Ulrik Gether

Ulrik Gether

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Ulrik Gether

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Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol.

Eur J Neurosci 2019 Aug 10;50(3):2156-2163. Epub 2018 Aug 10.

Faculty of Health and Medical Sciences, Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Panum Institute - Maersk Tower 7.5, University of Copenhagen, Blegdamsvej 3, Copenhagen, DK-2200, Denmark.

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http://dx.doi.org/10.1111/ejn.14082DOI Listing
August 2019

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout.

PLoS Genet 2019 Aug 26;15(8):e1008352. Epub 2019 Aug 26.

Departments of pharmacology and physiology, Department of neurosciences, Central Nervous System Research Group (GRSNC), Faculty of Medicine, Université de Montréal, Québec, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1008352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730950PMC
August 2019

G protein-coupled receptor pharmacology-The next generation.

Basic Clin Pharmacol Toxicol 2019 Jul 13. Epub 2019 Jul 13.

Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/bcpt.13291DOI Listing
July 2019

G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization.

Neuropharmacology 2019 Jun 4. Epub 2019 Jun 4.

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.06.002DOI Listing
June 2019

Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges.

Pharmacol Rev 2019 04;71(2):123-156

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience (A.H.R., D.P.D.W., A.T.S., U.G.) and Department of Drug Design and Pharmacology (C.M.F., J.T.A.), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.1124/pr.117.013995DOI Listing
April 2019

Conformational dynamics of the human serotonin transporter during substrate and drug binding.

Nat Commun 2019 04 11;10(1):1687. Epub 2019 Apr 11.

Protein Analysis Group, Department of Pharmacy, University of Copenhagen, Copenhagen, 2100, Denmark.

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http://www.nature.com/articles/s41467-019-09675-z
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http://dx.doi.org/10.1038/s41467-019-09675-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459873PMC
April 2019

Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice.

Neuroscience 2019 03 19;401:106-116. Epub 2019 Jan 19.

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2019.01.013DOI Listing
March 2019

Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets.

Elife 2019 Jan 3;8. Epub 2019 Jan 3.

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.7554/eLife.39180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345565PMC
January 2019

Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes.

J Biol Chem 2018 05 20;293(19):7250-7262. Epub 2018 Mar 20.

From the Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, Panum Institute-Maersk Tower 07.05, University of Copenhagen, DK-2200 Copenhagen, Denmark

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http://dx.doi.org/10.1074/jbc.RA118.001753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950020PMC
May 2018

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.

Sci Adv 2018 05 11;4(5):eaar6179. Epub 2018 May 11.

Protein Analysis Group, Department of Pharmacy, University of Copenhagen, 2100 Copenhagen O, Denmark.

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http://dx.doi.org/10.1126/sciadv.aar6179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947982PMC
May 2018

An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.

Cell Rep 2018 05;23(7):2056-2069

Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183063
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http://dx.doi.org/10.1016/j.celrep.2018.04.074DOI Listing
May 2018

Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research.

Basic Clin Pharmacol Toxicol 2017 Nov 10;121(5):373-381. Epub 2017 Jul 10.

Molecular Neuropharmacology and Genetics Laboratory, Center for Neuroscience, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/bcpt.12819DOI Listing
November 2017

Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm.

J Neurosci Methods 2017 Sep 12;289:85-92. Epub 2017 Jul 12.

Molecular Neuropharmacology and Genetics Laboratory, Center for Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2017.07.010DOI Listing
September 2017

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains.

Nat Commun 2017 09 29;8(1):740. Epub 2017 Sep 29.

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41467-017-00790-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622129PMC
September 2017

Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake.

J Vis Exp 2017 09 21(127). Epub 2017 Sep 21.

Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen;

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http://dx.doi.org/10.3791/56093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752313PMC
September 2017

The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway.

J Biol Chem 2017 04 9;292(17):6910-6926. Epub 2017 Mar 9.

From the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark and

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http://dx.doi.org/10.1074/jbc.M116.762385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409461PMC
April 2017

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.

Sci Rep 2017 04 18;7:46355. Epub 2017 Apr 18.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

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http://www.nature.com/articles/srep46355
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http://dx.doi.org/10.1038/srep46355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394417PMC
April 2017

Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice.

Eur J Neurosci 2017 01 22;45(1):121-128. Epub 2016 Aug 22.

Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/ejn.13347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294347PMC
January 2017

The Environment Shapes the Inner Vestibule of LeuT.

PLoS Comput Biol 2016 Nov 11;12(11):e1005197. Epub 2016 Nov 11.

Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria.

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http://dx.doi.org/10.1371/journal.pcbi.1005197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105988PMC
November 2016

A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function.

Neurochem Int 2016 09 26;98:103-14. Epub 2016 Mar 26.

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, Panum Institute 18.6, University of Copenhagen, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2016.03.013DOI Listing
September 2016

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290.

J Biol Chem 2016 09 29;291(38):19786-99. Epub 2016 Jul 29.

From the Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York 10065, the Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York 10065.

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http://dx.doi.org/10.1074/jbc.M116.731455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025669PMC
September 2016

Transition metal ion FRET uncovers K regulation of a neurotransmitter/sodium symporter.

Nat Commun 2016 Sep 28;7:12755. Epub 2016 Sep 28.

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N 2200, Denmark.

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http://dx.doi.org/10.1038/ncomms12755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052704PMC
September 2016

No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial.

Acta Neuropsychiatr 2016 Apr 17;28(2):101-9. Epub 2015 Nov 17.

1Psychiatric Centre Copenhagen,Rigshospitalet,Copenhagen University Hospital,Copenhagen,Denmark.

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http://dx.doi.org/10.1017/neu.2015.55DOI Listing
April 2016

Structural biology: Antidepressants at work.

Nature 2016 Apr 6;532(7599):320-1. Epub 2016 Apr 6.

Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nature17883DOI Listing
April 2016

Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini.

J Biol Chem 2016 Mar 19;291(11):5634-51. Epub 2016 Jan 19.

From the Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, Panum Institute 18.6, University of Copenhagen, DK-2200 Copenhagen, Denmark,

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http://dx.doi.org/10.1074/jbc.M115.702050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786704PMC
March 2016

A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity.

Eur J Neurosci 2015 Oct 30;42(7):2438-54. Epub 2015 Sep 30.

Department of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/ejn.13046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789538PMC
October 2015

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

J Biol Chem 2015 Oct 11;290(44):26725-38. Epub 2015 Sep 11.

From the Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark,

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http://dx.doi.org/10.1074/jbc.M115.677658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646326PMC
October 2015

[Optogenetics brings hidden neural mechanisms into the light and could become a future therapy].

Ugeskr Laeger 2015 Aug;177(34)

Laboratorium for Neural Plasticitet, Institut for Neurovidenskab og Farmakologi, Københavns Universitet, Symbion, Fruebjergvej 3, 2100 København Ø.

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August 2015

Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering.

Structure 2015 Jul 11;23(7):1258-1270. Epub 2015 Jun 11.

Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute 18.6, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1016/j.str.2015.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502314PMC
July 2015

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

J Biol Chem 2015 May 13;290(22):13992-4003. Epub 2015 Apr 13.

From the Department of Physiology and Biophysics and Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York, 10065, the Computational Chemistry and Molecular Biophysics Unit, NIDA, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224

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http://dx.doi.org/10.1074/jbc.M114.625343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447972PMC
May 2015

Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

J Neurosci 2015 May;35(21):8258-71

Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria; Center for Addiction Research and Science, Medical University of Vienna, 1090 Vienna, Austria.

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http://dx.doi.org/10.1523/JNEUROSCI.4034-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444546PMC
May 2015

Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors.

EBioMedicine 2015 Feb;2(2):135-146

Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, United States ; Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, United States ; Neuroscience Program in Substance Abuse, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, United States ; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-8548, United States.

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http://dx.doi.org/10.1016/j.ebiom.2015.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353922PMC
February 2015

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.

J Biol Chem 2014 Sep 13;289(36):25327-40. Epub 2014 Jul 13.

From the Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute 18.6, University of Copenhagen, 2200 Copenhagen N and

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http://dx.doi.org/10.1074/jbc.M114.548743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155694PMC
September 2014

The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride.

J Biol Chem 2014 Sep 25;289(37):25764-73. Epub 2014 Jul 25.

From the Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute 18.6, University of Copenhagen, 2200 Copenhagen N, Denmark and

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http://dx.doi.org/10.1074/jbc.M114.574269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162178PMC
September 2014

The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation.

J Biol Chem 2014 Aug 27;289(33):23004-19. Epub 2014 Jun 27.

From the Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, and.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.495754
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http://dx.doi.org/10.1074/jbc.M113.495754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132800PMC
August 2014

The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.

J Neurosci 2014 Aug;34(32):10688-700

Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences and Lundbeck Foundation Center for Biomembranes in Nanomedicine, University of Copenhagen, 2200N Copenhagen, Denmark, and

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http://dx.doi.org/10.1523/JNEUROSCI.5132-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122802PMC
August 2014

Serotonin-induced down-regulation of cell surface serotonin transporter.

Neurochem Int 2014 Jul 22;73:107-12. Epub 2014 Jan 22.

Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, The Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2014.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058363PMC
July 2014

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.

ACS Med Chem Lett 2014 Jun 27;5(6):696-9. Epub 2014 Mar 27.

Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health , 333 Cassell Drive, Baltimore, Maryland 21224, United States.

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http://dx.doi.org/10.1021/ml5000806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060933PMC
June 2014

Novel tripod amphiphiles for membrane protein analysis.

Chemistry 2013 Nov 2;19(46):15645-51. Epub 2013 Oct 2.

Department of Bionano Engineering, Hanyang University Ansan, 426-791 (Korea), Fax: (+81) 31-436-8146.

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http://dx.doi.org/10.1002/chem.201301423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947462PMC
November 2013

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

PLoS Biol 2013 23;11(4):e1001542. Epub 2013 Apr 23.

Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1371/journal.pbio.1001542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635866PMC
October 2013

Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

J Biol Chem 2013 Sep 24;288(38):27534-44. Epub 2013 Jul 24.

From the Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1074/jbc.M112.441295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779749PMC
September 2013

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons.

Proc Natl Acad Sci U S A 2013 Aug 12;110(35):14426-31. Epub 2013 Aug 12.

Molecular Neuropharmacology Laboratory and Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute 18.6, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1073/pnas.1312982110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761605PMC
August 2013

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter.

Nat Commun 2013 ;4:1580

Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ncomms2568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646413PMC
June 2013

The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial.

Psychiatry Res 2012 Dec 14;200(2-3):354-60. Epub 2012 Jun 14.

Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Denmark.

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http://dx.doi.org/10.1016/j.psychres.2012.05.015DOI Listing
December 2012

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.

J Biol Chem 2012 Nov 24;287(47):39316-26. Epub 2012 Sep 24.

Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.371765
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http://dx.doi.org/10.1074/jbc.M112.371765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501018PMC
November 2012

The solute carrier 6 family of transporters.

Br J Pharmacol 2012 Sep;167(2):256-78

Research School of Biology, Australian National University, Canberra, ACT, Australia.

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http://dx.doi.org/10.1111/j.1476-5381.2012.01975.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481037PMC
September 2012

Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway.

J Biol Chem 2012 Apr 2;287(15):12293-308. Epub 2012 Feb 2.

Molecular Neuropharmacology Laboratory and Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1074/jbc.M111.294702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320979PMC
April 2012

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.

Biochemistry 2012 Jan 6;51(2):586-96. Epub 2012 Jan 6.

Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1021/bi2014689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312318PMC
January 2012

Differences between early and late onset adult depression.

Clin Pract Epidemiol Ment Health 2011 10;7:140-7. Epub 2011 Aug 10.

Psychiatric Center Copenhagen, Denmark.

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http://dx.doi.org/10.2174/1745017901107010140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158434PMC
November 2011

SLC6 neurotransmitter transporters: structure, function, and regulation.

Pharmacol Rev 2011 Sep 13;63(3):585-640. Epub 2011 Jul 13.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1124/pr.108.000869DOI Listing
September 2011

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.

Comb Chem High Throughput Screen 2011 Aug;14(7):590-600

Molecular Neuropharmacology Group, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej, Denmark.

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August 2011

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

Neuropharmacology 2011 Jan 6;60(1):182-90. Epub 2010 Sep 6.

Molecular Neuropharmacology Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.neuropharm.2010.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703859PMC
January 2011

Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression.

J Affect Disord 2010 Dec 26;127(1-3):199-202. Epub 2010 Jun 26.

Psychiatric Center Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jad.2010.05.023DOI Listing
December 2010

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.

Org Biomol Chem 2010 Oct 29;8(19):4281-8. Epub 2010 Jul 29.

Department of Medicinal Chemistry, University of Copenhagen, Universitetsparken 2, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1039/c0ob00025fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614091PMC
October 2010

Does bereavement-related first episode depression differ from other kinds of first depressions?

Soc Psychiatry Psychiatr Epidemiol 2010 Aug 20;45(8):801-8. Epub 2009 Aug 20.

Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Rigshospitalet, Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1007/s00127-009-0121-6DOI Listing
August 2010

David versus Goliath.

Nanomedicine 2010 Aug 22;6(4):504-9. Epub 2010 Apr 22.

The Lundbeck Foundation Nanomedicine Research Center for Cancer Stem Cell Targeting Therapeutics (NanoCAN), University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.1016/j.nano.2010.04.002DOI Listing
August 2010

Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons.

J Biol Chem 2010 Aug 15;285(35):27289-301. Epub 2010 Jun 15.

Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1074/jbc.M110.131003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930728PMC
August 2010

Gender differences among patients with a single depressive episode.

Psychopathology 2010 27;43(3):159-69. Epub 2010 Feb 27.

Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark.

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http://dx.doi.org/10.1159/000288638DOI Listing
July 2010

The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression.

Psychopathology 2010 6;43(3):197-204. Epub 2010 Apr 6.

Department of Psychiatry, University Hospital of Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000304176DOI Listing
July 2010

No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment.

Eur Neuropsychopharmacol 2010 May;20(5):327-35

Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark.

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http://dx.doi.org/10.1016/j.euroneuro.2009.11.004DOI Listing
May 2010

Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges.

J Neurochem 2010 Apr 18;113(1):27-41. Epub 2010 Jan 18.

Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, Copenhagen N, Denmark.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06599.xDOI Listing
April 2010

The N terminus of monoamine transporters is a lever required for the action of amphetamines.

J Biol Chem 2010 Apr 29;285(14):10924-38. Epub 2010 Jan 29.

Center of Biomolecular Medicine and Pharmacology, Institute of Pharmacology, Medical University Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1074/jbc.M109.083154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856298PMC
April 2010

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

Proc Natl Acad Sci U S A 2010 Jan 14;107(1):413-8. Epub 2009 Dec 14.

Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0902225107
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http://dx.doi.org/10.1073/pnas.0902225107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806717PMC
January 2010

Interaction between genetic polymorphisms and stressful life events in first episode depression.

J Affect Disord 2009 Dec 31;119(1-3):107-15. Epub 2009 Mar 31.

Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jad.2009.02.023DOI Listing
December 2009

How curved membranes recruit amphipathic helices and protein anchoring motifs.

Nat Chem Biol 2009 Nov 13;5(11):835-41. Epub 2009 Sep 13.

Bio-Nanotechnology Laboratory, Department of Neuroscience and Pharmacology & Nano-Science Center, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nchembio.213DOI Listing
November 2009

PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.

J Comp Neurol 2009 Nov;517(3):313-32

Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/cne.22155DOI Listing
November 2009

Amphipathic motifs in BAR domains are essential for membrane curvature sensing.

EMBO J 2009 Nov 8;28(21):3303-14. Epub 2009 Oct 8.

Bio-Nanotechnology Laboratory, Department of Neuroscience and Pharmacology & Nano-Science Center, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/emboj.2009.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776096PMC
November 2009

Do stressful life events predict medical treatment outcome in first episode of depression?

Soc Psychiatry Psychiatr Epidemiol 2009 Sep 5;44(9):752-60. Epub 2009 Feb 5.

Dept. of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1007/s00127-008-0491-1DOI Listing
September 2009

A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation.

Neuropharmacology 2009 Sep 3;57(3):287-94. Epub 2009 Jun 3.

Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.neuropharm.2009.05.009DOI Listing
September 2009

Elucidating conformational changes in the gamma-aminobutyric acid transporter-1.

J Biol Chem 2009 Jun 10;284(24):16226-35. Epub 2009 Apr 10.

Department of Biology, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1074/jbc.M109.003137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713550PMC
June 2009

Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs.

J Neurosci 2009 May;29(21):6794-808

Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1523/JNEUROSCI.4177-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849467PMC
May 2009

Validity of the diagnosis of a single depressive episode in a case register.

Clin Pract Epidemiol Ment Health 2009 Feb 12;5. Epub 2009 Feb 12.

Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/1745-0179-5-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660321PMC
February 2009

Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.

Mol Pharmacol 2008 Oct 10;74(4):1101-8. Epub 2008 Jul 10.

Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Centerfor Research on Human Development, Vanderbilt University, 7124 MRBIII, 465 21st Avenue S., Nashville, TN 37232, USA.

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http://dx.doi.org/10.1124/mol.108.048447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728020PMC
October 2008