Publications by authors named "Ulrich Hommel"

18Publications

Comprehensive and High-Throughput Exploration of Chemical Space Using Broadband F NMR-Based Screening.

Angew Chem Int Ed Engl 2020 May 3. Epub 2020 May 3.

Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, CA, 94608, USA.

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May 2020

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.

Protein Sci 2010 Nov;19(11):2096-109

Lead Discovery Informatics, Lead Finding Platform, Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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November 2010

Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine.

J Am Chem Soc 2009 Sep;131(36):12949-59

Novartis Institute for Biomedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland.

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September 2009

Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment.

J Biomol NMR 2008 Oct 2;42(2):111-27. Epub 2008 Sep 2.

Institute of Biomolecular Structural Chemistry, Max F. Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5/1, Vienna, Austria.

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October 2008

"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.

J Med Chem 2008 Apr 22;51(8):2481-91. Epub 2008 Mar 22.

Center for Proteomic Chemistry, Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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April 2008

Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.

Biomol NMR Assign 2007 Jul 11;1(1):51-3. Epub 2007 May 11.

Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E6BT, UK.

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July 2007

Aspartic proteases in drug discovery.

Curr Pharm Des 2007 ;13(3):271-85

Novartis Institutes for BioMedical Research, Expertise Platform Proteases, CH-4002 Basel, Switzerland.

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March 2007

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Nat Struct Mol Biol 2006 Apr 12;13(4):372-3. Epub 2006 Mar 12.

Novartis Institutes for Biomedical Research, Protease Platform, 4002 Basel, Switzerland.

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April 2006

Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.

J Mol Biol 2006 Jan 8;355(2):249-61. Epub 2005 Nov 8.

Protease Platform, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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January 2006

1,4-Diazepane-2-ones as novel inhibitors of LFA-1.

Bioorg Med Chem Lett 2003 Feb;13(3):499-502

Novartis Institute for Biomedical Research, Novartis Pharmaceuticals Corporation, 556 Morris Avenue, Summit, NJ 07901, USA.

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February 2003

Structure and allosteric regulation of the alpha X beta 2 integrin I domain.

Proc Natl Acad Sci U S A 2003 Feb 28;100(4):1873-8. Epub 2003 Jan 28.

Center for Blood Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

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February 2003