Ulf Dettmer

Ulf Dettmer

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Ulf Dettmer

Ulf Dettmer

Publications by authors named "Ulf Dettmer"

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Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.

Proc Natl Acad Sci U S A 2019 Oct 23;116(41):20760-20769. Epub 2019 Sep 23.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1903216116DOI Listing
October 2019

Studying α-Synuclein Conformation by Intact-Cell Cross-Linking.

Methods Mol Biol 2019 ;1948:77-91

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-9124-2_8DOI Listing
July 2019

Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration.

Neurobiol Dis 2019 Jul 24;132:104543. Epub 2019 Jul 24.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104543DOI Listing
July 2019

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.

Neuron 2018 10;100(1):75-90.e5

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211795PMC
October 2018

Rationally Designed Variants of α-Synuclein Illuminate Its Structural Properties in Health and Disease.

Authors:
Ulf Dettmer

Front Neurosci 2018 25;12:623. Epub 2018 Sep 25.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fnins.2018.00623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167557PMC
September 2018

New insights into cellular α-synuclein homeostasis in health and disease.

Curr Opin Neurobiol 2016 Feb 15;36:15-22. Epub 2015 Aug 15.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2015.07.007DOI Listing
February 2016

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Proc Natl Acad Sci U S A 2015 Aug 7;112(31):9596-601. Epub 2015 Jul 7.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1505953112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534262PMC
August 2015

ExPLAining early synucleinopathies.

Brain 2015 Jun;138(Pt 6):1449-51

Ann Romney Centre for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1093/brain/awv099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614127PMC
June 2015

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Nat Commun 2015 Jun 16;6:7314. Epub 2015 Jun 16.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms8314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490410PMC
June 2015

A new method for quantitative immunoblotting of endogenous α-synuclein.

PLoS One 2013 20;8(11):e81314. Epub 2013 Nov 20.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081314PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835431PMC
January 2015

Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.

Biochemistry 2015 Jan 23;54(2):279-92. Epub 2014 Dec 23.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://pubs.acs.org/doi/10.1021/bi501188a
Publisher Site
http://dx.doi.org/10.1021/bi501188aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303315PMC
January 2015

Defining the native state of α-synuclein.

Neurodegener Dis 2014 30;13(2-3):114-7. Epub 2013 Oct 30.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass., USA.

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http://dx.doi.org/10.1159/000355516DOI Listing
September 2014

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.

J Biol Chem 2013 Mar 14;288(9):6371-85. Epub 2013 Jan 14.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M112.403311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585072PMC
March 2013

Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex.

J Biol Chem 2010 Aug 10;285(34):26174-81. Epub 2010 Jun 10.

German Center for Neurodegenerative Diseases (DZNE) and the Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, D-80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M110.132548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924024PMC
August 2010

The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex.

J Biol Chem 2007 Apr 29;282(14):10632-8. Epub 2007 Jan 29.

Center of Integrated Protein Science and the Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig-Maximilians-University, D-80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M611033200DOI Listing
April 2007