Twan van Beucken

Twan van den Beucken

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Twan van Beucken

Twan van den Beucken

Publications by authors named "Twan van den Beucken"

37Publications

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1PubMed Central Citations

Phosphorylation of eIF2α promotes cell survival in response to benzo[a]pyrene exposure.

Toxicol In Vitro 2019 Feb 29;54:330-337. Epub 2018 Oct 29.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2018.10.015DOI Listing
February 2019

Translational regulation is a key determinant of the cellular response to benzo[a]pyrene.

Toxicol Lett 2018 Oct 12;295:144-152. Epub 2018 Jun 12.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, 6200MD, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2018.06.009DOI Listing
October 2018

A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases.

Toxicol In Vitro 2018 Apr 9;48:318-328. Epub 2018 Feb 9.

Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.tiv.2018.02.006DOI Listing
April 2018

Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics.

Toxicology 2017 09 4;390:74-82. Epub 2017 Sep 4.

Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.09.002DOI Listing
September 2017

Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study.

Toxicology 2017 Jan 17;375:58-63. Epub 2016 Oct 17.

Department of Toxicogenomics, Maastricht University, Maastricht, 6229 ER, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2016.10.009DOI Listing
January 2017

Dynamic Interplay between the Transcriptome and Methylome in Response to Oxidative and Alkylating Stress.

Chem Res Toxicol 2016 09 24;29(9):1428-38. Epub 2016 Aug 24.

Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University , 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00090DOI Listing
September 2016

Cigarette smoke extract induces a phenotypic shift in epithelial cells; involvement of HIF1α in mesenchymal transition.

PLoS One 2014 16;9(10):e107757. Epub 2014 Oct 16.

Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107757PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199572PMC
June 2015

Canonical autophagy does not contribute to cellular radioresistance.

Radiother Oncol 2015 Mar 13;114(3):406-12. Epub 2015 Mar 13.

Department of Radiation Oncology (Maastro Lab), GROW School for Oncology & Developmental Biology, Maastricht University Medical Center+, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2015.02.019DOI Listing
March 2015

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

PLoS One 2014 28;9(2):e89997. Epub 2014 Feb 28.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada ; Maastricht Radiation Oncology (MaastRO) Lab, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands ; Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938561PMC
October 2014

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.

Nat Commun 2014 Oct 29;5:5202. Epub 2014 Oct 29.

1] Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [3] Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncomms6202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215647PMC
October 2014

Two phases of disulfide bond formation have differing requirements for oxygen.

J Cell Biol 2013 Nov 18;203(4):615-27. Epub 2013 Nov 18.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1083/jcb.201307185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840938PMC
November 2013

Regulation of TRIB3 mRNA and protein in breast cancer.

PLoS One 2012 20;7(11):e49439. Epub 2012 Nov 20.

Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049439PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502484PMC
May 2013

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS.

Proc Natl Acad Sci U S A 2013 Mar 7;110(12):4622-7. Epub 2013 Mar 7.

Department of Radiation Oncology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1210633110
Publisher Site
http://dx.doi.org/10.1073/pnas.1210633110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607059PMC
March 2013

Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.

Radiother Oncol 2011 Oct 29;101(1):190-7. Epub 2011 Jun 29.

Ontario Cancer Institute and Campbell Family Institute for Cancer Research, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1016/j.radonc.2011.05.059DOI Listing
October 2011

Translational control is a major contributor to hypoxia induced gene expression.

Radiother Oncol 2011 Jun 28;99(3):379-84. Epub 2011 Jun 28.

Department of Radiation Oncology (Maastro Lab), Maastricht University, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2011.05.058DOI Listing
June 2011

Deficient carbonic anhydrase 9 expression in UPR-impaired cells is associated with reduced survival in an acidic microenvironment.

Radiother Oncol 2009 Sep 15;92(3):437-42. Epub 2009 Jul 15.

Department of Radiation Oncology (Maastro Lab), Maastricht University, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2009.06.018DOI Listing
September 2009

Radioprotective effects of ATP in human blood ex vivo.

Biochem Biophys Res Commun 2008 Mar 28;367(2):383-7. Epub 2007 Dec 28.

Department of Epidemiology, NUTRIM Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.bbrc.2007.12.125DOI Listing
March 2008

The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency.

Proteomics 2008 Mar;8(5):1019-28

Department of Radiation Oncology (Maastro Lab), GROW Research Institute, Maastricht University, Maastricht, The Netherlands.

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http://doi.wiley.com/10.1002/pmic.200700551
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http://dx.doi.org/10.1002/pmic.200700551DOI Listing
March 2008

Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia.

Radiother Oncol 2007 Jun 17;83(3):346-52. Epub 2007 May 17.

Department of Radiation Oncology, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2007.04.026DOI Listing
June 2007

Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.

Radiother Oncol 2007 Jun 24;83(3):353-61. Epub 2007 May 24.

Department of Radiation Oncology (Maastro Lab), GROW Research Institute, Maastricht University, Maastricht, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S016781400700162
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http://dx.doi.org/10.1016/j.radonc.2007.04.031DOI Listing
June 2007

Control of the hypoxic response through regulation of mRNA translation.

Semin Cell Dev Biol 2005 Aug-Oct;16(4-5):487-501

Department of Radiation Oncology, Maastricht Radiation Oncology (Maastro) Lab, GROW Research Institute, USN50/23 University of Maastricht, P.O. Box 616, 6200MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.semcdb.2005.03.009DOI Listing
July 2006

Translational control of gene expression during hypoxia.

Cancer Biol Ther 2006 Jul 1;5(7):749-55. Epub 2006 Jul 1.

Department of Radiation Oncology, Maastricht Radiation Oncology (Maastro) Lab, GROW Research Institute, Maastricht, The Netherlands.

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http://dx.doi.org/10.4161/cbt.5.7.2972DOI Listing
July 2006

The hypoxic proteome is influenced by gene-specific changes in mRNA translation.

Radiother Oncol 2005 Aug;76(2):177-86

Department of Radiation Oncology (MAASTRO Lab), Research Institute Growth and Development, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.radonc.2005.06.036DOI Listing
August 2005

Targeting hypoxia tolerance in cancer.

Drug Resist Updat 2004 Feb;7(1):25-40

Maastricht Radiation Oncology (Maastro) Lab, GROW Research Institute, University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.drup.2003.12.004DOI Listing
February 2004