Publications by authors named "Ulrika Warpman Berglund"

36Publications

MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG.

Cancer Res 2020 09 20;80(17):3530-3541. Epub 2020 Apr 20.

Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

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September 2020

Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

Oncotarget 2020 Feb 25;11(8):827. Epub 2020 Feb 25.

Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Karolinska Institutet, Stockholm, Sweden.

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February 2020

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model.

EBioMedicine 2020 Mar 7;53:102704. Epub 2020 Mar 7.

Université de Nantes, INSERM, U1238, Sarcomes osseux et remodelage des tissus calcifiés, Team 3, Epistress, Rue Gaston Veil, 44035 Nantes cedex, France. Electronic address:

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March 2020

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.

J Biol Chem 2020 04 6;295(15):4761-4772. Epub 2020 Mar 6.

Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden

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April 2020

AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma.

Cell Death Differ 2020 Jul 9;27(7):2081-2098. Epub 2020 Jan 9.

Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, S-171 64, Stockholm, Sweden.

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July 2020

Karonudib is a promising anticancer therapy in hepatocellular carcinoma.

Ther Adv Med Oncol 2019 23;11:1758835919866960. Epub 2019 Aug 23.

Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, Tomtebodav.23A, Stockholm, 171 21, Sweden.

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August 2019

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.

Nucleic Acids Res 2018 11;46(20):10888-10904

Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.

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November 2018

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.

Biochemistry 2018 02 16;57(5):593-603. Epub 2018 Jan 16.

Department of Biochemistry and Biophysics, Stockholm University , S-106 91 Stockholm, Sweden.

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February 2018

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

Oncotarget 2017 Oct 20;8(49):84671-84684. Epub 2017 Jul 20.

Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Karolinska Institutet, Stockholm, Sweden.

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October 2017

Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.

J Med Chem 2017 10 3;60(19):8160-8169. Epub 2017 Oct 3.

Science for Life Laboratory, Department of Cell and Molecular Biology, BMC, Uppsala University , Box 596, SE-751 24 Uppsala, Sweden.

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October 2017

Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level.

Biomolecules 2017 07 3;7(3). Epub 2017 Jul 3.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, S171 21, Sweden.

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July 2017

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.

Cancer Res 2016 04 9;76(8):2366-75. Epub 2016 Feb 9.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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April 2016

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.

Cell Rep 2016 Jan 31;14(2):298-309. Epub 2015 Dec 31.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 21 Stockholm, Sweden. Electronic address:

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January 2016