Publications by authors named "Ugo Testa"

100Publications

Genetic Alterations of Metastatic Colorectal Cancer.

Biomedicines 2020 Oct 13;8(10). Epub 2020 Oct 13.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/biomedicines8100414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601984PMC
October 2020

Cancer stem cell targeted therapies.

Ann Ist Super Sanita 2020 Jul-Sep;56(3):336-350

Dipartimento di Oncologia, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.4415/ANN_20_03_12DOI Listing
September 2020

Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias.

Cancers (Basel) 2020 Aug 26;12(9). Epub 2020 Aug 26.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/cancers12092427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564409PMC
August 2020

Genetic Alterations in Renal Cancers: Identification of The Mechanisms Underlying Cancer Initiation and Progression and of Therapeutic Targets.

Medicines (Basel) 2020 Jul 29;7(8). Epub 2020 Jul 29.

Department of Oncology, Istituto Superiore di Sanità, Vaile Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medicines7080044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459851PMC
July 2020

Endothelial Progenitors in the Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1263:85-115

Department of Oncology, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1007/978-3-030-44518-8_7DOI Listing
July 2020

Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.

Med Sci (Basel) 2020 Mar 23;8(1). Epub 2020 Mar 23.

Department of Oncology, Istituto Superiore di Sanità, Regina Elena 299, 00161 Rome,Italy.

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http://dx.doi.org/10.3390/medsci8010018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151639PMC
March 2020

Understanding mechanisms of cancer initiation and development supports the need for an implementation of primary and secondary cancer prevention.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):371-379

Dipartimento oncologia e medicina molecolare, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.4415/ANN_19_04_11DOI Listing
May 2020

CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies.

Cancers (Basel) 2019 Sep 12;11(9). Epub 2019 Sep 12.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/cancers11091358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769702PMC
September 2019

Transcription factors implicated in late megakaryopoiesis as markers of outcome after azacitidine and allogeneic stem cell transplantation in myelodysplastic syndrome.

Leuk Res 2019 09 19;84:106191. Epub 2019 Jul 19.

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy; Fondazione Santa Lucia, Laboratorio di Neuro-Oncoematologia, Roma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2019.106191DOI Listing
September 2019

Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications.

Medicines (Basel) 2019 Jul 30;6(3). Epub 2019 Jul 30.

Department of Oncology, Istituto Superiore di Sanità, Vaile Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medicines6030082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789661PMC
July 2019

Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism.

Cancers (Basel) 2019 Feb 22;11(2). Epub 2019 Feb 22.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/cancers11020260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406361PMC
February 2019

Genetic Abnormalities, Clonal Evolution, and Cancer Stem Cells of Brain Tumors.

Med Sci (Basel) 2018 Oct 2;6(4). Epub 2018 Oct 2.

Department of Oncology, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://www.mdpi.com/2076-3271/6/4/85
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http://dx.doi.org/10.3390/medsci6040085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313628PMC
October 2018

Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells.

Cancers (Basel) 2018 Jul 27;10(8). Epub 2018 Jul 27.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/cancers10080248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116004PMC
July 2018

miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development.

Noncoding RNA 2017 Jun 26;3(3). Epub 2017 Jun 26.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/ncrna3030022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831915PMC
June 2017

Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.

Med Sci (Basel) 2018 Apr 13;6(2). Epub 2018 Apr 13.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medsci6020031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024750PMC
April 2018

Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells.

Medicines (Basel) 2018 Feb 1;5(1). Epub 2018 Feb 1.

Department of Oncology and Molecular Medicine, Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medicines5010016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874581PMC
February 2018

Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.

Onco Targets Ther 2018 28;11:131-155. Epub 2017 Dec 28.

Department of Oncology, Istituto Superiore di Sanità, Rome, Italy.

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https://www.dovepress.com/targeting-histone-methyltransferas
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http://dx.doi.org/10.2147/OTT.S145971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749389PMC
December 2017

Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells.

Med Sci (Basel) 2017 Nov 20;5(4). Epub 2017 Nov 20.

Department of Oncology, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medsci5040028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753657PMC
November 2017

Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.

Biomedicines 2017 Nov 18;5(4). Epub 2017 Nov 18.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome 00135, Italy.

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http://dx.doi.org/10.3390/biomedicines5040065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744089PMC
November 2017

Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation.

Blood Cells Mol Dis 2018 03 21;69:57-64. Epub 2017 Sep 21.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2017.09.005DOI Listing
March 2018

Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution.

Medicines (Basel) 2017 Sep 14;4(3). Epub 2017 Sep 14.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00141 Rome, Italy.

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http://dx.doi.org/10.3390/medicines4030067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622402PMC
September 2017

Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.

Cancers (Basel) 2017 Sep 20;9(9). Epub 2017 Sep 20.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome 00141, Italy.

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http://dx.doi.org/10.3390/cancers9090127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615342PMC
September 2017

Targeted therapies in the treatment of adult acute myeloid leukemias: current status and future perspectives.

Int J Hematol Oncol 2016 Dec 7;5(4):143-164. Epub 2017 Feb 7.

Department of Hematology, Oncology & Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.

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https://www.futuremedicine.com/doi/10.2217/ijh-2016-0011
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http://dx.doi.org/10.2217/ijh-2016-0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172000PMC
December 2016

Conditioned medium from human umbilical vein endothelial cells markedly improves the proliferation and differentiation of circulating endothelial progenitors.

Blood Cells Mol Dis 2016 10 18;61:58-65. Epub 2016 Aug 18.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 200, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2016.07.007DOI Listing
October 2016

Endothelial progenitor cells in hematologic malignancies.

Stem Cell Investig 2016 1;3:26. Epub 2016 Jul 1.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.21037/sci.2016.06.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981702PMC
September 2016

Oxidative stress and hypoxia in normal and leukemic stem cells.

Exp Hematol 2016 07 12;44(7):540-60. Epub 2016 May 12.

Departement of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.exphem.2016.04.012DOI Listing
July 2016

PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response.

J Hematol Oncol 2016 Apr 7;9:33. Epub 2016 Apr 7.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1186/s13045-016-0262-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823896PMC
April 2016

Prognostic factors in acute promyelocytic leukemia: strategies to define high-risk patients.

Ann Hematol 2016 Apr 26;95(5):673-80. Epub 2016 Feb 26.

Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1007/s00277-016-2622-1DOI Listing
April 2016

Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.

Blood Cells Mol Dis 2015 Dec 26;55(4):336-46. Epub 2015 Jul 26.

Department of Hematology, Oncology and Molecular Medicine, Istituto Suepriore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2015.07.015DOI Listing
December 2015

Experimental and investigational therapies for chemotherapy-induced anemia.

Expert Opin Investig Drugs 2015 10;24(11):1433-45. Epub 2015 Sep 10.

a Istituto Superiore di Sanità, Department of Hematology, Oncology and Molecular Medicine , Viale Regina Elena 299, Rome, Italy

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http://dx.doi.org/10.1517/13543784.2015.1085505DOI Listing
May 2016

Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines.

Ann Hematol 2015 Nov 12;94(11):1807-16. Epub 2015 Aug 12.

Department of Medical, Surgical and Neurological Sciences, University of Siena, Polo Scientifico San Miniato, Via A. Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1007/s00277-015-2464-2DOI Listing
November 2015

Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy.

Haematologica 2015 Sep 4;100(9):1160-71. Epub 2015 Jun 4.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, University of Rome "Tor Vergata", Rome, Italy

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http://dx.doi.org/10.3324/haematol.2014.120295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800689PMC
September 2015

Targeting of leukemia-initiating cells in acute promyelocytic leukemia.

Stem Cell Investig 2015 29;2. Epub 2015 Apr 29.

1 Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy ; 2 Department of Biomedicine and Prevention, University of Rome "Tor Vergata" and Fondazione Santa Lucia, Rome, Italy.

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http://dx.doi.org/10.3978/j.issn.2306-9759.2015.04.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923659PMC
June 2016

miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias.

Leuk Res 2015 Feb 18;39(2):221-8. Epub 2014 Nov 18.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2014.11.001DOI Listing
February 2015

Human cord blood-derived hemogenic endothelium generates mast cells.

Blood Cells Mol Dis 2015 Feb 15;54(2):195-7. Epub 2014 Nov 15.

Department of Hmatology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2014.11.002DOI Listing
February 2015

SCF-mediated γ-globin gene expression in adult human erythroid cells is associated with KLF1, BCL11A and SOX6 down-regulation.

Blood Cells Mol Dis 2015 Jan 3;54(1):1-3. Epub 2014 Nov 3.

Dept. of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2014.10.004DOI Listing
January 2015

MicroRNAs expressed in hematopoietic stem/progenitor cells are deregulated in acute myeloid leukemias.

Leuk Lymphoma 2015 May 21;56(5):1466-74. Epub 2015 Jan 21.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità , Rome , Italy.

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http://dx.doi.org/10.3109/10428194.2014.955019DOI Listing
May 2015

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies.

Biomark Res 2014 Feb 10;2(1). Epub 2014 Feb 10.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1186/2050-7771-2-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928610PMC
February 2014

Endothelial progenitors.

Blood Cells Mol Dis 2014 Apr 9;52(4):186-94. Epub 2013 Dec 9.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2013.11.004DOI Listing
April 2014

The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias.

Leuk Res Treatment 2013 9;2013:275760. Epub 2013 Jul 9.

Department of Hematology, Oncology and Molecular Medicine, Upper Health Institute, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1155/2013/275760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725705PMC
August 2013

The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer.

J Hematol Oncol 2012 Mar 27;5:13. Epub 2012 Mar 27.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1186/1756-8722-5-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342163PMC
March 2012

Human umbilical cord is a unique and safe source of various types of stem cells suitable for treatment of hematological diseases and for regenerative medicine.

Blood Cells Mol Dis 2012 Jun 23;49(1):20-8. Epub 2012 Mar 23.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2012.02.007DOI Listing
June 2012

Immunophenotypic features of acute myeloid leukaemia patients exhibiting high FLT3 expression not associated with mutations.

Br J Haematol 2011 Apr 20;153(1):33-42. Epub 2011 Feb 20.

Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08577.xDOI Listing
April 2011

Leukemia stem cells.

Authors:
Ugo Testa

Ann Hematol 2011 Mar 25;90(3):245-71. Epub 2010 Nov 25.

Department of Hematology, Oncology and Molecular Medicine, Istituto Supeirore di Sanità, Viale Regina Elena 299, Rome, Italy.

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http://dx.doi.org/10.1007/s00277-010-1118-7DOI Listing
March 2011

CDDO-Im is a stimulator of megakaryocytic differentiation.

Leuk Res 2011 Apr 29;35(4):534-44. Epub 2010 Oct 29.

Department of Hematology, Oncology and Molecular Medicine, Istituto Suepriore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.leukres.2010.09.013DOI Listing
April 2011

Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise.

J Appl Physiol (1985) 2010 Jul 6;109(1):60-7. Epub 2010 May 6.

Biomedical Department, Internal and Specialistic Medicine (DIBIMIS), Section of Pneumology, University of Palermo, Via Trabucco, 180, 90146 Palermo, Italy.

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http://dx.doi.org/10.1152/japplphysiol.01344.2009DOI Listing
July 2010

The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor.

Blood Cells Mol Dis 2010 Jun 4;45(1):86-92. Epub 2010 May 4.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S10799796100011
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http://dx.doi.org/10.1016/j.bcmd.2010.03.008DOI Listing
June 2010

Transcriptional silencing of the ETS1 oncogene contributes to human granulocytic differentiation.

Haematologica 2010 Oct 30;95(10):1633-41. Epub 2010 Apr 30.

Dept. of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, viale Regina Elena 299, Rome, Italy.

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http://dx.doi.org/10.3324/haematol.2010.023267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948087PMC
October 2010

TRAIL/TRAIL-R in hematologic malignancies.

Authors:
Ugo Testa

J Cell Biochem 2010 May;110(1):21-34

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.

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http://dx.doi.org/10.1002/jcb.22549DOI Listing
May 2010

Erythropoietic stimulating agents.

Authors:
Ugo Testa

Expert Opin Emerg Drugs 2010 Mar;15(1):119-38

Istituto Superiore di Sanità, Department of Hematology, Oncology and Molecular Medicine, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1517/14728210903499273DOI Listing
March 2010

Primary ovarian cancer cells are sensitive to the proaptotic effects of proteasome inhibitors.

Int J Oncol 2010 Mar;36(3):707-13

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.3892/ijo_00000546DOI Listing
March 2010

Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.

Respir Physiol Neurobiol 2010 Jan 4;170(1):23-31. Epub 2009 Nov 4.

Department of Clinical Medicine, La Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1016/j.resp.2009.10.003DOI Listing
January 2010

Triterpenoids as new promising anticancer drugs.

Anticancer Drugs 2009 Nov;20(10):880-92

Department of Hematology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1097/CAD.0b013e328330fd90DOI Listing
November 2009

TfR2 expression in human colon carcinomas.

Blood Cells Mol Dis 2009 Nov-Dec;43(3):243-9. Epub 2009 Sep 2.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2009.08.001DOI Listing
December 2009

Proteasome inhibitors in cancer therapy.

Authors:
Ugo Testa

Curr Drug Targets 2009 Oct;10(10):968-81

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.2174/138945009789577909DOI Listing
October 2009

MicroRNAs in normal and malignant myelopoiesis.

Leuk Res 2009 Dec 30;33(12):1584-93. Epub 2009 May 30.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.leukres.2009.04.039DOI Listing
December 2009

[Physiopathology and possible clinical use of hematopoietic stem cells. Recent advances].

Authors:
Ugo Testa

Recenti Prog Med 2009 Mar;100(3):144-55

Dipartimento di Ematologia, Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Roma.

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March 2009

High sensitivity of ovarian cancer cells to the synthetic triterpenoid CDDO-Imidazolide.

Cancer Lett 2009 Sep 11;282(2):214-28. Epub 2009 Apr 11.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.canlet.2009.03.018DOI Listing
September 2009

Role of stem cell factor in the reactivation of human fetal hemoglobin.

Mediterr J Hematol Infect Dis 2009 Nov 13;1(1):e2009009. Epub 2009 Nov 13.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, ROME, ITALY.

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http://dx.doi.org/10.4084/MJHID.2009.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033162PMC
November 2009

Regulation of transferrin receptor 2 in human cancer cell lines.

Blood Cells Mol Dis 2009 Jan-Feb;42(1):5-13. Epub 2008 Nov 18.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2008.10.001DOI Listing
February 2009

Fetal hemoglobin chemical inducers for treatment of hemoglobinopathies.

Authors:
Ugo Testa

Ann Hematol 2009 Jun 15;88(6):505-28. Epub 2008 Nov 15.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1007/s00277-008-0637-yDOI Listing
June 2009

Vascular endothelial growth factors in cardiovascular medicine.

J Cardiovasc Med (Hagerstown) 2008 Dec;9(12):1190-221

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Italy.

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December 2008

A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis.

Nat Cell Biol 2008 Jul 22;10(7):788-801. Epub 2008 Jun 22.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.1038/ncb1741DOI Listing
July 2008

Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels.

Leuk Res 2008 Aug 4;32(8):1244-58. Epub 2008 Mar 4.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.leukres.2007.12.008DOI Listing
August 2008

Effective erythropoiesis and HbF reactivation induced by kit ligand in beta-thalassemia.

Blood 2008 Jan 19;111(1):421-9. Epub 2007 Oct 19.

Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena, 299-00161 Rome, Italy.

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http://dx.doi.org/10.1182/blood-2007-06-097550DOI Listing
January 2008

M4 and M5 acute myeloid leukaemias display a high sensitivity to Bortezomib-mediated apoptosis.

Br J Haematol 2007 Oct;139(2):194-205

Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06757.xDOI Listing
October 2007

MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation.

Nat Cell Biol 2007 Jul 24;9(7):775-87. Epub 2007 Jun 24.

Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.

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http://dx.doi.org/10.1038/ncb1613DOI Listing
July 2007

Methylation damage response in hematopoietic progenitor cells.

DNA Repair (Amst) 2007 Aug 15;6(8):1170-8. Epub 2007 May 15.

Section of Experimental Carcinogenesis, Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.dnarep.2007.03.024DOI Listing
August 2007

Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts.

Stem Cells 2007 Aug 19;25(8):1862-71. Epub 2007 Apr 19.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.

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http://dx.doi.org/10.1634/stemcells.2006-0700DOI Listing
August 2007

Transferrin receptor 2 is frequently expressed in human cancer cell lines.

Blood Cells Mol Dis 2007 Jul-Aug;39(1):82-91. Epub 2007 Apr 10.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2007.02.003DOI Listing
September 2007

A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.

Gynecol Oncol 2007 May 9;105(2):481-92. Epub 2007 Feb 9.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.ygyno.2007.01.011DOI Listing
May 2007

Proteasome inhibitors sensitize ovarian cancer cells to TRAIL induced apoptosis.

Apoptosis 2007 Apr;12(4):635-55

Medical Oncology Section, Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1007/s10495-006-0025-9DOI Listing
April 2007

Deregulation of apoptosis in acute myeloid leukemia.

Haematologica 2007 Jan;92(1):81-94

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3324/haematol.10279DOI Listing
January 2007

Coordinate release of angiogenic growth factors after acute myocardial infarction: evidence of a two-wave production.

J Cardiovasc Med (Hagerstown) 2006 Dec;7(12):872-9

Institute of Heart and Great Vessels Attilio Reale, University of Rome La Sapienza, Rome, Italy.

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http://dx.doi.org/10.2459/01.JCM.0000253831.61974.b9DOI Listing
December 2006

Podocalyxin is expressed in normal and leukemic monocytes.

Blood Cells Mol Dis 2006 Nov-Dec;37(3):218-25. Epub 2006 Oct 23.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2006.09.001DOI Listing
February 2007

TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway.

J Cell Sci 2006 Nov 17;119(Pt 21):4486-98. Epub 2006 Oct 17.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1242/jcs.03228DOI Listing
November 2006

Circulating CD34+ cells are decreased in chronic obstructive pulmonary disease.

Proc Am Thorac Soc 2006 Aug;3(6):537-8

Department of Medicine, Pneumology, Physiology and Nutrition, DIMPEPINU, University of Palermo, Via Trabucco 180, 90146 Palermo, Italy.

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http://dx.doi.org/10.1513/pats.200603-090MSDOI Listing
August 2006

Relation of various plasma growth factor levels in patients with stable angina pectoris and total occlusion of a coronary artery to the degree of coronary collaterals.

Am J Cardiol 2006 Feb 20;97(4):472-6. Epub 2005 Dec 20.

Laboratory of Interventional Cardiology and Department of Cardiology, Clinica Mediterranea, Naples, Italy.

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http://dx.doi.org/10.1016/j.amjcard.2005.09.076DOI Listing
February 2006

Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes.

J Cell Sci 2006 Feb 31;119(Pt 4):744-52. Epub 2006 Jan 31.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.

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http://dx.doi.org/10.1242/jcs.02784DOI Listing
February 2006