Tyler J Harrison

Tyler J Harrison

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Tyler J Harrison

Tyler J Harrison

Publications by authors named "Tyler J Harrison"

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12Publications

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Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor.

ACS Med Chem Lett 2019 Aug 20;10(8):1128-1133. Epub 2019 Jun 20.

Global Discovery Chemistry, Cardiovascular and Metabolism, and PK Sciences, Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691483PMC
August 2019

Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.

J Pharmacol Exp Ther 2018 10 3;367(1):147-154. Epub 2018 Aug 3.

Cardiovascular and Metabolic Diseases (M.L.M., L.L., X.R., L.Ax., M.H.-S., N.C., D.C., L.Am., S.L., L.Z., T.H., J.M., J.B.R.), Global Discovery Chemistry (A.W.P., A.P., T.J.H., J.P.N.P., L.G.H.), PK Sciences (L.D.), Technical R&D (A.R.), and Chemical Biology and Therapeutics (J.B.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts

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http://dx.doi.org/10.1124/jpet.118.248435DOI Listing
October 2018

High and dry? Comparing active dry EEG electrodes to active and passive wet electrodes.

Psychophysiology 2017 01;54(1):74-82

Department of Psychology, Faculty of Science, Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1111/psyp.12536DOI Listing
January 2017

An "aprotic" Tamao oxidation/syn-selective tautomerization reaction for the efficient synthesis of the C1-C9 fragment of fludelone.

Org Lett 2012 Sep 5;14(18):4890-3. Epub 2012 Sep 5.

Department of Chemistry, Columbia University, New York, New York 10027, USA.

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http://dx.doi.org/10.1021/ol302221sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466590PMC
September 2012

Toward more "ideal" polyketide natural product synthesis: a step-economical synthesis of zincophorin methyl ester.

J Am Chem Soc 2011 May 27;133(19):7308-11. Epub 2011 Apr 27.

Department of Chemistry, Columbia University, New York, New York 10027, USA.

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http://dx.doi.org/10.1021/ja201467zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092851PMC
May 2011

Enamides and enesulfonamides as nucleophiles: formation of complex ring systems through a platinum(II)-catalyzed addition/Friedel-Crafts pathway.

J Org Chem 2009 Sep;74(18):6929-35

Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.

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https://pubs.acs.org/doi/10.1021/jo901512m
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http://dx.doi.org/10.1021/jo901512mDOI Listing
September 2009

Platinum(II)-catalyzed cyclizations forming quaternary carbon centers, using enesulfonamides, enecarbamates, or enamides as nucleophiles.

Org Lett 2007 Jan;9(2):367-70

Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.

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http://pubs.acs.org/doi/abs/10.1021/ol062939g
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http://dx.doi.org/10.1021/ol062939gDOI Listing
January 2007

Pyrrole synthesis catalyzed by AgOTf or cationic Au(I) complexes.

J Org Chem 2006 Jun;71(12):4525-9

Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, BC, Canada, V6T 1Z1.

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http://dx.doi.org/10.1021/jo060382cDOI Listing
June 2006

An expeditious, high-yielding construction of the food aroma compounds 6-acetyl-1,2,3,4-tetrahydropyridine and 2-acetyl-1-pyrroline.

J Org Chem 2005 Dec;70(26):10872-4

Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.

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http://dx.doi.org/10.1021/jo051940aDOI Listing
December 2005

Pt(II) or Ag(I) salt catalyzed cycloisomerizations and tandem cycloadditions forming functionalized azacyclic arrays.

Org Lett 2004 Dec;6(26):5023-6

Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.

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http://dx.doi.org/10.1021/ol047696bDOI Listing
December 2004

A modular and concise total synthesis of (+/-)-daurichromenic acid and analogues.

J Org Chem 2004 May;69(11):3782-6

Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6.

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http://dx.doi.org/10.1021/jo049703fDOI Listing
May 2004