Publications by authors named "Uma Sudhakar"

20 Publications

  • Page 1 of 1

Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma-A Systematic Review and Meta-Analysis.

Curr Issues Mol Biol 2021 Aug 28;43(2):1019-1035. Epub 2021 Aug 28.

Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.

Objective: To qualitative and quantitatively review published literature assessing the oxidative stress marker malondialdehyde (MDA) in oral squamous cell carcinoma (OSCC).

Methodology: Pubmed (MeSH), Science Direct, Scopus, Web of Science, Willey Online Library, Cochrane, and Cross Reference were searched for studies assessing MDA levels in OSCC samples.

Results: From the 1008 articles identified, 849 were excluded based on title and abstract screening due to duplication and irrelevance to the topic of interest. Full-text assessment of the remaining 159 articles led to the inclusion of only 46 articles that satisfied the selection criteria. Of these, only 26 studies had data compatible for quantitative analysis. The MDA levels in OSCC groups are significantly increased ( < 0.00001) in plasma, serum, and saliva samples in the majority of the studies evaluated. In contrast, MDA levels in OSCC tissue samples are significantly attenuated ( < 0.00001) compared to healthy controls, supported by fewer studies.

Conclusions: The augmented MDA levels in plasma, serum, and saliva samples of the OSCC reflect the heightened oxidative stress level accurately. Further studies are required to understand the attenuated MDA levels in the tissue samples of OSCC. Correlation analysis between MDA levels with established clinicopathological prognostic markers could aid in formulating oxidative stress-based prognostication and treatment planning.
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http://dx.doi.org/10.3390/cimb43020072DOI Listing
August 2021

Evaluation of association between and visfatin levels in chronic periodontitis patients.

J Indian Soc Periodontol 2020 Nov-Dec;24(6):530-534. Epub 2020 Sep 21.

Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, India.

Background: Periodontal disease is one of the most common prevailing diseases, where the destruction occurs due to the direct effect of microorganisms and indirectly by the stimulation of host cells. The diverse inflammatory action of visfatin made this adipokine a potential periodontal biomarker of choice along with the periopathogen Porphyromonas gingivalis.

Aim: Our study was carried out to evaluate the visfatin levels in gingival crevicular fluid (GCF) and levels in subgingival plaque in periodontal health and disease.

Materials And Methods: A total of 60 participants were divided into two groups of thirty participants each as Group I - patients who have healthy periodontium and Group II - patients with generalized chronic periodontitis. The clinical parameters assessed for the participants were plaque index, probing pocket depth, papillary bleeding index, and clinical attachment loss. The subgingival plaque samples were obtained to estimate levels and GCF was collected to check visfatin levels.

Results: The clinical parameters, , and GCF visfatin levels between the two groups showed a notable significant difference. A significant positive correlation was noted on the correlation of GCF visfatin levels with clinical parameters.

Conclusion: Our study outcomes propose that can be the bonafide periopathogen which modulate the visfatin levels in individuals with periodontal disease and GCF visfatin can also be evaluated as a biomarker in periodontal disease.
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http://dx.doi.org/10.4103/jisp.jisp_641_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781248PMC
September 2020

A novel soft tissue cone-beam computed tomography study in the evaluation of gingival thickness associated with subepithelial connective tissue graft versus acellular dermal matrix in the management of gingival recession: A clinical study.

J Indian Soc Periodontol 2020 Sep-Oct;24(5):421-427. Epub 2020 Sep 1.

Department of Periodontics, Thai Moogambigai Dental College and Hospital, Chennai, Tamil Nadu, India.

Background: Dental esthetic awareness among patients led the clinicians to introduce newer materials and predictable techniques that satisfy the patients' esthetic demands.

Aim: To evaluate and compare the efficacy of subepithelial connective tissue graft (SECTG) and acellular dermal matrix (ACDM) allograft in the treatment of Millers Class I or Class II recession with the determination of gingival thickness using an impertinent method, soft tissue cone-beam computed tomography (ST-CBCT).

Materials And Methods: A split-mouth study with a total of ten patients with bilateral Millers class I or class II recession is randomly assigned by a coin toss method as Group I (SECTG) and Group II (ACDM) along with coronally advanced flap. Clinical parameters including recession height (RH), recession width (RW), probing depth, clinical attachment level (CAL), and height of keratinized tissue (HKT) were evaluated at baseline, 90 day, and 180 day for both groups. The thickness of keratinized tissue (TKT) was determined by most reliable, predictable and noninvasive method called ST-CBCT.

Results: Statistically significant reduction in RH and RW, gain in CAL, and increase in HKT and TKT in both Group I and Group II were seen in 90 day and 180 day. However, when both Group I and Group II were compared between 0 and 180 day, the change in RH and RW, gain in CAL, and increase in HKT and TKT did not show any statistically significant change.

Conclusion: The present study suggested that root coverage with both SECTG and ACDM is very predictable procedure and it is stable for 6 months. ST-CBCT is a newer dimension in periodontal imaging and will certainly aid clinicians in the execution of various treatment modalities with increased predictability.
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http://dx.doi.org/10.4103/jisp.jisp_508_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592622PMC
September 2020

Comparative Evaluation of Serum and Gingival Crevicular Fluid Periostin Levels in Periodontal Health and Disease: A Biochemical Study.

Cureus 2020 Mar 9;12(3):e7218. Epub 2020 Mar 9.

Periodontics, Thai Moogambigai Dental College & Hospital, Chennai, IND.

Introduction Periostin, a secreted adhesion molecule, is a matricellular protein secreted most in periodontal ligament and periosteum. This periostin is needed for integrity and maturation of periodontal tissue. The present study was conducted to estimate and compare the gingival crevicular fluid and serum periostin levels in subjects having chronic periodontitis, gingivitis and healthy periodontium. Methods Ninety patients belonging to both sexes were categorized into three groups, 30 patients each as healthy periodontium (Group I), chronic gingivitis (Group II) and generalised chronic periodontitis (Group III). The clinical parameters included assessment of plaque index (PI), gingival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL). Gingival crevicular fluid (GCF) and serum samples were collected and the enzyme-linked immunosorbent assay was used to estimate periostin levels. Results Periostin levels in GCF were comparatively low in the chronic periodontitis than in the gingivitis and healthy periodontium groups and the difference was statistically significant. No statistical difference was found for serum periostin levels among Group I, Group II and Group III. On comparison of clinical parameters, significant difference was noticed among the three groups. GCF periostin levels were correlated inversely with the clinical parameters in chronic periodontitis patients. Conclusion GCF periostin levels were gradually reduced with the increase in severity of periodontal disease. This novel biomarker has role in maintaining normal periodontal tissue function and may be used as a potential marker in periodontal disease activity evaluation.
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http://dx.doi.org/10.7759/cureus.7218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141796PMC
March 2020

Efficacy of low-level laser therapy as an adjunct to button anchored coronally advanced flap for gingival recession: A Doppler study.

J Indian Soc Periodontol 2018 Jul-Aug;22(4):365-368

Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, India.

Coverage of the exposed root is one of the periodontal plastic surgical procedures, which is one of the important periodontal treatment modalities. The introduction of innovation in new interdisciplinary treatment modalities has allowed us the use of orthodontic button in root coverage procedures using a coronally advanced flap (CAF) to provide the initial stabilization. This case report also evaluates the effectiveness of low-level laser therapy (LLLT) to detect the microvascular blood flow changes in the gingiva and alveolar mucosa where LLLT has been given after button-anchored CAF procedure during postoperative healing to detect blood flow changes of mucosa where LLLT was not given in other surgical sites. Three-month postoperative results showed that the LLLT used as an adjunct to CAF with the orthodontic button for stabilization is an effective surgical approach in the management of Miller's Class I recession defects.
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http://dx.doi.org/10.4103/jisp.jisp_194_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077971PMC
August 2018

Comparison of serum tumor necrosis factor-α levels in rheumatoid arthritis individuals with and without chronic periodontitis: A biochemical study.

J Indian Soc Periodontol 2018 Mar-Apr;22(2):116-121

Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, India.

Background: Tumor necrosis factor-alpha (TNF-α) is indicated to play a major function in chronic inflammatory disorders.

Objective: To assess and compare the cytokine level (TNF-α) in the serum of chronic periodontitis (CP), rheumatoid arthritis (RA), RA with CP, and healthy volunteers.

Materials And Methods: This original research was carried out on 80 participants, divided into Group-I 20 RA patients, Group-II 20 CP patients, Group III 20 RA with CP (RA + CP), and Group IV 20 healthy volunteers. Clinical periodontal and rheumatological parameters were assessed in all the four groups. Blood serum samples have been collected from all individuals and investigated for levels of TNF-α by mean of enzyme-linked immunosorbent assay.

Results: TNF-α level were remarkably elevated in the RA+CP group (30.5±2.2) followed by RA group (17.9 ± 3.6), and CP group (11.9 ± 0.96) when compared with the controls (5.5 ± 3.3). The results showed a statistical significance of P < 0.001. Correlation was not observed on comparision of clinical periodontal parameters and Rheumatological parameters with TNF-α levels.

Conclusion: The outcome of this present research revealed the presence of higher levels of TNF-α in individuals with RA with CP in our samples.
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http://dx.doi.org/10.4103/jisp.jisp_362_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939018PMC
May 2018

Comparison of anti-plaque and anti-gingivitis effect of curcumin and chlorhexidine mouth rinse in the treatment of gingivitis: A clinical and biochemical study.

J Indian Soc Periodontol 2017 Nov-Dec;21(6):478-483

Department of Periodontics, Thai Moogambigai Dental College and Hospital, Chennai, Tamil Nadu, India.

Background: To evaluate and compare the effect of curcumin (CMN) mouth rinse with chlorhexidine (CHX) mouth rinse on clinical parameters and reactive oxygen metabolites (ROM) levels in participants with chronic gingivitis.

Materials And Methods: Thirty plaque-induced generalized chronic gingivitis participants were randomly assigned to three groups - Group I (control/saline), Group II (CHX), and Group III (CMN), respectively. Baseline plaque index (PI), gingival index (GI), and salivary ROM were estimated, and oral prophylaxis was done. The parameters were recorded and evaluated again at the end of 4 weeks.

Results: Overall, the three groups have shown a significant reduction in PI, GI, and ROM levels at the end of 4 weeks. However, on intragroup comparison, only CMN group have shown significant reduction in ROM levels at the end of 4 weeks ( < 0.05).

Conclusion: CMN mouth rinse can be considered as an alternative antigingivitis agent to CHX because of its anti-inflammatory and antioxidant properties.
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http://dx.doi.org/10.4103/jisp.jisp_116_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846245PMC
March 2018

Indagation of serum and salivary reactive oxygen metabolite and cortisol levels in chronic periodontitis and stress-induced chronic periodontitis patients.

J Indian Soc Periodontol 2017 Sep-Oct;21(5):371-375

Department of Periodontics, Thai Moogambigai Dental College and Hospital, Chennai, Tamil Nadu, India.

Background: Periodontal disease is not a conventional bacterial infection but is an inflammatory disease initiated by immune response against a group of microorganisms in susceptible hosts. There are many intriguing researches that unfold the secrets of chronic periodontitis. The current researches in chronic periodontitis are directed toward an approach that respects the scientific relationship between the various risk factors, the genetic factors, and the progression of the disease.

Aim: This study aims to evaluate the cortisol and reactive oxygen metabolites (ROM) concentration in serum and to find out their association in periodontal health and disease.

Materials And Methods: In this study, totally thirty patients have been taken and divided into two groups of chronic periodontitis (Group I) and stress-induced chronic periodontitis (Group II) and evaluated the correlation between the ROM and cortisol levels in them. This is the first study, where both the levels of ROM and cortisol are checked in the serum and saliva. The analysis is done to check the association between them.

Statistical Analysis: The data were statistically analyzed using software program (SPSSV 16), Pearson correlation, and paired -test.

Results: Comparison of the mean ROM levels in Group I and Group II showed that mean ROM level in Group II is highly significant than Group I.

Conclusion: Our study suggests that stress can have a role in the progression of periodontal disease by increasing the cortisol and ROM levels.
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http://dx.doi.org/10.4103/jisp.jisp_6_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827503PMC
March 2018

Comparative Analysis of Salivary Alkaline Phosphatase in Post menopausal Women with and without Periodontitis.

J Clin Diagn Res 2017 Jan 1;11(1):ZC122-ZC124. Epub 2017 Jan 1.

Senior Lecturer, Department of Periodontics, Thaimoogambigai Dental College , Chennai, Tamil Nadu, India .

Introduction: Alkaline phosphatase is an intracellular destruction enzyme in the periodontium, and it takes part in the normal turnover of the periodontal ligament, alveolar bone, and root cementum formation and maintenance.

Aim: The aim of this case control study was to evaluate the enzyme Alkaline Phosphatase (ALP) level in saliva of post menopausal women with and without chronic periodontitis.

Materials And Methods: In this study, 40 individuals, satisfying the study inclusion and exclusion criteria, were recruited. They were categorically divided, on the basis of gingival index, probing pocket depth and clinical attachment level, into two groups: Group I (post menopausal women with a clinically healthy periodontium, n=20); and Group II (post menopausal women with generalized chronic periodontitis, n=20). Clinical parameters assessed were Plaque Index (PI), Gingival Index (GI), Clinical Attachment Level (CAL) and Probing Pocket Depth (PPD). Unstimulated salivary samples were obtained in which the ALP concentration was measured using p-Nitrophenylphosphate, and 2-amino-2-methyl-1-propanol reagents in Beckman and Coulter, AU 480 auto analyser. Mann-Whitney U test was used to find statistical difference with respect to all clinical parameters such as PI, GI, CAL, PPD and salivary ALP levels.

Results: The mean ALP in saliva was found to be higher in Group II compared to Group I and the difference was statistically significant with the p-value of 0.008.

Conclusion: A noteworthy increase in the ALP concentration was seen in saliva in our study (Group II) may be due to increased periodontal inflammation in post menopausal women. Thus salivary ALP can be taken as an additional biomarker to early diagnosis, development and progression of periodontitis especially among post menopausal women.
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http://dx.doi.org/10.7860/JCDR/2017/24654.9309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324486PMC
January 2017

Evaluation of plasma reactive oxygen metabolites levels in obese subjects with periodontal disease.

Indian J Dent Res 2016 Mar-Apr;27(2):155-9

Department of Periodontics, Sree Balaji Dental College, Chennai, Tamil Nadu, India.

Background: Obesity represents the systemic condition capable of influencing the onset and progression of periodontal disease. Obesity is associated with oxidative stress. Plasma level of reactive oxidative metabolites (ROMs) is measured as an indicator of oxidative stress in the body. The aim of this study is to assess and compare the plasma ROM levels in obese subjects with healthy and inflammatory periodontal status.

Materials And Methods: Sixty subjects selected were grouped as 15 obese or overweight subjects with generalized chronic periodontitis, 15 obese or overweight subjects with generalized chronic gingivitis, 15 obese or overweight subjects with healthy periodontium, and 15 nonobese and healthy periodontium. The clinical periodontal parameters such as plaque index, gingival index, probing pocket depth, and clinical attachment level were measured. Blood samples were obtained to measure the plasma levels of ROM.

Result And Conclusion: In this study, obese subjects with chronic periodontitis (Group I) had mean plasma ROM levels (442.3 ± 15.65 Carratelli unit [CARR U]) showing 100% subjects with high oxidative stress. Obese subjects with chronic gingivitis (Group II) had mean plasma ROM levels (358.7 ± 20.61 CARR U) indicating 86.7% subjects with oxidative stress. Obese subjects with healthy periodontium (Group III) had 46.7% subjects with slight oxidative stress, and the mean ROM level was 320.2 ± 17.57. Nonobese subjects with healthy periodontium (Group IV) had 80% of subjects with normal oxidative stress and the mean plasma ROM level was 296.9 ± 20.35 CARR U. The intra- and inter-group comparison showed significant difference (P < 0.001). From our study, we report that obese subjects with periodontitis have more oxidative stress compared to obese subjects with healthy periodontium.
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http://dx.doi.org/10.4103/0970-9290.183117DOI Listing
October 2017

Bonebiomarkers in periodontal disease: a review article.

J Clin Diagn Res 2015 Jan 1;9(1):ZE07-10. Epub 2015 Jan 1.

Dean, Professor and HOD, Department of Orthodontics, Thai Moogambigai Dental College , Chennai, Tamil Nadu, India .

Periodontitis, is an inflammatory state of the tooth supporting structures and if left untreated, the disease continues to progressive bone destruction and subsequent tooth loss. The increasing prevelance of periodontal disease paved way to the development of new diagnostic tests that could detect the presence of active disease,the course of the disease and its response to treatment. Bone is a metabolically active tissue and undergo continuous remodelling, a process that largely relies on the activity of osteoclasts to remove bone and of osteoblasts to form bone. In health ,bone resorption and formation are coupled to each other and its long term maintenance of skeletal balance is brought about by the systemic hormones and local mediators.In contrasts,during disease there is a pronounced in balance in bone turnover. Bone biomarkers which are produced either in health or in disease state are tell tale markers which would be used to monitor the health status. This review highlights, the recent advances in the use of biomarkers of bone remodelling,that could facilitate the screening, diagnosis and management of periodontal diseases.
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http://dx.doi.org/10.7860/JCDR/2015/11268.5438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347190PMC
January 2015

Effect of low level laser therapy on revascularization of free gingival graft using ultrasound Doppler flowmetry.

J Indian Soc Periodontol 2014 May;18(3):403-7

Department of Periodontics, Thai Moogambigai Dental College, Golden George Nagar, Chennai, Tamil Nadu, India.

Low level laser therapy (LLLT) is widely used during the post-operative period to accelerate the healing process. It promotes beneficial biological action on neovascularization with anti-inflammatory and analgesic effects. Two systemically healthy patients with Miller's grade II recession on 33 and 41, respectively, were treated with free gingival graft. After surgery, second patient received LLLT using a 830 nm diode laser, with output power of 0.1 W on the first day half hour following surgery, on the third day, seventh day, and lastly on the ninth day. Both the patients were asked to assess the pain on second, fourth and tenth day using a Numerical Rating Scale and revascularization of the grafted area was assessed using a color Doppler ultrasound imaging on the fourth and the ninth day. Neovascularization was noted in both the patients but the second patient elicited marked increase in vascularity on the fourth as well as the tenth day and drastic reduction in pain on day four, with no change on the tenth day. The results showed that LLLT was an effective adjunctive treatment in promoting reevascularization and pain control during early healing of free gingival graft.
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http://dx.doi.org/10.4103/0972-124X.134592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095639PMC
May 2014

Comparative analysis of gingival crevicular fluid neopterin levels in health and periodontal disease: a biochemical study.

Indian J Dent Res 2013 Sep-Oct;24(5):582-6

Department of Periodontics, Saveetha Dental College, Chennai, India.

Background: Periodontitis involves intricate interactions of the biofilm with the host immunoinflammatory response and subsequent alterations in bone and connective tissue homeostasis. Neopterin is a marker, belonging to the class of pteridines, which is associated with cell-mediated immunity. It is produced by interferon-γ stimulated macrophages. The levels of neopterin in body fluids are elevated in infections, autoimmune diseases, malignancies and allograft rejections. This investigation was designed to estimate the levels of neopterin in gingival crevicular fluid (GCF) in health, chronic gingivitis and chronic periodontitis.

Materials And Methods: Thirty subjects were divided into three groups of ten subjects each as with healthy periodontium (Group 1), chronic gingivitis (Group 2) and chronic periodontitis (Group 3). The GCF samples were obtained from the subjects by placing color-coded calibrated, volumetric, micro-capillary pipettes extracrevicularly. The samples were placed in plastic vials and stored at -70°C until the time of neopterin estimation using enzyme immunoassay.

Results: The mean neopterin level in Group 3 (126.28 ± 37.70 nmol/L) is significantly higher than the mean neopterin level in Group 1 (48.66 ± 18.82 nmol/L) and Group 2 (70.68 ± 18.26 nmol/L) (P < 0.05). However, there is no significant relationship between neopterin levels and various clinical parameters in each study group (P > 0.05).

Conclusions: The results of our study indicate that the neopterin levels in GCF are positively associated with periodontal disease, which may provide a useful tool in monitoring its progression. Nevertheless, further longitudinal studies are required with larger sample sizes in which neopterin levels are progressively estimated and compared to baseline values.
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http://dx.doi.org/10.4103/0970-9290.123376DOI Listing
October 2015

Evaluation of anti-inflammatory effect of statins in chronic periodontitis.

Indian J Pharmacol 2013 Jul-Aug;45(4):391-4

Department of Periodontology, Thaimoogambigai Dental College and Hospital, Chennai, India.

Objectives: Statins are the group of lipid-lowering drugs commonly used to control cardiovascular and cerebrovascular diseases. Statins have potential anti-inflammatory effect by blocking the intermediate metabolites of the mevalonate pathway. The objective of this study was to evaluate the anti-inflammatory effect of statin medication in chronic periodontitis patients.

Materials And Methods: Thirty patients of age group between 40 and 60 years were selected from the outpatient pool of Department of Periodontics, Thaimoogambigai Dental College and Hospital, Chennai. Thirty patients selected were grouped into two groups, Group-I consists of patients with generalized chronic periodontitis and on statin medication and Group-II consists of patients with generalized chronic periodontitis. Clinical parameters were recorded and gingival crevicular fluid (GCF) samples were analyzed for interleukin (IL)-1β using commercially available enzyme-linked immunosorbent assay.

Results: The mean GCF IL-1β levels in generalized chronic periodontitis patients who are on statin medication (Group-I) were lower than the generalized chronic periodontitis patients without statin medication (Group-II).

Conclusion: Reduction of GCF IL-1β levels in statin users indicate that statins have anti-inflammatory effect on periodontal disease.
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http://dx.doi.org/10.4103/0253-7613.115017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757610PMC
March 2014

A novel surgical procedure for papilla reconstruction using platelet rich fibrin.

Contemp Clin Dent 2012 Oct;3(4):467-70

Department of Periodontics, Thai Moogambigai Dental College, Golden George Nagar, Chennai, Tamil Nadu, India.

Loss of interdental papilla predisposes to phonetic, functional, and esthetic problem. Surgical techniques are manifold, but are challenging and very unpredictable. The purpose of this case report is to present the use of platelet rich fibrin (PRF) in the reconstruction of papilla in the maxiallry anterior region of a forty year old woman who presented with loss of interdental papillae in 11, 12 and 11, 21 region. PRF was tucked in to the pouch created with a semilunar pedicle flap and the entire gingivopapillary unit was displaced coronally. Optimal fill was noted at 3 and 6 months postoperatively. Use of PRF may thus be the panacea for interdental papilla augmentation.
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http://dx.doi.org/10.4103/0976-237X.107443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636838PMC
October 2012

Periodontal management in Paget's disease: Case presentation and a brief review of literature.

J Indian Soc Periodontol 2012 Jan;16(1):129-33

Department of Periodontics, Thai Moogambigai Dental College and Hospital, Chennai, Tamilnadu, India.

Paget's disease of bone is a common condition characterized by increased and disorganized bone turnover which can affect one or several bones throughout the skeleton. These abnormalities disrupt normal bone architecture and lead to various complications such as bone pain, osteoarthritis, pathological fracture, bone deformity, deafness, and nerve compression syndromes. Genetic factors and environmental factors like paramyxovirus infection have been implicated in etiology. This is a case report of a patient who presented with Paget's disease and the periodontal surgical management, after the pretreatment was employed with diagnostic procedures like computed tomography and serum alkaline phosphatase tests.
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http://dx.doi.org/10.4103/0972-124X.94622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357023PMC
January 2012

The efficacy of flapless implant surgery on soft-tissue profile comparing immediate loading implants to delayed loading implants: A comparative clinical study.

J Indian Soc Periodontol 2010 Oct;14(4):245-51

Department of Periodontology and Implatology, Meenakshi Ammal Dental College, Chennai, India.

Aims And Objectives: To assess the efficacy of flapless implant surgery on soft-tissue profile and to compare the clinical outcomes of flapless implant therapy on immediate loading (IL) implants to delayed loading (DL) implants.

Materials And Methods: The study sample consisted of 20 patients who were partially edentulous in the anterior maxillary region. They were divided into two groups. In group I (IL) 10 implants were placed and immediately provisionalized and restored with a metal ceramic crown on the 14th day. In group II (DL) 10 implants were placed and loaded after 4 months. Single-piece implants were used for the IL group and two-piece implants were used for the DL group. All soft tissue parameters i.e., modified plaque index (mPI), modified bleeding index (mBI), papillary index (PPI), marginal level of soft tissue (ML) and width of keratinized mucosa (WKM) were recorded at baseline, Day 60, Day 120 and Day 180.

Results: The success rate in group I was found to be 80%, which was lower than the success rate in group II which was found to be 90%. On comparison, there is no statistically significant difference in success rate between the two study groups. There was no statistically significant difference between the groups over time in parameters like mPI, mBI, ML and WKM. The mean PPI score in group II showed a significant increase from when compared to group I.

Conclusion: The results of this study indicated that flapless implant surgery using either immediately loading implants or DL implants, demonstrate enhancement of implant esthetics.
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http://dx.doi.org/10.4103/0972-124X.76930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118076PMC
October 2010

Isolation of Helicobacter pylori from dental plaque: A microbiological study.

J Indian Soc Periodontol 2008 Sep;12(3):67-72

Department of Periodontics, Meenakshi Ammal Dental College, Maher University, Chennai, Tamilanadu, India.

Aim: The aim of our study was to isolate H. pylori from dental plaque in gastric and duodenal ulcer patients and compare it with dental plaque of healthy subjects.

Materials And Methods: Fifty patients in the age range of 25-50 years who were endoscopically proven cases of duodenal and gastric ulcer were chosen. H. pylorus was isolated from the dental plaque of these patients using culture method and rapid urease test (RUT). It was compared with the dental plaque from control group (25 students). The specificity and sensitivity of RUT was compared with culture method. The oral hygiene index (OHI) score and plaque index were assessed.

Results: Ten percent positivity was observed in the study group by culture. Though RUT showed 70% positive isolation it is neither a specific test nor a conclusive test as compared to culture. The result correlates with oral hygiene in study population.

Conclusion: Further, more studies are needed to compare RUT and culture, with serology and polymerase chain reactions. The ability to detect H. pylori from dental plaque using these methods offer the potential for the noninvasive test for infection and would aid in support of oral transmission of H. pylori.
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http://dx.doi.org/10.4103/0972-124X.44098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813563PMC
September 2008

Evidence-based periodontal therapy: An overview.

J Indian Soc Periodontol 2008 Sep;12(3):62-6

Lecturer, Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai - 600 095, India.

Dentists need to make clinical decisions based on limited scientific evidence. In clinical practice, a clinician must weigh a myriad of evidences every day. The goal of evidence-based dentistry is to help practitioners provide their patients with optimal care. This is achieved by integrating sound research evidence with personal clinical expertise and patient values to determine the best course of treatment. Periodontology has a rich background of research and scholarship. Therefore, efficient use of this wealth of research data needs to be a part of periodontal practice. Evidence-based periodontology aims to facilitate such an approach and it offers a bridge from science to clinical practice. The clinician must integrate the evidence with patient preference, scientific knowledge, and personal experience. Most important, it allows us to care for our patients. Therefore, evidence-based periodontology is a tool to support decision-making and integrating the best evidence available with clinical practice.
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http://dx.doi.org/10.4103/0972-124X.44097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813561PMC
September 2008

Principles of gene therapy.

Indian J Dent Res 2007 Oct-Dec;18(4):196-200

Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Maduravoyal, Chennai, India.

Genes are specific sequences of bases that encode instructions to make proteins. When genes are altered so that encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is designed to introduce genetic material into cells to compensate for abnormal genes or to make a beneficial protein. This article reviews the fundamentals in gene therapy and its various modes of administration with an insight into the role of gene therapy in Periodontics and future percepts and the technical and ethical issues of using gene therapy.
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http://dx.doi.org/10.4103/0970-9290.35832DOI Listing
February 2008
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