Publications by authors named "Tyler Wieland"

2 Publications

  • Page 1 of 1

Retinal Nerve Fibre Layer Thickness Increases with Decreasing Spectralis OCT Signal Strength in Normal Eyes.

Neuroophthalmology 2020 Apr 29;44(2):100-103. Epub 2019 Oct 29.

Department of Ophthalmology & Visual Neurosciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

We sought to determine effect of signal strength on mean retinal nerve fibre layer (RNFL) using Spectralis optical coherence tomography (S-OCT). Thirty normal subjects (18 female, mean 37.9 years, range 24-61) were imaged with S-OCT using variably dense Bangerter foils to alter Q value (1 unit signal strength = 4 units Q). We found a statistically significant (p < 0.01) linear relationship (R = 0.8643) between Q and RNFL (1 unit decrease Q = 0.181 um mean RNFL increase). Unlike previous observations of Cirrus and Stratus OCT, we found RNFL thickness does not decrease with decreasing signal strength in S-OCT.
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http://dx.doi.org/10.1080/01658107.2019.1653934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202426PMC
April 2020

Reproducibility of Fixed-luminance and Multi-luminance Flicker Electroretinography in Patients With Diabetic Retinopathy Using an Office-based Testing Paradigm.

J Diabetes Sci Technol 2020 11 22;14(6):1095-1103. Epub 2019 Oct 22.

Diopsys, Inc., Pine Brook, NJ, USA.

Background: We evaluated the reproducibility of office-based flicker electroretinography (ERG) in patients with nonproliferative diabetic retinopathy (NPDR).

Methods: An observational study was conducted in which ultra-widefield fluorescein angiography (UWF-FA) was performed on 20 patients with mild-to-moderate NPDR; images were graded by the Fundus Photography Reading Center (Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA). Fixed- and multi-luminance flicker ERG was repeated four times (greater than or equal to seven days apart). Recording consistency was assessed using intra-class correlation coefficients (ICCs), coefficients of variation, and Pearson correlations.

Results: 82.5% and 17.5% of eyes had mild and moderate NPDR using UWF-FA; 90% of the angiograms were given a high confidence grade. Fixed-luminance phase values were highly reproducible (ICC: 0.949;  < .001). There was a significant negative correlation between fixed-luminance phase and log-corrected ischemic index values (-0.426;  = .015).

Conclusions: Office-based, fixed-luminance phase values are highly reproducible and negatively correlate with retinal ischemia in NPDR, suggesting that global retinal dysfunction may be reliably quantified early in patients with diabetes.
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http://dx.doi.org/10.1177/1932296819882719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645135PMC
November 2020
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