Publications by authors named "Unmesh Jadhav"

19Publications

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.

Cell Stem Cell 2020 03 20;26(3):377-390.e6. Epub 2020 Feb 20.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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March 2020

Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters.

Mol Cell 2020 04 5;78(1):141-151.e5. Epub 2020 Feb 5.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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April 2020

Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA.

Mol Cell 2019 05 21;74(3):542-554.e5. Epub 2019 Mar 21.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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May 2019

Dissecting Cell Lineages: From Microscope to Kaleidoscope.

Cell 2019 02;176(5):949-951

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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February 2019

Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development.

Genes Dev 2018 11 26;32(21-22):1430-1442. Epub 2018 Oct 26.

Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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November 2018

Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains.

Genes Dev 2017 12 10;31(23-24):2391-2404. Epub 2018 Jan 10.

Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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December 2017

Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells.

Cell Stem Cell 2017 07 22;21(1):65-77.e5. Epub 2017 Jun 22.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address:

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July 2017

Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine.

Cell Mol Gastroenterol Hepatol 2016 Nov 26;2(6):714-715. Epub 2016 Sep 26.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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November 2016

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells.

Cell Rep 2016 08 11;16(8):2053-2060. Epub 2016 Aug 11.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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August 2016

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells.

Cell 2016 Jun 19;165(6):1389-1400. Epub 2016 May 19.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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June 2016

SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas.

Cell Mol Gastroenterol Hepatol 2015 Nov;1(6):598-609.e6

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA ; Department of Medicine, Harvard Medical School, 45 Shattuck Street, Boston, MA 02115, USA.

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November 2015

Hypogonadotropic hypogonadism in subjects with DAX1 mutations.

Mol Cell Endocrinol 2011 Oct 13;346(1-2):65-73. Epub 2011 Jun 13.

Division of Endocrinology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

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October 2011

Steroidogenic factor-1 (SF-1)-driven differentiation of murine embryonic stem (ES) cells into a gonadal lineage.

Endocrinology 2011 Jul 24;152(7):2870-82. Epub 2011 May 24.

Department of Medicine, Northwestern University Feinberg School of Medicine, Arthur J. Rubloff Building, 420 East Superior Street, 12th Floor, Chicago, Illinois 60611, USA.

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July 2011

The hemopexin domain of MMP-9 inhibits angiogenesis and retards the growth of intracranial glioblastoma xenograft in nude mice.

Int J Cancer 2009 Jan;124(2):306-15

Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61656, USA.

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January 2009

Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells.

J Pharmacol Sci 2007 Feb;103(2):247-51

Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL 61605, USA.

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February 2007

Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells.

Int J Mol Med 2007 Mar;19(3):353-61

Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61605, USA.

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March 2007

Response of neuroblastoma cells to ionizing radiation: modulation of in vitro invasiveness and angiogenesis of human microvascular endothelial cells.

Int J Oncol 2006 Dec;29(6):1525-31

Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61656, USA.

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December 2006

Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells.

Int J Oncol 2004 Nov;25(5):1407-14

Program of Cancer Biology, Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA.

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November 2004