Publications by authors named "Ulrich M Zanger"

100Publications

Tri-allelic haplotypes determine and differentiate functionally normal allele CYP2D6*2 and impaired allele CYP2D6*41.

Clin Pharmacol Ther 2020 Oct 12. Epub 2020 Oct 12.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, and University of Tuebingen, Stuttgart, Germany, Tuebingen, Germany.

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http://dx.doi.org/10.1002/cpt.2078DOI Listing
October 2020

Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression.

Breast Cancer Res 2020 07 13;22(1):75. Epub 2020 Jul 13.

Department of Obstetrics and Gynecology, University Hospital and Medical Faculty of the Heinrich-Heine University Duesseldorf, Life Science Center, Merowingerplatz 1A, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1186/s13058-020-01312-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359014PMC
July 2020

Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression.

Hum Genet 2020 Feb 30;139(2):137-149. Epub 2019 Nov 30.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1007/s00439-019-02093-7DOI Listing
February 2020

MiR-155 and other microRNAs downregulate drug metabolizing cytochromes P450 in inflammation.

Biochem Pharmacol 2020 01 21;171:113725. Epub 2019 Nov 21.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Eberhard Karls University, Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.113725DOI Listing
January 2020

Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody.

Drug Metab Dispos 2019 05 28;47(5):444-452. Epub 2019 Feb 28.

Centre Hospitalier Universitaire (CHU) de Québec Research Centre and Faculty of Medicine (J.-P.É., S.D., H.H., H.B., L.L., M.P., B.T., E.L.) and CHU de Québec Research Centre and Faculty of Pharmacy, Laval University (A.L., M.R., L.V., P.C., C.G.), and Statistical and Clinical Research Platform, CHU de Québec Research Centre (D.S.), Québec, Canada.); Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S.); and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany (K.K., U.M.Z.)

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http://dx.doi.org/10.1124/dmd.119.086330DOI Listing
May 2019

The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway.

Food Chem Toxicol 2019 Jan 17;123:481-491. Epub 2018 Nov 17.

German Federal Institute for Risk Assessment, Dept. Food Safety, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2018.11.039DOI Listing
January 2019

Epigenetics and MicroRNAs in Pharmacogenetics.

Adv Pharmacol 2018 23;83:33-64. Epub 2018 Apr 23.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1016/bs.apha.2018.02.003DOI Listing
July 2019

Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates.

Drug Metab Dispos 2018 04 17;46(4):387-396. Epub 2018 Jan 17.

NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.); Department of Clinical Pharmacology, University of Tuebingen, Tübingen, Germany (K.K., U.M.Z.); Departments of Surgical Sciences (A.N.) and Pharmacy (C.W., P.A.), Uppsala University, Uppsala, Sweden; and Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, Mölndal, Sweden (C.W.)

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http://dx.doi.org/10.1124/dmd.117.078626DOI Listing
April 2018

Regulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG Cells.

Drug Metab Dispos 2018 04 12;46(4):326-335. Epub 2018 Jan 12.

German Federal Institute for Risk Assessment, Department Food Safety, Berlin (N.T., L.K., C.L., L.B., A.L., A.B.), and Dr. Margarete Fischer-Bosch-Institute for Clinical Pharmacology, Stuttgart (M.T., U.H., U.M.Z.), Germany

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http://dx.doi.org/10.1124/dmd.117.078675DOI Listing
April 2018

The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes.

Arch Toxicol 2018 Mar 28;92(3):1099-1112. Epub 2017 Dec 28.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and University of Tübingen, Auerbachstr. 112, 70376, Stuttgart, Germany.

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http://dx.doi.org/10.1007/s00204-017-2147-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866846PMC
March 2018

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function.

Front Pharmacol 2017 27;8:881. Epub 2017 Nov 27.

Department of Molecular and Cell Biology, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.3389/fphar.2017.00881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712015PMC
November 2017

Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia.

Hepatology 2018 04 2;67(4):1609-1619. Epub 2018 Mar 2.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1002/hep.29599DOI Listing
April 2018

Effect of Genetic Variability in the , , and Genes on Liver mRNA Levels and Warfarin Response.

Front Pharmacol 2017 31;8:323. Epub 2017 May 31.

Wolfson Centre for Personalized Medicine, Department of Molecular and Clinical Pharmacology, The University of LiverpoolLiverpool, United Kingdom.

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http://dx.doi.org/10.3389/fphar.2017.00323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449482PMC
May 2017

Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions - Focus on Interactions with Cytochromes P450.

Front Pharmacol 2017 27;8:159. Epub 2017 Mar 27.

Department of Molecular and Cell Biology, Dr. Margarete Fischer-Bosch-Institute of Clinical PharmacologyStuttgart, Germany; Eberhard-Karls-UniversityTübingen, Germany.

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http://dx.doi.org/10.3389/fphar.2017.00159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366339PMC
March 2017

Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels.

Arch Toxicol 2017 Oct 22;91(10):3329-3339. Epub 2017 Mar 22.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112, 70376, Stuttgart, Germany.

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http://dx.doi.org/10.1007/s00204-017-1955-4DOI Listing
October 2017

Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.

PLoS Comput Biol 2016 07 27;12(7):e1005018. Epub 2016 Jul 27.

Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany.

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http://dx.doi.org/10.1371/journal.pcbi.1005018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963125PMC
July 2016

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers.

Drug Metab Pharmacokinet 2016 Apr 29;31(2):107-16. Epub 2015 Jul 29.

Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2015.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974081PMC
April 2016

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.

Biochim Biophys Acta 2016 09 17;1859(9):1218-1227. Epub 2016 Mar 17.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University Hospital, Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2016.03.007DOI Listing
September 2016

Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data.

Lancet Oncol 2015 Dec 23;16(16):1639-50. Epub 2015 Oct 23.

Department of Clinical Pharmacology, Netherlands Cancer Institute, Amsterdam, Netherlands; Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands. Electronic address:

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http://www.thelancet.com/pdfs/journals/lanonc/PIIS1470-2045(
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http://linkinghub.elsevier.com/retrieve/pii/S147020451500286
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http://dx.doi.org/10.1016/S1470-2045(15)00286-7DOI Listing
December 2015

Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice.

BMC Syst Biol 2015 Nov 20;9:83. Epub 2015 Nov 20.

Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.

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http://dx.doi.org/10.1186/s12918-015-0229-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654904PMC
November 2015

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8.

Front Pharmacol 2015 4;6:261. Epub 2015 Nov 4.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart, Germany ; University of Tuebingen Tuebingen, Germany.

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http://dx.doi.org/10.3389/fphar.2015.00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631943PMC
November 2015

Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists.

Drug Metab Dispos 2015 Nov 26;43(11):1781-7. Epub 2015 Aug 26.

Department of Food Safety, Federal Institute for Risk Assessment, Berlin, Germany (A.B.); Dr.-Margarethe-Fischer-Bosch-Institute for Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany (M.T., U.H., J.J., W.S., U.M.Z.); Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Tübingen, Germany (A.B., S.V., E.Z., B.P., M.S.); Regensburg University Hospital, Regensburg, Germany (T.S.W.).

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http://dx.doi.org/10.1124/dmd.115.064667DOI Listing
November 2015

Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease.

J Hepatol 2016 Jan 26;64(1):44-52. Epub 2015 Jul 26.

Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691383PMC
January 2016

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes.

BMC Cancer 2015 Jun 30;15:488. Epub 2015 Jun 30.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112, 70736, Stuttgart, and University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1186/s12885-015-1500-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485637PMC
June 2015

Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential.

Drug Metab Dispos 2015 Sep 15;43(9):1331-5. Epub 2015 Jun 15.

Pharmacogenomics Laboratory, Centre Hospitalier Universitaire (CHU) de Québec and Faculty of Pharmacy, Université Laval, Québec, Canada (G.M., M.R., P.C., L.V., C.G.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Tübingen, Germany (K.K., U.M.Z.); Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (J.K.F., P.C.S.); Canada Research Chair in Pharmacogenomics (C.G.)

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http://dx.doi.org/10.1124/dmd.115.065391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538857PMC
September 2015

Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained.

Epigenetics Chromatin 2015 18;8:12. Epub 2015 Mar 18.

Institute of Biochemistry, Faculty of Chemistry, Stuttgart University, Pfaffenwaldring 55, 70569 Stuttgart, Germany.

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http://dx.doi.org/10.1186/s13072-015-0002-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404288PMC
April 2015

Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells.

Mol Pharmacol 2015 Jun 30;87(6):1013-20. Epub 2015 Mar 30.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, and University of Tuebingen, Tuebingen, Germany (M.T., C.B., U.H., U.M.Z.); Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tübingen, Tübingen, Germany (S.V., M.S.); and Department of Food Safety, Federal Institute for Risk Assessment, Berlin, Germany (A.B.).

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http://dx.doi.org/10.1124/mol.114.097402DOI Listing
June 2015

Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9.

Drug Metab Dispos 2015 Jun 23;43(6):884-8. Epub 2015 Mar 23.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology (J.K.R., S.R., U.H., M.S., U.M.Z.) and Department of Clinical Pharmacology (M.S.), University of Tuebingen, Tuebingen, Germany

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http://dx.doi.org/10.1124/dmd.114.062844DOI Listing
June 2015

Role of ABC transporters in fluoropyrimidine-based chemotherapy response.

Adv Cancer Res 2015 8;125:217-43. Epub 2015 Jan 8.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1016/bs.acr.2014.10.007DOI Listing
October 2015

Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression.

Cell Physiol Biochem 2015 30;35(2):803-15. Epub 2015 Jan 30.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1159/000369739DOI Listing
October 2015

Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.

Cell Signal 2015 Mar 3;27(3):555-67. Epub 2015 Jan 3.

Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University of Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.12.016DOI Listing
March 2015

A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells.

Drug Metab Dispos 2015 Feb 5;43(2):273-83. Epub 2014 Dec 5.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Tuebingen, Germany (M.K., M.T., U.H., U.M.Z.); and Department of General, Visceral, and Transplantation Surgery, Charité University Medicine Berlin, Berlin, Germany (D.S., G.D.)

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http://dx.doi.org/10.1124/dmd.114.060962DOI Listing
February 2015

Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.

J Clin Oncol 2014 Apr 3;32(10):1031-9. Epub 2014 Mar 3.

Dan Rosmarin, Claire Palles, David Church, Enric Domingo, Angela Jones, Ian Tomlinson, Wellcome Trust Centre for Human Genetics, NIHR Comprehensive Biomedical Research Centre, University of Oxford; Dan Rosmarin, David Church, Elaine Johnstone, Haitao Wang, Sharon Love, Patrick Julier, Claire Scudder, George Nicholson, Rachel Midgley, David Kerr, and George Nicholson, University of Oxford, Oxford; Michael Braun, The Christie NHS Foundation Trust, Manchester; Matthew Seymour, St James's University Hospital, Leeds; Lindsay Thompson, Medical Research Council Clinical Trials Unit; Rohini Sharma, Imperial College Healthcare NHS Trust, Hammersmith and Charing Cross Hospitals, London, United Kingdom; Anna Gonzalez-Neira, Spanish National Cancer Research Centre; Miguel Martin, Instituto de Investigacion Sanitaria Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid; Nuria Ribelles, Hospital Universitario Virgen de la Victoria, Málaga; Eva Martinez-Balibrea, Institut Català d'Oncologia, Institut de Recerca Sanitària Germans Trias i Pujol, Barcelona; Jesus Garcia-Foncillas, University Clinic of Navarra, University of Navarra, Pamplona, Spain; Daniel Sargent, Erin Green, Mayo Clinic, Rochester, MN; Howard McLeod, University of North Carolina, Chapel Hill, NC; Ulrich M. Zanger, Matthias Schwab, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Ulrich M. Zanger, Matthias Schwab, University Hospital Tuebingenl, Tuebingen, Germany; Benjamin Lacas, Valérie Boige, Jean-Pierre Pignon, Institut Gustave Roussy, Villejuif; Marie-Christine Etienne-Grimaldi, Gérard Milano, Centre Antoine Lacassagne, Nice; Thierry Lecomte, Pierre Laurent-Puig, Assistance Publique Hopitaux de Paris, Hopital Européen Georges Pompidou, Paris; Alain Morel, Institut National de la Sante et de la Recherche Medicale U564, Centre Paul Papin, Angers, France; Shoaib Afzal, Henrik Enghusen, Laboratory of Clinical Pharmacology, Rigshospitalet, Copenhagen; Sør

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http://dx.doi.org/10.1200/JCO.2013.51.1857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879695PMC
April 2014

No activation of human pregnane X receptor by hyperforin-related phloroglucinols.

J Pharmacol Exp Ther 2014 Mar 20;348(3):393-400. Epub 2013 Nov 20.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (B.A.K., U.M.Z.); University of Tübingen, Tübingen, Germany (B.A.K., U.M.Z.); Collaborations in Chemistry, Fuquay-Varina, North Carolina (S.E.); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (S.E.); Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School, Piscataway, New Jersey (S.E.); Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina (S.E.); Molecular and Clinical Pharmacy, Friedrich-Alexander University, Erlangen-Nuremberg, Germany (K.L.); Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians University, Munich, Germany (W.E.T.); and Institute of Pharmacology and Toxicology, Interfaculty Centre for Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany (C.H.).

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http://dx.doi.org/10.1124/jpet.113.209916DOI Listing
March 2014

ABCC11/MRP8 polymorphisms affect 5-fluorouracil-induced severe toxicity and hepatic expression.

Pharmacogenomics 2013 Sep;14(12):1433-48

Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany.

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http://dx.doi.org/10.2217/pgs.13.139DOI Listing
September 2013

Expression variability of absorption, distribution, metabolism, excretion-related microRNAs in human liver: influence of nongenetic factors and association with gene expression.

Drug Metab Dispos 2013 Oct 3;41(10):1752-62. Epub 2013 Jun 3.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; and University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1124/dmd.113.052126DOI Listing
October 2013

The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro.

Drug Metab Dispos 2013 Jun 2;41(6):1264-72. Epub 2013 Apr 2.

Discipline of Pharmacology, The University of Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1124/dmd.113.051631DOI Listing
June 2013

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance.

Front Genet 2013 5;4:24. Epub 2013 Mar 5.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology Stuttgart, Germany ; The University of Tuebingen Tuebingen, Germany.

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http://dx.doi.org/10.3389/fgene.2013.00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588594PMC
March 2013

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.

Front Genet 2013 25;4:12. Epub 2013 Feb 25.

Dr. Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart Stuttgart, Germany ; University of Tübingen Tübingen, Germany.

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http://dx.doi.org/10.3389/fgene.2013.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580761PMC
February 2013

Novel CYP2B6 enzyme variants in a Rwandese population: functional characterization and assessment of in silico prediction tools.

Hum Mutat 2013 May 11;34(5):725-34. Epub 2013 Mar 11.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1002/humu.22295DOI Listing
May 2013

Molecular Interactions between NAFLD and Xenobiotic Metabolism.

Front Genet 2013 22;4. Epub 2013 Jan 22.

Faculty of Computer Sciences and Informatics, University of Ljubljana Ljubljana, Slovenia.

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http://dx.doi.org/10.3389/fgene.2013.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3550596PMC
January 2013

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.

Pharmacol Ther 2013 Apr 16;138(1):103-41. Epub 2013 Jan 16.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112 D, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.1016/j.pharmthera.2012.12.007DOI Listing
April 2013

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1.

Genome Med 2013 11;5(1). Epub 2013 Jan 11.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany, and University of Tübingen.

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http://dx.doi.org/10.1186/gm405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706890PMC
May 2014

Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).

Mol Pharmacol 2013 Mar 7;83(3):709-18. Epub 2013 Jan 7.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.1124/mol.112.082503DOI Listing
March 2013

Cytochrome P450 2B6: function, genetics, and clinical relevance.

Drug Metabol Drug Interact 2012 ;27(4):185-97

Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.

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http://www.degruyter.com/dg/viewarticle.fullcontentlink:pdfe
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http://dx.doi.org/10.1515/dmdi-2012-0027DOI Listing
June 2013

Omics and drug response.

Annu Rev Pharmacol Toxicol 2013 5;53:475-502. Epub 2012 Nov 5.

Division of Pharmacology and Neurobiology, Biozentrum of the University of Basel, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1146/annurev-pharmtox-010510-100502DOI Listing
July 2013

PPARA: a novel genetic determinant of CYP3A4 in vitro and in vivo.

Clin Pharmacol Ther 2012 Jun;91(6):1044-52

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1038/clpt.2011.336DOI Listing
June 2012

MIRNA-DISTILLER: A Stand-Alone Application to Compile microRNA Data from Databases.

Front Genet 2011 8;2:39. Epub 2011 Jul 8.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tuebingen Stuttgart, Germany.

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http://journal.frontiersin.org/article/10.3389/fgene.2011.00
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http://dx.doi.org/10.3389/fgene.2011.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268593PMC
October 2012

Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism.

Toxicology 2012 Mar 18;293(1-3):115-122. Epub 2012 Jan 18.

Department of Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY 14214, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935332PMC
March 2012

Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease.

PLoS One 2011 12;6(8):e23506. Epub 2011 Aug 12.

Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155567PMC
February 2012

Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis.

Front Pharmacol 2011 27;2:41. Epub 2011 Jul 27.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tuebingen Stuttgart, Germany.

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http://dx.doi.org/10.3389/fphar.2011.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147178PMC
November 2011

Inferring statin-induced gene regulatory relationships in primary human hepatocytes.

Bioinformatics 2011 Sep 14;27(18):2473-7. Epub 2011 Jul 14.

Center for Bioinformatics Tuebingen, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btr416DOI Listing
September 2011

Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

Front Pharmacol 2010 2;1:129. Epub 2010 Nov 2.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tuebingen Stuttgart, Germany.

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http://dx.doi.org/10.3389/fphar.2010.00129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171976PMC
November 2011

Pharmacogenetics - challenges and opportunities ahead.

Authors:
Ulrich M Zanger

Front Pharmacol 2010 20;1:112. Epub 2010 Aug 20.

Robert-Bosch Foundation, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart, Germany.

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http://dx.doi.org/10.3389/fphar.2010.00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095373PMC
July 2011

RNA-interference approach to study functions of NADPH : cytochrome P450 oxidoreductase in human hepatocytes.

Chem Biodivers 2009 Nov;6(11):2084-91

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Auerbachstrasse 112, DE-70376 Stuttgart.

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http://dx.doi.org/10.1002/cbdv.200900135DOI Listing
November 2009

Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver.

Proteomics 2009 May;9(9):2313-23

Funktionelle Proteomik, Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1002/pmic.200800680DOI Listing
May 2009

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation.

Pharmacogenomics 2009 Apr;10(4):579-99

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Auerbachstrasse 112, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.2217/pgs.09.7DOI Listing
April 2009

Distinction between human cytochrome P450 (CYP) isoforms and identification of new phosphorylation sites by mass spectrometry.

J Proteome Res 2008 Nov 2;7(11):4678-88. Epub 2008 Oct 2.

Functional Proteomics, Medizinisches Proteom-Center, Ruhr-Universitaet Bochum, Universitaetsstr. 150, ZKF, D-44801 Bochum, Germany.

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http://dx.doi.org/10.1021/pr800231wDOI Listing
November 2008

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation.

Anal Bioanal Chem 2008 Nov 10;392(6):1093-108. Epub 2008 Aug 10.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112, 70376, Stuttgart, Germany.

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http://link.springer.com/10.1007/s00216-008-2291-6
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November 2008

Highly multiplexed genotyping of thiopurine s-methyltransferase variants using MALD-TOF mass spectrometry: reliable genotyping in different ethnic groups.

Clin Chem 2008 Oct 7;54(10):1637-47. Epub 2008 Aug 7.

Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1373/clinchem.2008.103457DOI Listing
October 2008

Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver.

Drug Metab Dispos 2008 Oct 17;36(10):2113-20. Epub 2008 Jul 17.

Department of Pharmacology, Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 67, D-55101 Mainz, Germany.

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http://dx.doi.org/10.1124/dmd.108.022251DOI Listing
October 2008

Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver.

J Pharmacol Exp Ther 2008 Apr 2;325(1):284-92. Epub 2008 Jan 2.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany and University of Tübingen, Auerbachstrasse 112, 70376 Stuttgart, Germany.

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http://dx.doi.org/10.1124/jpet.107.133306DOI Listing
April 2008

Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C.

Mol Genet Genomics 2008 Feb 8;279(2):149-57. Epub 2007 Nov 8.

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-University Erlangen-Nuremberg, Fahrstrasse 17, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00438-007-0303-4DOI Listing
February 2008

Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance.

Pharmacogenomics 2007 Jul;8(7):743-59

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany.

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http://dx.doi.org/10.2217/14622416.8.7.743DOI Listing
July 2007

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro.

Pharmacogenomics 2007 Jun;8(6):547-58

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, 1001 West 10th Street, WD Myers Bldg., W7123, Indianapolis, IN 46202, USA.

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https://www.futuremedicine.com/doi/10.2217/14622416.8.6.547
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June 2007

Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene.

Cancer Chemother Pharmacol 2008 Mar 5;61(3):481-8. Epub 2007 May 5.

Laboratoire de Pharmacologie des Agents Anticancéreux, Institut Bergonié, Université Victor Segalen Bordeaux 2, France.

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http://dx.doi.org/10.1007/s00280-007-0493-9DOI Listing
March 2008

Sex-dependent genetic markers of CYP3A4 expression and activity in human liver microsomes.

Pharmacogenomics 2007 May;8(5):443-53

Georg-August University, Department of Clinical Pharmacology, Göttingen, Germany.

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http://dx.doi.org/10.2217/14622416.8.5.443DOI Listing
May 2007

A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6.

Drug Metab Dispos 2007 Aug 25;35(8):1247-50. Epub 2007 Apr 25.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Auerbachstr. 112, D-70376 Stuttgart, Germany.

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http://dx.doi.org/10.1124/dmd.107.015149DOI Listing
August 2007

Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine.

Drug Metab Dispos 2007 Jun 7;35(6):946-54. Epub 2007 Mar 7.

Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany.

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http://dx.doi.org/10.1124/dmd.106.013565DOI Listing
June 2007

Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine.

Clin Pharmacol Ther 2006 Nov;80(5):440-456

Division of Pharmacology/Neurobiology, Biozentrum, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.clpt.2006.08.013DOI Listing
November 2006

MALDI-TOF mass spectrometry for multiplex genotyping of CYP2B6 single-nucleotide polymorphisms.

Clin Chem 2007 Jan 2;53(1):24-33. Epub 2006 Nov 2.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1373/clinchem.2006.074856DOI Listing
January 2007

A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6.

Pharmacogenet Genomics 2006 Oct;16(10):767-70

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1097/01.fpc.0000236331.03681.24DOI Listing
October 2006

Three novel thiopurine S-methyltransferase allelic variants (TPMT*20, *21, *22) - association with decreased enzyme function.

Hum Mutat 2006 Sep;27(9):976

Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://doi.wiley.com/10.1002/humu.9450
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September 2006

Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

Hepatology 2006 Jul;44(1):62-74

Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland.

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http://dx.doi.org/10.1002/hep.21214DOI Listing
July 2006