Ulrich Brandt

Ulrich Brandt

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Ulrich Brandt

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COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome.

Bioinformatics 2019 Sep;35(17):3083-3091

CMBI, Radboud Centre for Mitochondrial Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btz025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735710PMC
September 2019

Complexome analysis of the nitrite-dependent methanotroph Methylomirabilis lanthanidiphila.

Biochim Biophys Acta Bioenerg 2019 09 31;1860(9):734-744. Epub 2019 Jul 31.

Microbial Physiology Group, Max Planck Institute for Marine Microbiology, Bremen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2019.07.011DOI Listing
September 2019

Adaptations of an ancient modular machine.

Authors:
Ulrich Brandt

Science 2019 01;363(6424):230-231

Radboud Institute for Molecular Life Sciences, Department of Pediatrics, Radboud University Medical Center, Geert Grooteplein-Zuid 10, Route 772, 6525 GA Nijmegen, Netherlands.

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http://dx.doi.org/10.1126/science.aaw0493DOI Listing
January 2019

Barth syndrome cells display widespread remodeling of mitochondrial complexes without affecting metabolic flux distribution.

Biochim Biophys Acta Mol Basis Dis 2018 11 1;1864(11):3650-3658. Epub 2018 Sep 1.

Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology & Metabolism, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.08.041DOI Listing
November 2018

Cryo-EM structure of respiratory complex I at work.

Elife 2018 10 2;7. Epub 2018 Oct 2.

Cluster of Excellence Macromolecular Complexes, Goethe University Frankfurt, Frankfurt, Germany.

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https://elifesciences.org/articles/39213
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http://dx.doi.org/10.7554/eLife.39213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168287PMC
October 2018

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps.

Nat Commun 2018 10 29;9(1):4500. Epub 2018 Oct 29.

Radboud Institute for Molecular Life Sciences, Department of Pediatrics, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6525, GA, Nijmegen, The Netherlands.

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http://www.nature.com/articles/s41467-018-06955-y
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http://dx.doi.org/10.1038/s41467-018-06955-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206036PMC
October 2018

Compound heterozygosity for severe and hypomorphic mutations cause non-syndromic LHON-like optic neuropathy.

J Med Genet 2017 05 28;54(5):346-356. Epub 2016 Dec 28.

Laboratory of Genetics in Ophthalmology (LGO), INSERM UMR1163, Institute of Genetic Diseases, Imagine, Paris Descartes University, Paris, France.

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http://dx.doi.org/10.1136/jmedgenet-2016-104212DOI Listing
May 2017

The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.

Cell Metab 2017 01 6;25(1):128-139. Epub 2016 Oct 6.

OXPHOS Biogenesis Group, Radboud Center for Mitochondrial Medicine, Department of Pediatrics, Radboud University Medical Center, Geert-Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.002DOI Listing
January 2017

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.

EMBO Rep 2016 12 13;17(12):1844-1856. Epub 2016 Oct 13.

Institute for Genetics Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), and University of Cologne, Cologne, Germany

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http://embor.embopress.org/lookup/doi/10.15252/embr.20164269
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http://dx.doi.org/10.15252/embr.201642698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283581PMC
December 2016

Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism.

Biochim Biophys Acta 2016 12 30;1857(12):1935-1942. Epub 2016 Sep 30.

Max Planck Institute of Biophysics, Department of Structural Biology, Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2016.09.014DOI Listing
December 2016

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.

Mol Cell 2016 10 15;64(1):148-162. Epub 2016 Sep 15.

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine (CMMC), University of Cologne, 50931 Cologne, Germany; Max Planck Institute for Biology of Aging, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.08.020DOI Listing
October 2016

Structure and function of mitochondrial complex I.

Biochim Biophys Acta 2016 Jul 24;1857(7):902-14. Epub 2016 Feb 24.

Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe-University, Frankfurt am Main, Germany; Cluster of Excellence Frankfurt "Macromolecular Complexes, Goethe-University, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2016.02.013DOI Listing
July 2016

Preface to complex I special issue.

Biochim Biophys Acta 2016 Jul 21;1857(7):861-2. Epub 2016 Apr 21.

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http://dx.doi.org/10.1016/j.bbabio.2016.04.006DOI Listing
July 2016

Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation.

Int J Cancer 2016 May 18;138(9):2231-46. Epub 2016 Jan 18.

Dr. Senckenberg Institute of Pathology, Goethe-University Hospital, Theodor-Stern-Kai 7, Frankfurt Am Main, 60596, Germany.

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http://dx.doi.org/10.1002/ijc.29934DOI Listing
May 2016

Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex.

Biochim Biophys Acta 2016 Jan 23;1863(1):91-101. Epub 2015 Oct 23.

Nijmegen Centre for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen, The Netherlands; Cluster of Excellence Frankfurt "Macromolecular Complexes", Goethe-University, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2015.10.009DOI Listing
January 2016

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

Cell Metab 2015 Sep;22(3):399-407

Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.08.002DOI Listing
September 2015

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.

Proc Natl Acad Sci U S A 2015 May 20;112(18):5685-90. Epub 2015 Apr 20.

Structural Bioenergetics Group, Institute of Biochemistry II, Medical School, Goethe University, 60438 Frankfurt am Main, Germany; Cluster of Excellence Frankfurt "Macromolecular Complexes", Goethe University, 60438 Frankfurt am Main, Germany;

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http://dx.doi.org/10.1073/pnas.1424353112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426432PMC
May 2015

NOVA: a software to analyze complexome profiling data.

Bioinformatics 2015 Feb 9;31(3):440-1. Epub 2014 Oct 9.

Molecular Bioinformatics Group, Institute of Computer Science, Faculty of Computer Science and Mathematics, Cluster of Excellence Frankfurt "Macromolecular Complexes", Goethe-University, Robert-Mayer-Str. 11-15, 60325 Frankfurt am Main, Germany, Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt "Macromolecular Complexes", Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany, Functional Proteomics, SFB815 core unit, Medical School, Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany and Nijmegen Centre for Mitochondrial Disorders, Radboud University Medical Centre, 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btu623DOI Listing
February 2015

Generator-specific targets of mitochondrial reactive oxygen species.

Free Radic Biol Med 2015 Jan 29;78:1-10. Epub 2014 Oct 29.

Molecular Bioenergetics Group, Goethe-University, D-60590 Frankfurt am Main, Germany; Clinic of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.511DOI Listing
January 2015

Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I.

Science 2015 Jan;347(6217):44-9

Cluster of Excellence Frankfurt "Macromolecular Complexes," Goethe-University, 60438 Frankfurt am Main, Germany. Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

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http://dx.doi.org/10.1126/science.1259859DOI Listing
January 2015

Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation.

Biochim Biophys Acta 2014 Aug 19;1844(8):1344-54. Epub 2014 Feb 19.

Functional Proteomics, SFB 815 Core Unit, Faculty of Medicine, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany; Cluster of Excellence "Macromolecular Complexes", Goethe-University, Frankfurt am Main, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S15709639140002
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http://dx.doi.org/10.1016/j.bbapap.2014.02.006DOI Listing
August 2014

The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity.

Proc Natl Acad Sci U S A 2014 Apr 24;111(14):5207-12. Epub 2014 Mar 24.

Institute of Biochemistry II, Structural Bioenergetics Group, Medical School, Goethe University Frankfurt, 60438 Frankfurt, Germany.

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http://dx.doi.org/10.1073/pnas.1322438111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986132PMC
April 2014

Age-related changes in the mitochondrial proteome of the fungus Podospora anserina analyzed by 2D-DIGE and LC-MS/MS.

J Proteomics 2013 Oct 19;91:358-74. Epub 2013 Jul 19.

Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt Macromolecular Complexes, Centre for Membrane Proteomics, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.jprot.2013.07.008DOI Listing
October 2013

Inside view of a giant proton pump.

Authors:
Ulrich Brandt

Angew Chem Int Ed Engl 2013 Jul 23;52(29):7358-60. Epub 2013 May 23.

Exzellenzcluster Macromolecular Complexes, Goethe-Universität, Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1002/anie.201303403
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http://dx.doi.org/10.1002/anie.201303403DOI Listing
July 2013

Tracing the tail of ubiquinone in mitochondrial complex I.

Biochim Biophys Acta 2012 Oct 29;1817(10):1776-84. Epub 2012 Mar 29.

Goethe-University, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2012.03.021DOI Listing
October 2012

Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex.

Cell Metab 2012 Oct 13;16(4):538-49. Epub 2012 Sep 13.

Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt Macromolecular Complexes, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.cmet.2012.08.009DOI Listing
October 2012

Xentrivalpeptides A-Q: depsipeptide diversification in Xenorhabdus.

J Nat Prod 2012 Oct 1;75(10):1717-22. Epub 2012 Oct 1.

Institut für Molekulare Biowissenschaften, Goethe Universität Frankfurt, 60438 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1021/np300279gDOI Listing
October 2012

Molecular mechanisms of superoxide production by the mitochondrial respiratory chain.

Adv Exp Med Biol 2012 ;748:145-69

Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/978-1-4614-3573-0_6DOI Listing
September 2012

Primary skin fibroblasts as a model of Parkinson's disease.

Mol Neurobiol 2012 Aug 19;46(1):20-7. Epub 2012 Feb 19.

Experimental Neurology, Department of Neurology, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s12035-012-8245-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443476PMC
August 2012

Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve.

J Proteomics 2012 Jul 14;75(13):3987-4004. Epub 2012 May 14.

Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, 60590 Frankfurt am Main, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S18743919120029
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http://dx.doi.org/10.1016/j.jprot.2012.05.006DOI Listing
July 2012

Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development.

Cell Cycle 2011 Dec 15;10(24):4280-90. Epub 2011 Dec 15.

Goethe University, Faculty for Biosciences & Cluster of Excellence Macromolecular Complexes Frankfurt, Institute of Molecular Biosciences, Frankfurt, Germany.

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http://dx.doi.org/10.4161/cc.10.24.18560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272260PMC
December 2011

A two-state stabilization-change mechanism for proton-pumping complex I.

Authors:
Ulrich Brandt

Biochim Biophys Acta 2011 Oct 2;1807(10):1364-9. Epub 2011 May 2.

Center for Membrane Proteomics, Goethe-University, Frankfurt am Main, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00052728110009
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http://dx.doi.org/10.1016/j.bbabio.2011.04.006DOI Listing
October 2011

Functional dissection of the proton pumping modules of mitochondrial complex I.

PLoS Biol 2011 Aug 23;9(8):e1001128. Epub 2011 Aug 23.

Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt Macromolecular Complexes, Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany.

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http://dx.doi.org/10.1371/journal.pbio.1001128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160329PMC
August 2011

A high-definition native polyacrylamide gel electrophoresis system for the analysis of membrane complexes.

Plant J 2011 Jul 28;67(1):181-94. Epub 2011 Apr 28.

Institute of Biology - Plant Physiology, Martin Luther University Halle-Wittenberg, Weinbergweg 10, D-06120 Halle/Saale, Germany.

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http://dx.doi.org/10.1111/j.1365-313X.2011.04577.xDOI Listing
July 2011

A common mechanism links differently acting complex II inhibitors to cardioprotection: modulation of mitochondrial reactive oxygen species production.

Mol Pharmacol 2011 May 28;79(5):814-22. Epub 2011 Jan 28.

Molecular Bioenergetics Group, Cluster of Excellence Frankfurt "Macromolecular Complexes," Medical School, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1124/mol.110.070342DOI Listing
May 2011

The role of a conserved tyrosine in the 49-kDa subunit of complex I for ubiquinone binding and reduction.

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):625-32. Epub 2010 Feb 1.

Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt Macromolecular Complexes, Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2010.01.029DOI Listing
January 2011

Quinone binding and reduction by respiratory complex I.

Biochim Biophys Acta 2010 Dec 20;1797(12):1883-90. Epub 2010 May 20.

Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt "Macromolecular Complexes," Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2010.05.009DOI Listing
December 2010

Functional modules and structural basis of conformational coupling in mitochondrial complex I.

Science 2010 Jul 1;329(5990):448-51. Epub 2010 Jul 1.

Institute for Biochemistry and Molecular Biology, Centre for Biological Signalling Studies (BIOSS), University of Freiburg, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1126/science.1191046DOI Listing
July 2010

Small single transmembrane domain (STMD) proteins organize the hydrophobic subunits of large membrane protein complexes.

FEBS Lett 2010 Jun 14;584(12):2516-25. Epub 2010 Apr 14.

Goethe-Universität, Fachbereich Medizin, Molekulare Bioenergetik, Cluster of Excellence Frankfurt "Macromolecular Complexes", Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1016/j.febslet.2010.04.021
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http://dx.doi.org/10.1016/j.febslet.2010.04.021DOI Listing
June 2010

Laser-induced liquid bead ion desorption-MS of protein complexes from blue-native gels, a sensitive top-down proteomic approach.

Proteomics 2010 Apr;10(7):1401-7

Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt Macromolecular Complexes, Centre for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1002/pmic.200900756
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http://dx.doi.org/10.1002/pmic.200900756DOI Listing
April 2010

Characterization of two different acyl carrier proteins in complex I from Yarrowia lipolytica.

Biochim Biophys Acta 2010 Feb 17;1797(2):152-9. Epub 2009 Sep 17.

Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt Macromolecular Complexes, Centre for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2009.09.007DOI Listing
February 2010

Multifrequency pulsed electron paramagnetic resonance on metalloproteins.

Acc Chem Res 2010 Feb;43(2):181-9

Cluster of Excellence Macromolecular Complexes, Goethe-University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1021/ar900050dDOI Listing
February 2010

Phospholipase A2-modified low density lipoprotein induces mitochondrial uncoupling and lowers reactive oxygen species in phagocytes.

Atherosclerosis 2010 Jan 15;208(1):142-7. Epub 2009 Jul 15.

Goethe-University, Faculty of Medicine, Institute of Biochemistry I/ZAFES, Theodor-Stern-Kai 7, Frankfurt, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S002191500900548
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http://dx.doi.org/10.1016/j.atherosclerosis.2009.07.020DOI Listing
January 2010

Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I.

Mol Cell Biol 2009 Nov 14;29(22):6059-73. Epub 2009 Sep 14.

Institut für Zytobiologie, Philipps-Universität Marburg, Robert-Koch-Strasse 6, 35033 Marburg, Germany.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00817-09
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http://dx.doi.org/10.1128/MCB.00817-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772561PMC
November 2009

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice.

Proc Natl Acad Sci U S A 2009 Nov 6;106(47):20057-62. Epub 2009 Nov 6.

Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland.

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http://dx.doi.org/10.1073/pnas.0905529106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774257PMC
November 2009

Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage.

Arterioscler Thromb Vasc Biol 2009 Jun 5;29(6):929-35. Epub 2009 Mar 5.

Molecular Cardiology, Department of Internal Medicine III, Centre of Biological Chemistry, University of Frankfurt, Germany.

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http://dx.doi.org/10.1161/ATVBAHA.109.185546DOI Listing
June 2009

Chapter 26 Measurement of superoxide formation by mitochondrial complex I of Yarrowia lipolytica.

Methods Enzymol 2009 ;456:475-90

Molecular Bioenergetics Group, Cluster of Excellence Frankfurt Macromolecular Complexes, Medical School, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S007668790804426
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http://dx.doi.org/10.1016/S0076-6879(08)04426-1DOI Listing
June 2009

Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III.

Biochim Biophys Acta 2009 Jun 6;1790(6):558-65. Epub 2009 Feb 6.

Molecular Bioenergetics Group, Cluster of Excellence Frankfurt Macromolecular Complexes, Medical School, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S030441650900017
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http://dx.doi.org/10.1016/j.bbagen.2009.01.011DOI Listing
June 2009

New pulsed EPR methods and their application to characterize mitochondrial complex I.

Biochim Biophys Acta 2009 Jun 12;1787(6):584-92. Epub 2009 Feb 12.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.bbabio.2009.02.003DOI Listing
June 2009

Architecture of complex I and its implications for electron transfer and proton pumping.

Biochim Biophys Acta 2009 Jun 7;1787(6):574-83. Epub 2009 Feb 7.

Goethe-Universität, Fachbereich Medizin, Molekulare Bioenergetik, ZBC, Theodor-Stern-Kai 7, Haus 26, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2009.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699368PMC
June 2009

Two-dimensional native electrophoretic analysis of respiratory supercomplexes from Yarrowia lipolytica.

Proteomics 2009 May;9(9):2408-18

Cluster of Excellence Macromolecular Complexes, Molekulare Bioenergetik, Zentrum der Biologischen Chemie, Goethe-Universität Frankfurt, Frankfurt, Germany.

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http://doi.wiley.com/10.1002/pmic.200800632
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http://dx.doi.org/10.1002/pmic.200800632DOI Listing
May 2009

Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice.

J Mol Med (Berl) 2008 Nov 16;86(11):1255-67. Epub 2008 Aug 16.

Neurobiology Laboratory, Psychiatric University Clinic Basel, Wilhelm Klein-Strasse 27, 4025, Basel, Switzerland.

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http://link.springer.com/10.1007/s00109-008-0391-6
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http://dx.doi.org/10.1007/s00109-008-0391-6DOI Listing
November 2008

The Toxoplasma gondii type-II NADH dehydrogenase TgNDH2-I is inhibited by 1-hydroxy-2-alkyl-4(1H)quinolones.

Biochim Biophys Acta 2008 Nov 22;1777(11):1455-62. Epub 2008 Aug 22.

Institute of Medical Microbiology, University of Göttingen, Kreuzbergring 57, Göttingen D-37075, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S000527280800658
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http://dx.doi.org/10.1016/j.bbabio.2008.08.006DOI Listing
November 2008

Subunit mass fingerprinting of mitochondrial complex I.

Biochim Biophys Acta 2008 Oct 15;1777(10):1384-91. Epub 2008 Aug 15.

Institute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2008.08.001DOI Listing
October 2008

Challenges in elucidating structure and mechanism of proton pumping NADH:ubiquinone oxidoreductase (complex I).

J Bioenerg Biomembr 2008 Oct 4;40(5):475-83. Epub 2008 Nov 4.

Fachbereich Medizin, Molekulare Bioenergetik, Cluster of Excellence Frankfurt, Macromolecular Complexes, ZBC, Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s10863-008-9171-9DOI Listing
October 2008

The three families of respiratory NADH dehydrogenases.

Results Probl Cell Differ 2008 ;45:185-222

Molecular Bioenergetics Group, Centre of Excellence Macromolecular Complexes, Johann Wolfgang Goethe-Universität, 60590, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/400_2007_028DOI Listing
August 2008

Exploring the inhibitor binding pocket of respiratory complex I.

Biochim Biophys Acta 2008 Jul-Aug;1777(7-8):660-5. Epub 2008 Apr 30.

Johann Wolfgang Goethe-Universität, Fachbereich Medizin, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Cluster of Excellence Frankfurt Macromolecular Complexes, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2008.04.033DOI Listing
August 2008

The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex.

J Biol Chem 2008 Aug 3;283(31):21649-54. Epub 2008 Jun 3.

Molecular Bioenergetics Group, Cluster of Excellence Frankfurt-Macromolecular Complexes, Medical School, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1074/jbc.M803236200DOI Listing
August 2008

Identification of the mitochondrial ND3 subunit as a structural component involved in the active/deactive enzyme transition of respiratory complex I.

J Biol Chem 2008 Jul 23;283(30):20907-13. Epub 2008 May 23.

Molecular Bioenergetics Group, Cluster of Excellence Frankfurt Macromolecular complexes, Medical School, Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1074/jbc.M803190200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475694PMC
July 2008

Exploring the ubiquinone binding cavity of respiratory complex I.

J Biol Chem 2007 Oct 6;282(40):29514-20. Epub 2007 Aug 6.

Johann Wolfgang Goethe-Universität, Fachbereich Medizin, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Centre of Excellence Frankfurt Macromolecular Complexes, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1074/jbc.M704519200DOI Listing
October 2007

Direct localization of the 51 and 24 kDa subunits of mitochondrial complex I by three-dimensional difference imaging.

J Struct Biol 2007 Sep 17;159(3):433-42. Epub 2007 May 17.

University of Vermont, College of Medicine, Department Molecular Physiology and Biophysics, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1016/j.jsb.2007.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700006PMC
September 2007

Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells.

Mol Pharmacol 2007 Jun 26;71(6):1535-44. Epub 2007 Feb 26.

Department of Biochemistry I-Pathobiochemistry, Johann Wolfgang Goethe University, Faculty of Medicine, Frankfurt, Main, Germany.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.107.03
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http://dx.doi.org/10.1124/mol.107.034371DOI Listing
June 2007

Characterization of a subcomplex of mitochondrial NADH:ubiquinone oxidoreductase (complex I) lacking the flavoprotein part of the N-module.

Biochim Biophys Acta 2007 May 15;1767(5):393-400. Epub 2007 Mar 15.

Johann Wolfgang Goethe-Universität, Fachbereich Medizin, Molekulare Bioenergetik, Centre of Excellence Frankfurt Macromolecular Complexes, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2007.03.005DOI Listing
May 2007

Energy converting NADH:quinone oxidoreductase (complex I).

Authors:
Ulrich Brandt

Annu Rev Biochem 2006 ;75:69-92

Universität Frankfurt, Fachbereich Medizin, Zentrum der Biologischen Chemie, D-60590 Frankfurt am Main, Germany.

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http://www.annualreviews.org/doi/10.1146/annurev.biochem.75.
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http://dx.doi.org/10.1146/annurev.biochem.75.103004.142539DOI Listing
February 2007

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

Neurobiol Dis 2007 Feb 30;25(2):401-11. Epub 2006 Nov 30.

Section for Molecular Neurogenetics, Clinic for Neurology, University Hospital, Theodor Stern Kai 7, 60590 Frankfurt/M., Germany.

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http://dx.doi.org/10.1016/j.nbd.2006.10.007DOI Listing
February 2007

Tight binding of NADPH to the 39-kDa subunit of complex I is not required for catalytic activity but stabilizes the multiprotein complex.

Biochim Biophys Acta 2006 Dec 19;1757(12):1676-82. Epub 2006 Sep 19.

Universität Frankfurt, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Theodor-Stern-Kai 7, Haus 26, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2006.09.003DOI Listing
December 2006

The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes.

Biochim Biophys Acta 2006 Dec 7;1757(12):1575-81. Epub 2006 Oct 7.

Universität Frankfurt, Fachbereich Medizin, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Theodor-Stern-Kai 7, Haus 26, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2006.10.001DOI Listing
December 2006

Substrate-inducible versions of internal alternative NADH: ubiquinone oxidoreductase from Yarrowia lipolytica.

Yeast 2006 Dec;23(16):1129-36

Universität Frankfurt, Fachbereich Medizin, Zentrum der Biologischen Chemie, Theodor-Stern-Kai 7, Haus 26, 60590 Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1002/yea.1426
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December 2006

Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins.

Biochem J 2006 Aug;398(1):107-12

Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital Heidelberg, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1042/BJ20060221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525008PMC
August 2006

K+-independent actions of diazoxide question the role of inner membrane KATP channels in mitochondrial cytoprotective signaling.

J Biol Chem 2006 Aug 18;281(33):23733-9. Epub 2006 May 18.

Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Universitätsklinikum Frankfurt, Haus 26, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M602570200
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August 2006

The Redox-Bohr group associated with iron-sulfur cluster N2 of complex I.

J Biol Chem 2006 Aug 7;281(32):23013-7. Epub 2006 Jun 7.

Universität Frankfurt, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1074/jbc.M603442200DOI Listing
August 2006

ATR-FTIR redox difference spectroscopy of Yarrowia lipolytica and bovine complex I.

Biochemistry 2006 May;45(17):5458-67

Glynn Laboratory of Bioenergetics, Department of Biology, University College London, UK.

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http://dx.doi.org/10.1021/bi052561eDOI Listing
May 2006

Subcomplexes of human ATP synthase mark mitochondrial biosynthesis disorders.

Ann Neurol 2006 Feb;59(2):265-75

Unit of Molecular Medicine, Bambino Gesù Hospital and Research Institute, Rome, Italy.

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http://dx.doi.org/10.1002/ana.20729DOI Listing
February 2006

Heterocyclic analogues of squamocin as inhibitors of mitochondrial complex I. On the role of the terminal lactone of annonaceous acetogenins.

Biochemistry 2006 Feb;45(8):2721-8

Laboratoire de Pharmacognosie (BioCIS, UMR 8076 CNRS), Faculté de Pharmacie, University Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1021/bi051261uDOI Listing
February 2006

Semisynthesis and screening of a small library of pro-apoptotic squamocin analogues: selection and study of a benzoquinone hybrid with an improved biological profile.

ChemMedChem 2006 Jan;1(1):118-29

Laboratoire de Pharmacognosie associé au CNRS (BioCIS, UMR 8076), Université Paris-Sud 11, Centre d'Etudes Pharmaceutiques, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry CEDEX, France.

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http://dx.doi.org/10.1002/cmdc.200500011DOI Listing
January 2006

Proton pumping by complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica reconstituted into proteoliposomes.

Biochim Biophys Acta 2005 Dec 26;1710(2-3):87-95. Epub 2005 Oct 26.

Universität Frankfurt, Fachbereich Medizin, Molekulare Bioenergetik, Theodor-Stern-Kai 7, Haus 26, D-60590 Frankfurt am Main, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S000527280500232
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http://dx.doi.org/10.1016/j.bbabio.2005.10.001DOI Listing
December 2005

Functional sulfurtransferase is associated with mitochondrial complex I from Yarrowia lipolytica, but is not required for assembly of its iron-sulfur clusters.

FEBS Lett 2005 Dec 21;579(30):6781-5. Epub 2005 Nov 21.

Ulrich Brandt, Universität Frankfurt, Fachbereich Medizin, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Theodor-Stern-Kai 7, Haus 26, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.febslet.2005.11.008DOI Listing
December 2005

Remarkable substituent effect: beta-aminosquamocin, a potent dual inhibitor of mitochondrial complexes I and III.

Biochim Biophys Acta 2005 Sep;1709(3):191-4

Laboratoire de Pharmacognosie associé au CNRS (UMR 8076, BioCIS), Centre d'Etudes Pharmaceutiques, Université Paris-Sud 11, 92296 Châtenay-Malabry CEDEX, France.

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http://dx.doi.org/10.1016/j.bbabio.2005.07.011DOI Listing
September 2005

Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica.

J Biol Chem 2005 Aug 28;280(34):30129-35. Epub 2005 Jun 28.

Universität Frankfurt, Fachbereich Medizin, Zentrum der Biologischen Chemie, D-60590 Frankfurt am Main, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M504709200
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August 2005

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.

J Biol Chem 2005 Jun 14;280(25):23802-14. Epub 2005 Apr 14.

Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland.

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http://dx.doi.org/10.1074/jbc.M500356200DOI Listing
June 2005

HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism.

J Biol Chem 2005 Feb 8;280(5):3138-42. Epub 2004 Nov 8.

Universität Frankfurt, Fachbereich Medizin, Institut für Biochemie I, Frankfurt am Main D-60490, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M411217200
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February 2005

Histidine 129 in the 75-kDa subunit of mitochondrial complex I from Yarrowia lipolytica is not a ligand for [Fe4S4] cluster N5 but is required for catalytic activity.

J Biol Chem 2005 Feb 30;280(7):5622-5. Epub 2004 Nov 30.

Universität Frankfurt, Fachbereich Medizin, Institut für Biochemie I, F-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1074/jbc.M411488200DOI Listing
February 2005

5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids.

J Physiol 2005 Jan 28;562(Pt 2):307-18. Epub 2004 Oct 28.

Institut für Normale und Pathologische Physiologie, Universität Marburg, Deutschhausstrasse 2, 35037 Marburg, Germany.

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http://dx.doi.org/10.1113/jphysiol.2004.073932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665522PMC
January 2005

Application of the yeast Yarrowia lipolytica as a model to analyse human pathogenic mutations in mitochondrial complex I (NADH:ubiquinone oxidoreductase).

Biochim Biophys Acta 2004 Dec;1659(2-3):197-205

Johann Wolfgang Goethe, Universität Frankfurt, Fachbereich Medizin, Institut für Biochemie I, ZBC, Molekulaire Bioenergetik, Theodor-Stern-Kai 7, Haus 25B, Frankfurt am Main, D-60590, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S000527280400230
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http://dx.doi.org/10.1016/j.bbabio.2004.07.006DOI Listing
December 2004

Analysis of dichlorodihydrofluorescein and dihydrocalcein as probes for the detection of intracellular reactive oxygen species.

Free Radic Res 2004 Dec;38(12):1257-67

Institut für Kardiovaskuläre Physiologie, Klinikum der JW Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1080/10715760400022145DOI Listing
December 2004

Processing of the 24 kDa subunit mitochondrial import signal is not required for assembly of functional complex I in Yarrowia lipolytica.

Eur J Biochem 2004 Sep;271(17):3588-95

Universität Frankfurt, Fachbereich Medizin, Institut für Biochemie I, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/j.0014-2956.2004.04296.xDOI Listing
September 2004

Significance of respirasomes for the assembly/stability of human respiratory chain complex I.

J Biol Chem 2004 Aug 18;279(35):36349-53. Epub 2004 Jun 18.

Institut für Biochemie I, Zentrum der Biologischen Chemie, Fachbereich Medizin, Universität Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1074/jbc.M404033200DOI Listing
August 2004

Subunit composition of mitochondrial complex I from the yeast Yarrowia lipolytica.

Biochim Biophys Acta 2004 Jul;1658(1-2):148-56

Fachbereich Medizin, Institut für Biochemie I, ZBC, Universität Frankfurt, Theodor-Stern-Kai 7, Haus 25B, D-60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2004.04.019DOI Listing
July 2004