Udo Oppermann

Udo Oppermann

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Udo Oppermann

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Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).

J Med Chem 2019 Oct 24;62(20):8996-9007. Epub 2019 Jul 24.

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00522DOI Listing
October 2019

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.

J Steroid Biochem Mol Biol 2019 05 12;189:218-227. Epub 2019 Feb 12.

Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.02.002DOI Listing
May 2019

Immunophenotypic expression of UCP1 in hibernoma and other adipose/non adipose soft tissue tumours.

Clin Sarcoma Res 2019 13;9. Epub 2019 May 13.

1Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX7 HE UK.

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https://clinicalsarcomaresearch.biomedcentral.com/articles/1
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http://dx.doi.org/10.1186/s13569-019-0118-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515671PMC
May 2019

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.

ACS Catal 2019 Apr 1;9(4):2962-2968. Epub 2019 Mar 1.

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, 8010 Graz, Austria.

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http://pubs.acs.org/doi/10.1021/acscatal.9b00064
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http://dx.doi.org/10.1021/acscatal.9b00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454399PMC
April 2019

Divergent roles of prostacyclin and PGE in human tendinopathy.

Arthritis Res Ther 2019 Mar 13;21(1):74. Epub 2019 Mar 13.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, OX3 7LD, UK.

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-019-1855-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416900PMC
March 2019

Periostin expression in neoplastic and non-neoplastic diseases of bone and joint.

Clin Sarcoma Res 2018 5;8:18. Epub 2018 Sep 5.

1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal and Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, OX3 7HE UK.

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http://dx.doi.org/10.1186/s13569-018-0105-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123976PMC
September 2018

A novel INS mutation in a family with maturity-onset diabetes of the young: Variable insulin secretion and putative mechanisms.

Pediatr Diabetes 2018 08 22;19(5):905-909. Epub 2018 May 22.

Faculty of Medicine, The University of Queensland, Herston, QLD, Australia.

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http://doi.wiley.com/10.1111/pedi.12679
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http://dx.doi.org/10.1111/pedi.12679DOI Listing
August 2018

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases.

Bioorg Med Chem 2018 07 19;26(11):2984-2991. Epub 2018 Mar 19.

Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom; Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380468PMC
July 2018

Virtual Fragment Screening Identification of a Quinoline-5,8-dicarboxylic Acid Derivative as a Selective JMJD3 Inhibitor.

ChemMedChem 2018 06 22;13(12):1160-1164. Epub 2018 May 22.

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano (Salerno), Italy.

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http://dx.doi.org/10.1002/cmdc.201800198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055880PMC
June 2018

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.

Arthritis Rheumatol 2018 02 29;70(2):255-265. Epub 2017 Dec 29.

Queensland University of Technology and Princess Alexandra Hospital, Brisbane, Queensland, Australia.

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http://doi.wiley.com/10.1002/art.40369
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http://dx.doi.org/10.1002/art.40369DOI Listing
February 2018

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.

J Biol Chem 2018 02 4;293(7):2422-2437. Epub 2018 Jan 4.

From the Botnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute of Health Research Oxford Biomedical Research Unit (BRU), University of Oxford, Oxford OX3 7DQ, United Kingdom,

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http://dx.doi.org/10.1074/jbc.RA117.000698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818173PMC
February 2018

Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein.

Biochim Biophys Acta Mol Basis Dis 2017 12 7;1863(12):3294-3302. Epub 2017 Sep 7.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, OX3 7DQ Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.09.002DOI Listing
December 2017

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.

J Mol Biol 2017 09 18;429(19):2895-2906. Epub 2017 Aug 18.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636616PMC
September 2017

Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy.

Sci Rep 2017 09 8;7(1):11009. Epub 2017 Sep 8.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington, OX3 7LD, UK.

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http://dx.doi.org/10.1038/s41598-017-11188-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591234PMC
September 2017

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function.

Cell Rep 2017 06;19(11):2193-2201

Laboratory of Cancer Biology, Medical Sciences Division, Department of Oncology, University of Oxford, Old Road Campus Research Building, Old Road Campus, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478878PMC
June 2017

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia.

Haematologica 2017 03 3;102(3):e80-e84. Epub 2016 Nov 3.

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK

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http://dx.doi.org/10.3324/haematol.2016.155655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394973PMC
March 2017

The first international workshop on the epigenetics of osteoarthritis.

Connect Tissue Res 2017 01 30;58(1):37-48. Epub 2016 Mar 30.

f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.

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http://dx.doi.org/10.3109/03008207.2016.1168409DOI Listing
January 2017

Sclerostin expression in bone tumours and tumour-like lesions.

Histopathology 2016 Sep 8;69(3):470-8. Epub 2016 Apr 8.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK.

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http://dx.doi.org/10.1111/his.12953DOI Listing
September 2016

Advances and challenges in understanding histone demethylase biology.

Curr Opin Chem Biol 2016 08 29;33:151-9. Epub 2016 Jun 29.

Structural Genomics Consortium, University of Oxford, Headington OX3 7DQ, UK; Botnar Research Centre, NIHR Oxford Biomedical Research Unit, Oxford OX3 7LD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2016.06.021DOI Listing
August 2016

A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report.

BMC Cancer 2016 08 12;16:629. Epub 2016 Aug 12.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, OX3 7HE, UK.

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http://dx.doi.org/10.1186/s12885-016-2669-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983003PMC
August 2016

H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis.

Arthritis Res Ther 2016 07 7;18(1):158. Epub 2016 Jul 7.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Headington, OX3 7LD, Oxford, UK.

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http://dx.doi.org/10.1186/s13075-016-1053-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936015PMC
July 2016

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.

Nucleic Acids Res 2016 05 17;44(9):e88. Epub 2016 Feb 17.

Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg 79104, Germany BIOSS Centre of Biological Signalling Studies, University of Freiburg, 79106 Freiburg, Germany German Cancer Research Centre (DKFZ), Heidelberg, Germany

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http://dx.doi.org/10.1093/nar/gkw089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872087PMC
May 2016

Animal models of epigenetic regulation in neuropsychiatric disorders.

Curr Top Behav Neurosci 2011 ;7:281-322

Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK,

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http://dx.doi.org/10.1007/7854_2010_104DOI Listing
April 2016

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.

Bone 2015 Dec 28;81:478-486. Epub 2015 Aug 28.

Botnar Research Centre, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7LD, UK; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2015.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652608PMC
December 2015

Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.

Ther Adv Musculoskelet Dis 2015 Oct;7(5):206-19

Botnar Research Centre, NIHR Oxford Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, and Structural Genomics Consortium, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1177/1759720X15598307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572365PMC
October 2015

Inflammation activation and resolution in human tendon disease.

Sci Transl Med 2015 Oct;7(311):311ra173

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Nuffield Orthopaedic Centre, Headington OX3 7LD, UK. NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.

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http://dx.doi.org/10.1126/scitranslmed.aac4269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883654PMC
October 2015

Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.

Chem Biol Interact 2015 Jun 16;234:114-25. Epub 2014 Dec 16.

Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK; Botnar Research Center, NIHR Oxford Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00092797140039
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http://dx.doi.org/10.1016/j.cbi.2014.12.013DOI Listing
June 2015

Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.

Chem Biol Interact 2015 Jun 22;234:105-13. Epub 2015 Jan 22.

Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Faculty of Biosciences, E-08193 Bellaterra (Barcelona), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2015.01.021DOI Listing
June 2015

Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.

J Biol Chem 2014 Jun 5;289(26):18302-13. Epub 2014 May 5.

the Structural Genomics Consortium, University of Oxford, Headington OX3 7DQ, United Kingdom, and

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http://dx.doi.org/10.1074/jbc.M114.555052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140284PMC
June 2014

The roles of Jumonji-type oxygenases in human disease.

Epigenomics 2014 Feb;6(1):89-120

Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK.

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http://dx.doi.org/10.2217/epi.13.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233403PMC
February 2014

A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency.

J Inherit Metab Dis 2013 Nov 19;36(6):983-7. Epub 2013 Feb 19.

Structural Genomics Consortium, University of Oxford, Oxford, OX3 7DQ, UK.

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http://dx.doi.org/10.1007/s10545-013-9589-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825524PMC
November 2013

Quantitative analysis of histone demethylase probes using fluorescence polarization.

J Med Chem 2013 Jun 13;56(12):5198-202. Epub 2013 Jun 13.

Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA.

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http://dx.doi.org/10.1021/jm3018628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724763PMC
June 2013

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase.

Chembiochem 2012 Jul 22;13(11):1559-63. Epub 2012 Jun 22.

Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/cbic.201200256DOI Listing
July 2012

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.

Biochemistry 2012 Jun 14;51(25):5083-90. Epub 2012 Jun 14.

Structural Genomics Consortium, NIHR Oxford Biomedical Research Unit, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.1021/bi300150yDOI Listing
June 2012

Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.

Biochem Biophys Res Commun 2012 Mar 14;419(3):485-9. Epub 2012 Feb 14.

Structural Genomics Consortium, Oxford, UK.

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http://dx.doi.org/10.1016/j.bbrc.2012.02.038DOI Listing
March 2012

Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates.

J Biol Chem 2012 Jan 28;287(3):2119-29. Epub 2011 Nov 28.

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, A-8010 Graz, Austria.

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http://dx.doi.org/10.1074/jbc.M111.313015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265891PMC
January 2012

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

J Biol Chem 2011 Dec 13;286(48):41616-25. Epub 2011 Sep 13.

Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA.

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http://dx.doi.org/10.1074/jbc.M111.283689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308871PMC
December 2011

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.

Proc Natl Acad Sci U S A 2011 Dec 12;108(52):21028-33. Epub 2011 Dec 12.

Structural Genomics Consortium, Old Road Research Campus Building, Oxford, United Kingdom OX3 7DQ.

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http://dx.doi.org/10.1073/pnas.1113921108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248551PMC
December 2011

Structure and mechanism of human UDP-glucose 6-dehydrogenase.

J Biol Chem 2011 Jul 18;286(27):23877-87. Epub 2011 Apr 18.

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12/1, A-8010 Graz, Austria.

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http://dx.doi.org/10.1074/jbc.M111.234682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129169PMC
July 2011

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

Nat Genet 2011 Jul 10;43(8):761-7. Epub 2011 Jul 10.

Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/ng.873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640413PMC
July 2011

High-throughput structural biology of metabolic enzymes and its impact on human diseases.

J Inherit Metab Dis 2011 Jun 22;34(3):575-81. Epub 2011 Feb 22.

Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.

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http://link.springer.com/10.1007/s10545-011-9296-6
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http://dx.doi.org/10.1007/s10545-011-9296-6DOI Listing
June 2011

Structural basis of fumarate hydratase deficiency.

J Inherit Metab Dis 2011 Jun 29;34(3):671-6. Epub 2011 Mar 29.

Structural Genomics Consortium, University of Oxford, Old Road Campus, Headington OX3 7DQ, UK.

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http://dx.doi.org/10.1007/s10545-011-9294-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109261PMC
June 2011

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.

Biochem Biophys Res Commun 2011 May 21;408(4):553-8. Epub 2011 Apr 21.

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.bbrc.2011.04.059DOI Listing
May 2011

Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.

Cell Mol Life Sci 2011 Mar 11;68(6):1065-77. Epub 2010 Sep 11.

Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.

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http://link.springer.com/10.1007/s00018-010-0508-2
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http://dx.doi.org/10.1007/s00018-010-0508-2DOI Listing
March 2011

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.

EMBO J 2011 Jan 30;30(2):317-27. Epub 2010 Nov 30.

Department of Clinical Pharmacology, Laboratory of Cancer Biology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/emboj.2010.311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025457PMC
January 2011

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

Chem Biol 2010 Dec;17(12):1316-24

The Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX13TA, UK.

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http://dx.doi.org/10.1016/j.chembiol.2010.09.016DOI Listing
December 2010

Structural genomics of histone tail recognition.

Bioinformatics 2010 Oct 24;26(20):2629-30. Epub 2010 Aug 24.

Structural Genomics Consortium, University of Oxford, Headington, Oxford OX37DQ, UK.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btq491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951094PMC
October 2010

UDP-glucose dehydrogenase: structure and function of a potential drug target.

Biochem Soc Trans 2010 Oct;38(5):1378-85

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12, A-8010 Graz, Austria.

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http://biochemsoctrans.org/lookup/doi/10.1042/BST0381378
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http://dx.doi.org/10.1042/BST0381378DOI Listing
October 2010

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

Anal Biochem 2010 Sep 21;404(1):86-93. Epub 2010 May 21.

Department of Chemistry and Oxford Centre for Integrative Systems Biology, University of Oxford, UK.

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http://dx.doi.org/10.1016/j.ab.2010.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673899PMC
September 2010

Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.

J Mol Biol 2010 Aug;401(2):211-22

Department of Chemistry and Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.

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August 2010

Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.

Biochemistry 2010 Jun;49(22):4687-94

Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada T2N 4N1.

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http://dx.doi.org/10.1021/bi901612yDOI Listing
June 2010

Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models.

FEBS J 2010 May;277(10):2375-86

IFM Bioinformatics, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1111/j.1742-4658.2010.07656.xDOI Listing
May 2010

Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities.

Biochem Biophys Res Commun 2010 May;396(1):125-30

Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2010.03.094DOI Listing
May 2010

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6.

J Mol Biol 2010 May 31. Epub 2010 May 31.

Department of Chemistry and Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1016/j.jmb.2010.05.054DOI Listing
May 2010