Vivo Julie E Buring Futao Zhang Todd L Edwards Sarah Jones Dorien O Daniëlle Peterse Kathryn M Rexrode Paul M Ridker Andrew J Schork Stuart MacGregor Nicholas G Martin Christian M Becker Sosuke Adachi Kosuke Yoshihara Takayuki Enomoto Atsushi Takahashi Yoichiro Kamatani Koichi Matsuda Michiaki Kubo Gudmar Thorleifsson Reynir T Geirsson Unnur Thorsteinsdottir Leanne M Wallace Jian Yang Digna R Velez Edwards Mette Nyegaard Siew-Kee Low Krina T Zondervan Stacey A Missmer Thomas D'Hooghe Grant W Montgomery Daniel I Chasman Kari Stefansson Joyce Y Tung Dale R Nyholt

Nat Commun 2017 05 24;8:15539. Epub 2017 May 24.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.

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May 2017

Diversity in non-repetitive human sequences not found in the reference genome.

Authors:
Birte Kehr Anna Helgadottir Pall Melsted Hakon Jonsson Hannes Helgason Adalbjörg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Arnaldur Gylfason Gisli H Halldorsson Snaedis Kristmundsdottir Gudmundur Thorgeirsson Isleifur Olafsson Hilma Holm Unnur Thorsteinsdottir Patrick Sulem Agnar Helgason Daniel F Gudbjartsson Bjarni V Halldorsson Kari Stefansson

Nat Genet 2017 Apr 27;49(4):588-593. Epub 2017 Feb 27.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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April 2017

Genetic variation at 16q24.2 is associated with small vessel stroke.

Authors:
Matthew Traylor Rainer Malik Mike A Nalls Ioana Cotlarciuc Farid Radmanesh Gudmar Thorleifsson Ken B Hanscombe Carl Langefeld Danish Saleheen Natalia S Rost Idil Yet Tim D Spector Jordana T Bell Eilis Hannon Jonathan Mill Ganesh Chauhan Stephanie Debette Joshua C Bis W T Longstreth M Arfan Ikram Lenore J Launer Sudha Seshadri Monica Anne Hamilton-Bruce Jordi Jimenez-Conde John W Cole Reinhold Schmidt Agnieszka Słowik Robin Lemmens Arne Lindgren Olle Melander Raji P Grewal Ralph L Sacco Tatjana Rundek Kathryn Rexrode Donna K Arnett Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Sara L Pulit Quenna Wong Stephen S Rich Paul I W de Bakker Patrick F McArdle Daniel Woo Christopher D Anderson Huichun Xu Laura Heitsch Myriam Fornage Christina Jern Kari Stefansson Unnur Thorsteinsdottir Solveig Gretarsdottir Cathryn M Lewis Pankaj Sharma Cathie L M Sudlow Peter M Rothwell Giorgio B Boncoraglio Vincent Thijs Chris Levi James F Meschia Jonathan Rosand Steven J Kittner Braxton D Mitchell Martin Dichgans Bradford B Worrall Hugh S Markus

Ann Neurol 2017 Mar;81(3):383-394

Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

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March 2017

A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.

Authors:
Dirk Smith Hannes Helgason Patrick Sulem Unnur Steina Bjornsdottir Ai Ching Lim Gardar Sveinbjornsson Haruki Hasegawa Michael Brown Randal R Ketchem Monica Gavala Logan Garrett Adalbjorg Jonasdottir Aslaug Jonasdottir Asgeir Sigurdsson Olafur T Magnusson Gudmundur I Eyjolfsson Isleifur Olafsson Pall Torfi Onundarson Olof Sigurdardottir David Gislason Thorarinn Gislason Bjorn Runar Ludviksson Dora Ludviksdottir H Marike Boezen Andrea Heinzmann Marcus Krueger Celeste Porsbjerg Tarunveer S Ahluwalia Johannes Waage Vibeke Backer Klaus A Deichmann Gerard H Koppelman Klaus Bønnelykke Hans Bisgaard Gisli Masson Unnur Thorsteinsdottir Daniel F Gudbjartsson James A Johnston Ingileif Jonsdottir Kari Stefansson

PLoS Genet 2017 03 8;13(3):e1006659. Epub 2017 Mar 8.

deCODE genetics / Amgen Inc., Reykjavík, Iceland.

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March 2017

Rare and low-frequency coding variants alter human adult height.

Authors:
Eirini Marouli Mariaelisa Graff Carolina Medina-Gomez Ken Sin Lo Andrew R Wood Troels R Kjaer Rebecca S Fine Yingchang Lu Claudia Schurmann Heather M Highland Sina Rüeger Gudmar Thorleifsson Anne E Justice David Lamparter Kathleen E Stirrups Valérie Turcot Kristin L Young Thomas W Winkler Tõnu Esko Tugce Karaderi Adam E Locke Nicholas G D Masca Maggie C Y Ng Poorva Mudgal Manuel A Rivas Sailaja Vedantam Anubha Mahajan Xiuqing Guo Goncalo Abecasis Katja K Aben Linda S Adair Dewan S Alam Eva Albrecht Kristine H Allin Matthew Allison Philippe Amouyel Emil V Appel Dominique Arveiler Folkert W Asselbergs Paul L Auer Beverley Balkau Bernhard Banas Lia E Bang Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Heiner Boeing Eric Boerwinkle Carsten A Böger Lori L Bonnycastle Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Amber A Burt Adam S Butterworth David J Carey Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox Gabriel Cuellar-Partida John Danesh Gail Davies Paul I W de Bakker Gert J de Borst Simon de Denus Mark C H de Groot Renée de Mutsert Ian J Deary George Dedoussis Ellen W Demerath Anneke I den Hollander Joe G Dennis Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Alison M Dunning Douglas F Easton Tapani Ebeling Todd L Edwards Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki Jessica D Faul Mary F Feitosa Shuang Feng Ele Ferrannini Marco M Ferrario Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Paul W Franks Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Ayush Giri Giorgia Girotto Scott D Gordon Penny Gordon-Larsen Mathias Gorski Niels Grarup Megan L Grove Vilmundur Gudnason Stefan Gustafsson Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Caroline Hayward Liang He Iris M Heid Kauko Heikkilä Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Lynne J Hocking Mette Hollensted Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Carel B Hoyng Paul L Huang Kristian Hveem M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Min A Jhun Yucheng Jia Xuejuan Jiang Stefan Johansson Marit E Jørgensen Torben Jørgensen Pekka Jousilahti J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Frank Kee Renske Keeman Lambertus A Kiemeney Hidetoshi Kitajima Kirsten B Kluivers Thomas Kocher Pirjo Komulainen Jukka Kontto Jaspal S Kooner Charles Kooperberg Peter Kovacs Jennifer Kriebel Helena Kuivaniemi Sébastien Küry Johanna Kuusisto Martina La Bianca Markku Laakso Timo A Lakka Ethan M Lange Leslie A Lange Carl D Langefeld Claudia Langenberg Eric B Larson I-Te Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Yeheng Liu Yongmei Liu Artitaya Lophatananon Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen David A Mackey Pamela A F Madden Alisa K Manning Satu Männistö Gaëlle Marenne Jonathan Marten Nicholas G Martin Angela L Mazul Karina Meidtner Andres Metspalu Paul Mitchell Karen L Mohlke Dennis O Mook-Kanamori Anna Morgan Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Matthias Nauck Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Ioanna Ntalla Jeffrey R O'Connel Heikki Oksa Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Thomas N Person Ailith Pirie Ozren Polasek Danielle Posthuma Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Paul M Ridker John D Rioux Neil Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Kevin Sandow Yadav Sapkota Naveed Sattar Marjanka K Schmidt Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati Shah Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert Vernon Smith Jennifer A Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Valgerdur Steinthorsdottir Heather M Stringham Michael Stumvoll Praveen Surendran Leen M 't Hart Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Sheila Ulivi Sander W van der Laan Andries R Van Der Leij Cornelia M van Duijn Natasja M van Schoor Jessica van Setten Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Henrik Vestergaard Veronique Vitart Thomas F Vogt Diego Vozzi Mark Walker Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Nicholas J Wareham Helen R Warren Jennifer Wessel Sara M Willems James G Wilson Daniel R Witte Michael O Woods Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao He Zheng Wei Zhou Jerome I Rotter Michael Boehnke Sekar Kathiresan Mark I McCarthy Cristen J Willer Kari Stefansson Ingrid B Borecki Dajiang J Liu Kari E North Nancy L Heard-Costa Tune H Pers Cecilia M Lindgren Claus Oxvig Zoltán Kutalik Fernando Rivadeneira Ruth J F Loos Timothy M Frayling Joel N Hirschhorn Panos Deloukas Guillaume Lettre

Nature 2017 02 1;542(7640):186-190. Epub 2017 Feb 1.

Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.

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February 2017

A genome-wide association study yields five novel thyroid cancer risk loci.

Authors:
Julius Gudmundsson Gudmar Thorleifsson Jon K Sigurdsson Lilja Stefansdottir Jon G Jonasson Sigurjon A Gudjonsson Daniel F Gudbjartsson Gisli Masson Hrefna Johannsdottir Gisli H Halldorsson Simon N Stacey Hannes Helgason Patrick Sulem Leigha Senter Huiling He Sandya Liyanarachchi Matthew D Ringel Esperanza Aguillo Angeles Panadero Enrique Prats Almudena Garcia-Castaño Ana De Juan Fernando Rivera Li Xu Lambertus A Kiemeney Gudmundur I Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Hoskuldur Kristvinsson Romana T Netea-Maier Thorvaldur Jonsson Jose I Mayordomo Theo S Plantinga Hannes Hjartarson Jon Hrafnkelsson Erich M Sturgis Unnur Thorsteinsdottir Thorunn Rafnar Albert de la Chapelle Kari Stefansson

Nat Commun 2017 02 14;8:14517. Epub 2017 Feb 14.

deCODE genetics/AMGEN, 101 Reykjavik, Iceland.

View Article
February 2017

Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.

Authors:
Gyda Bjornsdottir Stefania Benonisdottir Gardar Sveinbjornsson Unnur Styrkarsdottir Gudmar Thorleifsson G Bragi Walters Aron Bjornsson Ingvar H Olafsson Elfar Ulfarsson Arnor Vikingsson Ragnheidur Hansdottir Karl O Karlsson Thorunn Rafnar Ingileif Jonsdottir Michael L Frigge Augustine Kong Asmundur Oddsson Gisli Masson Olafur T Magnusson Tomas Gudbjartsson Hreinn Stefansson Patrick Sulem Daniel Gudbjartsson Unnur Thorsteinsdottir Thorgeir E Thorgeirsson Kari Stefansson

Nat Commun 2017 02 22;8:14265. Epub 2017 Feb 22.

deCODE Genetics/Amgen, Inc., Reykjavik IS-101, Iceland.

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February 2017

A frameshift deletion in the sarcomere gene MYL4 causes early-onset familial atrial fibrillation.

Authors:
Daniel F Gudbjartsson Hilma Holm Patrick Sulem Gisli Masson Asmundur Oddsson Olafur Th Magnusson Jona Saemundsdottir Hafdis Th Helgadottir Hannes Helgason Hrefna Johannsdottir Solveig Gretarsdottir Sigurjon A Gudjonsson Inger Njølstad Maja-Lisa Løchen Larry Baum Ronald C W Ma Gunnlaugur Sigfusson Augustine Kong Guðmundur Thorgeirsson Jon Th Sverrisson Unnur Thorsteinsdottir Kari Stefansson David O Arnar

Eur Heart J 2017 01 14;38(1):27-34. Epub 2016 Oct 14.

deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland

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January 2017

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Authors:
Gregory T Jones Gerard Tromp Helena Kuivaniemi Solveig Gretarsdottir Annette F Baas Betti Giusti Ewa Strauss Femke N G Van't Hof Thomas R Webb Robert Erdman Marylyn D Ritchie James R Elmore Anurag Verma Sarah Pendergrass Iftikhar J Kullo Zi Ye Peggy L Peissig Omri Gottesman Shefali S Verma Jennifer Malinowski Laura J Rasmussen-Torvik Kenneth M Borthwick Diane T Smelser David R Crosslin Mariza de Andrade Evan J Ryer Catherine A McCarty Erwin P Böttinger Jennifer A Pacheco Dana C Crawford David S Carrell Glenn S Gerhard David P Franklin David J Carey Victoria L Phillips Michael J A Williams Wenhua Wei Ross Blair Andrew A Hill Thodor M Vasudevan David R Lewis Ian A Thomson Jo Krysa Geraldine B Hill Justin Roake Tony R Merriman Grzegorz Oszkinis Silvia Galora Claudia Saracini Rosanna Abbate Raffaele Pulli Carlo Pratesi Athanasios Saratzis Ana R Verissimo Suzannah Bumpstead Stephen A Badger Rachel E Clough Gillian Cockerill Hany Hafez D Julian A Scott T Simon Futers Simon P R Romaine Katherine Bridge Kathryn J Griffin Marc A Bailey Alberto Smith Matthew M Thompson Frank M van Bockxmeer Stefan E Matthiasson Gudmar Thorleifsson Unnur Thorsteinsdottir Jan D Blankensteijn Joep A W Teijink Cisca Wijmenga Jacqueline de Graaf Lambertus A Kiemeney Jes S Lindholt Anne Hughes Declan T Bradley Kathleen Stirrups Jonathan Golledge Paul E Norman Janet T Powell Steve E Humphries Stephen E Hamby Alison H Goodall Christopher P Nelson Natzi Sakalihasan Audrey Courtois Robert E Ferrell Per Eriksson Lasse Folkersen Anders Franco-Cereceda John D Eicher Andrew D Johnson Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Leonard Lipovich Anne M Drolet Eric L Verhoeven Clark J Zeebregts Robert H Geelkerken Marc R van Sambeek Steven M van Sterkenburg Jean-Paul de Vries Kari Stefansson John R Thompson Paul I W de Bakker Panos Deloukas Robert D Sayers Seamus C Harrison Andre M van Rij Nilesh J Samani Matthew J Bown

Circ Res 2017 Jan 29;120(2):341-353. Epub 2016 Nov 29.

For the author affiliations, please see the Appendix.

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January 2017

Selection against variants in the genome associated with educational attainment.

Authors:
Augustine Kong Michael L Frigge Gudmar Thorleifsson Hreinn Stefansson Alexander I Young Florian Zink Gudrun A Jonsdottir Aysu Okbay Patrick Sulem Gisli Masson Daniel F Gudbjartsson Agnar Helgason Gyda Bjornsdottir Unnur Thorsteinsdottir Kari Stefansson

Proc Natl Acad Sci U S A 2017 01 17;114(5):E727-E732. Epub 2017 Jan 17.

deCODE genetics/Amgen Inc., Reykjavik 101, Iceland;

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January 2017

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Authors:
Nicola Barban Rick Jansen Ronald de Vlaming Ahmad Vaez Jornt J Mandemakers Felix C Tropf Xia Shen James F Wilson Daniel I Chasman Ilja M Nolte Vinicius Tragante Sander W van der Laan John R B Perry Augustine Kong Tarunveer S Ahluwalia Eva Albrecht Laura Yerges-Armstrong Gil Atzmon Kirsi Auro Kristin Ayers Andrew Bakshi Danny Ben-Avraham Klaus Berger Aviv Bergman Lars Bertram Lawrence F Bielak Gyda Bjornsdottir Marc Jan Bonder Linda Broer Minh Bui Caterina Barbieri Alana Cavadino Jorge E Chavarro Constance Turman Maria Pina Concas Heather J Cordell Gail Davies Peter Eibich Nicholas Eriksson Tõnu Esko Joel Eriksson Fahimeh Falahi Janine F Felix Mark Alan Fontana Lude Franke Ilaria Gandin Audrey J Gaskins Christian Gieger Erica P Gunderson Xiuqing Guo Caroline Hayward Chunyan He Edith Hofer Hongyan Huang Peter K Joshi Stavroula Kanoni Robert Karlsson Stefan Kiechl Annette Kifley Alexander Kluttig Peter Kraft Vasiliki Lagou Cecile Lecoeur Jari Lahti Ruifang Li-Gao Penelope A Lind Tian Liu Enes Makalic Crysovalanto Mamasoula Lindsay Matteson Hamdi Mbarek Patrick F McArdle George McMahon S Fleur W Meddens Evelin Mihailov Mike Miller Stacey A Missmer Claire Monnereau Peter J van der Most Ronny Myhre Mike A Nalls Teresa Nutile Ioanna Panagiota Kalafati Eleonora Porcu Inga Prokopenko Kumar B Rajan Janet Rich-Edwards Cornelius A Rietveld Antonietta Robino Lynda M Rose Rico Rueedi Kathleen A Ryan Yasaman Saba Daniel Schmidt Jennifer A Smith Lisette Stolk Elizabeth Streeten Anke Tönjes Gudmar Thorleifsson Sheila Ulivi Juho Wedenoja Juergen Wellmann Peter Willeit Jie Yao Loic Yengo Jing Hua Zhao Wei Zhao Daria V Zhernakova Najaf Amin Howard Andrews Beverley Balkau Nir Barzilai Sven Bergmann Ginevra Biino Hans Bisgaard Klaus Bønnelykke Dorret I Boomsma Julie E Buring Harry Campbell Stefania Cappellani Marina Ciullo Simon R Cox Francesco Cucca Daniela Toniolo George Davey-Smith Ian J Deary George Dedoussis Panos Deloukas Cornelia M van Duijn Eco J C de Geus Johan G Eriksson Denis A Evans Jessica D Faul Cinzia Felicita Sala Philippe Froguel Paolo Gasparini Giorgia Girotto Hans-Jörgen Grabe Karin Halina Greiser Patrick J F Groenen Hugoline G de Haan Johannes Haerting Tamara B Harris Andrew C Heath Kauko Heikkilä Albert Hofman Georg Homuth Elizabeth G Holliday John Hopper Elina Hyppönen Bo Jacobsson Vincent W V Jaddoe Magnus Johannesson Astanand Jugessur Mika Kähönen Eero Kajantie Sharon L R Kardia Bernard Keavney Ivana Kolcic Päivikki Koponen Peter Kovacs Florian Kronenberg Zoltan Kutalik Martina La Bianca Genevieve Lachance William G Iacono Sandra Lai Terho Lehtimäki David C Liewald Cecilia M Lindgren Yongmei Liu Robert Luben Michael Lucht Riitta Luoto Per Magnus Patrik K E Magnusson Nicholas G Martin Matt McGue Ruth McQuillan Sarah E Medland Christa Meisinger Dan Mellström Andres Metspalu Michela Traglia Lili Milani Paul Mitchell Grant W Montgomery Dennis Mook-Kanamori Renée de Mutsert Ellen A Nohr Claes Ohlsson Jørn Olsen Ken K Ong Lavinia Paternoster Alison Pattie Brenda W J H Penninx Markus Perola Patricia A Peyser Mario Pirastu Ozren Polasek Chris Power Jaakko Kaprio Leslie J Raffel Katri Räikkönen Olli Raitakari Paul M Ridker Susan M Ring Kathryn Roll Igor Rudan Daniela Ruggiero Dan Rujescu Veikko Salomaa David Schlessinger Helena Schmidt Reinhold Schmidt Nicole Schupf Johannes Smit Rossella Sorice Tim D Spector John M Starr Doris Stöckl Konstantin Strauch Michael Stumvoll Morris A Swertz Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Joyce Y Tung André G Uitterlinden Simona Vaccargiu Jorma Viikari Veronique Vitart Henry Völzke Peter Vollenweider Dragana Vuckovic Johannes Waage Gert G Wagner Jie Jin Wang Nicholas J Wareham David R Weir Gonneke Willemsen Johann Willeit Alan F Wright Krina T Zondervan Kari Stefansson Robert F Krueger James J Lee Daniel J Benjamin David Cesarini Philipp D Koellinger Marcel den Hoed Harold Snieder Melinda C Mills

Nat Genet 2016 12 31;48(12):1462-1472. Epub 2016 Oct 31.

Department of Sociology and Nuffield College, University of Oxford, Oxford, UK.

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December 2016

Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency.

Authors:
Margret Thorsteinsdottir Unnur A Thorsteinsdottir Finnur F Eiriksson Hrafnhildur L Runolfsdottir Inger M Sch Agustsdottir Steinunn Oddsdottir Baldur B Sigurdsson Hordur K Hardarson Nilesh R Kamble Snorri Th Sigurdsson Vidar O Edvardsson Runolfur Palsson

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Nov 14;1036-1037:170-177. Epub 2016 Sep 14.

University of Iceland, Reykjavik, Iceland; Division of Nephrology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. Electronic address:

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November 2016

The rate of meiotic gene conversion varies by sex and age.

Authors:
Bjarni V Halldorsson Marteinn T Hardarson Birte Kehr Unnur Styrkarsdottir Arnaldur Gylfason Gudmar Thorleifsson Florian Zink Adalbjorg Jonasdottir Aslaug Jonasdottir Patrick Sulem Gisli Masson Unnur Thorsteinsdottir Agnar Helgason Augustine Kong Daniel F Gudbjartsson Kari Stefansson

Nat Genet 2016 11 19;48(11):1377-1384. Epub 2016 Sep 19.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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November 2016

A sequence variant associating with educational attainment also affects childhood cognition.

Authors:
Bjarni Gunnarsson Guðrún A Jónsdóttir Gyða Björnsdóttir Bettina Konte Patrick Sulem Snædís Kristmundsdóttir Birte Kehr Ómar Gústafsson Hannes Helgason Paul D Iordache Sigurgeir Ólafsson Michael L Frigge Guðmar Þorleifsson Sunna Arnarsdóttir Berglind Stefánsdóttir Ina Giegling Srdjan Djurovic Kjetil S Sundet Thomas Espeseth Ingrid Melle Annette M Hartmann Unnur Thorsteinsdottir Augustine Kong Daníel F Guðbjartsson Ulrich Ettinger Ole A Andreassen Dan Rujescu Jónas G Halldórsson Hreinn Stefánsson Bjarni V Halldórsson Kári Stefánsson

Sci Rep 2016 11 4;6:36189. Epub 2016 Nov 4.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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November 2016

Multi-nucleotide de novo Mutations in Humans.

Authors:
Søren Besenbacher Patrick Sulem Agnar Helgason Hannes Helgason Helgi Kristjansson Aslaug Jonasdottir Adalbjorg Jonasdottir Olafur Th Magnusson Unnur Thorsteinsdottir Gisli Masson Augustine Kong Daniel F Gudbjartsson Kari Stefansson

PLoS Genet 2016 Nov 15;12(11):e1006315. Epub 2016 Nov 15.

deCODE genetics/Amgen, Inc., Iceland.

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November 2016

Epigenetic and genetic components of height regulation.

Authors:
Stefania Benonisdottir Asmundur Oddsson Agnar Helgason Ragnar P Kristjansson Gardar Sveinbjornsson Arna Oskarsdottir Gudmar Thorleifsson Olafur B Davidsson Gudny A Arnadottir Gerald Sulem Brynjar O Jensson Hilma Holm Kristjan F Alexandersson Laufey Tryggvadottir G Bragi Walters Sigurjon A Gudjonsson Lucas D Ward Jon K Sigurdsson Paul D Iordache Michael L Frigge Thorunn Rafnar Augustine Kong Gisli Masson Hannes Helgason Unnur Thorsteinsdottir Daniel F Gudbjartsson Patrick Sulem Kari Stefansson

Nat Commun 2016 11 16;7:13490. Epub 2016 Nov 16.

deCODE Genetics/Amgen, Inc., 101 Reykjavik, Iceland.

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November 2016

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.

Authors:
Janina S Ried Janina Jeff M Audrey Y Chu Jennifer L Bragg-Gresham Jenny van Dongen Jennifer E Huffman Tarunveer S Ahluwalia Gemma Cadby Niina Eklund Joel Eriksson Tõnu Esko Mary F Feitosa Anuj Goel Mathias Gorski Caroline Hayward Nancy L Heard-Costa Anne U Jackson Eero Jokinen Stavroula Kanoni Kati Kristiansson Zoltán Kutalik Jari Lahti Jian'an Luan Reedik Mägi Anubha Mahajan Massimo Mangino Carolina Medina-Gomez Keri L Monda Ilja M Nolte Louis Pérusse Inga Prokopenko Lu Qi Lynda M Rose Erika Salvi Megan T Smith Harold Snieder Alena Stančáková Yun Ju Sung Ioanna Tachmazidou Alexander Teumer Gudmar Thorleifsson Pim van der Harst Ryan W Walker Sophie R Wang Sarah H Wild Sara M Willems Andrew Wong Weihua Zhang Eva Albrecht Alexessander Couto Alves Stephan J L Bakker Cristina Barlassina Traci M Bartz John Beilby Claire Bellis Richard N Bergman Sven Bergmann John Blangero Matthias Blüher Eric Boerwinkle Lori L Bonnycastle Stefan R Bornstein Marcel Bruinenberg Harry Campbell Yii-Der Ida Chen Charleston W K Chiang Peter S Chines Francis S Collins Fracensco Cucca L Adrienne Cupples Francesca D'Avila Eco J C de Geus George Dedoussis Maria Dimitriou Angela Döring Johan G Eriksson Aliki-Eleni Farmaki Martin Farrall Teresa Ferreira Krista Fischer Nita G Forouhi Nele Friedrich Anette Prior Gjesing Nicola Glorioso Mariaelisa Graff Harald Grallert Niels Grarup Jürgen Gräßler Jagvir Grewal Anders Hamsten Marie Neergaard Harder Catharina A Hartman Maija Hassinen Nicholas Hastie Andrew Tym Hattersley Aki S Havulinna Markku Heliövaara Hans Hillege Albert Hofman Oddgeir Holmen Georg Homuth Jouke-Jan Hottenga Jennie Hui Lise Lotte Husemoen Pirro G Hysi Aaron Isaacs Till Ittermann Shapour Jalilzadeh Alan L James Torben Jørgensen Pekka Jousilahti Antti Jula Johanne Marie Justesen Anne E Justice Mika Kähönen Maria Karaleftheri Kay Tee Khaw Sirkka M Keinanen-Kiukaanniemi Leena Kinnunen Paul B Knekt Heikki A Koistinen Ivana Kolcic Ishminder K Kooner Seppo Koskinen Peter Kovacs Theodosios Kyriakou Tomi Laitinen Claudia Langenberg Alexandra M Lewin Peter Lichtner Cecilia M Lindgren Jaana Lindström Allan Linneberg Roberto Lorbeer Mattias Lorentzon Robert Luben Valeriya Lyssenko Satu Männistö Paolo Manunta Irene Mateo Leach Wendy L McArdle Barbara Mcknight Karen L Mohlke Evelin Mihailov Lili Milani Rebecca Mills May E Montasser Andrew P Morris Gabriele Müller Arthur W Musk Narisu Narisu Ken K Ong Ben A Oostra Clive Osmond Aarno Palotie James S Pankow Lavinia Paternoster Brenda W Penninx Irene Pichler Maria G Pilia Ozren Polašek Peter P Pramstaller Olli T Raitakari Tuomo Rankinen D C Rao Nigel W Rayner Rasmus Ribel-Madsen Treva K Rice Marcus Richards Paul M Ridker Fernando Rivadeneira Kathy A Ryan Serena Sanna Mark A Sarzynski Salome Scholtens Robert A Scott Sylvain Sebert Lorraine Southam Thomas Hempel Sparsø Valgerdur Steinthorsdottir Kathleen Stirrups Ronald P Stolk Konstantin Strauch Heather M Stringham Morris A Swertz Amy J Swift Anke Tönjes Emmanouil Tsafantakis Peter J van der Most Jana V Van Vliet-Ostaptchouk Liesbeth Vandenput Erkki Vartiainen Cristina Venturini Niek Verweij Jorma S Viikari Veronique Vitart Marie-Claude Vohl Judith M Vonk Gérard Waeber Elisabeth Widén Gonneke Willemsen Tom Wilsgaard Thomas W Winkler Alan F Wright Laura M Yerges-Armstrong Jing Hua Zhao M Carola Zillikens Dorret I Boomsma Claude Bouchard John C Chambers Daniel I Chasman Daniele Cusi Ron T Gansevoort Christian Gieger Torben Hansen Andrew A Hicks Frank Hu Kristian Hveem Marjo-Riitta Jarvelin Eero Kajantie Jaspal S Kooner Diana Kuh Johanna Kuusisto Markku Laakso Timo A Lakka Terho Lehtimäki Andres Metspalu Inger Njølstad Claes Ohlsson Albertine J Oldehinkel Lyle J Palmer Oluf Pedersen Markus Perola Annette Peters Bruce M Psaty Hannu Puolijoki Rainer Rauramaa Igor Rudan Veikko Salomaa Peter E H Schwarz Alan R Shudiner Jan H Smit Thorkild I A Sørensen Timothy D Spector Kari Stefansson Michael Stumvoll Angelo Tremblay Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa Uwe Völker Peter Vollenweider Nicholas J Wareham Hugh Watkins James F Wilson Eleftheria Zeggini Goncalo R Abecasis Michael Boehnke Ingrid B Borecki Panos Deloukas Cornelia M van Duijn Caroline Fox Leif C Groop Iris M Heid David J Hunter Robert C Kaplan Mark I McCarthy Kari E North Jeffrey R O'Connell David Schlessinger Unnur Thorsteinsdottir David P Strachan Timothy Frayling Joel N Hirschhorn Martina Müller-Nurasyid Ruth J F Loos

Nat Commun 2016 11 23;7:13357. Epub 2016 Nov 23.

The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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November 2016

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:
Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G William Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 11;48(12):1591

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November 2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Authors:
Georg B Ehret Teresa Ferreira Daniel I Chasman Anne U Jackson Ellen M Schmidt Toby Johnson Gudmar Thorleifsson Jian'an Luan Lousie A Donnelly Stavroula Kanoni Ann-Kristin Petersen Vasyl Pihur Rona J Strawbridge Dmitry Shungin Maria F Hughes Osorio Meirelles Marika Kaakinen Nabila Bouatia-Naji Kati Kristiansson Sonia Shah Marcus E Kleber Xiuqing Guo Leo-Pekka Lyytikäinen Cristiano Fava Niclas Eriksson Ilja M Nolte Patrik K Magnusson Elias L Salfati Loukianos S Rallidis Elizabeth Theusch Andrew J P Smith Lasse Folkersen Kate Witkowska Tune H Pers Roby Joehanes Stuart K Kim Lazaros Lataniotis Rick Jansen Andrew D Johnson Helen Warren Young Jin Kim Wei Zhao Ying Wu Bamidele O Tayo Murielle Bochud Devin Absher Linda S Adair Najaf Amin Dan E Arking Tomas Axelsson Damiano Baldassarre Beverley Balkau Stefania Bandinelli Michael R Barnes Inês Barroso Stephen Bevan Joshua C Bis Gyda Bjornsdottir Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Stefan R Bornstein Morris J Brown Michel Burnier Claudia P Cabrera John C Chambers I-Shou Chang Ching-Yu Cheng Peter S Chines Ren-Hua Chung Francis S Collins John M Connell Angela Döring Jean Dallongeville John Danesh Ulf de Faire Graciela Delgado Anna F Dominiczak Alex S F Doney Fotios Drenos Sarah Edkins John D Eicher Roberto Elosua Stefan Enroth Jeanette Erdmann Per Eriksson Tonu Esko Evangelos Evangelou Alun Evans Tove Fall Martin Farrall Janine F Felix Jean Ferrières Luigi Ferrucci Myriam Fornage Terrence Forrester Nora Franceschini Oscar H Franco Duran Anders Franco-Cereceda Ross M Fraser Santhi K Ganesh He Gao Karl Gertow Francesco Gianfagna Bruna Gigante Franco Giulianini Anuj Goel Alison H Goodall Mark O Goodarzi Mathias Gorski Jürgen Gräßler Christopher Groves Vilmundur Gudnason Ulf Gyllensten Göran Hallmans Anna-Liisa Hartikainen Maija Hassinen Aki S Havulinna Caroline Hayward Serge Hercberg Karl-Heinz Herzig Andrew A Hicks Aroon D Hingorani Joel N Hirschhorn Albert Hofman Jostein Holmen Oddgeir Lingaas Holmen Jouke-Jan Hottenga Phil Howard Chao A Hsiung Steven C Hunt M Arfan Ikram Thomas Illig Carlos Iribarren Richard A Jensen Mika Kähönen Hyun Kang Sekar Kathiresan Brendan J Keating Kay-Tee Khaw Yun Kyoung Kim Eric Kim Mika Kivimaki Norman Klopp Genovefa Kolovou Pirjo Komulainen Jaspal S Kooner Gulum Kosova Ronald M Krauss Diana Kuh Zoltan Kutalik Johanna Kuusisto Kirsti Kvaløy Timo A Lakka Nanette R Lee I-Te Lee Wen-Jane Lee Daniel Levy Xiaohui Li Kae-Woei Liang Honghuang Lin Li Lin Jaana Lindström Stéphane Lobbens Satu Männistö Gabriele Müller Martina Müller-Nurasyid François Mach Hugh S Markus Eirini Marouli Mark I McCarthy Colin A McKenzie Pierre Meneton Cristina Menni Andres Metspalu Vladan Mijatovic Leena Moilanen May E Montasser Andrew D Morris Alanna C Morrison Antonella Mulas Ramaiah Nagaraja Narisu Narisu Kjell Nikus Christopher J O'Donnell Paul F O'Reilly Ken K Ong Fred Paccaud Cameron D Palmer Afshin Parsa Nancy L Pedersen Brenda W Penninx Markus Perola Annette Peters Neil Poulter Peter P Pramstaller Bruce M Psaty Thomas Quertermous Dabeeru C Rao Asif Rasheed N William N W R Rayner Frida Renström Rainer Rettig Kenneth M Rice Robert Roberts Lynda M Rose Jacques Rossouw Nilesh J Samani Serena Sanna Jouko Saramies Heribert Schunkert Sylvain Sebert Wayne H-H Sheu Young-Ah Shin Xueling Sim Johannes H Smit Albert V Smith Maria X Sosa Tim D Spector Alena Stančáková Alice Stanton Kathleen E Stirrups Heather M Stringham Johan Sundstrom Amy J Swift Ann-Christine Syvänen E-Shyong Tai Toshiko Tanaka Kirill V Tarasov Alexander Teumer Unnur Thorsteinsdottir Martin D Tobin Elena Tremoli Andre G Uitterlinden Matti Uusitupa Ahmad Vaez Dhananjay Vaidya Cornelia M van Duijn Erik P A van Iperen Ramachandran S Vasan Germaine C Verwoert Jarmo Virtamo Veronique Vitart Benjamin F Voight Peter Vollenweider Aline Wagner Louise V Wain Nicholas J Wareham Hugh Watkins Alan B Weder Harm-Jan Westra Rainford Wilks Tom Wilsgaard James F Wilson Tien Y Wong Tsun-Po Yang Jie Yao Loic Yengo Weihua Zhang Jing Hua Zhao Xiaofeng Zhu Pascal Bovet Richard S Cooper Karen L Mohlke Danish Saleheen Jong-Young Lee Paul Elliott Hinco J Gierman Cristen J Willer Lude Franke G Kees Hovingh Kent D Taylor George Dedoussis Peter Sever Andrew Wong Lars Lind Themistocles L Assimes Inger Njølstad Peter Eh Schwarz Claudia Langenberg Harold Snieder Mark J Caulfield Olle Melander Markku Laakso Juha Saltevo Rainer Rauramaa Jaakko Tuomilehto Erik Ingelsson Terho Lehtimäki Kristian Hveem Walter Palmas Winfried März Meena Kumari Veikko Salomaa Yii-Der I Chen Jerome I Rotter Philippe Froguel Marjo-Riitta Jarvelin Edward G Lakatta Kari Kuulasmaa Paul W Franks Anders Hamsten H-Erich Wichmann Colin N A Palmer Kari Stefansson Paul M Ridker Ruth J F Loos Aravinda Chakravarti Panos Deloukas Andrew P Morris Christopher Newton-Cheh Patricia B Munroe

Nat Genet 2016 10 12;48(10):1171-1184. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

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October 2016

Adiposity-Dependent Regulatory Effects on Multi-tissue Transcriptomes.

Authors:
Craig A Glastonbury Ana Viñuela Alfonso Buil Gisli H Halldorsson Gudmar Thorleifsson Hannes Helgason Unnur Thorsteinsdottir Kari Stefansson Emmanouil T Dermitzakis Tim D Spector Kerrin S Small

Am J Hum Genet 2016 09;99(3):567-579

Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK. Electronic address:

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September 2016

Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Authors:
Manuel A Rivas Daniel Graham Patrick Sulem Christine Stevens A Nicole Desch Philippe Goyette Daniel Gudbjartsson Ingileif Jonsdottir Unnur Thorsteinsdottir Frauke Degenhardt Sören Mucha Mitja I Kurki Dalin Li Mauro D'Amato Vito Annese Severine Vermeire Rinse K Weersma Jonas Halfvarson Paulina Paavola-Sakki Maarit Lappalainen Monkol Lek Beryl Cummings Taru Tukiainen Talin Haritunians Leena Halme Lotta L E Koskinen Ashwin N Ananthakrishnan Yang Luo Graham A Heap Marijn C Visschedijk Daniel G MacArthur Benjamin M Neale Tariq Ahmad Carl A Anderson Steven R Brant Richard H Duerr Mark S Silverberg Judy H Cho Aarno Palotie Päivi Saavalainen Kimmo Kontula Martti Färkkilä Dermot P B McGovern Andre Franke Kari Stefansson John D Rioux Ramnik J Xavier Mark J Daly

Nat Commun 2016 09 13;7:12869. Epub 2016 Sep 13.

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September 2016

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Authors:
Manuel A Rivas Daniel Graham Patrick Sulem Christine Stevens A Nicole Desch Philippe Goyette Daniel Gudbjartsson Ingileif Jonsdottir Unnur Thorsteinsdottir Frauke Degenhardt Sören Mucha Mitja I Kurki Dalin Li Mauro D'Amato Vito Annese Severine Vermeire Rinse K Weersma Jonas Halfvarson Paulina Paavola-Sakki Maarit Lappalainen Monkol Lek Beryl Cummings Taru Tukiainen Talin Haritunians Leena Halme Lotta L E Koskinen Ashwin N Ananthakrishnan Yang Luo Graham A Heap Marijn C Visschedijk Daniel G MacArthur Benjamin M Neale Tariq Ahmad Carl A Anderson Steven R Brant Richard H Duerr Mark S Silverberg Judy H Cho Aarno Palotie Päivi Saavalainen Kimmo Kontula Martti Färkkilä Dermot P B McGovern Andre Franke Kari Stefansson John D Rioux Ramnik J Xavier Mark J Daly J Barrett K de Lane C Edwards A Hart C Hawkey L Jostins N Kennedy C Lamb J Lee C Lees J Mansfield C Mathew C Mowatt B Newman E Nimmo M Parkes M Pollard N Prescott J Randall D Rice J Satsangi A Simmons M Tremelling H Uhlig D Wilson C Abraham J P Achkar A Bitton G Boucher K Croitoru P Fleshner J Glas S Kugathasan J V Limbergen R Milgrom D Proctor M Regueiro P L Schumm Y Sharma J M Stempak S R Targan M H Wang

Nat Commun 2016 08 9;7:12342. Epub 2016 Aug 9.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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August 2016

Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.

Authors:
Jonathan S Mitchell Ni Li Niels Weinhold Asta Försti Mina Ali Mark van Duin Gudmar Thorleifsson David C Johnson Bowang Chen Britt-Marie Halvarsson Daniel F Gudbjartsson Rowan Kuiper Owen W Stephens Uta Bertsch Peter Broderick Chiara Campo Hermann Einsele Walter A Gregory Urban Gullberg Marc Henrion Jens Hillengass Per Hoffmann Graham H Jackson Ellinor Johnsson Magnus Jöud Sigurður Y Kristinsson Stig Lenhoff Oleg Lenive Ulf-Henrik Mellqvist Gabriele Migliorini Hareth Nahi Sven Nelander Jolanta Nickel Markus M Nöthen Thorunn Rafnar Fiona M Ross Miguel Inacio da Silva Filho Bhairavi Swaminathan Hauke Thomsen Ingemar Turesson Annette Vangsted Ulla Vogel Anders Waage Brian A Walker Anna-Karin Wihlborg Annemiek Broyl Faith E Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J Morgan Hartmut Goldschmidt Kari Hemminki Björn Nilsson Richard S Houlston

Nat Commun 2016 07 1;7:12050. Epub 2016 Jul 1.

Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

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July 2016

Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis.

Authors:
Valgerdur Steinthorsdottir Gudmar Thorleifsson Kristrun Aradottir Bjarke Feenstra Asgeir Sigurdsson Lilja Stefansdottir Anna M Kristinsdottir Florian Zink Gisli H Halldorsson Nete Munk Nielsen Frank Geller Mads Melbye Daniel F Gudbjartsson Reynir T Geirsson Unnur Thorsteinsdottir Kari Stefansson

Nat Commun 2016 07 25;7:12350. Epub 2016 Jul 25.

deCODE Genetics/Amgen, 101 Reykjavik, Iceland.

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July 2016

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:
Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G Iacono Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 07;48(8):970

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July 2016

Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation.

Authors:
Belinda Halling Sørensen Dorthe Nielsen Unnur Arna Thorsteinsdottir Else Kay Hoffmann Ian Henry Lambert

Am J Physiol Cell Physiol 2016 06 16;310(11):C857-73. Epub 2016 Mar 16.

Department of Biology, Section of Cell Biology and Physiology, The August Krogh Building, University of Copenhagen, Copenhagen, Denmark

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June 2016

Physical and neurobehavioral determinants of reproductive onset and success.

Authors:
Felix R Day Hannes Helgason Daniel I Chasman Lynda M Rose Po-Ru Loh Robert A Scott Agnar Helgason Augustine Kong Gisli Masson Olafur Th Magnusson Daniel Gudbjartsson Unnur Thorsteinsdottir Julie E Buring Paul M Ridker Patrick Sulem Kari Stefansson Ken K Ong John R B Perry

Nat Genet 2016 06 18;48(6):617-623. Epub 2016 Apr 18.

MRC Epidemiology Unit, University of Cambridge, UK.

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June 2016

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:
Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G Iacono Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 06 18;48(6):624-33. Epub 2016 Apr 18.

Department of Economics, New York University, New York, New York, USA.

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June 2016

Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease.

Authors:
Anna Helgadottir Solveig Gretarsdottir Gudmar Thorleifsson Eirikur Hjartarson Asgeir Sigurdsson Audur Magnusdottir Aslaug Jonasdottir Helgi Kristjansson Patrick Sulem Asmundur Oddsson Gardar Sveinbjornsson Valgerdur Steinthorsdottir Thorunn Rafnar Gisli Masson Ingileif Jonsdottir Isleifur Olafsson Gudmundur I Eyjolfsson Olof Sigurdardottir Maryam S Daneshpour Davood Khalili Fereidoun Azizi Dorine W Swinkels Lambertus Kiemeney Arshed A Quyyumi Allan I Levey Riyaz S Patel Salim S Hayek Ingibjorg J Gudmundsdottir Gudmundur Thorgeirsson Unnur Thorsteinsdottir Daniel F Gudbjartsson Hilma Holm Kari Stefansson

Nat Genet 2016 06 2;48(6):634-9. Epub 2016 May 2.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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June 2016

Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease.

Authors:
Paul Nioi Asgeir Sigurdsson Gudmar Thorleifsson Hannes Helgason Arna B Agustsdottir Gudmundur L Norddahl Anna Helgadottir Audur Magnusdottir Aslaug Jonasdottir Solveig Gretarsdottir Ingileif Jonsdottir Valgerdur Steinthorsdottir Thorunn Rafnar Dorine W Swinkels Tessel E Galesloot Niels Grarup Torben Jørgensen Henrik Vestergaard Torben Hansen Torsten Lauritzen Allan Linneberg Nele Friedrich Nikolaj T Krarup Mogens Fenger Ulrik Abildgaard Peter R Hansen Anders M Galløe Peter S Braund Christopher P Nelson Alistair S Hall Michael J A Williams Andre M van Rij Gregory T Jones Riyaz S Patel Allan I Levey Salim Hayek Svati H Shah Muredach Reilly Gudmundur I Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Lambertus A Kiemeney Arshed A Quyyumi Daniel J Rader William E Kraus Nilesh J Samani Oluf Pedersen Gudmundur Thorgeirsson Gisli Masson Hilma Holm Daniel Gudbjartsson Patrick Sulem Unnur Thorsteinsdottir Kari Stefansson

N Engl J Med 2016 Jun 18;374(22):2131-41. Epub 2016 May 18.

From deCODE Genetics-Amgen (P.N., A.S., G. Thorleifsson, H. Helgason, A.B.A., G.L.N., A.H., A.M., A.J., S.G., I.J., V.S., T.R., G.M., H. Holm, D.G., P.S., U.T., K.S.), Faculty of Medicine (A.H., I.J., G. Thorgeirsson, U.T., K.S.) and School of Engineering and Natural Sciences (H. Helgason, D.G.), University of Iceland, the Laboratory in Mjodd (G.I.E.), and the Department of Clinical Biochemistry (I.O.) and Division of Cardiology, Department of Internal Medicine (G. Thorgeirsson, H. Holm), Landspitali, National University Hospital of Iceland, Reykjavik, and the Department of Clinical Biochemistry, Akureyri Hospital, Akureyri (O.S.) - all in Iceland; Radboud Institute for Molecular Life Sciences, Department of Laboratory Medicine (D.W.S.), Radboud Institute for Health Sciences (T.E.G., L.A.K.), and the Department of Health Evidence (L.A.K.), Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics (N.G., H.V., T.H., N.T.K., O.P.), and Institute of Public Health, Faculty of Health and Medical Science (T.J., A.L.), University of Copenhagen, and Research Center for Prevention and Health, Capital Region of Denmark (T.J., A.L.), Copenhagen, Faculty of Medicine, University of Aalborg, Aalborg (T.J.), Faculty of Health Sciences, University of Southern Denmark, Odense (T.H.), Department of Public Health, Section of General Practice, University of Aarhus, Aarhus (T.L.), Department of Clinical Experimental Research, Rigshospitalet, Glostrup (A.L.), Department of Clinical Biochemistry, University Hospital of Copenhagen at Hvidovre, Hvidovre (M.F.), Department of Cardiology, Gentofte University Hospital, Hellerup (U.A., P.R.H., A.M.G.), and Department of Cardiology, Roskilde Hospital, Roskilde (A.M.G.) - all in Denmark; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany (N.F.); Department of Cardiovascular Sciences, Uni

View Article
June 2016

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Authors:
Thomas W Winkler Anne E Justice Mariaelisa Graff Llilda Barata Mary F Feitosa Su Chu Jacek Czajkowski Tõnu Esko Tove Fall Tuomas O Kilpeläinen Yingchang Lu Reedik Mägi Evelin Mihailov Tune H Pers Sina Rüeger Alexander Teumer Georg B Ehret Teresa Ferreira Nancy L Heard-Costa Juha Karjalainen Vasiliki Lagou Anubha Mahajan Michael D Neinast Inga Prokopenko Jeannette Simino Tanya M Teslovich Rick Jansen Harm-Jan Westra Charles C White Devin Absher Tarunveer S Ahluwalia Shafqat Ahmad Eva Albrecht Alexessander Couto Alves Jennifer L Bragg-Gresham Anton J M de Craen Joshua C Bis Amélie Bonnefond Gabrielle Boucher Gemma Cadby Yu-Ching Cheng Charleston W K Chiang Graciela Delgado Ayse Demirkan Nicole Dueker Niina Eklund Gudny Eiriksdottir Joel Eriksson Bjarke Feenstra Krista Fischer Francesca Frau Tessel E Galesloot Frank Geller Anuj Goel Mathias Gorski Tanja B Grammer Stefan Gustafsson Saskia Haitjema Jouke-Jan Hottenga Jennifer E Huffman Anne U Jackson Kevin B Jacobs Åsa Johansson Marika Kaakinen Marcus E Kleber Jari Lahti Irene Mateo Leach Benjamin Lehne Youfang Liu Ken Sin Lo Mattias Lorentzon Jian'an Luan Pamela A F Madden Massimo Mangino Barbara McKnight Carolina Medina-Gomez Keri L Monda May E Montasser Gabriele Müller Martina Müller-Nurasyid Ilja M Nolte Kalliope Panoutsopoulou Laura Pascoe Lavinia Paternoster Nigel W Rayner Frida Renström Federica Rizzi Lynda M Rose Kathy A Ryan Perttu Salo Serena Sanna Hubert Scharnagl Jianxin Shi Albert Vernon Smith Lorraine Southam Alena Stančáková Valgerdur Steinthorsdottir Rona J Strawbridge Yun Ju Sung Ioanna Tachmazidou Toshiko Tanaka Gudmar Thorleifsson Stella Trompet Natalia Pervjakova Jonathan P Tyrer Liesbeth Vandenput Sander W van der Laan Nathalie van der Velde Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Efthymia Vlachopoulou Lindsay L Waite Sophie R Wang Zhaoming Wang Sarah H Wild Christina Willenborg James F Wilson Andrew Wong Jian Yang Loïc Yengo Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Ehm A Andersson Stephan J L Bakker Damiano Baldassarre Karina Banasik Matteo Barcella Cristina Barlassina Claire Bellis Paola Benaglio John Blangero Matthias Blüher Fabrice Bonnet Lori L Bonnycastle Heather A Boyd Marcel Bruinenberg Aron S Buchman Harry Campbell Yii-Der Ida Chen Peter S Chines Simone Claudi-Boehm John Cole Francis S Collins Eco J C de Geus Lisette C P G M de Groot Maria Dimitriou Jubao Duan Stefan Enroth Elodie Eury Aliki-Eleni Farmaki Nita G Forouhi Nele Friedrich Pablo V Gejman Bruna Gigante Nicola Glorioso Alan S Go Omri Gottesman Jürgen Gräßler Harald Grallert Niels Grarup Yu-Mei Gu Linda Broer Annelies C Ham Torben Hansen Tamara B Harris Catharina A Hartman Maija Hassinen Nicholas Hastie Andrew T Hattersley Andrew C Heath Anjali K Henders Dena Hernandez Hans Hillege Oddgeir Holmen Kees G Hovingh Jennie Hui Lise L Husemoen Nina Hutri-Kähönen Pirro G Hysi Thomas Illig Philip L De Jager Shapour Jalilzadeh Torben Jørgensen J Wouter Jukema Markus Juonala Stavroula Kanoni Maria Karaleftheri Kay Tee Khaw Leena Kinnunen Steven J Kittner Wolfgang Koenig Ivana Kolcic Peter Kovacs Nikolaj T Krarup Wolfgang Kratzer Janine Krüger Diana Kuh Meena Kumari Theodosios Kyriakou Claudia Langenberg Lars Lannfelt Chiara Lanzani Vaneet Lotay Lenore J Launer Karin Leander Jaana Lindström Allan Linneberg Yan-Ping Liu Stéphane Lobbens Robert Luben Valeriya Lyssenko Satu Männistö Patrik K Magnusson Wendy L McArdle Cristina Menni Sigrun Merger Lili Milani Grant W Montgomery Andrew P Morris Narisu Narisu Mari Nelis Ken K Ong Aarno Palotie Louis Pérusse Irene Pichler Maria G Pilia Anneli Pouta Myriam Rheinberger Rasmus Ribel-Madsen Marcus Richards Kenneth M Rice Treva K Rice Carlo Rivolta Veikko Salomaa Alan R Sanders Mark A Sarzynski Salome Scholtens Robert A Scott William R Scott Sylvain Sebert Sebanti Sengupta Bengt Sennblad Thomas Seufferlein Angela Silveira P Eline Slagboom Jan H Smit Thomas H Sparsø Kathleen Stirrups Ronald P Stolk Heather M Stringham Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Barbara Thorand Anke Tönjes Angelo Tremblay Emmanouil Tsafantakis Peter J van der Most Uwe Völker Marie-Claude Vohl Judith M Vonk Melanie Waldenberger Ryan W Walker Roman Wennauer Elisabeth Widén Gonneke Willemsen Tom Wilsgaard Alan F Wright M Carola Zillikens Suzanne C van Dijk Natasja M van Schoor Folkert W Asselbergs Paul I W de Bakker Jacques S Beckmann John Beilby David A Bennett Richard N Bergman Sven Bergmann Carsten A Böger Bernhard O Boehm Eric Boerwinkle Dorret I Boomsma Stefan R Bornstein Erwin P Bottinger Claude Bouchard John C Chambers Stephen J Chanock Daniel I Chasman Francesco Cucca Daniele Cusi George Dedoussis Jeanette Erdmann Johan G Eriksson Denis A Evans Ulf de Faire Martin Farrall Luigi Ferrucci Ian Ford Lude Franke Paul W Franks Philippe Froguel Ron T Gansevoort Christian Gieger Henrik Grönberg Vilmundur Gudnason Ulf Gyllensten Per Hall Anders Hamsten Pim van der Harst Caroline Hayward Markku Heliövaara Christian Hengstenberg Andrew A Hicks Aroon Hingorani Albert Hofman Frank Hu Heikki V Huikuri Kristian Hveem Alan L James Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Sekar Kathiresan Lambertus A L M Kiemeney Mika Kivimaki Paul B Knekt Heikki A Koistinen Jaspal S Kooner Seppo Koskinen Johanna Kuusisto Winfried Maerz Nicholas G Martin Markku Laakso Timo A Lakka Terho Lehtimäki Guillaume Lettre Douglas F Levinson Lars Lind Marja-Liisa Lokki Pekka Mäntyselkä Mads Melbye Andres Metspalu Braxton D Mitchell Frans L Moll Jeffrey C Murray Arthur W Musk Markku S Nieminen Inger Njølstad Claes Ohlsson Albertine J Oldehinkel Ben A Oostra Lyle J Palmer James S Pankow Gerard Pasterkamp Nancy L Pedersen Oluf Pedersen Brenda W Penninx Markus Perola Annette Peters Ozren Polašek Peter P Pramstaller Bruce M Psaty Lu Qi Thomas Quertermous Olli T Raitakari Tuomo Rankinen Rainer Rauramaa Paul M Ridker John D Rioux Fernando Rivadeneira Jerome I Rotter Igor Rudan Hester M den Ruijter Juha Saltevo Naveed Sattar Heribert Schunkert Peter E H Schwarz Alan R Shuldiner Juha Sinisalo Harold Snieder Thorkild I A Sørensen Tim D Spector Jan A Staessen Bandinelli Stefania Unnur Thorsteinsdottir Michael Stumvoll Jean-Claude Tardif Elena Tremoli Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa André L M Verbeek Sita H Vermeulen Jorma S Viikari Veronique Vitart Henry Völzke Peter Vollenweider Gérard Waeber Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins Eleftheria Zeggini Aravinda Chakravarti Deborah J Clegg L Adrienne Cupples Penny Gordon-Larsen Cashell E Jaquish D C Rao Goncalo R Abecasis Themistocles L Assimes Inês Barroso Sonja I Berndt Michael Boehnke Panos Deloukas Caroline S Fox Leif C Groop David J Hunter Erik Ingelsson Robert C Kaplan Mark I McCarthy Karen L Mohlke Jeffrey R O'Connell David Schlessinger David P Strachan Kari Stefansson Cornelia M van Duijn Joel N Hirschhorn Cecilia M Lindgren Iris M Heid Kari E North Ingrid B Borecki Zoltán Kutalik Ruth J F Loos

PLoS Genet 2016 06 29;12(6):e1006166. Epub 2016 Jun 29.

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June 2016

Genome-wide association study identifies 74 loci associated with educational attainment.

Authors:
Aysu Okbay Jonathan P Beauchamp Mark Alan Fontana James J Lee Tune H Pers Cornelius A Rietveld Patrick Turley Guo-Bo Chen Valur Emilsson S Fleur W Meddens Sven Oskarsson Joseph K Pickrell Kevin Thom Pascal Timshel Ronald de Vlaming Abdel Abdellaoui Tarunveer S Ahluwalia Jonas Bacelis Clemens Baumbach Gyda Bjornsdottir Johannes H Brandsma Maria Pina Concas Jaime Derringer Nicholas A Furlotte Tessel E Galesloot Giorgia Girotto Richa Gupta Leanne M Hall Sarah E Harris Edith Hofer Momoko Horikoshi Jennifer E Huffman Kadri Kaasik Ioanna P Kalafati Robert Karlsson Augustine Kong Jari Lahti Sven J van der Lee Christiaan deLeeuw Penelope A Lind Karl-Oskar Lindgren Tian Liu Massimo Mangino Jonathan Marten Evelin Mihailov Michael B Miller Peter J van der Most Christopher Oldmeadow Antony Payton Natalia Pervjakova Wouter J Peyrot Yong Qian Olli Raitakari Rico Rueedi Erika Salvi Börge Schmidt Katharina E Schraut Jianxin Shi Albert V Smith Raymond A Poot Beate St Pourcain Alexander Teumer Gudmar Thorleifsson Niek Verweij Dragana Vuckovic Juergen Wellmann Harm-Jan Westra Jingyun Yang Wei Zhao Zhihong Zhu Behrooz Z Alizadeh Najaf Amin Andrew Bakshi Sebastian E Baumeister Ginevra Biino Klaus Bønnelykke Patricia A Boyle Harry Campbell Francesco P Cappuccio Gail Davies Jan-Emmanuel De Neve Panos Deloukas Ilja Demuth Jun Ding Peter Eibich Lewin Eisele Niina Eklund David M Evans Jessica D Faul Mary F Feitosa Andreas J Forstner Ilaria Gandin Bjarni Gunnarsson Bjarni V Halldórsson Tamara B Harris Andrew C Heath Lynne J Hocking Elizabeth G Holliday Georg Homuth Michael A Horan Jouke-Jan Hottenga Philip L de Jager Peter K Joshi Astanand Jugessur Marika A Kaakinen Mika Kähönen Stavroula Kanoni Liisa Keltigangas-Järvinen Lambertus A L M Kiemeney Ivana Kolcic Seppo Koskinen Aldi T Kraja Martin Kroh Zoltan Kutalik Antti Latvala Lenore J Launer Maël P Lebreton Douglas F Levinson Paul Lichtenstein Peter Lichtner David C M Liewald Anu Loukola Pamela A Madden Reedik Mägi Tomi Mäki-Opas Riccardo E Marioni Pedro Marques-Vidal Gerardus A Meddens George McMahon Christa Meisinger Thomas Meitinger Yusplitri Milaneschi Lili Milani Grant W Montgomery Ronny Myhre Christopher P Nelson Dale R Nyholt William E R Ollier Aarno Palotie Lavinia Paternoster Nancy L Pedersen Katja E Petrovic David J Porteous Katri Räikkönen Susan M Ring Antonietta Robino Olga Rostapshova Igor Rudan Aldo Rustichini Veikko Salomaa Alan R Sanders Antti-Pekka Sarin Helena Schmidt Rodney J Scott Blair H Smith Jennifer A Smith Jan A Staessen Elisabeth Steinhagen-Thiessen Konstantin Strauch Antonio Terracciano Martin D Tobin Sheila Ulivi Simona Vaccargiu Lydia Quaye Frank J A van Rooij Cristina Venturini Anna A E Vinkhuyzen Uwe Völker Henry Völzke Judith M Vonk Diego Vozzi Johannes Waage Erin B Ware Gonneke Willemsen John R Attia David A Bennett Klaus Berger Lars Bertram Hans Bisgaard Dorret I Boomsma Ingrid B Borecki Ute Bültmann Christopher F Chabris Francesco Cucca Daniele Cusi Ian J Deary George V Dedoussis Cornelia M van Duijn Johan G Eriksson Barbara Franke Lude Franke Paolo Gasparini Pablo V Gejman Christian Gieger Hans-Jörgen Grabe Jacob Gratten Patrick J F Groenen Vilmundur Gudnason Pim van der Harst Caroline Hayward David A Hinds Wolfgang Hoffmann Elina Hyppönen William G Iacono Bo Jacobsson Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Terho Lehtimäki Steven F Lehrer Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Neil Pendleton Brenda W J H Penninx Markus Perola Nicola Pirastu Mario Pirastu Ozren Polasek Danielle Posthuma Christine Power Michael A Province Nilesh J Samani David Schlessinger Reinhold Schmidt Thorkild I A Sørensen Tim D Spector Kari Stefansson Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier Joyce Y Tung André G Uitterlinden Veronique Vitart Peter Vollenweider David R Weir James F Wilson Alan F Wright Dalton C Conley Robert F Krueger George Davey Smith Albert Hofman David I Laibson Sarah E Medland Michelle N Meyer Jian Yang Magnus Johannesson Peter M Visscher Tõnu Esko Philipp D Koellinger David Cesarini Daniel J Benjamin

Nature 2016 05 11;533(7604):539-42. Epub 2016 May 11.

Center for Economic and Social Research, University of Southern California, Los Angeles, California 90089-3332, USA.

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May 2016

Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.

Authors:
Simon N Stacey Birte Kehr Julius Gudmundsson Florian Zink Aslaug Jonasdottir Sigurjon A Gudjonsson Asgeir Sigurdsson Bjarni V Halldorsson Bjarni A Agnarsson Kristrun R Benediktsdottir Katja K H Aben Sita H Vermeulen Ruben G Cremers Angeles Panadero Brian T Helfand Phillip R Cooper Jenny L Donovan Freddie C Hamdy Viorel Jinga Ichiro Okamoto Jon G Jonasson Laufey Tryggvadottir Hrefna Johannsdottir Anna M Kristinsdottir Gisli Masson Olafur T Magnusson Paul D Iordache Agnar Helgason Hannes Helgason Patrick Sulem Daniel F Gudbjartsson Augustine Kong Eirikur Jonsson Rosa B Barkardottir Gudmundur V Einarsson Thorunn Rafnar Unnur Thorsteinsdottir Ioan N Mates David E Neal William J Catalona José I Mayordomo Lambertus A Kiemeney Gudmar Thorleifsson Kari Stefansson

Hum Mol Genet 2016 Mar 5;25(5):1008-18. Epub 2016 Jan 5.

deCODE genetics/AMGEN, Sturlugata 8, 101 Reykjavik, Iceland, Faculty of Medicine,

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March 2016

HLA class II sequence variants influence tuberculosis risk in populations of European ancestry.

Authors:
Gardar Sveinbjornsson Daniel F Gudbjartsson Bjarni V Halldorsson Karl G Kristinsson Magnus Gottfredsson Jeffrey C Barrett Larus J Gudmundsson Kai Blondal Arnaldur Gylfason Sigurjon Axel Gudjonsson Hafdis T Helgadottir Adalbjorg Jonasdottir Aslaug Jonasdottir Ari Karason Ljiljana Bulat Kardum Jelena Knežević Helgi Kristjansson Mar Kristjansson Arthur Love Yang Luo Olafur T Magnusson Patrick Sulem Augustine Kong Gisli Masson Unnur Thorsteinsdottir Zlatko Dembic Sergey Nejentsev Thorsteinn Blondal Ingileif Jonsdottir Kari Stefansson

Nat Genet 2016 Mar 1;48(3):318-22. Epub 2016 Feb 1.

deCODE genetics/Amgen Inc., Reykjavik, Iceland.

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March 2016

Weighting sequence variants based on their annotation increases power of whole-genome association studies.

Authors:
Gardar Sveinbjornsson Anders Albrechtsen Florian Zink Sigurjón A Gudjonsson Asmundur Oddson Gísli Másson Hilma Holm Augustine Kong Unnur Thorsteinsdottir Patrick Sulem Daniel F Gudbjartsson Kari Stefansson

Nat Genet 2016 Mar 8;48(3):314-7. Epub 2016 Feb 8.

deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

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March 2016

Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase.

Authors:
Ragnar P Kristjansson Asmundur Oddsson Hannes Helgason Gardar Sveinbjornsson Gudny A Arnadottir Brynjar O Jensson Aslaug Jonasdottir Adalbjorg Jonasdottir G Bragi Walters Gerald Sulem Arna Oskarsdottir Stefania Benonisdottir Olafur B Davidsson Gisli Masson Olafur Th Magnusson Hilma Holm Olof Sigurdardottir Ingileif Jonsdottir Gudmundur I Eyjolfsson Isleifur Olafsson Daniel F Gudbjartsson Unnur Thorsteinsdottir Patrick Sulem Kari Stefansson

Nat Commun 2016 Feb 3;7:10572. Epub 2016 Feb 3.

deCODE genetics/Amgen, Inc., 101 Reykjavik, Iceland.

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February 2016

Protolichesterinic Acid, Isolated from the Lichen Cetraria islandica, Reduces LRRC8A Expression and Volume-Sensitive Release of Organic Osmolytes in Human Lung Epithelial Cancer Cells.

Authors:
Unnur Arna Thorsteinsdottir Margret Thorsteinsdottir Ian Henry Lambert

Phytother Res 2016 Jan 9;30(1):97-104. Epub 2015 Nov 9.

Department of Biology, Section of Cell biology and Physiology, University of Copenhagen, 13 Universitetsparken, Copenhagen, DK-2100, Denmark.

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January 2016

Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures.

Authors:
Unnur Styrkarsdottir Gudmar Thorleifsson Sigurjon A Gudjonsson Asgeir Sigurdsson Jacqueline R Center Seung Hun Lee Tuan V Nguyen Timothy C Y Kwok Jenny S W Lee Suzanne C Ho Jean Woo Ping-C Leung Beom-Jun Kim Thorunn Rafnar Lambertus A Kiemeney Thorvaldur Ingvarsson Jung-Min Koh Nelson L S Tang John A Eisman Claus Christiansen Gunnar Sigurdsson Unnur Thorsteinsdottir Kari Stefansson

Nat Commun 2016 Jan 6;7:10129. Epub 2016 Jan 6.

deCODE genetics/Amgen, 101 Reykjavik, Iceland.

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January 2016

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

Authors:
Kyle J Gaulton Teresa Ferreira Yeji Lee Anne Raimondo Reedik Mägi Michael E Reschen Anubha Mahajan Adam Locke N William Rayner Neil Robertson Robert A Scott Inga Prokopenko Laura J Scott Todd Green Thomas Sparso Dorothee Thuillier Loic Yengo Harald Grallert Simone Wahl Mattias Frånberg Rona J Strawbridge Hans Kestler Himanshu Chheda Lewin Eisele Stefan Gustafsson Valgerdur Steinthorsdottir Gudmar Thorleifsson Lu Qi Lennart C Karssen Elisabeth M van Leeuwen Sara M Willems Man Li Han Chen Christian Fuchsberger Phoenix Kwan Clement Ma Michael Linderman Yingchang Lu Soren K Thomsen Jana K Rundle Nicola L Beer Martijn van de Bunt Anil Chalisey Hyun Min Kang Benjamin F Voight Gonçalo R Abecasis Peter Almgren Damiano Baldassarre Beverley Balkau Rafn Benediktsson Matthias Blüher Heiner Boeing Lori L Bonnycastle Erwin P Bottinger Noël P Burtt Jason Carey Guillaume Charpentier Peter S Chines Marilyn C Cornelis David J Couper Andrew T Crenshaw Rob M van Dam Alex S F Doney Mozhgan Dorkhan Sarah Edkins Johan G Eriksson Tonu Esko Elodie Eury João Fadista Jason Flannick Pierre Fontanillas Caroline Fox Paul W Franks Karl Gertow Christian Gieger Bruna Gigante Omri Gottesman George B Grant Niels Grarup Christopher J Groves Maija Hassinen Christian T Have Christian Herder Oddgeir L Holmen Astradur B Hreidarsson Steve E Humphries David J Hunter Anne U Jackson Anna Jonsson Marit E Jørgensen Torben Jørgensen Wen-Hong L Kao Nicola D Kerrison Leena Kinnunen Norman Klopp Augustine Kong Peter Kovacs Peter Kraft Jasmina Kravic Cordelia Langford Karin Leander Liming Liang Peter Lichtner Cecilia M Lindgren Eero Lindholm Allan Linneberg Ching-Ti Liu Stéphane Lobbens Jian'an Luan Valeriya Lyssenko Satu Männistö Olga McLeod Julia Meyer Evelin Mihailov Ghazala Mirza Thomas W Mühleisen Martina Müller-Nurasyid Carmen Navarro Markus M Nöthen Nikolay N Oskolkov Katharine R Owen Domenico Palli Sonali Pechlivanis Leena Peltonen John R B Perry Carl G P Platou Michael Roden Douglas Ruderfer Denis Rybin Yvonne T van der Schouw Bengt Sennblad Gunnar Sigurðsson Alena Stančáková Gerald Steinbach Petter Storm Konstantin Strauch Heather M Stringham Qi Sun Barbara Thorand Emmi Tikkanen Anke Tonjes Joseph Trakalo Elena Tremoli Tiinamaija Tuomi Roman Wennauer Steven Wiltshire Andrew R Wood Eleftheria Zeggini Ian Dunham Ewan Birney Lorenzo Pasquali Jorge Ferrer Ruth J F Loos Josée Dupuis Jose C Florez Eric Boerwinkle James S Pankow Cornelia van Duijn Eric Sijbrands James B Meigs Frank B Hu Unnur Thorsteinsdottir Kari Stefansson Timo A Lakka Rainer Rauramaa Michael Stumvoll Nancy L Pedersen Lars Lind Sirkka M Keinanen-Kiukaanniemi Eeva Korpi-Hyövälti Timo E Saaristo Juha Saltevo Johanna Kuusisto Markku Laakso Andres Metspalu Raimund Erbel Karl-Heinz Jöcke Susanne Moebus Samuli Ripatti Veikko Salomaa Erik Ingelsson Bernhard O Boehm Richard N Bergman Francis S Collins Karen L Mohlke Heikki Koistinen Jaakko Tuomilehto Kristian Hveem Inger Njølstad Panagiotis Deloukas Peter J Donnelly Timothy M Frayling Andrew T Hattersley Ulf de Faire Anders Hamsten Thomas Illig Annette Peters Stephane Cauchi Rob Sladek Philippe Froguel Torben Hansen Oluf Pedersen Andrew D Morris Collin N A Palmer Sekar Kathiresan Olle Melander Peter M Nilsson Leif C Groop Inês Barroso Claudia Langenberg Nicholas J Wareham Christopher A O'Callaghan Anna L Gloyn David Altshuler Michael Boehnke Tanya M Teslovich Mark I McCarthy Andrew P Morris

Nat Genet 2015 Dec 9;47(12):1415-25. Epub 2015 Nov 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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December 2015

Corrigendum: Rare coding variants and X-linked loci associated with age at menarche.

Authors:
Kathryn L Lunetta Felix R Day Patrick Sulem Katherine S Ruth Joyce Y Tung David A Hinds Tõnu Esko Cathy E Elks Elisabeth Altmaier Chunyan He Jennifer E Huffman Evelin Mihailov Eleonora Porcu Antonietta Robino Lynda M Rose Ursula M Schick Lisette Stolk Alexander Teumer Deborah J Thompson Michela Traglia Carol A Wang Laura M Yerges-Armstrong Antonis C Antoniou Caterina Barbieri Andrea D Coviello Francesco Cucca Ellen W Demerath Alison M Dunning Ilaria Gandin Megan L Grove Daniel F Gudbjartsson Lynne J Hocking Albert Hofman Jinyan Huang Rebecca D Jackson David Karasik Jennifer Kriebel Ethan M Lange Leslie A Lange Claudia Langenberg Xin Li Jian'an Luan Reedik Mägi Alanna C Morrison Sandosh Padmanabhan Ailith Pirie Ozren Polasek David Porteous Alex P Reiner Fernando Rivadeneira Igor Rudan Cinzia F Sala David Schlessinger Robert A Scott Doris Stöckl Jenny A Visser Uwe Völker Diego Vozzi James G Wilson Marek Zygmunt Eric Boerwinkle Julie E Buring Laura Crisponi Douglas F Easton Caroline Hayward Frank B Hu Simin Liu Andres Metspalu Craig E Pennell Paul M Ridker Konstantin Strauch Elizabeth A Streeten Daniela Toniolo André G Uitterlinden Sheila Ulivi Henry Völzke Nicholas J Wareham Melissa Wellons Nora Franceschini Daniel I Chasman Unnur Thorsteinsdottir Anna Murray Kari Stefansson Joanne M Murabito Ken K Ong John R B Perry

Nat Commun 2015 Dec 17;6:10257. Epub 2015 Dec 17.

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December 2015

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

Authors:
Felix R Day Katherine S Ruth Deborah J Thompson Kathryn L Lunetta Natalia Pervjakova Daniel I Chasman Lisette Stolk Hilary K Finucane Patrick Sulem Brendan Bulik-Sullivan Tõnu Esko Andrew D Johnson Cathy E Elks Nora Franceschini Chunyan He Elisabeth Altmaier Jennifer A Brody Lude L Franke Jennifer E Huffman Margaux F Keller Patrick F McArdle Teresa Nutile Eleonora Porcu Antonietta Robino Lynda M Rose Ursula M Schick Jennifer A Smith Alexander Teumer Michela Traglia Dragana Vuckovic Jie Yao Wei Zhao Eva Albrecht Najaf Amin Tanguy Corre Jouke-Jan Hottenga Massimo Mangino Albert V Smith Toshiko Tanaka Goncalo Abecasis Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Volker Arndt Alice M Arnold Caterina Barbieri Matthias W Beckmann Alicia Beeghly-Fadiel Javier Benitez Leslie Bernstein Suzette J Bielinski Carl Blomqvist Eric Boerwinkle Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Anne-Lise Borresen-Dale Thibaud S Boutin Hiltrud Brauch Hermann Brenner Thomas Brüning Barbara Burwinkel Archie Campbell Harry Campbell Stephen J Chanock J Ross Chapman Yii-Der Ida Chen Georgia Chenevix-Trench Fergus J Couch Andrea D Coviello Angela Cox Kamila Czene Hatef Darabi Immaculata De Vivo Ellen W Demerath Joe Dennis Peter Devilee Thilo Dörk Isabel Dos-Santos-Silva Alison M Dunning John D Eicher Peter A Fasching Jessica D Faul Jonine Figueroa Dieter Flesch-Janys Ilaria Gandin Melissa E Garcia Montserrat García-Closas Graham G Giles Giorgia G Girotto Mark S Goldberg Anna González-Neira Mark O Goodarzi Megan L Grove Daniel F Gudbjartsson Pascal Guénel Xiuqing Guo Christopher A Haiman Per Hall Ute Hamann Brian E Henderson Lynne J Hocking Albert Hofman Georg Homuth Maartje J Hooning John L Hopper Frank B Hu Jinyan Huang Keith Humphreys David J Hunter Anna Jakubowska Samuel E Jones Maria Kabisch David Karasik Julia A Knight Ivana Kolcic Charles Kooperberg Veli-Matti Kosma Jennifer Kriebel Vessela Kristensen Diether Lambrechts Claudia Langenberg Jingmei Li Xin Li Sara Lindström Yongmei Liu Jian'an Luan Jan Lubinski Reedik Mägi Arto Mannermaa Judith Manz Sara Margolin Jonathan Marten Nicholas G Martin Corrado Masciullo Alfons Meindl Kyriaki Michailidou Evelin Mihailov Lili Milani Roger L Milne Martina Müller-Nurasyid Michael Nalls Ben M Neale Heli Nevanlinna Patrick Neven Anne B Newman Børge G Nordestgaard Janet E Olson Sandosh Padmanabhan Paolo Peterlongo Ulrike Peters Astrid Petersmann Julian Peto Paul D P Pharoah Nicola N Pirastu Ailith Pirie Giorgio Pistis Ozren Polasek David Porteous Bruce M Psaty Katri Pylkäs Paolo Radice Leslie J Raffel Fernando Rivadeneira Igor Rudan Anja Rudolph Daniela Ruggiero Cinzia F Sala Serena Sanna Elinor J Sawyer David Schlessinger Marjanka K Schmidt Frank Schmidt Rita K Schmutzler Minouk J Schoemaker Robert A Scott Caroline M Seynaeve Jacques Simard Rossella Sorice Melissa C Southey Doris Stöckl Konstantin Strauch Anthony Swerdlow Kent D Taylor Unnur Thorsteinsdottir Amanda E Toland Ian Tomlinson Thérèse Truong Laufey Tryggvadottir Stephen T Turner Diego Vozzi Qin Wang Melissa Wellons Gonneke Willemsen James F Wilson Robert Winqvist Bruce B H R Wolffenbuttel Alan F Wright Drakoulis Yannoukakos Tatijana Zemunik Wei Zheng Marek Zygmunt Sven Bergmann Dorret I Boomsma Julie E Buring Luigi Ferrucci Grant W Montgomery Vilmundur Gudnason Tim D Spector Cornelia M van Duijn Behrooz Z Alizadeh Marina Ciullo Laura Crisponi Douglas F Easton Paolo P Gasparini Christian Gieger Tamara B Harris Caroline Hayward Sharon L R Kardia Peter Kraft Barbara McKnight Andres Metspalu Alanna C Morrison Alex P Reiner Paul M Ridker Jerome I Rotter Daniela Toniolo André G Uitterlinden Sheila Ulivi Henry Völzke Nicholas J Wareham David R Weir Laura M Yerges-Armstrong Alkes L Price Kari Stefansson Jenny A Visser Ken K Ong Jenny Chang-Claude Joanne M Murabito John R B Perry Anna Murray

Nat Genet 2015 Nov 28;47(11):1294-1303. Epub 2015 Sep 28.

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.

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November 2015

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Authors:
Thomas W Winkler Anne E Justice Mariaelisa Graff Llilda Barata Mary F Feitosa Su Chu Jacek Czajkowski Tõnu Esko Tove Fall Tuomas O Kilpeläinen Yingchang Lu Reedik Mägi Evelin Mihailov Tune H Pers Sina Rüeger Alexander Teumer Georg B Ehret Teresa Ferreira Nancy L Heard-Costa Juha Karjalainen Vasiliki Lagou Anubha Mahajan Michael D Neinast Inga Prokopenko Jeannette Simino Tanya M Teslovich Rick Jansen Harm-Jan Westra Charles C White Devin Absher Tarunveer S Ahluwalia Shafqat Ahmad Eva Albrecht Alexessander Couto Alves Jennifer L Bragg-Gresham Anton J M de Craen Joshua C Bis Amélie Bonnefond Gabrielle Boucher Gemma Cadby Yu-Ching Cheng Charleston W K Chiang Graciela Delgado Ayse Demirkan Nicole Dueker Niina Eklund Gudny Eiriksdottir Joel Eriksson Bjarke Feenstra Krista Fischer Francesca Frau Tessel E Galesloot Frank Geller Anuj Goel Mathias Gorski Tanja B Grammer Stefan Gustafsson Saskia Haitjema Jouke-Jan Hottenga Jennifer E Huffman Anne U Jackson Kevin B Jacobs Åsa Johansson Marika Kaakinen Marcus E Kleber Jari Lahti Irene Mateo Leach Benjamin Lehne Youfang Liu Ken Sin Lo Mattias Lorentzon Jian'an Luan Pamela A F Madden Massimo Mangino Barbara McKnight Carolina Medina-Gomez Keri L Monda May E Montasser Gabriele Müller Martina Müller-Nurasyid Ilja M Nolte Kalliope Panoutsopoulou Laura Pascoe Lavinia Paternoster Nigel W Rayner Frida Renström Federica Rizzi Lynda M Rose Kathy A Ryan Perttu Salo Serena Sanna Hubert Scharnagl Jianxin Shi Albert Vernon Smith Lorraine Southam Alena Stančáková Valgerdur Steinthorsdottir Rona J Strawbridge Yun Ju Sung Ioanna Tachmazidou Toshiko Tanaka Gudmar Thorleifsson Stella Trompet Natalia Pervjakova Jonathan P Tyrer Liesbeth Vandenput Sander W van der Laan Nathalie van der Velde Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Efthymia Vlachopoulou Lindsay L Waite Sophie R Wang Zhaoming Wang Sarah H Wild Christina Willenborg James F Wilson Andrew Wong Jian Yang Loïc Yengo Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Ehm A Andersson Stephan J L Bakker Damiano Baldassarre Karina Banasik Matteo Barcella Cristina Barlassina Claire Bellis Paola Benaglio John Blangero Matthias Blüher Fabrice Bonnet Lori L Bonnycastle Heather A Boyd Marcel Bruinenberg Aron S Buchman Harry Campbell Yii-Der Ida Chen Peter S Chines Simone Claudi-Boehm John Cole Francis S Collins Eco J C de Geus Lisette C P G M de Groot Maria Dimitriou Jubao Duan Stefan Enroth Elodie Eury Aliki-Eleni Farmaki Nita G Forouhi Nele Friedrich Pablo V Gejman Bruna Gigante Nicola Glorioso Alan S Go Omri Gottesman Jürgen Gräßler Harald Grallert Niels Grarup Yu-Mei Gu Linda Broer Annelies C Ham Torben Hansen Tamara B Harris Catharina A Hartman Maija Hassinen Nicholas Hastie Andrew T Hattersley Andrew C Heath Anjali K Henders Dena Hernandez Hans Hillege Oddgeir Holmen Kees G Hovingh Jennie Hui Lise L Husemoen Nina Hutri-Kähönen Pirro G Hysi Thomas Illig Philip L De Jager Shapour Jalilzadeh Torben Jørgensen J Wouter Jukema Markus Juonala Stavroula Kanoni Maria Karaleftheri Kay Tee Khaw Leena Kinnunen Steven J Kittner Wolfgang Koenig Ivana Kolcic Peter Kovacs Nikolaj T Krarup Wolfgang Kratzer Janine Krüger Diana Kuh Meena Kumari Theodosios Kyriakou Claudia Langenberg Lars Lannfelt Chiara Lanzani Vaneet Lotay Lenore J Launer Karin Leander Jaana Lindström Allan Linneberg Yan-Ping Liu Stéphane Lobbens Robert Luben Valeriya Lyssenko Satu Männistö Patrik K Magnusson Wendy L McArdle Cristina Menni Sigrun Merger Lili Milani Grant W Montgomery Andrew P Morris Narisu Narisu Mari Nelis Ken K Ong Aarno Palotie Louis Pérusse Irene Pichler Maria G Pilia Anneli Pouta Myriam Rheinberger Rasmus Ribel-Madsen Marcus Richards Kenneth M Rice Treva K Rice Carlo Rivolta Veikko Salomaa Alan R Sanders Mark A Sarzynski Salome Scholtens Robert A Scott William R Scott Sylvain Sebert Sebanti Sengupta Bengt Sennblad Thomas Seufferlein Angela Silveira P Eline Slagboom Jan H Smit Thomas H Sparsø Kathleen Stirrups Ronald P Stolk Heather M Stringham Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Barbara Thorand Anke Tönjes Angelo Tremblay Emmanouil Tsafantakis Peter J van der Most Uwe Völker Marie-Claude Vohl Judith M Vonk Melanie Waldenberger Ryan W Walker Roman Wennauer Elisabeth Widén Gonneke Willemsen Tom Wilsgaard Alan F Wright M Carola Zillikens Suzanne C van Dijk Natasja M van Schoor Folkert W Asselbergs Paul I W de Bakker Jacques S Beckmann John Beilby David A Bennett Richard N Bergman Sven Bergmann Carsten A Böger Bernhard O Boehm Eric Boerwinkle Dorret I Boomsma Stefan R Bornstein Erwin P Bottinger Claude Bouchard John C Chambers Stephen J Chanock Daniel I Chasman Francesco Cucca Daniele Cusi George Dedoussis Jeanette Erdmann Johan G Eriksson Denis A Evans Ulf de Faire Martin Farrall Luigi Ferrucci Ian Ford Lude Franke Paul W Franks Philippe Froguel Ron T Gansevoort Christian Gieger Henrik Grönberg Vilmundur Gudnason Ulf Gyllensten Per Hall Anders Hamsten Pim van der Harst Caroline Hayward Markku Heliövaara Christian Hengstenberg Andrew A Hicks Aroon Hingorani Albert Hofman Frank Hu Heikki V Huikuri Kristian Hveem Alan L James Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Sekar Kathiresan Lambertus A L M Kiemeney Mika Kivimaki Paul B Knekt Heikki A Koistinen Jaspal S Kooner Seppo Koskinen Johanna Kuusisto Winfried Maerz Nicholas G Martin Markku Laakso Timo A Lakka Terho Lehtimäki Guillaume Lettre Douglas F Levinson Lars Lind Marja-Liisa Lokki Pekka Mäntyselkä Mads Melbye Andres Metspalu Braxton D Mitchell Frans L Moll Jeffrey C Murray Arthur W Musk Markku S Nieminen Inger Njølstad Claes Ohlsson Albertine J Oldehinkel Ben A Oostra Lyle J Palmer James S Pankow Gerard Pasterkamp Nancy L Pedersen Oluf Pedersen Brenda W Penninx Markus Perola Annette Peters Ozren Polašek Peter P Pramstaller Bruce M Psaty Lu Qi Thomas Quertermous Olli T Raitakari Tuomo Rankinen Rainer Rauramaa Paul M Ridker John D Rioux Fernando Rivadeneira Jerome I Rotter Igor Rudan Hester M den Ruijter Juha Saltevo Naveed Sattar Heribert Schunkert Peter E H Schwarz Alan R Shuldiner Juha Sinisalo Harold Snieder Thorkild I A Sørensen Tim D Spector Jan A Staessen Bandinelli Stefania Unnur Thorsteinsdottir Michael Stumvoll Jean-Claude Tardif Elena Tremoli Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa André L M Verbeek Sita H Vermeulen Jorma S Viikari Veronique Vitart Henry Völzke Peter Vollenweider Gérard Waeber Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins Eleftheria Zeggini Aravinda Chakravarti Deborah J Clegg L Adrienne Cupples Penny Gordon-Larsen Cashell E Jaquish D C Rao Goncalo R Abecasis Themistocles L Assimes Inês Barroso Sonja I Berndt Michael Boehnke Panos Deloukas Caroline S Fox Leif C Groop David J Hunter Erik Ingelsson Robert C Kaplan Mark I McCarthy Karen L Mohlke Jeffrey R O'Connell David Schlessinger David P Strachan Kari Stefansson Cornelia M van Duijn Joel N Hirschhorn Cecilia M Lindgren Iris M Heid Kari E North Ingrid B Borecki Zoltán Kutalik Ruth J F Loos

PLoS Genet 2015 Oct 1;11(10):e1005378. Epub 2015 Oct 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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October 2015

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome.

Authors:
Felix R Day David A Hinds Joyce Y Tung Lisette Stolk Unnur Styrkarsdottir Richa Saxena Andrew Bjonnes Linda Broer David B Dunger Bjarni V Halldorsson Debbie A Lawlor Guillaume Laval Iain Mathieson Wendy L McCardle Yvonne Louwers Cindy Meun Susan Ring Robert A Scott Patrick Sulem André G Uitterlinden Nicholas J Wareham Unnur Thorsteinsdottir Corrine Welt Kari Stefansson Joop S E Laven Ken K Ong John R B Perry

Nat Commun 2015 Sep 29;6:8464. Epub 2015 Sep 29.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

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September 2015

Genetic analysis for a shared biological basis between migraine and coronary artery disease.

Authors:
Bendik S Winsvold Christopher P Nelson Rainer Malik Padhraig Gormley Verneri Anttila Jason Vander Heiden Katherine S Elliott Line M Jacobsen Priit Palta Najaf Amin Boukje de Vries Eija Hämäläinen Tobias Freilinger M Arfan Ikram Thorsten Kessler Markku Koiranen Lannie Ligthart George McMahon Linda M Pedersen Christina Willenborg Hong-Hee Won Jes Olesen Ville Artto Themistocles L Assimes Stefan Blankenberg Dorret I Boomsma Lynn Cherkas George Davey Smith Stephen E Epstein Jeanette Erdmann Michel D Ferrari Hartmut Göbel Alistair S Hall Marjo-Riitta Jarvelin Mikko Kallela Jaakko Kaprio Sekar Kathiresan Terho Lehtimäki Ruth McPherson Winfried März Dale R Nyholt Christopher J O'Donnell Lydia Quaye Daniel J Rader Olli Raitakari Robert Roberts Heribert Schunkert Markus Schürks Alexandre F R Stewart Gisela M Terwindt Unnur Thorsteinsdottir Arn M J M van den Maagdenberg Cornelia van Duijn Maija Wessman Tobias Kurth Christian Kubisch Martin Dichgans Daniel I Chasman Chris Cotsapas John-Anker Zwart Nilesh J Samani Aarno Palotie

Neurol Genet 2015 Jun 2;1(1):e10. Epub 2015 Jul 2.

Author affiliations are provided at the end of the article.

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June 2015