Ulf Diczfalusy

Ulf Diczfalusy

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Ulf Diczfalusy

Publications by authors named "Ulf Diczfalusy"

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Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol-an Interaction Study in Healthy Volunteers.

AAPS J 2019 04 24;21(4):58. Epub 2019 Apr 24.

Center for Psychopharmacology, Diakonhjemmet Hospital, PO Box 85, Vinderen, N-0319, Oslo, Norway.

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http://dx.doi.org/10.1208/s12248-019-0330-1DOI Listing
April 2019

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients.

BMC Pharmacol Toxicol 2018 06 25;19(1):33. Epub 2018 Jun 25.

Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, SE-141 86, Stockholm, Sweden.

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https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40360-018-0221-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020207PMC
June 2018

Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.

Br J Clin Pharmacol 2016 12 20;82(6):1539-1549. Epub 2016 Sep 20.

Department of Microbiology and Immunology, KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/bcp.13083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099550PMC
December 2016

Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity.

AAPS J 2016 09 27;18(5):1056-1066. Epub 2016 Jun 27.

Drug Metabolism and Pharmacokinetics, Novartis, East Hanover, New Jersey, USA.

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http://dx.doi.org/10.1208/s12248-016-9949-3DOI Listing
September 2016

CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity.

Drug Metab Dispos 2016 09 11;44(9):1480-9. Epub 2016 Jul 11.

Cardiovascular and Metabolic Diseases, Drug Metabolism and Pharmacokinetics (M.A.H., X.-Q.L., T.B.A.) and Respiratory, Inflammation and Autoimmune Disease, Medicinal Chemistry (G.G.), Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden (U.D.); Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (T.B.A.)

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http://dx.doi.org/10.1124/dmd.116.070805DOI Listing
September 2016

Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study.

Medicine (Baltimore) 2016 Aug;95(34):e4631

aDepartment of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden bDepartment of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia cDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden dDepartment of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/MD.0000000000004631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400328PMC
August 2016

Effect of Statin Treatment on Plasma 4β-Hydroxycholesterol Concentrations.

Basic Clin Pharmacol Toxicol 2016 Jun 14;118(6):499-502. Epub 2016 Jan 14.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bcpt.12537DOI Listing
June 2016

No impact of vitamin D on the CYP3A biomarker 4β-hydroxycholesterol in patients with abnormal glucose regulation.

PLoS One 2015 2;10(4):e0121984. Epub 2015 Apr 2.

Department of Laboratory Medicine, Division of Clinical Chemistry at Karolinska Institutet, Karolinska University Hospital, C1.74, Huddinge, SE-141 86, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121984PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383380PMC
March 2016

miRNA-27b levels are associated with CYP3A activity in vitro and in vivo.

Pharmacol Res Perspect 2015 12 27;3(6):e00192. Epub 2015 Oct 27.

Division of Clinical Microbiology Department of Laboratory Medicine Karolinska Institutet Karolinska University Hospital, Huddinge SE-141 86 Stockholm Sweden; Palliative Home Care and Hospice Ward ASIH Stockholm Södra Långbro Park Bergtallsvägen 12SE-125 59 Älvsjö Sweden.

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http://dx.doi.org/10.1002/prp2.192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777245PMC
December 2015

Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin.

Drug Metab Pharmacokinet 2014 11;29(4):352-5. Epub 2014 Feb 11.

Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge.

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http://dx.doi.org/10.2133/dmpk.dmpk-13-sh-138DOI Listing
May 2015

Plasma levels of 25-hydroxyvitamin D3 and in vivo markers of cytochrome P450 3A activity in Swedes and Koreans: effects of a genetic polymorphism and oral contraceptives.

Basic Clin Pharmacol Toxicol 2014 Oct 11;115(4):366-71. Epub 2014 Apr 11.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bcpt.12230DOI Listing
October 2014

Immediate effect of passive smoking on microcirculatory flow.

Microcirculation 2014 Oct;21(7):587-92

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/micc.12137DOI Listing
October 2014

Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity.

J Antimicrob Chemother 2014 Jul 2;69(7):1933-7. Epub 2014 Apr 2.

Department of Pharmacology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany

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http://dx.doi.org/10.1093/jac/dku086DOI Listing
July 2014

Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin.

Drug Metab Dispos 2013 Aug 14;41(8):1488-93. Epub 2013 May 14.

Division of Clinical Pharmacology C1-68, Karolinska University Hospital, Huddinge, Karolinska Institutet, SE-141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1124/dmd.113.052316DOI Listing
August 2013

Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation study.

Drug Metab Dispos 2013 Apr 5;41(4):704-8. Epub 2013 Feb 5.

Karolinska Institutet, Department of Laboratory Medicine, Divisions of Clinical Pharmacology, Stockholm, Sweden.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.113.051136
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http://dx.doi.org/10.1124/dmd.113.051136DOI Listing
April 2013

On the formation and possible biological role of 25-hydroxycholesterol.

Authors:
Ulf Diczfalusy

Biochimie 2013 Mar 23;95(3):455-60. Epub 2012 Jun 23.

Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S030090841200251
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http://dx.doi.org/10.1016/j.biochi.2012.06.016DOI Listing
March 2013

Metabolism of alprazolam (a marker of CYP3A4) in hemodialysis patients with persistent inflammation.

Eur J Clin Pharmacol 2012 May 9;68(5):571-7. Epub 2011 Dec 9.

Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00228-011-1163-8
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http://dx.doi.org/10.1007/s00228-011-1163-8DOI Listing
May 2012

Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria.

J Biol Chem 2012 Feb 27;287(9):6307-17. Epub 2011 Dec 27.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177 Stockholm.

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http://dx.doi.org/10.1074/jbc.M111.328237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307252PMC
February 2012

Microvascular reactivity in response to smoking and oral antioxidants in humans.

Microcirculation 2012 Jan;19(1):86-93

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1549-8719.2011.00125.xDOI Listing
January 2012

Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol.

J Lipid Res 2011 Aug 7;52(8):1447-9. Epub 2011 Jun 7.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1194/jlr.E017806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137011PMC
August 2011

Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol.

Eur J Clin Pharmacol 2011 Jul 19;67(7):715-22. Epub 2011 Jan 19.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00228-010-0984-1
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http://dx.doi.org/10.1007/s00228-010-0984-1DOI Listing
July 2011

Detecting oxysterols in the human circulation.

Nat Immunol 2011 Jun 20;12(7):577; author reply 577-8. Epub 2011 Jun 20.

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http://dx.doi.org/10.1038/ni0711-577aDOI Listing
June 2011

4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.

Br J Clin Pharmacol 2011 Feb;71(2):183-9

Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2010.03773.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040538PMC
February 2011

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels.

Invest Ophthalmol Vis Sci 2009 Dec 24;50(12):5712-7. Epub 2009 Jun 24.

Eye and Nutrition Research Group, UMR1129 FLAVIC (Flaveur, vision et comportement du consommateur; Flavor, Vision, and Consumer Behavior), INRA (French National Institute for Agricultural Research), Dijon, France.

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http://dx.doi.org/10.1167/iovs.09-3655DOI Listing
December 2009

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.

J Lipid Res 2009 Nov 5;50(11):2258-64. Epub 2009 Jun 5.

Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1194/jlr.M900107-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759831PMC
November 2009

Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones.

Basic Clin Pharmacol Toxicol 2009 Nov 20;105(5):339-44. Epub 2009 Jul 20.

Department of Applied Environmental Science, Stockholm University, Stockholm, Sweden.

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http://doi.wiley.com/10.1111/j.1742-7843.2009.00455.x
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http://dx.doi.org/10.1111/j.1742-7843.2009.00455.xDOI Listing
November 2009

4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin.

Br J Clin Pharmacol 2009 Jan 6;67(1):38-43. Epub 2008 Nov 6.

Division of Clinical Chemistry, Department of Laboratory Medicine at Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2008.03309.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668082PMC
January 2009

Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy.

Br J Clin Pharmacol 2008 May 12;65(5):708-15. Epub 2008 Feb 12.

Division of Paediatrics, Department of Clinical Sciences, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1111/j.1365-2125.2007.03078.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2432481PMC
May 2008

4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.

Pharmacogenet Genomics 2008 Mar;18(3):201-8

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1097/FPC.0b013e3282f50ee9DOI Listing
March 2008

Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Sep 29;856(1-2):15-9. Epub 2007 May 29.

Division of Clinical Chemistry, Karolinska University Hospital, Huddinge and Solna, Sweden.

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http://dx.doi.org/10.1016/j.jchromb.2007.05.019DOI Listing
September 2007

In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress.

Free Radic Biol Med 2007 Sep 10;43(5):695-701. Epub 2007 May 10.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, SE-141 86 Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S089158490700320
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http://dx.doi.org/10.1016/j.freeradbiomed.2007.04.033DOI Listing
September 2007

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina.

Curr Eye Res 2007 Apr;32(4):361-6

Eye and Nutrition Research Group, UMR 1129 FLAVIC, INRA, ENESAD, University of Burgundy, Dijon, France, and Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://www.tandfonline.com/doi/full/10.1080/0271368070123185
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http://dx.doi.org/10.1080/02713680701231857DOI Listing
April 2007

Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin.

Pharmacogenet Genomics 2006 Aug;16(8):565-8

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

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http://dx.doi.org/10.1097/01.fpc.0000215070.52212.0eDOI Listing
August 2006

Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes.

J Biol Chem 2006 Feb 30;281(7):3810-20. Epub 2005 Nov 30.

Divisions of Clinical Chemistry and Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M505179200DOI Listing
February 2006

Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study.

Clin Sci (Lond) 2005 Jun;108(6):507-13

Division of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm SE-141 86, Sweden.

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http://dx.doi.org/10.1042/CS20040291DOI Listing
June 2005

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.

J Lipid Res 2005 May 1;46(5):1047-52. Epub 2005 Mar 1.

Department of Surgical Sciences, Karolinska University Hospital, Solna, Sweden.

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http://dx.doi.org/10.1194/jlr.M500024-JLR200DOI Listing
May 2005

Novel pathways of bile acid metabolism involving CYP3A4.

Biochim Biophys Acta 2005 Feb;1687(1-3):84-93

Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Huddinge, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbalip.2004.11.003DOI Listing
February 2005

24(S),25-epoxycholesterol--a potential friend.

Arterioscler Thromb Vasc Biol 2004 Dec;24(12):2209-10

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http://dx.doi.org/10.1161/01.ATV.0000148704.72481.28DOI Listing
December 2004

Analysis of cholesterol oxidation products in biological samples.

Authors:
Ulf Diczfalusy

J AOAC Int 2004 Mar-Apr;87(2):467-73

Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Chemistry, Huddinge University Hospital C1.74, SE-141 86 Huddinge, Sweden.

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August 2004

Phospholipid plasmalogen, a surrogate marker of oxidative stress, is associated with increased cardiovascular mortality in patients on renal replacement therapy.

Nephrol Dial Transplant 2004 Apr;19(4):972-6

Department of Renal Medicine K56, Huddinge University Hospital, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1093/ndt/gfh035DOI Listing
April 2004

Diagnostic use of cerebral and extracerebral oxysterols.

Clin Chem Lab Med 2004 Feb;42(2):186-91

Department of Experimental and Clinical Biomedical Science (DSBSC), University of Insubria, Varese, Italy.

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http://dx.doi.org/10.1515/CCLM.2004.034DOI Listing
February 2004

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease.

J Lipid Res 2004 Jan 1;45(1):186-93. Epub 2003 Oct 1.

Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1194/jlr.M300320-JLR200DOI Listing
January 2004

Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque.

Arterioscler Thromb Vasc Biol 2004 Jan 30;24(1):136-40. Epub 2003 Oct 30.

Dipartimento di Medicina Interna, University La Sapienza, Via del Policlinico, 155. 00161 Rome, Italy.

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http://dx.doi.org/10.1161/01.ATV.0000104028.07929.72DOI Listing
January 2004

Quantitation of receptor ligands by mass spectrometry.

Methods Enzymol 2003 ;364:24-37

Merck Research Laboratories, RY80W-250, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1016/s0076-6879(03)64002-4DOI Listing
December 2003

Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.

Free Radic Biol Med 2003 Oct;35(8):922-8

Research Institute of Public Health, University of Kuopio, Kuopio, Finland.

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http://dx.doi.org/10.1016/s0891-5849(03)00433-7DOI Listing
October 2003

On the origin of the cholestenoic acids in human circulation.

Steroids 2003 Sep;68(7-8):595-601

Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1016/s0039-128x(03)00081-3DOI Listing
September 2003

Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers.

J Lipid Res 2003 Apr 1;44(4):793-9. Epub 2003 Feb 1.

Department of Experimental and Clinical Biomedical Science, University of Insubria, Varese, Italy.

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http://dx.doi.org/10.1194/jlr.M200434-JLR200DOI Listing
April 2003

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function.

J Lipid Res 2002 Dec;43(12):2130-5

Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1194/jlr.m200293-jlr200DOI Listing
December 2002

Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis.

Neurosci Lett 2002 Oct;331(3):163-6

Department of Experimental and Clinical Biomedical Science (DSBSC), University of Insubria, Varese, Italy.

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http://dx.doi.org/10.1016/s0304-3940(02)00887-xDOI Listing
October 2002

Metabolism of 4 beta -hydroxycholesterol in humans.

J Biol Chem 2002 Aug 20;277(35):31534-40. Epub 2002 Jun 20.

Department of Medical Laboratory Sciences and Technology, Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Huddinge, Sweden.

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http://dx.doi.org/10.1074/jbc.M201712200DOI Listing
August 2002

Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1).

Arterioscler Thromb Vasc Biol 2002 Jul;22(7):1129-35

Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1161/01.atv.0000022600.61391.a5DOI Listing
July 2002

Oxysterols in human circulation: which role do they have?

Curr Opin Lipidol 2002 Jun;13(3):247-53

Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Sweden.

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http://dx.doi.org/10.1097/00041433-200206000-00003DOI Listing
June 2002

Oxysterols: friends, foes, or just fellow passengers?

Arterioscler Thromb Vasc Biol 2002 May;22(5):734-42

Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden.

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http://dx.doi.org/10.1161/01.atv.0000013312.32196.49DOI Listing
May 2002