Publications by authors named "Uday W Narlawar"

7 Publications

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Infectious causes of acute encephalitis syndrome hospitalizations in Central India, 2018-20.

J Clin Virol 2022 Aug 28;153:105194. Epub 2022 May 28.

Kakatiya Medical College, Warangal, Telangana, India.

Background: We enhanced surveillance of hospitalizations of all ages for acute encephalitis syndrome (AES) along with infectious aetiologies, including the Japanese encephalitis virus (JEV).

Methods: From October 2018 to September 2020, we screened neurological patients for AES in all age groups in Maharashtra and Telangana States. AES cases were enrolled at study hospitals along with other referrals and sampled with cerebrospinal fluid, acute and convalescent sera. We tested specimens for non-viral aetiologies viz. leptospirosis, typhoid, scrub typhus, malaria and acute bacterial meningitis, along with viruses - JEV, Dengue virus (DENV), Chikungunya virus (CHIKV), Chandipura virus (CHPV) and Herpes simplex virus (HSV).

Results: Among 4977 neurological hospitalizations at three study site hospitals over two years period, 857 (17.2%) were AES. However, only 287 (33.5%) AES cases were eligible. Among 278 (96.9%) enrolled AES cases, infectious aetiologies were identified in 115 (41.4%) cases, including non-viral in 17 (6.1%) cases - leptospirosis (8), scrub-typhus (3) and typhoid (6); and viral in 98 (35.3%) cases - JEV (58, 20.9%), HSV (22, 7.9%), DENV (15, 5.4%) and CHPV (3, 1.1%). JEV confirmation was significantly higher in enrolled cases than referred cases (10.2%) (p < 0.05). However, the contribution of JEV in AES cases was similar in both children and adults. JE was reported year-round and from adjacent non-endemic districts.

Conclusions: The Japanese encephalitis virus continues to be the leading cause of acute encephalitis syndrome in central India despite vaccination among children. Surveillance needs to be strengthened along with advanced diagnostic testing for assessing the impact of vaccination.
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http://dx.doi.org/10.1016/j.jcv.2022.105194DOI Listing
August 2022

Awareness and Satisfaction About COVAXIN Vaccination Services at an Immunization Clinic in Nagpur: A Cross-Sectional Study.

Cureus 2022 Jan 6;14(1):e20983. Epub 2022 Jan 6.

Department of Community Medicine, Government Medical College & Hospital, Nagpur, IND.

Introduction Initially, coronavirus disease 2019 (COVID-19) vaccination was started in India for the elderly above 60 years of age. Adults with any comorbidity have been gradually included in the vaccination drive. It is empirical to gain insight into the satisfaction of these beneficiaries with the vaccination as it may act as an influencing factor for receiving the vaccine. Materials and methods This was a descriptive cross-sectional study carried out at the COVID-19 vaccination clinic of the Government Medical College and Hospital, Nagpur, among individuals above 60 years of age and those from 45 to 60 years of age with comorbidity. The survey tool was a predesigned structured questionnaire that had close-ended questions on various aspects of awareness about the COVID-19 vaccines and their satisfaction with the immunization center. Interviews were conducted by two interviewers on each day. Data were analyzed using open software Epi Info (CDC, Atlanta, Georgia). The chi-square test was applied as a test of significance. Results A total of 290 subjects participated in the study. The majority had correct knowledge about COVID-19 vaccination and appropriate COVID-19 behavior after vaccination. Fever and body ache were known to most of the subjects as adverse effects following immunization. Social media was the most common source of knowledge. The majority of the subjects were satisfied with the services provided at the vaccination center, but there was no difference as per age, gender, or residential status of the subjects. Conclusion Despite mixed rumors about the COVID-19 vaccine, the majority of the study subjects were well satisfied with the vaccination. They were apparently having fair awareness about the vaccine.
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http://dx.doi.org/10.7759/cureus.20983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820477PMC
January 2022

Independent association of meteorological characteristics with initial spread of Covid-19 in India.

Sci Total Environ 2021 Apr 16;764:142801. Epub 2020 Oct 16.

Lata Medical Research Foundation, Nagpur, India; M&H Research, LLC, San Antonio, TX, USA.

Whether weather plays a part in the transmissibility of the novel Coronavirus Disease-19 (COVID-19) is still not established. We tested the hypothesis that meteorological factors (air temperature, relative humidity, air pressure, wind speed and rainfall) are independently associated with transmissibility of COVID-19 quantified using the basic reproduction rate (R). We used publicly available datasets on daily COVID-19 case counts (total n = 108,308), three-hourly meteorological data and community mobility data over a three-month period. Estimated R varied between 1.15 and 1.28. Mean daily air temperature (inversely), wind speed (positively) and countrywide lockdown (inversely) were significantly associated with time dependent R, but the contribution of countrywide lockdown to variability in R was over three times stronger as compared to that of temperature and wind speed combined. Thus, abating temperatures and easing lockdown may concur with increased transmissibility of COVID-19 in India.
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http://dx.doi.org/10.1016/j.scitotenv.2020.142801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566664PMC
April 2021

Effect of indoor air pollution during cooking on peak expiratory flow rate and its association with exposure index in rural women.

Indian J Physiol Pharmacol 2013 Apr-Jun;57(2):184-8

Routine exposure to domestic cooking fuels is an important source of indoor air pollution causing deterioration of lung function. We conducted a community based cross-sectional study in 760 non-smoking rural women involved in household cooking with four types of cooking fuels i.e. Biomass, Kerosene stove, Liquid Petroleum Gas (LPG) and Mixed (combination of two and more cooking fuels). Peak Expiratory Flow Rate (PEFR) less than 80% of the predicted was considered as abnormal PEFR. The overall prevalence of abnormal PEFR was found to be 29.1% with greater predominance among biomass fuel users (43.3%) with high risk ratio (1.86) as compared to kerosene (0.63), LPG (0.75) and mixed (0.66) fuel users. However the pair wise comparison of different groups of cooking fuels by Marascuilo procedure reported significant differences within different groups except kerosene--mixed group. The study also demonstrated a negative correlation between observed PEFR and exposure indices in different cooking fuels (r = -0.51). Our results indicate that prolonged exposure to cooking fuels particularly biomass fuels as a source of cooking adversely affects PEFR in nonsmoking rural women.
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May 2014

Indoor air pollution from biomass combustion and its adverse health effects in central India: an exposure-response study.

Indian J Community Med 2013 Jul;38(3):162-7

Department of Preventive and Social Medicine, Indira Gandhi Government Medical College, Nagpur, India.

Background: Some of the highest exposures to air pollutants in developing countries occur inside homes where biofuels are used for daily cooking. Inhalation of these pollutants may cause deleterious effects on health.

Objectives: To assess the respiratory and other morbidities associated with use of various types of cooking fuels in rural area of Nagpur and to study the relationship between the duration of exposure (exposure index [EI]) and various morbidities.

Materials And Methods: A total of 760 non-smoking, non-pregnant women aged 15 years and above (mean age 32.51 ΁ 14.90 years) exposed to domestic smoke from cooking fuels from an early age, working in poorly ventilated kitchen were selected and on examination presented with various health problems. Exposure was calculated as the average hours spent daily for cooking multiplied by the number of years. Symptoms were enquired by means of a standard questionnaire adopted from that of the British Medical Research Council. Lung function was assessed by the measurement of peak expiratory flow rate (PEFR). PEFR less than 80% of the predicted was considered as abnormal pulmonary function.

Results And Conclusions: Symptoms like eye irritation, headache, and diminution of vision were found to be significantly higher in biomass users (P < 0.05). Abnormal pulmonary function, chronic bronchitis, and cataract in biomass users was significantly higher than other fuel users (P < 0.05). Moreover an increasing trend in prevalence of symptoms/morbid conditions was observed with increase in EI. The presence of respiratory symptoms/morbid conditions was associated with lower values of both observed and percent predicted PEFR (P < 0.05 to 0.001). Thus women exposed to biofuels smoke suffer more from health problems and respiratory illnesses when compared with other fuel users.
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http://dx.doi.org/10.4103/0970-0218.116353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760325PMC
July 2013

The respiratory health of rural Indian women: does the domestic cooking fuel really matter?

J Clin Diagn Res 2013 Feb 1;7(2):411-2. Epub 2013 Feb 1.

Assistant Professor, Department of Preventive and Social Medicine. IGGMC Nagpur, India .

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http://dx.doi.org/10.7860/JCDR/2013/4326.2748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592330PMC
February 2013

Hypertension and hearing impairment in workers of iron and steel industry.

Indian J Physiol Pharmacol 2006 Jan-Mar;50(1):60-6

Department of Preventive and Social Medicine, Indira Gandhi Govt. Medical College, Nagpur 440 015.

The objectives of the present study were to study the (i) prevalence of hypertension and hearing impairment in iron and steel industry workers, (ii) association between hypertension and hearing impairment, (iii) association between hypertension and hearing impairment, with duration of exposure, and (iv) correlation between levels of sound and noise induced health problems viz. hypertension and hearing impairment in a cross sectional study involving Workers working in iron and steel industry at Nagpur. Of a total of 804 workers, 770 workers participated in the study. There were five sections in the factory; Steel melting section (SMS), rolling mill section (RMS), quality control department (QCD), maintenance department (MD) and administration department (AD). Workers working in SMS, RMS, & QCD formed a continuously exposed group (CEG); workers of MD and AD formed intermittently exposed group (IEG). Workers were interviewed, examined and information was collected in a pre-tested pro-forma. Blood pressure was measured, and tuning fork tests were done to assess hearing ability. Prevalence of hypertension among CEG (25.51%) was significantly higher than IEG (14.05%). (X2-14.28, df-1, P<0.001). There was positive association between duration of exposure and prevalence of hypertension. The prevalence of hearing impairment was significantly more in CEG (20.5%) as compared to IEG (8.91%). (X2-11.69, df-1, P<0.001). Occurrence of hearing impairment was also directly proportional to the duration of exposure. The correlation between level of sound exposure and hearing impairment was found to be significant (r=0.98; P<0.05), the correlation between level of sound and hypertension was found to be statistically insignificant (r=0.84; P>0.05). The results of the present study indicate that hypertension and hearing impairment are commoner in workers continuously exposed to high levels of occupational noise.
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November 2006
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