Publications by authors named "Umberto Malapelle"

100Publications

Next-Generation Sequencing in Tumor Diagnosis and Treatment.

Diagnostics (Basel) 2020 Nov 17;10(11). Epub 2020 Nov 17.

Department of Public Health, University of Naples Federico II, 80131 Naples, Italy.

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http://dx.doi.org/10.3390/diagnostics10110962DOI Listing
November 2020

A narrative review of lung cancer cytology in the times of coronavirus: what physicians should know.

Transl Lung Cancer Res 2020 Oct;9(5):2074-2081

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.21037/tlcr-20-795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653120PMC
October 2020

Biomarkers predictive value in early stage non-small cell lung cancer.

Transl Lung Cancer Res 2020 Aug;9(4):956-959

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.21037/tlcr.2020.04.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481621PMC
August 2020

Molecular predictive testing in precision oncology: The Italian experience.

Cancer Cytopathol 2020 Sep;128(9):622-628

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1002/cncy.22290DOI Listing
September 2020

Corrigendum to "Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)" [Crit. Rev. Oncol. Hematol. 151 (July) (2020) 102978].

Crit Rev Oncol Hematol 2020 Oct 18;154:103058. Epub 2020 Aug 18.

Centre for Genomics and Oncological Research - GENYO, Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain; Bio-Health Research Institute (Instituto de Investigación Biosanitaria ibs. GRANADA), Spain; Complejo Hospitalario Universitario Granada (CHUG), Department of Medical Oncology, University of Granada, Granada, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2020.103058DOI Listing
October 2020

KRAS inhibition in non-small cell lung cancer: Past failures, new findings and upcoming challenges.

Eur J Cancer 2020 Sep 31;137:57-68. Epub 2020 Jul 31.

Department of Oncology, University of Turin, S. Luigi Gonzaga Hospital, Orbassano (TO), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2020.06.023DOI Listing
September 2020

Thyroid cytology smear slides: An untapped resource for ThyroSeq testing.

Cancer Cytopathol 2020 Jul 22. Epub 2020 Jul 22.

Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/cncy.22331DOI Listing
July 2020

A BRAF new world.

Crit Rev Oncol Hematol 2020 Aug 26;152:103008. Epub 2020 May 26.

Department of Oncology, Geneva University Hospital, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2020.103008DOI Listing
August 2020

Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB).

Crit Rev Oncol Hematol 2020 Jul 5;151:102978. Epub 2020 May 5.

Centre for Genomics and Oncological Research - GENYO, Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain; Bio-Health Research Institute (Instituto de Investigación Biosanitaria ibs. GRANADA), Spain; Complejo Hospitalario Universitario Granada (CHUG), Department of Medical Oncology, University of Granada, Granada, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2020.102978DOI Listing
July 2020

Cytology in the time of coronavirus disease (covid-19): an Italian perspective.

J Clin Pathol 2020 Apr 20. Epub 2020 Apr 20.

Department of Public Health, University of Naples Federico II, Naples, Italy

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http://dx.doi.org/10.1136/jclinpath-2020-206614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211103PMC
April 2020

Overcoming resistance to osimertinib in non-small cell lung cancer: Hopes, doubts, and in-between.

Cancer 2020 Jun 10;126(11):2594-2596. Epub 2020 Mar 10.

Division of Thoracic Oncology, European Institute of Oncology, IRCCS, Milan, Italy.

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http://dx.doi.org/10.1002/cncr.32810DOI Listing
June 2020

Predictive biomarkers for molecular pathology in lung cancer.

Biomark Med 2020 03 3;14(4):253-257. Epub 2020 Mar 3.

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.2217/bmm-2019-0490DOI Listing
March 2020

The significance of epidermal growth factor receptor uncommon mutations in non-small cell lung cancer: A systematic review and critical appraisal.

Cancer Treat Rev 2020 Apr 21;85:101994. Epub 2020 Feb 21.

Department of Section of Medical Oncology, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2020.101994DOI Listing
April 2020

Targeting emerging molecular alterations in the treatment of non-small cell lung cancer: current challenges and the way forward.

Expert Opin Investig Drugs 2020 Apr 26;29(4):363-372. Epub 2020 Feb 26.

Division of Medical Oncology, Fondazione IRCCS "Casa Sollievo Della Sofferenza", San Giovanni Rotondo (FG), Italy.

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http://dx.doi.org/10.1080/13543784.2020.1732922DOI Listing
April 2020

Comparison between two different next generation sequencing platforms for clinical relevant gene mutation test in solid tumours.

J Clin Pathol 2020 Sep 14;73(9):602-604. Epub 2020 Feb 14.

Azienda USL Toscana Centro, Complex Unit of Pathological Anatomy Empoli-Prato, S. Stefano Hospital, Prato, Italy.

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http://dx.doi.org/10.1136/jclinpath-2019-206422DOI Listing
September 2020

Pharmacodynamics of current and emerging PD-1 and PD-L1 inhibitors for the treatment of non-small cell lung cancer.

Expert Opin Drug Metab Toxicol 2020 Feb 30;16(2):87-96. Epub 2020 Jan 30.

Division of Medical Oncology, "S.G. Moscati" Hospital, Avellino, Italy.

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http://dx.doi.org/10.1080/17425255.2020.1721460DOI Listing
February 2020

Next generation sequencing identifies novel potential actionable mutations for grade I meningioma treatment.

Histol Histopathol 2020 Jul 24;35(7):741-749. Epub 2019 Dec 24.

Department of Pathology, Gregorio Marañon University Hospital, Madrid, Spain.

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http://dx.doi.org/10.14670/HH-18-195DOI Listing
July 2020

Lung Cancer in Italy.

J Thorac Oncol 2019 12;14(12):2046-2052

Department of Oncology, University of Turin, San Luigi Hospital, Orbassano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2019.05.019DOI Listing
December 2019

Relationship between performance status or younger age and osimertinib therapy in T790M-positive NSCLC: are the available data convincing?

J Thorac Dis 2019 Sep;11(Suppl 15):S1837-S1840

Comprehesive Cancer Center, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy.

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http://dx.doi.org/10.21037/jtd.2019.08.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783785PMC
September 2019

Liquid biopsy tracking of lung tumor evolutions over time.

Expert Rev Mol Diagn 2019 12 16;19(12):1099-1108. Epub 2019 Oct 16.

Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1080/14737159.2020.1680287DOI Listing
December 2019

Prognostic Factors and Biomarkers of Responses to Immune Checkpoint Inhibitors in Lung Cancer.

Int J Mol Sci 2019 Oct 5;20(19). Epub 2019 Oct 5.

Department of Precision Medicine, University of Campania "L Vanvitelli", 80131 Naples, Italy.

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http://dx.doi.org/10.3390/ijms20194931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801651PMC
October 2019

USP11 role in colorectal cancer growing and metastatisation.

EBioMedicine 2019 Oct 17;48:5-6. Epub 2019 Sep 17.

Department of Public Health, University Federico II of Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838450PMC
October 2019

Liquid biopsy as a follow-up tool: Comment on longitudinal monitoring of somatic genetic alterations in circulating cell-free DNA during treatment with epidermal growth factor receptor-tyrosine kinase inhibitors.

Cancer 2020 01 10;126(1):22-25. Epub 2019 Sep 10.

Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/cncr.32482DOI Listing
January 2020

Mismatch repair proteins and microsatellite instability in solid pseudopapillary neoplasm of the pancreas.

Hepatobiliary Pancreat Dis Int 2019 Oct 22;18(5):491-492. Epub 2019 Aug 22.

Department of Public Health, University of Naples Federico II, Via Pansini 5, 80131 Napoli, Italy.

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http://dx.doi.org/10.1016/j.hbpd.2019.08.003DOI Listing
October 2019

Intensive first-line FIr-C/FOx-C association of triplet chemotherapy plus cetuximab in wild-type metastatic colorectal cancer patients: preliminary phase II data and prediction of individual limiting toxicity syndromes by pharmacogenomic biomarkers.

Ther Adv Med Oncol 2019 10;11:1758835919846421. Epub 2019 May 10.

U.O.S.D. Oncology Territorial Care, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, L'Aquila 67100, Italy.

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http://dx.doi.org/10.1177/1758835919846421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535746PMC
May 2019

Bird's eye view of modern cytopathology: Report from the seventh international Molecular Cytopathology Meeting in Naples, Italy, 2018.

Cancer Cytopathol 2019 06 28;127(6):350-357. Epub 2019 May 28.

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1002/cncy.22118DOI Listing
June 2019

Emerging angiogenesis inhibitors for non-small cell lung cancer.

Expert Opin Emerg Drugs 2019 06 22;24(2):71-81. Epub 2019 May 22.

b Division of Medical Oncology , Fondazione IRCCS Casa Sollievo della Sofferenza , San Giovanni Rotondo (Foggia) , Italy.

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http://dx.doi.org/10.1080/14728214.2019.1619696DOI Listing
June 2019

Role of Cytomorphology in the Era of Liquid Biopsy.

Acta Cytol 2019 3;63(6):497-505. Epub 2019 Apr 3.

Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.

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http://dx.doi.org/10.1159/000499338DOI Listing
October 2019

BRAF Mutations in Lung Cancer.

Acta Cytol 2019 6;63(3):247-250. Epub 2019 Mar 6.

Department of Public Health, University of Naples Federico II, Naples, Italy,

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http://dx.doi.org/10.1159/000496478DOI Listing
June 2019

Circulating Tumour Cells in Predictive Molecular Pathology: Focus on Drug-Sensitive Assays and 3D Culture.

Acta Cytol 2019 13;63(3):171-181. Epub 2019 Feb 13.

Department of Public Health, University of Naples Federico II, Naples, Italy,

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http://dx.doi.org/10.1159/000496213DOI Listing
June 2019

Detection of epidermal growth factor receptor mutations in circulating tumor DNA: reviewing BENEFIT clinical trial.

J Thorac Dis 2018 Dec;10(12):6388-6391

Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.21037/jtd.2018.11.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344757PMC
December 2018

Liquid Biopsy and Lung Cancer.

Acta Cytol 2019 19;63(6):489-496. Epub 2018 Dec 19.

Department of Public Health, University of Naples Federico II, Naples, Italy,

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https://www.karger.com/Article/FullText/492710
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http://dx.doi.org/10.1159/000492710DOI Listing
October 2019

Cytology versus histology for programmed death-ligand 1 expression evaluation in the landscape of non-small cell lung cancer patients selection for immunotherapy.

Transl Lung Cancer Res 2018 Sep;7(Suppl 3):S221-S224

Division of Medical Oncology, Scientific Institute for Research and Health Care (IRCCS) "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.

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http://tlcr.amegroups.com/article/view/23598/18271
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http://dx.doi.org/10.21037/tlcr.2018.08.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193894PMC
September 2018

Osimertinib.

Recent Results Cancer Res 2018;211:257-276

Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, via Dottori, 1, 06156, Perugia, Italy.

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http://dx.doi.org/10.1007/978-3-319-91442-8_18DOI Listing
November 2018

Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives.

Gastroenterol Res Pract 2018 13;2018:2397863. Epub 2018 Jun 13.

Unit of General Surgery, Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, Università degli Studi della Campania "Luigi Vanvitelli", Piazza Miraglia 2, 80138 Naples, Italy.

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https://www.hindawi.com/journals/grp/2018/2397863/
Publisher Site
http://dx.doi.org/10.1155/2018/2397863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020538PMC
June 2018

Idylla assay and next generation sequencing: an integrated EGFR mutational testing algorithm.

J Clin Pathol 2018 Aug 24;71(8):745-750. Epub 2018 May 24.

Division of Pathology and Laboratory Medicine, Istituto Europeo di Oncologia, Milan, Italy.

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http://dx.doi.org/10.1136/jclinpath-2018-205197DOI Listing
August 2018

Targeting immune checkpoints in non small cell lung cancer.

Curr Opin Pharmacol 2018 06 9;40:46-50. Epub 2018 Mar 9.

Department of Cardio-Thoracic and Respiratory Sciences - University of Campania "L Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.1016/j.coph.2018.02.006DOI Listing
June 2018

ALK and ROS1 testing on lung cancer cytologic samples: Perspectives.

Cancer Cytopathol 2017 Nov 25;125(11):817-830. Epub 2017 Jul 25.

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1002/cncy.21899DOI Listing
November 2017

How to prepare cytological samples for molecular testing.

J Clin Pathol 2017 Oct 24;70(10):819-826. Epub 2017 Jul 24.

Department of Public Health, Anatomic Pathology Unit, University of Napoli Federico II School of Medicine, Napoli, Italy.

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http://dx.doi.org/10.1136/jclinpath-2017-204561DOI Listing
October 2017

Editorial: Second Line Treatment of Non-Small Cell Lung Cancer: Clinical, Pathological and Molecular Aspects of Novel Promising Drugs.

Front Med (Lausanne) 2017 22;4:63. Epub 2017 May 22.

Institute of Experimental Endocrinology and Oncology (IEOS) "G. Salvatore", National Research Council (CNR), Naples, Italy.

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http://dx.doi.org/10.3389/fmed.2017.00063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439169PMC
May 2017

Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR.

Oncotarget 2017 Apr;8(14):23020-23032

Oncologia Medica, Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale "F. Magrassi e A. Lanzara," Università degli studi della Campania "Luigi Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.18632/oncotarget.15479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410282PMC
April 2017

miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene.

BMC Cancer 2017 03 4;17(1):170. Epub 2017 Mar 4.

Istituto di Endocrinologia ed Oncologia Sperimentale "G. Salvatore" - CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II", Naples, Italy.

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http://dx.doi.org/10.1186/s12885-017-3158-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336640PMC
March 2017

Profile of the Roche cobas® EGFR mutation test v2 for non-small cell lung cancer.

Expert Rev Mol Diagn 2017 03 9;17(3):209-215. Epub 2017 Feb 9.

c Department of Medical Oncology , Hospital General Universitario de Valencia , Valencia , Spain.

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http://dx.doi.org/10.1080/14737159.2017.1288568DOI Listing
March 2017

New perspectives in the second-line treatment of non squamous NSCLC patients: Results from a large Italian Lung Cancer Working Group.

Crit Rev Oncol Hematol 2017 Jan 25;109:35-41. Epub 2016 Nov 25.

SC Thoracic Medical Oncology Istituto Nazionale Tumori, "Fondazione G. Pascale"-IRCCS, Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2016.11.015DOI Listing
January 2017

Microsatellite instability evaluation by automated microfluidic electrophoresis: an update.

J Clin Pathol 2017 Jan 21;70(1):90-91. Epub 2016 Nov 21.

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1136/jclinpath-2016-204200DOI Listing
January 2017

mutation detection on lung cancer cytological specimens by the novel fully automated PCR-based Idylla Mutation Assay.

J Clin Pathol 2017 Apr 19;70(4):295-300. Epub 2016 Aug 19.

Department of Public Health, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1136/jclinpath-2016-203989DOI Listing
April 2017

Fully automated PCR detection of KRAS mutations on pancreatic endoscopic ultrasound fine-needle aspirates.

J Clin Pathol 2016 Apr 27. Epub 2016 Apr 27.

Department of Public Health, Anatomic Pathology Unit, University of Napoli Federico II School of Medicine, Napoli, Italy.

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http://jcp.bmj.com/content/early/2016/04/27/jclinpath-2016-2
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http://dx.doi.org/10.1136/jclinpath-2016-203696DOI Listing
April 2016

UbcH10 overexpression is less pronounced in older colorectal cancer patients.

Int J Colorectal Dis 2016 Jul 7;31(7):1367-8. Epub 2016 Jan 7.

Unit of Colorectal Surgery, Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Piazza Miraglia 2, 80138, Naples, Italy.

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http://dx.doi.org/10.1007/s00384-015-2481-6DOI Listing
July 2016