Ultan McDermott

Ultan McDermott

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Ultan McDermott

Publications by authors named "Ultan McDermott"

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A lentiviral vector-based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma.

Pigment Cell Melanoma Res 2019 03 19;32(2):332-335. Epub 2018 Oct 19.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1111/pcmr.12737DOI Listing
March 2019

Large-scale compound screens and pharmacogenomic interactions in cancer.

Authors:
Ultan McDermott

Curr Opin Genet Dev 2019 Feb 7;54:12-16. Epub 2019 Mar 7.

Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK.

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http://dx.doi.org/10.1016/j.gde.2019.02.002DOI Listing
February 2019

Cancer cell lines as patient avatars for drug response prediction.

Authors:
Ultan McDermott

Nat Genet 2018 10;50(10):1350-1351

IMED Oncology, AstraZeneca, Cambridge, UK.

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http://www.nature.com/articles/s41588-018-0245-2
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http://dx.doi.org/10.1038/s41588-018-0245-2DOI Listing
October 2018

The germline genetic component of drug sensitivity in cancer cell lines.

Nat Commun 2018 08 23;9(1):3385. Epub 2018 Aug 23.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.

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http://www.nature.com/articles/s41467-018-05811-3
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http://dx.doi.org/10.1038/s41467-018-05811-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107640PMC
August 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Pathway-based dissection of the genomic heterogeneity of cancer hallmarks' acquisition with SLAPenrich.

Sci Rep 2018 04 30;8(1):6713. Epub 2018 Apr 30.

European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, CB10 1SD, UK.

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http://dx.doi.org/10.1038/s41598-018-25076-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928049PMC
April 2018

Steps forward for cancer precision medicine.

Nat Rev Drug Discov 2018 01 24;17(1):1-2. Epub 2017 Nov 24.

EORTC Headquarters, 1200 Brussels, Belgium.

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http://dx.doi.org/10.1038/nrd.2017.218DOI Listing
January 2018

Societal challenges of precision medicine: Bringing order to chaos.

Eur J Cancer 2017 10 4;84:325-334. Epub 2017 Sep 4.

EORTC Headquarters, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.07.028DOI Listing
October 2017

The Pursuit of Therapeutic Biomarkers with High-Throughput Cancer Cell Drug Screens.

Cell Chem Biol 2017 Sep 20;24(9):1066-1074. Epub 2017 Jul 20.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456173022
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http://dx.doi.org/10.1016/j.chembiol.2017.06.011DOI Listing
September 2017

Molecular diagnoses of century-old childhood tumours.

Lancet Oncol 2017 05;18(5):e237

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK; Department of Paediatrics, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30226-7DOI Listing
May 2017

Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy.

Sci Rep 2016 11 23;6:36812. Epub 2016 Nov 23.

Netherlands Cancer Institute, Amsterdam, and The Faculty of EEMCS, Delft University of Technology, Delft, The Netherlands.

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http://dx.doi.org/10.1038/srep36812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120272PMC
November 2016

FANCD2 limits replication stress and genome instability in cells lacking BRCA2.

Nat Struct Mol Biol 2016 08 20;23(8):755-757. Epub 2016 Jun 20.

The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.1038/nsmb.3252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973888PMC
August 2016

Next-generation sequencing and empowering personalised cancer medicine.

Authors:
Ultan McDermott

Drug Discov Today 2015 Dec 19;20(12):1470-5. Epub 2015 Oct 19.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2015.10.008DOI Listing
December 2015

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.

Nat Med 2015 Jul 1;21(7):741-50. Epub 2015 Jun 1.

1] Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Catalonia, Spain. [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. [3] Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1038/nm.3863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968631PMC
July 2015

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.

Proc Natl Acad Sci U S A 2015 Jul 10;112(29):E3800-5. Epub 2015 Jul 10.

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1500925112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517206PMC
July 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
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http://www.nature.com/doifinder/10.1038/ng.3221
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http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

COSMIC: exploring the world's knowledge of somatic mutations in human cancer.

Nucleic Acids Res 2015 Jan 29;43(Database issue):D805-11. Epub 2014 Oct 29.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, CB10 1SA.

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http://dx.doi.org/10.1093/nar/gku1075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383913PMC
January 2015

Reading between the lines; understanding drug response in the post genomic era.

Mol Oncol 2014 Sep 10;8(6):1112-9. Epub 2014 Jun 10.

Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, UK.

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http://dx.doi.org/10.1016/j.molonc.2014.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528621PMC
September 2014

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Nat Commun 2014 Apr 3;5:3608. Epub 2014 Apr 3.

1] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, 08908 Catalonia, Spain [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Spain [3] Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010 Catalonia, Spain.

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http://dx.doi.org/10.1038/ncomms4608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988805PMC
April 2014

Editorial overview: cancer genomics: kill it. Kill it dead.

Curr Opin Genet Dev 2014 Feb 23;24:v-vi. Epub 2014 Feb 23.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1016/j.gde.2013.12.006DOI Listing
February 2014

The evolving role of cancer cell line-based screens to define the impact of cancer genomes on drug response.

Curr Opin Genet Dev 2014 Feb 5;24:114-9. Epub 2014 Mar 5.

Cancer Genome Project, Wellcome Trust Sanger Institute Hinxton, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2013.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003351PMC
February 2014

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

Exploiting genetic complexity in cancer to improve therapeutic strategies.

Drug Discov Today 2012 Mar 8;17(5-6):188-93. Epub 2012 Feb 8.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1016/j.drudis.2012.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672976PMC
March 2012

Genomics and the continuum of cancer care.

N Engl J Med 2011 Jan;364(4):340-50

Wellcome Trust Sanger Institute,Hinxton, Cambridge, United Kingdom.

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http://www.nejm.org/doi/10.1056/NEJMra0907178
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http://dx.doi.org/10.1056/NEJMra0907178DOI Listing
January 2011

Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency.

Cancer Res 2010 Feb 2;70(4):1625-34. Epub 2010 Feb 2.

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057521PMC
February 2010

Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology.

J Clin Oncol 2009 Nov 26;27(33):5650-9. Epub 2009 Oct 26.

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

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http://ascopubs.org/doi/10.1200/JCO.2009.22.9054
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http://dx.doi.org/10.1200/JCO.2009.22.9054DOI Listing
November 2009

High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor.

Methods Enzymol 2008 ;438:331-41

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)38023-3DOI Listing
June 2008

Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer.

Cancer Res 2005 Oct;65(19):8951-60

Drug Resistance Group, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-0961DOI Listing
October 2005

The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites.

Clin Cancer Res 2004 May;10(10):3562-71

Department of Oncology, Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland.

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http://dx.doi.org/10.1158/1078-0432.CCR-03-0532DOI Listing
May 2004

Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling.

Cancer Res 2003 Aug;63(15):4602-6

Department of Oncology, Cancer Research Centre, Queen's University Belfast, University Floor, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland.

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August 2003

Predictive markers for colorectal cancer: current status and future prospects.

Clin Colorectal Cancer 2003 Feb;2(4):223-30

Department of Oncology, Cancer Research Centre, Queen's University Belfast, Northern Ireland.

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http://dx.doi.org/10.3816/CCC.2003.n.003DOI Listing
February 2003