Umit Yasar

Umit Yasar

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Umit Yasar

Publications by authors named "Umit Yasar"

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Does celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2?

Authors:
Umit Yasar

Drug Des Devel Ther 2018;12:2169-2172. Epub 2018 Jul 11.

Department of Medical Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey,

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http://dx.doi.org/10.2147/DDDT.S169358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047855PMC
April 2019

Increased risk for cerebral ischemic stroke in diabetes: genetically polymorphic CYP mediated production of neuroprotective EETs and sulfonylurea metabolism in relation with K channels.

Acta Pharmacol Sin 2019 Apr 25;40(4):569-570. Epub 2018 Sep 25.

Department of Medical Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1038/s41401-018-0088-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461895PMC
April 2019

Extracorporeal circulation systems in coronary artery bypass surgery can affect pharmacokinetics of drugs: may altered CYP-mediated liver function be a possible reason?

Eur J Clin Pharmacol 2018 Aug 9;74(8):1095. Epub 2018 May 9.

Department of Pharmacology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1007/s00228-018-2475-8DOI Listing
August 2018

Two-sided action of Danshen on cytoprotective endogenous substances, epoxyeicosatrienoic acids.

Authors:
Umit Yasar

Chem Biol Interact 2018 08 20;291:152. Epub 2018 Jun 20.

Hacettepe University, Faculty of Medicine, Department of Medical Pharmacology, Ankara, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2018.06.023DOI Listing
August 2018

The role of pharmacogenetics of cytochrome P450s in phenytoin-induced DRESS syndrome.

Authors:
Ümit Yaşar

Cent Eur J Immunol 2018 30;43(2):220-221. Epub 2018 Jun 30.

Department of Medical Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.5114/ceji.2018.77393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102610PMC
June 2018

Decreased Activity and Genetic Polymorphisms of CYP2C19 in Behçet's Disease.

Basic Clin Pharmacol Toxicol 2017 Oct;121(4):266-271

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1111/bcpt.12710DOI Listing
October 2017

Effects of Genetic Polymorphisms of Cytochrome P450 Enzymes and MDR1 Transporter on Pantoprazole Metabolism and Helicobacter pylori Eradication.

Basic Clin Pharmacol Toxicol 2017 Feb 2;120(2):199-206. Epub 2016 Nov 2.

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1111/bcpt.12667DOI Listing
February 2017

Improved anti-emetic efficacy of 5-HT3 receptor antagonists in cancer patients with genetic polymorphisms of ABCB1 (MDR1) drug transporter.

Basic Clin Pharmacol Toxicol 2015 Apr 6;116(4):354-60. Epub 2014 Nov 6.

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1111/bcpt.12334DOI Listing
April 2015

Association between ADH1C and ALDH2 polymorphisms and alcoholism in a Turkish sample.

Nord J Psychiatry 2015 Apr 5;69(3):233-9. Epub 2014 Nov 5.

Yavuz Ayhan, Hacettepe University, Faculty of Medicine, Department of Psychiatry , 06100, Sıhhiye, Ankara , Turkey.

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http://dx.doi.org/10.3109/08039488.2014.972450DOI Listing
April 2015

A biomimetic growth factor delivery strategy for enhanced regeneration of iliac crest defects.

Biomed Mater 2013 Aug 19;8(4):045009. Epub 2013 Jun 19.

Department of Biomedical Engineering, Faculty of Engineering and Architecture, Cukurova University, Adana, Turkey.

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http://dx.doi.org/10.1088/1748-6041/8/4/045009DOI Listing
August 2013

The therapeutic effects of melatonin and nimodipine in rats after cerebral cortical injury.

Turk Neurosurg 2012 ;22(6):740-6

Suleyman Demirel University, Medical Faculty Hospital, Department of Neurosurgery, Isparta, Turkey.

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http://dx.doi.org/10.5137/1019-5149.JTN.6197-12.1DOI Listing
June 2013

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers.

J Pharm Pharmacol 2013 Jun 21;65(6):874-83. Epub 2013 Mar 21.

Comparative and Molecular Pharmacogenomics Laboratory, Tufts University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1111/jphp.12053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195312PMC
June 2013

Ocular pharmacokinetics, safety and efficacy of intracameral moxifloxacin 0.5% solution in a rabbit model.

Curr Eye Res 2013 Apr 1;38(4):472-9. Epub 2013 Feb 1.

Department of Ophthalmology, Faculty of Medicine, Baskent University, Ankara, Turkey.

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http://dx.doi.org/10.3109/02713683.2012.763101DOI Listing
April 2013

Acenocoumarol sensitivity and pharmacokinetic characterization of CYP2C9 *5/*8,*8/*11,*9/*11 and VKORC1*2 in black African healthy Beninese subjects.

Eur J Drug Metab Pharmacokinet 2012 Jun 3;37(2):125-32. Epub 2011 Aug 3.

Unité de Pharmacologie, Faculté des Sciences de la Santé de Cotonou, Université d'Abomey-Calavi, Campus du Champ de Foire, 01 BP 188, Cotonou, Benin.

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http://dx.doi.org/10.1007/s13318-011-0056-7DOI Listing
June 2012

Evaluation of lansoprazole as a probe for assessing cytochrome P450 2C19 activity and genotype-phenotype correlation in childhood.

Eur J Clin Pharmacol 2012 May 11;68(5):629-36. Epub 2011 Nov 11.

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, Turkey.

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http://dx.doi.org/10.1007/s00228-011-1151-zDOI Listing
May 2012

Aqueous humour penetration of moxifloxocin and gatifloxacin eye drops in different dosing regimens before phacoemulsification surgery.

Br J Ophthalmol 2011 Sep 28;95(9):1272-5. Epub 2010 Oct 28.

Department of Ophthalmology, Basxkent University, Faculty of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1136/bjo.2010.179762DOI Listing
September 2011

Effect of atorvastatin on CYP2C9 metabolic activity as measured by the formation rate of losartan metabolite in hypercholesterolaemic patients.

Basic Clin Pharmacol Toxicol 2011 Aug 16;109(2):73-7. Epub 2011 Mar 16.

Departments of Pharmacology, Hacettepe University, Sihhiye, Ankara, Turkey.

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http://dx.doi.org/10.1111/j.1742-7843.2011.00687.xDOI Listing
August 2011

Functional effects of endothelial nitric oxide synthase genetic polymorphisms on haemorheological parameters in healthy human individuals.

Basic Clin Pharmacol Toxicol 2011 Mar 27;108(3):171-6. Epub 2010 Oct 27.

Department of Pharmacology, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey.

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http://dx.doi.org/10.1111/j.1742-7843.2010.00637.xDOI Listing
March 2011

Association between the Glu298Asp and T(-786)C polymorphisms of the endothelial nitric oxide synthase gene and respiratory distress in preterm neonates.

Turk J Pediatr 2010 Mar-Apr;52(2):145-9

Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

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August 2010

Disposition of a CYP2C9 phenotyping agent, losartan, is not influenced by the common 3435C > T variation of the drug transporter gene ABCB1 (MDR1).

Basic Clin Pharmacol Toxicol 2008 Aug;103(2):176-9

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1111/j.1742-7843.2008.00283.xDOI Listing
August 2008

Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene.

Epilepsy Res 2008 Jul 23;80(1):42-6. Epub 2008 Apr 23.

Hacettepe University, Institute of Neurological Sciences and Psychiatry, Sihhiye 06100, Ankara, Turkey.

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https://linkinghub.elsevier.com/retrieve/pii/S09201211080007
Publisher Site
http://dx.doi.org/10.1016/j.eplepsyres.2008.03.004DOI Listing
July 2008

Effect of raloxifene on cerebral vasospasm following experimental subarachnoid hemorrhage in rats.

Neurol Med Chir (Tokyo) 2007 Dec;47(12):537-42; discussion 542

Department of Neurosurgery, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.2176/nmc.47.537DOI Listing
December 2007

Successful treatment of propafenone, digoxin and warfarin overdosage with plasma exchange therapy and rifampicin.

Clin Drug Investig 2007 ;27(7):505-8

Department of Pediatrics, Division of Pediatric Hematology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.2165/00044011-200727070-00008DOI Listing
August 2007

Association of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever.

J Rheumatol 2007 Jul 15;34(7):1540-4. Epub 2007 Jun 15.

Division of Rheumatology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey.

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July 2007

Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients.

Basic Clin Pharmacol Toxicol 2007 Jun;100(6):383-6

Department of Pharmacology, Madical Faculty, Gazi University, Ankara, Turkey.

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http://dx.doi.org/10.1111/j.1742-7843.2007.00061.xDOI Listing
June 2007

Capecitabine-induced severe hypertriglyceridemia: report of two cases.

Ann Pharmacother 2006 Feb 3;40(2):328-31. Epub 2006 Jan 3.

Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1345/aph.1G348DOI Listing
February 2006

Inhibitory effect of 5-fluorouracil on cytochrome P450 2C9 activity in cancer patients.

Basic Clin Pharmacol Toxicol 2006 Feb;98(2):197-200

Department of Pharmacology, Gazi University, Medical Faculty, Ankara, Turkey.

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http://dx.doi.org/10.1111/j.1742-7843.2006.pto_304.xDOI Listing
February 2006

Pharmacogenetics of cyclophosphamide in patients with hematological malignancies.

Eur J Pharm Sci 2006 Jan 23;27(1):54-61. Epub 2005 Sep 23.

Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, SE 141-86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.ejps.2005.08.008DOI Listing
January 2006

Functional impact of CYP2C95, CYP2C96, CYP2C98, and CYP2C911 in vivo among black Africans.

Clin Pharmacol Ther 2004 Aug;76(2):113-8

Centre d'Investigations Cliniques et de Recherches Thérapeutiques, Cové, République du Bénin.

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http://dx.doi.org/10.1016/j.clpt.2004.04.001DOI Listing
August 2004

CYP2C9 genetic variants and losartan oxidation in a Turkish population.

Eur J Clin Pharmacol 2004 Jul 10;60(5):337-42. Epub 2004 Jun 10.

Department of Pharmacology, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey.

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http://dx.doi.org/10.1007/s00228-004-0785-5DOI Listing
July 2004

Warfarin resistance with poor CYP2C9 activity and CYP2C9*1*2 genotype.

Ann Pharmacother 2004 May 23;38(5):899. Epub 2004 Mar 23.

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http://dx.doi.org/10.1345/aph.1D450DOI Listing
May 2004

Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction.

Pharmacogenetics 2003 Dec;13(12):715-20

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1097/00008571-200312000-00002DOI Listing
December 2003

A screening study on the liability of eight different female sex steroids to inhibit CYP2C9, 2C19 and 3A4 activities in human liver microsomes.

Pharmacol Toxicol 2003 Aug;93(2):77-81

Department of Medical Laboratory Sciences & Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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August 2003

CYP2C9 genotypes and diclofenac metabolism in Spanish healthy volunteers.

Eur J Clin Pharmacol 2003 Jul 7;59(3):221-5. Epub 2003 May 7.

Department of Pharmacology and Psychiatry, Faculty of Medicine, University of Extremadura, Av. de Elvas s/n, 06071 Badajoz, Spain.

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http://dx.doi.org/10.1007/s00228-003-0588-0DOI Listing
July 2003

Bioactivation of cyclophosphamide: the role of polymorphic CYP2C enzymes.

Eur J Clin Pharmacol 2003 Jun 9;59(2):103-9. Epub 2003 Apr 9.

Department of Medical Laboratory Sciences and Technology, Karolinska Institutet at Huddinge University Hospital, 14186 Stockholm, Sweden.

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http://link.springer.com/content/pdf/10.1007/s00228-003-0590
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http://link.springer.de/link/service/journals/00228/contents
Publisher Site
http://dx.doi.org/10.1007/s00228-003-0590-6DOI Listing
June 2003

The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.

Clin Pharmacol Ther 2003 Jun;73(6):517-28

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/S0009-9236(03)00050-XDOI Listing
June 2003

Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway.

Drug Metab Dispos 2002 Dec;30(12):1368-71

Department of Medical Laboratory Sciences and Technology, Hospital Pharmacy at Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1124/dmd.30.12.1368DOI Listing
December 2002

Linkage between the CYP2C8 and CYP2C9 genetic polymorphisms.

Biochem Biophys Res Commun 2002 Nov;299(1):25-8

Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0006-291x(02)02592-5DOI Listing
November 2002

Analysis of CYP2C9*5 in Caucasian, Oriental and black-African populations.

Eur J Clin Pharmacol 2002 Nov 1;58(8):555-8. Epub 2002 Nov 1.

Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sewden.

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http://dx.doi.org/10.1007/s00228-002-0518-6DOI Listing
November 2002

Oxidation of celecoxib by polymorphic cytochrome P450 2C9 and alcohol dehydrogenase.

Br J Clin Pharmacol 2002 Oct;54(4):423-9

Division of Clinical Pharmacology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874434PMC
http://dx.doi.org/10.1046/j.1365-2125.2002.01660.xDOI Listing
October 2002

Pharmacokinetics of losartan and its metabolite E-3174 in relation to the CYP2C9 genotype.

Clin Pharmacol Ther 2002 Jan;71(1):89-98

Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet at Huddinge University Hospital, Stockholm.

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http://dx.doi.org/10.1067/mcp.2002.121216DOI Listing
January 2002