Ulrich Dirnagl

Ulrich Dirnagl

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Ulrich Dirnagl

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Resolving the Tension Between Exploration and Confirmation in Preclinical Biomedical Research.

Authors:
Ulrich Dirnagl

Handb Exp Pharmacol 2020 ;257:71-79

Department of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1007/164_2019_278DOI Listing
March 2020

Preregistration of exploratory research: Learning from the golden age of discovery.

Authors:
Ulrich Dirnagl

PLoS Biol 2020 Mar 26;18(3):e3000690. Epub 2020 Mar 26.

QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1371/journal.pbio.3000690DOI Listing
March 2020

An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models.

J Cereb Blood Flow Metab 2020 Feb 7;40(2):276-287. Epub 2019 Feb 7.

Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1177/0271678X19827251DOI Listing
February 2020

Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative.

PLoS Biol 2020 Feb 11;18(2):e3000576. Epub 2020 Feb 11.

QUEST Center for Transforming Biomedical Research, Berlin Institute of Health (BIH), Berlin, Germany.

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http://dx.doi.org/10.1371/journal.pbio.3000576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012388PMC
February 2020

Checklists for Authors Improve the Reporting of Basic Science Research.

Stroke 2020 Jan 13;51(1):6-7. Epub 2019 Nov 13.

Department of Neurology, Bethel-EvKB, Bielefeld, Germany (W.-R.S.).

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http://dx.doi.org/10.1161/STROKEAHA.119.027626DOI Listing
January 2020

Result dissemination from clinical trials conducted at German university medical centers was delayed and incomplete.

J Clin Epidemiol 2019 Nov 10;115:37-45. Epub 2019 Jun 10.

Institute for Ethics, History, and Philosophy of Medicine, Hannover Medical School, Hannover, Germany; QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Germany; Charité Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jclinepi.2019.06.002DOI Listing
November 2019

The p value wars (again).

Authors:
Ulrich Dirnagl

Eur J Nucl Med Mol Imaging 2019 Nov;46(12):2421-2423

Berlin Institute of Health, QUEST Center for Transforming Biomedical Research, Berlin, Germany.

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http://dx.doi.org/10.1007/s00259-019-04467-5DOI Listing
November 2019

Outcome heterogeneity and bias in acute experimental spinal cord injury: A meta-analysis.

Neurology 2019 07 7;93(1):e40-e51. Epub 2019 Jun 7.

From Charité-Universitätsmedizin Berlin (R.W., M.A.K., J.R., U.D., J.M.S.), corporate member of the Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Neurology and Experimental Neurology (R.W., M.A.K., J.R., J.M.S.), Charité Campus Mitte, Clinical and Experimental Spinal Cord Injury Research Laboratory (Neuroparaplegiology), Charité-Universitätsmedizin Berlin; Department of Neurosurgery (R.W.), Freiburg University Medical Center, Germany; Department of Neuroscience (A.A.), Central Clinical School, Monash University, Melbourne; Stroke Division (E.S.S., M.M., D.W.H.), Melbourne, Victoria, Australia; Departments of Neurology and Clinical Neurosciences (E.S.S., M.M.), University of Edinburgh, UK; Center for Stroke Research Berlin (U.D.) and Excellence Cluster Neurocure (U.D.), Charité-Universitätsmedizin, Berlin, Germany; German Center for Neurodegenerative Diseases (U.D.), Bonn; Berlin Institute of Health (M.A.K., U.D.), Germany; University of Tasmania (D.W.H.), School of Medicine, Faculty of Health, Medical Sciences Precinct, Hobart, Australia; Department of Neurology (J.M.S.), Spinal Cord Injury Medicine (Paraplegiology), and Belford Center for Spinal Cord Injury (J.M.S.), Departments of Neuroscience and Physical Medicine and Rehabilitation, The Neurological Institute, The Ohio State University, Wexner Medical Center, Columbus.

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http://dx.doi.org/10.1212/WNL.0000000000007718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659001PMC
July 2019

Exact replication: Foundation of science or game of chance?

PLoS Biol 2019 04 9;17(4):e3000188. Epub 2019 Apr 9.

Center for Stroke Research, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.plos.org/10.1371/journal.pbio.3000188
Publisher Site
http://dx.doi.org/10.1371/journal.pbio.3000188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456162PMC
April 2019

Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition.

ALTEX 2019 18;36(4):555-571. Epub 2019 Apr 18.

Department of Neurology and Department of Experimental Neurology, Neurocure Cluster of Excellence, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.14573/altex.1812231DOI Listing
April 2019

Atlas registration for edema-corrected MRI lesion volume in mouse stroke models.

J Cereb Blood Flow Metab 2019 02 22;39(2):313-323. Epub 2017 Aug 22.

1 Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), and NeuroCure, Charité University Medicine Berlin, Berlin, Germany.

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http://dx.doi.org/10.1177/0271678X17726635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360485PMC
February 2019

Longitudinal 19F magnetic resonance imaging of brain oxygenation in a mouse model of vascular cognitive impairment using a cryogenic radiofrequency coil.

MAGMA 2019 Feb 12;32(1):105-114. Epub 2018 Nov 12.

Department of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1007/s10334-018-0712-xDOI Listing
February 2019

Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.

Sci Rep 2019 02 28;9(1):3183. Epub 2019 Feb 28.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, Department of Experimental Neurology, Berlin, Germany.

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http://dx.doi.org/10.1038/s41598-019-39438-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395706PMC
February 2019

Rethinking research reproducibility.

Authors:
Ulrich Dirnagl

EMBO J 2019 01 5;38(2). Epub 2018 Dec 5.

QUEST Center for Transforming Biomedical Research, Berlin Institute of Health (BIH), Berlin, Germany.

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http://dx.doi.org/10.15252/embj.2018101117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331711PMC
January 2019

Quality management for academic laboratories: burden or boon? Professional quality management could be very beneficial for academic research but needs to overcome specific caveats.

EMBO Rep 2018 11 19;19(11). Epub 2018 Oct 19.

Department of Experimental Neurology and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.15252/embr.201847143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216282PMC
November 2018

Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse.

Front Neurol 2018 19;9:937. Epub 2018 Nov 19.

Department of Experimental Neurology, Charité - Universitätsmedizin, Corporate Member of Freie Universität Berlin, Humboldt Universitäts zu Berlin and Berlin Institute of Health, Berlin, Germany.

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https://www.frontiersin.org/article/10.3389/fneur.2018.00937
Publisher Site
http://dx.doi.org/10.3389/fneur.2018.00937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254134PMC
November 2018

Presentation abstracts.

Authors:
Laura Rice JongHun Sung Kathleen Keane Elizabeth Peterson Jacob Sosnoff Gary Farkas Ann Swartz Scott Strath Ashraf Gorgey Arthur Berg David Gater Trevor Dyson-Hudson Gerard Malanga Chris Cherian Monica Michalec Steven Kirshblum Carrie Miller Kristin Garlanger Sam Kortes Alyssa Schnorenberg Brooke Slavens Kenneth Lee Kelsey Potter-Baker Frederick Frost Ela Plow Ryan Solinsky Catherine Wilson Carrie Ann Henry Alexander Lombard Matthew Maher Joseph Weir Sana Saeed Christopher Cirnigliaro Adam Specht Erica Garbarini Jonathan Augustine Gail Forrest William Bauman Jill Wecht Matthew Maher Joseph Weir Alexander Lombard Sana Saeed Steven Kirshblum William Bauman Jill Wecht Jasmine Hearn Imaduddin S Razvi Catherine Wilson Carrie Ann Henry Seema Sikka Librada Callender Monica Bennett Keston Robertson Simon Driver Cristina Kline-Quiroz Jayne Donovan Amanda Botticello Dannae Arnold Nancy Latham Bethlyn Houlihan Timothy Bickmore Ha Trinh Ameneh Shamekhi Teresa Ellis Sherri L LaVela Elizabeth Burkhart Ibuola Kale Charles Bombardier Ellen Snoxell Steven Knezevic EunKyoung Hong Pierre Asselin Christopher Cirnigliaro Stephen Kornfeld Peter Gorman Gail Forrest William Bauman Ann Spungen Gary Farkas Arthur Berg Camilo Castillo David Gater Christine Cleveland Joelle Gabet Amanda Harrington Patricia Arenth Gary Farkas Ashraf Gorgey David Dolbow Arthur Berg David Gater Stephen Luther Dezon Finch Lina Bouayad Christopher Cirnigliaro Jayne Donovan Gail Forrest David Gater Marcel Kopp Ralf Watzlawick Peter Martus Vieri Failli Felix Finkenstaedt Yuying Chen Michael DeVivo Ulrich Dirnagl Jan Schwab James LiMonta Sana Saeed Tiffany Santiago Matthew Maher Yu-Kuang Wu Noam Harel Kimberley Monden Zina Trost Nguyen Nguyen Leslie Morse Adriel Boals Lisa Wenzel Stephanie Silveira Rosemary Hughes Margaret Nosek Tracey LeDoux Heather Taylor Lauren Diaz Susan Robinson-Whelen Eric Garshick Kendra Betz James Krause Yue Cao Chao Li Beverly Hon Steven Kirshblum Cria-May Khong Ben Dirlikov Kazuko Shem Susan Charlifue Shawn Song Stephen Burns

J Spinal Cord Med 2018 Sep;41(5):599-622

bw VA Puget Sound Health Care System , Seattle , Washington , USA.

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http://dx.doi.org/10.1080/10790268.2018.1498262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025696PMC
September 2018

Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex.

Nat Neurosci 2017 Nov 18;20(11):1549-1559. Epub 2017 Sep 18.

Department of Neurology and Experimental Neurology, Clinical and Experimental Spinal Cord Injury Research (Neuroparaplegiology), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1038/nn.4643DOI Listing
November 2017

Preclinical research: Meet patients to sharpen up research.

Nature 2017 Nov;551(7680):300

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http://dx.doi.org/10.1038/d41586-017-06024-2DOI Listing
November 2017

Preclinical research: Meet patients to sharpen up research.

Nature 2017 11;551(7680):300

Charité — University Medicine Berlin, Germany.

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http://dx.doi.org/10.1038/d41586-017-06024-2DOI Listing
November 2017

Stage 1 Registered Report: Effect of deficient phagocytosis on neuronal survival and neurological outcome after temporary middle cerebral artery occlusion (tMCAo).

F1000Res 2017 12;6:1827. Epub 2017 Oct 12.

Department of Experimental Neurology and Center for Stroke Research, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.12688/f1000research.12537.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664978PMC
October 2017

Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment.

Behav Brain Res 2017 03 11;321:201-208. Epub 2017 Jan 11.

Department of Experimental Neurology, Center for Stroke Research Berlin, Charité University Medicine Berlin, Germany; Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2016.12.041DOI Listing
March 2017

Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment.

Stroke 2017 02 9;48(2):468-475. Epub 2017 Jan 9.

From the Department of Experimental Neurology, Center for Stroke Research Berlin (CSB) (P.B.-S., M.F., M.F., S.M., M.Z., U.D., T.D.F.), Charité Core Facility 7T Experimental MRIs (P.B.-S., S.M.), Department of Neuropathology (J.L.R.), and German Centre for Neurodegenerative Diseases (DZNE), Berlin site (M.F., U.D.), Charité University Medicine Berlin, Germany; and School of Life Sciences (R.C.T., T.D.F.) and School of Mathematics (T.K., L.S.), University of Nottingham, United Kingdom.

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http://dx.doi.org/10.1161/STROKEAHA.116.014394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266417PMC
February 2017

Long-term functional outcome in patients with acquired infections after acute spinal cord injury.

Neurology 2017 Feb 27;88(9):892-900. Epub 2017 Jan 27.

From the Department of Neurology and Experimental Neurology, Clinical and Experimental Spinal Cord Injury Research (Neuroparaplegiology) (M.A.K., R.W., V.F., F.W.F., J.M.S.), and Center for Stroke Research Berlin (U.D.), Charité-Universitätsmedizin Berlin; Department of Clinical Epidemiology and Applied Biostatistics (P.M.), Eberhard Karls Universität Tübingen, Germany; National Spinal Cord Injury Statistical Center (Y.C., M.J.D.), Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham; Paraplegiology (Spinal Cord Injury Division), Department of Neurology (J.M.S.), and Departments of Neuroscience and Center for Brain and Spinal Cord Repair and Physical Medicine and Rehabilitation, The Neurological Institute (J.M.S.), The Ohio State University, Wexner Medical Center, Columbus.

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http://dx.doi.org/10.1212/WNL.0000000000003652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331871PMC
February 2017

A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine.

PLoS Biol 2016 Dec 1;14(12):e2000705. Epub 2016 Dec 1.

Department of Experimental Neurology and Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1371/journal.pbio.2000705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131907PMC
December 2016

Methylprednisolone blocks interleukin 1 beta induced calcitonin gene related peptide release in trigeminal ganglia cells.

J Headache Pain 2016 1;17:19. Epub 2016 Mar 1.

Department of Neurology and Experimental Neurology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

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http://dx.doi.org/10.1186/s10194-016-0609-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773314PMC
October 2016

The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke.

Neurotherapeutics 2016 10;13(4):762-774

Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1007/s13311-016-0475-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081128PMC
October 2016

Thomas Willis Lecture: Is Translational Stroke Research Broken, and if So, How Can We Fix It?

Authors:
Ulrich Dirnagl

Stroke 2016 Aug 28;47(8):2148-53. Epub 2016 Jun 28.

From the Department of Experimental Neurology, NeuroCure Clinical Research Center, Center for Stroke Research, Charité Universitätsmedizin Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE) and German Center for Cardiovascular Research (DZHK), Berlin Site, Berlin, Germany; and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1161/STROKEAHA.116.013244DOI Listing
August 2016

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation.

Lancet Neurol 2016 07 11;15(8):869-881. Epub 2016 May 11.

Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer, Barcelona, Spain; Department of Brain Ischemia and Neurodegeneration, Institut d'Investigacions Biomèdiques de Barcelona, Consejo Superior de Investigaciones Científicas, Barcelona, Spain.

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http://www.thelancet.com/pdfs/journals/laneur/PIIS1474-4422(
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http://dx.doi.org/10.1016/S1474-4422(16)00114-9DOI Listing
July 2016

SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol.

BMJ Open 2016 07 26;6(7):e010651. Epub 2016 Jul 26.

Department of Neurology and Experimental Neurology, Spinal Cord Injury Research, Charité-Universitätsmedizin Berlin, Berlin, Germany Treatment Centre for Spinal Cord Injury, Trauma Hospital Berlin, Berlin, Germany Department of Neurology, Spinal Cord Injury Division, The Ohio State University, Wexner Medical Center, Columbus, USA Department of Neuroscience and Center for Brain and Spinal Cord Repair, Department of Physical Medicine and Rehabilitation, The Neurological Institute, The Ohio State University, Wexner Medical Center, Columbus, USA.

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http://dx.doi.org/10.1136/bmjopen-2015-010651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964175PMC
July 2016

Gut microbiota impact on stroke outcome: Fad or fact?

J Cereb Blood Flow Metab 2016 05 4;36(5):891-8. Epub 2016 Mar 4.

Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany NeuroCure Clinical Research, Charité - Universitätsmedizin Berlin, Berlin, Germany Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany German Center for Neurodegeneration Research (DZNE), Berlin, Germany German Center for Cardiovascular Research (DZHK), Berlin, Germany

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http://dx.doi.org/10.1177/0271678X16636890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853845PMC
May 2016

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke.

Stroke 2016 05 7;47(5):1354-63. Epub 2016 Apr 7.

From the Department of Experimental Neurology (K.W., O.E., P.K., N.O., A.M., U.D.), NeuroCure Clinical Research (K.W., C.C., A.M., U.D.), Center for Stroke Research Berlin (K.W., O.E., P.K., A.M., U.D.), Department of Microbiology and Hygiene (M.M.H., A.F., S.B.), Institute for Medical Immunology (C.D., C.M.), and Department of Neurology (A.M., U.D.), Charité - Universitätsmedizin Berlin, Germany; Institute of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universität Berlin, Germany (O.K., A.D.G.); German Rheumatism Research Center (DRFZ), Berlin, Germany (C.C.); and German Center for Neurodegeneration Research (DZNE), partner site Berlin, Germany (U.D.).

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http://dx.doi.org/10.1161/STROKEAHA.115.011800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839545PMC
May 2016

Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis.

PLoS Biol 2016 05 31;14(5):e1002468. Epub 2016 May 31.

Department of Neurology and Experimental Neurology, Charité Campus Mitte, Clinical and Experimental Spinal Cord Injury Research Laboratory (Neuroparaplegiology), Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1371/journal.pbio.1002468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886956PMC
May 2016

Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level.

Brain 2016 Mar 10;139(Pt 3):692-707. Epub 2016 Jan 10.

1 Department of Neurology and Experimental Neurology, Spinal Cord Injury Research (Molecular Neuroparaplegiology), Charité - Universitätsmedizin Berlin, Germany 8 Department of Neurology, Spinal Cord Injury Division, The Neurological Institute, The Ohio State University, Wexner Medical Centre, Columbus, OH 43210, USA 9 Department of Neuroscience and Centre for Brain and Spinal Cord Repair, Department of Physical Medicine and Rehabilitation, The Neurological Institute, The Ohio State University, Wexner Medical Centre, Columbus, OH 43210, USA

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http://dx.doi.org/10.1093/brain/awv375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014125PMC
March 2016

A new home for the Journal of Cerebral Blood Flow and Metabolism.

J Cereb Blood Flow Metab 2016 Feb;36(2):277

Rigshospitalet, Glostrup, Denmark.

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http://dx.doi.org/10.1177/0271678X15621576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759684PMC
February 2016

A pocket guide to electronic laboratory notebooks in the academic life sciences.

F1000Res 2016 4;5. Epub 2016 Jan 4.

Department of Experimental Neurology and Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, 10117, Germany.

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http://dx.doi.org/10.12688/f1000research.7628.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722687PMC
February 2016

Infarct Volume Prediction by Early Magnetic Resonance Imaging in a Murine Stroke Model Depends on Ischemia Duration and Time of Imaging.

Stroke 2015 Nov 8;46(11):3249-59. Epub 2015 Oct 8.

From the Department of Experimental Neurology, Charité Universitätsmedizin, Berlin, Germany (C.L., M.F., D.J., S.M., U.D., G.R.); Center for Stroke Research Berlin, Berlin, Germany (C.L., D.J., S.M., U.D., G.R.); NeuroCure Cluster of Excellence, Berlin, Germany (C.L., U.D.); German Center for Neurodegenerative Diseases (DZNE) (M.F., U.D.) and German Center for Cardiovascular Diseases (DZHK) (U.D.), Berlin site, Charitéplatz, Berlin, Germany; and Department of Neurology, University of Lübeck, Lübeck, Germany (G.R.).

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http://dx.doi.org/10.1161/STROKEAHA.114.007832DOI Listing
November 2015

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.

Stroke 2015 Nov 8;46(11):3232-40. Epub 2015 Oct 8.

From the Department of Experimental Neurology (O.E., K.W., M.T., U.D., A.M.), Department of Neurology (U.D., A.M.), NeuroCure Clinical Research (U.D., A.M.), Institute for Medical Immunology (L.A., C.D., H.D.V., C.M.), BCRT Berlin Brandenburg Centre for Regenerative Medicine (L.A., H.D.V.), Department of Neuropsychiatry and Laboratory of Molecular Psychiatry (C.B., J.P.), and Center for Stroke Research Berlin (O.E., K.W., M.T., U.D., A.M.), Charité University Medicine Berlin, Berlin, Germany; German Center for Neurodegeneration Research (DZNE), partner site Berlin, Germany (J.P., U.D.); Department of Internal Medicine II, Justus-Liebig-University, Universities Giessen and Marburg Lung Center, Member of the German Center for Lung Research (DZL) (S.H.); and Max Delbrück Center for Molecular Medicine, Berlin, Germany (A.C.d.C.G.).

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http://dx.doi.org/10.1161/STROKEAHA.115.008989DOI Listing
November 2015

Robust research: Institutions must do their part for reproducibility.

Nature 2015 Sep;525(7567):25-7

Center for Stroke Research at the Universitätsmedizin Charité Berlin, Germany.

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http://dx.doi.org/10.1038/525025aDOI Listing
September 2015

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.

Sci Transl Med 2015 Aug;7(299):299ra121

Institute for Stroke and Dementia Research, Klinikum der Universität München, Feodor-Lynen-Straße 17, 81377 Munich, Germany. Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.

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http://dx.doi.org/10.1126/scitranslmed.aaa9853DOI Listing
August 2015

Histone acetylation and CREB binding protein are required for neuronal resistance against ischemic injury.

PLoS One 2014 18;9(4):e95465. Epub 2014 Apr 18.

Department of Experimental Neurology, Center for Stroke Research Berlin (CSB) and Klinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, Berlin, Germany; ExcellenceCluster NeuroCure, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095465PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991684PMC
May 2015

Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.

Circulation 2015 May 20;131(20):1772-82. Epub 2015 Mar 20.

From Center for Stroke Research Berlin (C.J.H., U.H., A.R., U.G., G.L-T., U.D., M.E., C.H.) and Department of Neurology (C.J.H., U.H., M.E., C.H.), Charité-Universitätsmedizin Berlin, Germany; Max-Delbrück Center for Molecular Medicine, Berlin, Germany (F.S., S.A.W., H.K.); Institute of Clinical Neurobiology, University Hospital, University of Würzburg, Germany (M.S.); Cluster of Excellence NeuroCure, Charité-Universitätsmedizin Berlin, Germany (H.K., U.D., M.E.); and German Center for Neurodegenerative Diseases (U.D., M.E.) and German Center for Cardiovascular Diseases (U.D., M.E.), Partner Site, Berlin, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.013003DOI Listing
May 2015

Neurovascular coupling during cortical spreading depolarization and -depression.

Stroke 2015 May 16;46(5):1392-401. Epub 2015 Apr 16.

From the Center of Functionally Integrative Neuroscience and MINDLab, Department of Clinical Medicine, Aarhus University, Denmark (L.Ø., S.N.J.); Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark (L.Ø.); Center for Stroke Research and Departments of Experimental Neurology and Neurology, Charité Universitätsmedizin, Berlin, Germany (J.P.D., U.D.); Pathophysiology and Cognition Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School (N.H.); Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark (S.N.J.); and Institute of Neurological Sciences and Psychiatry and Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey (T.D.).

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http://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.114.
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http://dx.doi.org/10.1161/STROKEAHA.114.008077DOI Listing
May 2015

Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.

J Neurosci 2015 May;35(20):7777-94

Center for Stroke Research, Department for Experimental Neurology, Department of Neurology, NeuroCure Clinical Research Center, Charité Universitätsmedizin Berlin, 10098 Berlin, Germany,

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http://dx.doi.org/10.1523/JNEUROSCI.1532-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795191PMC
May 2015

Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment.

Behav Brain Res 2015 Apr 2;283:215-26. Epub 2015 Feb 2.

Department of Experimental Neurology, Center for Stroke Research Berlin, Charité University Medicine, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany. Electronic address:

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April 2015

Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment.

J Cereb Blood Flow Metab 2015 Mar 10;35(3):476-84. Epub 2014 Dec 10.

Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1038/jcbfm.2014.221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348389PMC
March 2015

Catabolic signaling and muscle wasting after acute ischemic stroke in mice: indication for a stroke-specific sarcopenia.

Stroke 2014 Dec 28;45(12):3675-83. Epub 2014 Oct 28.

From the Department of Innovative Clinical Trials, University Medical Centre, Göttingen, Germany (J.S., S.v.H., S.D.A.); Centre for Stroke Research Berlin (S.S., K.P., A.R., N.S., U.D., W.D.), Applied Cachexia Research, Department of Cardiology, Virchow-Klinikum (A.T., S.v.H., S.D.A.), Departments of Neurology and Experimental Neurology (A.R., O.E., A.M., U.D.), NeuroCure Clinical Research Center (A.M.), and Experimental and Clinical Research Center (M.B.), Charité-Universitätsmedizin Berlin, Berlin, Germany; and German Center for Cardiovascular Diseases (DZHK), Partner Site, Berlin, Germany (U.D., W.D.).

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http://dx.doi.org/10.1161/STROKEAHA.114.006258DOI Listing
December 2014

A dual-labeled Annexin A5 is not suited for SPECT imaging of brain cell death in experimental murine stroke.

J Cereb Blood Flow Metab 2014 Sep 2;34(9). Epub 2014 Jul 2.

Center for Stroke Research Berlin (CSB) and Department of Experimental Neurology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.

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http://dx.doi.org/10.1038/jcbfm.2014.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158671PMC
September 2014

Modeling immunity and inflammation in stroke: can mice be trusted?

Authors:
Ulrich Dirnagl

Stroke 2014 Sep 24;45(9):e177-8. Epub 2014 Jul 24.

From the Departments of Neurology and Experimental Neurology Charité, Center for Stroke Research Berlin, Charité, ExcellenceCluster NeuroCure-Universitätsmedizin Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Partner Site, Berlin, Germany; and German Center for Cardiovascular Diseases (DZHK), Partner Site, Berlin, Germany.

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http://dx.doi.org/10.1161/STROKEAHA.114.005640DOI Listing
September 2014

Are we ready to translate T-cell transmigration in stroke?

Stroke 2014 Jun 17;45(6):1610-1. Epub 2014 Apr 17.

From the Department of Neurology, EvKB-Bethel, Bielefeld, Germany (W.-R.S.); and Center for Stroke Research, Charite Universitätsmedizin, Berlin, Germany (U.D.).

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June 2014

Found in translation: preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes.

Stroke 2014 May 20;45(5):1510-8. Epub 2014 Mar 20.

From the Departments of Neurology and Experimental Neurology, Center for Stroke Research Berlin, and Excellence Cluster NeuroCure, Charité-Universitätsmedizin Berlin, Berlin, Germany (U.D., M.E.); German Center for Neurodegeneration Research (DZNE), Partner Site, Berlin, Germany (U.D.); and German Center for Cardiovascular Diseases (DZHK), Partner Site, Berlin, Germany (U.D., M.E.).

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May 2014

Distinguishing between exploratory and confirmatory preclinical research will improve translation.

PLoS Biol 2014 May 20;12(5):e1001863. Epub 2014 May 20.

Departments of Neurology and Experimental Neurology, Center for Stroke Research Berlin, and Excellence Cluster NeuroCure Charité - Universitätsmedizin Berlin, Berlin, Germany; German Center for Neurodegeneration Research (DZNE), partner site Berlin, Germany; Center for Cardiovascular Diseases (DZHK), partner site Berlin, Germany.

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http://dx.doi.org/10.1371/journal.pbio.1001863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028181PMC
May 2014

Single-cell resolution mapping of neuronal damage in acute focal cerebral ischemia using thallium autometallography.

J Cereb Blood Flow Metab 2014 Jan 16;34(1):144-52. Epub 2013 Oct 16.

1] Department of Auditory Learning and Speech, Leibniz Institute for Neurobiology, Magdeburg, Germany [2] Clinic for Neurology, Otto-von-Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1038/jcbfm.2013.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887354PMC
January 2014

Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis.

JAMA Neurol 2014 Jan;71(1):91-9

Department of Neurology and Experimental Neurology, Charité Campus Mitte, Clinical and Experimental Spinal Cord Injury Research Laboratory (Neuroparaplegiology), Charité-Universitätsmedizin, Berlin, Germany7Spinal Cord Injury Center, Trauma Hospital Berli.

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http://dx.doi.org/10.1001/jamaneurol.2013.4684DOI Listing
January 2014

Biomedical research: increasing value, reducing waste.

Lancet 2014 Jan 8;383(9912):101-4. Epub 2014 Jan 8.

Centre for Research in Evidence-Based Practice, Bond University, Robina, Gold Coast, QLD, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736136232
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http://dx.doi.org/10.1016/S0140-6736(13)62329-6DOI Listing
January 2014

Stroke induced Sarcopenia: muscle wasting and disability after stroke.

Int J Cardiol 2013 Dec 14;170(2):89-94. Epub 2013 Oct 14.

Centre for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2013.10.031DOI Listing
December 2013

A concerted appeal for international cooperation in preclinical stroke research.

Stroke 2013 Jun 18;44(6):1754-60. Epub 2013 Apr 18.

Department of Neurology and Experimental Neurology, Center for Stroke Research Berlin, Charité University Medicine, Campus Mitte, D-10098 Berlin, Germany.

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http://dx.doi.org/10.1161/STROKEAHA.113.000734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933930PMC
June 2013

The microcircualtion--fantastic voyage: introduction.

Stroke 2013 Jun;44(6 Suppl 1):S83

Brain and Mind Research Institute, Weill Cornell Medical College, 407 E. 61st Street, New York, NY, USA.

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http://dx.doi.org/10.1161/STROKEAHA.112.680215DOI Listing
June 2013

Electrochemical failure of the brain cortex is more deleterious when it is accompanied by low perfusion.

Stroke 2013 Feb 3;44(2):490-6. Epub 2013 Jan 3.

Center for Stroke Research Berlin, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.

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http://dx.doi.org/10.1161/STROKEAHA.112.660589DOI Listing
February 2013

The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons.

Neurotoxicology 2013 Jan 13;34:254-63. Epub 2012 Sep 13.

REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.1016/j.neuro.2012.09.005DOI Listing
January 2013

Brain perfusion SPECT in the mouse: normal pattern according to gender and age.

Neuroimage 2012 Dec 23;63(4):1807-17. Epub 2012 Aug 23.

Department of Nuclear Medicine, Charité-Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2012.08.038DOI Listing
December 2012

Functional neurological recovery after spinal cord injury is impaired in patients with infections.

Brain 2012 Nov 25;135(Pt 11):3238-50. Epub 2012 Oct 25.

Department of Neurology and Experimental Neurology, Clinical and Experimental Spinal Cord Injury Research, Neuroparaplegiology, Charité—Universitätsmedizin Berlin, D-10117 Berlin, Germany.

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http://dx.doi.org/10.1093/brain/aws267DOI Listing
November 2012

Pathobiology of injury after stroke: the neurovascular unit and beyond.

Authors:
Ulrich Dirnagl

Ann N Y Acad Sci 2012 Sep;1268:21-5

Department of Neurology, Charité Universitäts Medizin, Berlin, Germany.

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http://dx.doi.org/10.1111/j.1749-6632.2012.06691.xDOI Listing
September 2012

Celebrating the 30th anniversary of our journal.

J Cereb Blood Flow Metab 2012 Jul 9;32(7):1097. Epub 2012 May 9.

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http://dx.doi.org/10.1038/jcbfm.2012.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390815PMC
July 2012

Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF.

Cephalalgia 2012 Jul 30;32(9):659-67. Epub 2012 May 30.

Department of Neurology, Charité - Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1177/0333102412447701DOI Listing
July 2012

Evidence of intrathecal immunoglobulin synthesis in stroke: a cohort study.

Arch Neurol 2012 Jun;69(6):714-7

Department of Neurology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

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http://dx.doi.org/10.1001/archneurol.2011.3252DOI Listing
June 2012

Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives.

J Cereb Blood Flow Metab 2012 Feb 16;32(2):213-31. Epub 2011 Nov 16.

Department of Experimental Neurology, Center for Stroke Research Berlin, Charité-University Medicine Berlin, Berlin, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272608PMC
February 2012

Body weight after stroke: lessons from the obesity paradox.

Stroke 2011 Dec 29;42(12):3646-50. Epub 2011 Sep 29.

Center for Stroke Research Berlin, Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1161/STROKEAHA.111.619163DOI Listing
December 2011

SUMO2/3 conjugation is an endogenous neuroprotective mechanism.

J Cereb Blood Flow Metab 2011 Nov 24;31(11):2152-9. Epub 2011 Aug 24.

Center for Stroke Research Berlin, Department of Experimental Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1038/jcbfm.2011.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210338PMC
November 2011

Protective conditioning of the brain: expressway or roadblock?

J Physiol 2011 Sep 27;589(17):4147-55. Epub 2011 Jun 27.

Center for Stroke Research Berlin (CSB), Department of Neurology and Experimental Neurology, Charité - University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.

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http://dx.doi.org/10.1113/jphysiol.2011.209718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180575PMC
September 2011

Acute pathophysiological processes after ischaemic and traumatic brain injury.

Best Pract Res Clin Anaesthesiol 2010 Dec 29;24(4):495-509. Epub 2010 Nov 29.

Department of Neurology, Center for Stroke Research Berlin, Charité - University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany.

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http://dx.doi.org/10.1016/j.bpa.2010.10.001DOI Listing
December 2010