Ulrich Hommel

Lead Discovery Informatics, Lead Finding Platform, Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

View Article and Find Full Text PDF

November 2010

Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine.

Authors:

Anna Vulpetti Ulrich Hommel Gregory Landrum Richard Lewis Claudio Dalvit

J Am Chem Soc 2009 Sep;131(36):12949-59

Novartis Institute for Biomedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF

September 2009

Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment.

Authors:

Andreas Schedlbauer Renate Auer Karin Ledolter Martin Tollinger Karin Kloiber Roman Lichtenecker Simon Ruedisser Ulrich Hommel Walther Schmid Robert Konrat Georg Kontaxis

J Biomol NMR 2008 Oct 2;42(2):111-27. Epub 2008 Sep 2.

Institute of Biomolecular Structural Chemistry, Max F. Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5/1, Vienna, Austria.

View Article and Find Full Text PDF

October 2008

"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.

Authors:

Thomas J Crisman Andreas Bender Mariusz Milik Jeremy L Jenkins Josef Scheiber Sai Chetan K Sukuru Jasna Fejzo Ulrich Hommel John W Davies Meir Glick

J Med Chem 2008 Apr 22;51(8):2481-91. Epub 2008 Mar 22.

Center for Proteomic Chemistry, Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

View Article and Find Full Text PDF

April 2008

Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.

Authors:

Richard Harris Ulf Eidhoff Daniela Vinzenz Martin Renatus Bernd Gerhartz Ulrich Hommel Paul C Driscoll

Biomol NMR Assign 2007 Jul 11;1(1):51-3. Epub 2007 May 11.

Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E6BT, UK.

View Article and Find Full Text PDF

July 2007

Automated backbone and side-chain assignment of mitochondrial matrix cyclophilin D.

Authors:

Andreas Schedlbauer Bernd Hoffmann Georg Kontaxis Simon Rüdisser Ulrich Hommel Robert Konrat

J Biomol NMR 2007 Jul 25;38(3):267. Epub 2007 May 25.

View Article and Find Full Text PDF

July 2007

Aspartic proteases in drug discovery.

Authors:

Jörg Eder Ulrich Hommel Frederic Cumin Bruno Martoglio Bernd Gerhartz

Curr Pharm Des 2007 ;13(3):271-85

Novartis Institutes for BioMedical Research, Expertise Platform Proteases, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF

March 2007

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Authors:

Paul Erbel Nikolaus Schiering Allan D'Arcy Martin Renatus Markus Kroemer Siew Pheng Lim Zheng Yin Thomas H Keller Subhash G Vasudevan Ulrich Hommel

Nat Struct Mol Biol 2006 Apr 12;13(4):372-3. Epub 2006 Mar 12.

Novartis Institutes for Biomedical Research, Protease Platform, 4002 Basel, Switzerland.

View Article and Find Full Text PDF

April 2006

Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.

Authors:

Nils Ostermann Jörg Eder Ulf Eidhoff Florence Zink Ulrich Hassiepen Susanne Worpenberg Jürgen Maibaum Oliver Simic Ulrich Hommel Bernd Gerhartz

J Mol Biol 2006 Jan 8;355(2):249-61. Epub 2005 Nov 8.

Protease Platform, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF

January 2006

1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.

Authors:

Sompong Wattanasin Joerg Kallen Stewart Myers Qin Guo Michael Sabio Claus Ehrhardt Rainer Albert Ulrich Hommel Gisbert Weckbecker Karl Welzenbach Gabriele Weitz-Schmidt

Bioorg Med Chem Lett 2005 Feb;15(4):1217-20

Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

View Article and Find Full Text PDF

February 2005

1,4-Diazepane-2-ones as novel inhibitors of LFA-1.

Authors:

Sompong Wattanasin Rainer Albert Claus Ehrhardt Didier Roche Michael Sabio Ulrich Hommel Karl Welzenbach Gabriele Weitz-Schmidt

Bioorg Med Chem Lett 2003 Feb;13(3):499-502

Novartis Institute for Biomedical Research, Novartis Pharmaceuticals Corporation, 556 Morris Avenue, Summit, NJ 07901, USA.

View Article and Find Full Text PDF

February 2003

Structure and allosteric regulation of the alpha X beta 2 integrin I domain.

Authors:

Thomas Vorup-Jensen Christian Ostermeier Motomu Shimaoka Ulrich Hommel Timothy A Springer

Proc Natl Acad Sci U S A 2003 Feb 28;100(4):1873-8. Epub 2003 Jan 28.

Center for Blood Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

View Article and Find Full Text PDF

February 2003

Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition.

Authors:

Karl Welzenbach Ulrich Hommel Gabriele Weitz-Schmidt

J Biol Chem 2002 Mar 7;277(12):10590-8. Epub 2002 Jan 7.

Novartis Pharma AG, Preclinical Research, Basel CH-4002, Switzerland.

View Article and Find Full Text PDF

March 2002

Publications by authors named "Ulrich Hommel"

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors: