Publications by authors named "Ulrike Ackert"

2 Publications

  • Page 1 of 1

Non-small cell lung carcinoma in an adolescent manifested by acute paraplegia due to spinal metastases: a case report.

J Med Case Rep 2011 Sep 28;5:486. Epub 2011 Sep 28.

University Children's Hospital Rostock, Ernst-Heydemann-Strasse 8, D-18057 Rostock, Germany.

Introduction: Bronchial carcinomas in childhood and adolescence are extremely rare; only individual cases have been reported previously.

Case Presentation: We report on a 16-year-old Caucasian German boy with non-small cell lung carcinoma (squamous cell non-small cell lung carcinoma) stage IV, T4N2M1, without epidermal growth factor receptor overexpression and/or mutation or k-ras mutation. He presented with paraplegia due to spinal metastases of the bronchial carcinoma. No familial predisposition or toxin exposure was identified. Treatment following adult protocols consisted of surgical intervention for spinal metastases, first-line cisplatinum and gemcitabine, irradiation and second-line docetaxel. After a transient response our patient experienced disease progression and died about 10 months later.

Conclusion: Response and survival in our 16-year-old patient were similar to adult patients with stage IV non-small cell lung carcinoma.
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http://dx.doi.org/10.1186/1752-1947-5-486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193824PMC
September 2011

Impaired somatic growth and delayed lung development in infants with congenital diaphragmatic hernia--evidence from a 10-year, single center prospective follow-up study.

J Pediatr Surg 2009 Jul;44(7):1309-14

Department of Neonatology, Charité Campus Mitte, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.

Purpose: In infants with congenital diaphragmatic hernia (CDH), somatic growth and pulmonary development are key issues beyond the time of intensive care treatment. The aim of the study was to investigate the somatic growth and pulmonary function after discharge and to compare CDH patients with a group of matched controls.

Methods: Anthropometric measurements and lung function tests were performed in 26 infants after surgical repair of CDH and 26 non-CDH intensive care patients, matched for gestational age and birth weight. Spontaneously breathing infants were tested at a mean of 44 weeks postconceptional age (range, 36-58 weeks). Body weight, body length, respiratory rate (RR), tidal volume (V(T)), functional residual capacity by body plethysmography (FRC(pleth)), respiratory compliance (C(rs)), and respiratory resistance (R(rs)) were measured.

Results: The mean (SD) weight gain per week in the CDH infants was significantly lower compared to non-CDH infants (89 [39] g vs 141 [49] g; P = .002). The breathing pattern between both groups differed considerably. In CDH infants, V(T) was significantly lower (P < .001) and RR significantly higher (P = .005). The respiratory compliance was also significantly (P < .001) reduced, whereas R(rs) did not differ significantly. No statistically significant differences were seen in FRC(pleth) related to the body weight between CDH and non-CDH infants (20.3 [4.4] mL/kg vs 21.5 [4.9] mL/kg).

Conclusion: Despite apparently well-inflated lungs after surgery, evidence of early and significantly reduced weight gain and impaired lung function in CHD patients should prompt careful dietary monitoring and regular lung function testing.
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http://dx.doi.org/10.1016/j.jpedsurg.2008.10.047DOI Listing
July 2009